4TH MERIAL FORUM HAVE WE GOT PCVD &SWINE INFLUENZA UNDER       CONTROL?
Reduction ofHigher Health             antibiotics in theNetherlands, field cases                   Frans Dirven           ...
Agenda•   1 introduction•   2 reduction of antibiotics; why? how much?•   3 reduction of antibiotics; how? results•   4 mo...
1 introduction;Lintjeshof practice• 25 vets/16 specialized in Swine, 4 locations covering  the Netherlands, 2 locations in...
5
6
Lintjeshof practice• approximately 25 % market share in NL•   swine ( 80 % )                    •    14 vets•   cattle ( 8...
Pharmacy, operation and managementVet practice and lab6/5/2012               lintjeshof                                  88
Vet. Pharma companies                   wholesalersLicence traders         Veterinary pharmacy         Veterinary clinic+ ...
Current situation• Farms are becoming bigger (1000-2000 sows),  small breeding farms disappear• Productivity is going up t...
Data• 900.000 sows• 7 million piglets exported Germany!• Production cost piglet 25kg: 49 euro• Per sow highest production ...
Total of farms decreasing, total      animals pro farm increasing12
Facts•   Strong focus on costs•   Continuous system (many movement of pigs)•   Higher health difficult to obtain (many dis...
Agenda•   1 introduction•   2 reduction of antibiotics; why? how much?•   3 reduction of antibiotics; how?•   4 moment of ...
2 reduction of antibiotics; why?              how much?• High usage of ab has become a political item• Increasing resistan...
Volkskrant                                               20076/5/2012   presentatie f.dirven lintjeshof           16      ...
17
Average daily doses per animal/year                                      18
Antibiotic-resistance
Prevalence of MRSA
Moment of consideration•   How much reduction? 2008-2013: 50%•   Separation between vet practice and pharmacy?•   Vet is g...
Agenda•   1 introduction•   2 reduction of antibiotics; why? How much?•   3 reduction of antibiotics; how? results•   4 mo...
reduction of antibiotics; how? results•   Introducing ddy•   Introducing vetcis (databank)•   Introducing SDA (vet drugs a...
vetcis
reduction of antibiotics; how? results• Prudent use (dosage, days, diagnosis)• Alternatives : MCFA’s, probiotics , immune ...
Strategy to higher health• Improvement veterinary strategy• Improvement management at farmlevel• Improvement feed strategy
Improvement veterinary strategyNo more “old school”:• lots of emergency therapies• farewell and entry medications• vaccina...
Improvement veterinary strategy• Proper diagnosis!! Define the primary agent• Vaccinate against primary diseases  (prrs, f...
6/5/2012   lintjeshof   3636
Improvement of veterinary strategyPrevention by vaccination:• New vaccins (mycoplasma, flu, prrs, circo, glasser etc)  com...
Improvement of veterinary strategyPainkillers• Symptomatic, mostly viral infections• Less anorexia (dg fatteners)• Reducin...
Serological monitoring by spc
Fieldcases antibiotic reductionCase 1:• Closed herd (500 sows, 4000 fatteners)• Problems fatteners: diarrhea, runts, high ...
Results case 1    before vaccination                transition                        all vaccinated animals8             ...
Fieldcases antibiotic reductionCase 2• Sow farm (expanding from 900-1800 sows)• 30 piglets sow/year (weekly production)• P...
Fieldcases antibiotic reductionCase 2• PCR fetus: parvovirus- (vaccinated), prrs-, circo-• Bloodsamples: csf-• Bloodsample...
diagnostics case 2            Influenza no seroconversion 9                                                         9 8   ...
diagnostics case 2            Prrs no seroconversion4,0                                                       4,03,5      ...
diagnostics case 2            App no seroconversion 2,2                                                       2,2 2,0     ...
diagnostics case 2      Circo IgM/IgG seroconversion2,2                                                 2,22,0            ...
Results case 2• After 6 weeks increase of problems• No effect extra SIV vaccination or antibiotics• Lab results:  herd vac...
Fieldcases antibiotic reductionCase 3• The effect of the application of mono-lauric acid  with glycerol mono-laurate in we...
Results case 3; 34 farm with la/gml140                                                                                    ...
Results case 3; 37 farms without la/gml250                                                                                ...
Results case 3• Significant reduction in antibiotic use on farms  using LZ/GML•   De Snoeck1*, S., van der Wolf2 P.,, Swar...
Fieldcases antibiotic reductionCase 4• Breeding herd 800 sows , high health• Piglets: seronegative (prrs, app, mhyo, pia) ...
Results case 4Product                   amount   Period 1   Period 2Doxycyclin 100% 1kg                2          2Trim/su...
Improvement of general farm             management• Very important, not only health-management  also total farm-management...
Improvement of general farm             managementStructural changes in housing systems;• continuous productionsystems vs ...
ADD fixed week production system57
Improvement of general farm               management•   Stock density!! Many farms +10-20%•   SPF monitoring system (Denma...
Agenda•   1 introduction•   2 reduction of antibiotics; why? how much?•   3 reduction of antibiotics; how? results•   4 mo...
4 moment of consideration•   vetcis: reduction about 32 %•   Sda gives ddy (sows+piglets 20, fatteners 13)•   No more prev...
teteten
62
Challenge• New decrease 20% (with swine sector)• Veterinarian becomes “health” director at farmlevel  (1 on 1 relation) wi...
Another challenge:Big ChallengeTEAM LINTJESHOF
Threats?• Therapeutic bandwidth• Are certain problems without antibiotics kept under  control (e.g. strep. suis)• Unable t...
Agenda•   1 introduction•   2 reduction of antibiotics; why? how much?•   3 reduction of antibiotics; how? results•   4 mo...
Conclusions• Profitability in swine production strongly influenced by  farm health status• Food producers (decrease of ant...
Thank you for your attention
03antibiotics r aerts
03antibiotics r aerts
03antibiotics r aerts
03antibiotics r aerts
03antibiotics r aerts
03antibiotics r aerts
03antibiotics r aerts
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03antibiotics r aerts

  1. 1. 4TH MERIAL FORUM HAVE WE GOT PCVD &SWINE INFLUENZA UNDER CONTROL?
  2. 2. Reduction ofHigher Health antibiotics in theNetherlands, field cases Frans Dirven Vet. Practice Lintjeshof Rob Aerts DVM Nederweert, The Netherlands Lintjeshof Netherlands 2 2
  3. 3. Agenda• 1 introduction• 2 reduction of antibiotics; why? how much?• 3 reduction of antibiotics; how? results• 4 moment of consideration• 5 conclusions
  4. 4. 1 introduction;Lintjeshof practice• 25 vets/16 specialized in Swine, 4 locations covering the Netherlands, 2 locations in Germany (1 in Belgium)• The service we offer: – Vet expertise /consultancy – Diagnostic lab and monitoring – Pharmacy with product display
  5. 5. 5
  6. 6. 6
  7. 7. Lintjeshof practice• approximately 25 % market share in NL• swine ( 80 % ) • 14 vets• cattle ( 8 % ) • 3 vets • 1 vet• poultry ( 7 % ) • 4 vets• companion Animals (5 %) • All Specialized• 25 vets, 3 laboratory assistants• 14 Secretarial staff• MT (operational-,financial manager and managing director)• Iso-nen certified
  8. 8. Pharmacy, operation and managementVet practice and lab6/5/2012 lintjeshof 88
  9. 9. Vet. Pharma companies wholesalersLicence traders Veterinary pharmacy Veterinary clinic+ pharmacy Antihelmintics Farmvet prescription under prescription Farmer9
  10. 10. Current situation• Farms are becoming bigger (1000-2000 sows), small breeding farms disappear• Productivity is going up to 30 piglets / sow / year• Total piglet production is rising• Producer is more dependant on export (large units up to 5000 sows)• Family farms, closed herds ( 300- 500 sows, 2500 – 5000 fatteners) rather independent
  11. 11. Data• 900.000 sows• 7 million piglets exported Germany!• Production cost piglet 25kg: 49 euro• Per sow highest production of meat (kg)/year (followed by Denmark and France)• Production cost of 1kg porc: 1,46 euro
  12. 12. Total of farms decreasing, total animals pro farm increasing12
  13. 13. Facts• Strong focus on costs• Continuous system (many movement of pigs)• Higher health difficult to obtain (many diseases)• SPF difficult to maintain (swine density)• No support for “megafarms”• High usage of antibiotics (political statement)• Highly dependant on export!!! Health is most important topic
  14. 14. Agenda• 1 introduction• 2 reduction of antibiotics; why? how much?• 3 reduction of antibiotics; how?• 4 moment of consideration• 5 conclusions
  15. 15. 2 reduction of antibiotics; why? how much?• High usage of ab has become a political item• Increasing resistance (MRSA,Klebsiella, E Coli)• ESB-L issues…..• Transfer of resistant bacteria/ genes direct; poor hygiene indirect; environment (soil,surface waters)• vet held responsible for increase in usage…
  16. 16. Volkskrant 20076/5/2012 presentatie f.dirven lintjeshof 16 16
  17. 17. 17
  18. 18. Average daily doses per animal/year 18
  19. 19. Antibiotic-resistance
  20. 20. Prevalence of MRSA
  21. 21. Moment of consideration• How much reduction? 2008-2013: 50%• Separation between vet practice and pharmacy?• Vet is gatekeeper for animal and human health• Curative use only, preventive use prohibited?• Separation of human/ animal ab (cephalosporines, quinolones banned since 1jan2012) (ab for human use only and vice versa)
  22. 22. Agenda• 1 introduction• 2 reduction of antibiotics; why? How much?• 3 reduction of antibiotics; how? results• 4 moment of consideration• 5 conclusions Lintjeshof, 30 maart 2011
  23. 23. reduction of antibiotics; how? results• Introducing ddy• Introducing vetcis (databank)• Introducing SDA (vet drugs authority)• Benchmark farmers and vets (penalties?)• Separation vet pharmacy and practice (pervert)?• Income of vet independent margin on drugs
  24. 24. vetcis
  25. 25. reduction of antibiotics; how? results• Prudent use (dosage, days, diagnosis)• Alternatives : MCFA’s, probiotics , immune stimulating products, vitamines, antioxydantia, mycotoxin binders• Vaccines (circo, myco, prrs, flu, parvo….)• Symptomatic therapies in case of acute illness ( nasa, metacam, paracetamol)• Focus on higher health
  26. 26. Strategy to higher health• Improvement veterinary strategy• Improvement management at farmlevel• Improvement feed strategy
  27. 27. Improvement veterinary strategyNo more “old school”:• lots of emergency therapies• farewell and entry medications• vaccination at entry fattening unit because of mistrust between breeder, fattener and trader• Many combinations of abWe are producing food, not only kg of meat
  28. 28. Improvement veterinary strategy• Proper diagnosis!! Define the primary agent• Vaccinate against primary diseases (prrs, flu, circo, mhyo, parvo)• Antibiotics just for secondary infections (pasteurella, app, glässer….strep suis???)• Painkillers in case of fever/ severe illness to increase feed/water intake• Blood monitoring for diagnostics and herd-health- passport• Improving of general farm management
  29. 29. 6/5/2012 lintjeshof 3636
  30. 30. Improvement of veterinary strategyPrevention by vaccination:• New vaccins (mycoplasma, flu, prrs, circo, glasser etc) combi vaccins• Top down (young gilts, sows,piglet, fatteners)• Decrease of antibiotics (kg) is the objective and improvement of technical results• Higher healthstatus (prrs neg piglets)• Return on investment !!!(proper diagnosis)
  31. 31. Improvement of veterinary strategyPainkillers• Symptomatic, mostly viral infections• Less anorexia (dg fatteners)• Reducing fever (most sows abort due to fever)• Total health at higher level• Less secondary infections ( combination management)• If so, individual antibiotic use. Lintjeshof, 30 maart 2011
  32. 32. Serological monitoring by spc
  33. 33. Fieldcases antibiotic reductionCase 1:• Closed herd (500 sows, 4000 fatteners)• Problems fatteners: diarrhea, runts, high mortality (5-6%), no lung problems• Tiamutin used on regular basis• Brachyspira-, salmonella-, pia+• Bloodsampling and necropsy: high viral load pcv2• Vaccination against pcv at 3 weeks of age
  34. 34. Results case 1 before vaccination transition all vaccinated animals8 60,07 50,06 40,054 30,03 20,02 10,010 0,0 Jan - April 09 May - Aug 09 Sept - Dec 09 Jan - April 10 May - Aug 10 Sept - Nov 10 mortality % Average number of Daily Dosage per animal year
  35. 35. Fieldcases antibiotic reductionCase 2• Sow farm (expanding from 900-1800 sows)• 30 piglets sow/year (weekly production)• Positive on prrs and influenza• Vaccination: piglets: circo 3 wk, sows: prrs and influenza• 2010 (august) reproductive problems (abortions, fever, reduced feed intake, 3% mortality)• No effect antibiotics, only pracetam (fever) Lintjeshof, 30 maart 2011
  36. 36. Fieldcases antibiotic reductionCase 2• PCR fetus: parvovirus- (vaccinated), prrs-, circo-• Bloodsamples: csf-• Bloodsamples: influenza, prrs, app, circo• Extra influenza vaccination started no effect
  37. 37. diagnostics case 2 Influenza no seroconversion 9 9 8 8 7 7 6 6HI-waarde HI-waarde 5 5 4 4 3 3 2 2 1 1 0 0 1 2 3 4 5 6 7 8 9 10 1 2 3 4 5 6 7 8 9 10 11 12 13 14 buisnummer buisnummer
  38. 38. diagnostics case 2 Prrs no seroconversion4,0 4,03,5 3,53,0 3,02,5 2,5S/P ratio S/P ratio2,0 2,01,5 1,51,0 1,00,5 0,50,0 0,0 1 2 3 4 5 6 7 8 9 10 1 2 3 4 5 6 7 8 9 10 11 12 13 14 buisnummer buisnummer
  39. 39. diagnostics case 2 App no seroconversion 2,2 2,2 2,0 2,0 1,8 1,8 1,6 1,6 1,4 1,4S/P ratio S/P ratio 1,2 1,2 1,0 1,0 0,8 0,8 0,6 0,6 0,4 0,4 0,2 0,2 0,0 0,0 1 2 3 4 5 6 7 8 9 10 1 2 3 4 5 6 7 8 9 10 11 12 13 14 buisnummer buisnummer
  40. 40. diagnostics case 2 Circo IgM/IgG seroconversion2,2 2,22,0 2,01,8 1,81,6 1,61,4 1,4OD OD1,2 1,21,0 1,00,8 0,80,6 0,60,4 0,40,2 0,20,0 0,0 1 2 3 4 5 6 7 8 9 10 1 2 3 4 5 6 7 8 9 10 11 12 13 14 buisnummer buisnummer
  41. 41. Results case 2• After 6 weeks increase of problems• No effect extra SIV vaccination or antibiotics• Lab results: herd vaccination circovac after 2 weeks strong improvement (until today)• Vaccination scheme: gilts: 3 weeks and before first insemination sows: at 10 weeks of gestation piglets: 3 weeks of age
  42. 42. Fieldcases antibiotic reductionCase 3• The effect of the application of mono-lauric acid with glycerol mono-laurate in weaned piglets on the use of antimicrobials in sow herds.• Effect against gram+ bacteria ( streptococcus, staphylococcus)• Product used for 6 months in nursery feed• Effect on use of trimethoprim/sulfa, amoxicillin
  43. 43. Results case 3; 34 farm with la/gml140 dagdosering zeugen voor120100 dagdosering zeugen na 80 60 40 20 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34
  44. 44. Results case 3; 37 farms without la/gml250 dagdosering zeug 1e periode200 dagdosering zeug 2e periode15010050 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37
  45. 45. Results case 3• Significant reduction in antibiotic use on farms using LZ/GML• De Snoeck1*, S., van der Wolf2 P.,, Swart2, W., Heiiman3, E., Ebbinge3, B.• 1 Veterinary Practice Lintjeshof, Nederweert, The Netherlands• 2 Animal Health Service, Deventer, The Netherlands• 3 Daavision B.V., Oss, The Netherlands Box and Whisker Plot 40 10 deltaDD -20 -50 0 1 Lintjeshof, 30 maart 2011 laur 62 cases
  46. 46. Fieldcases antibiotic reductionCase 4• Breeding herd 800 sows , high health• Piglets: seronegative (prrs, app, mhyo, pia) monitoring every 4 months• Vaccination: sow: prrs, influenza, ery/parvo, app, e.coli piglets: glässer, pcv2• Problems in nursery (light coughing, low feedintake after weaning, mortality 3%, high use of ab (tetracyclin, trim/sulf)• Week 1+2 after weaning pracetam in feed
  47. 47. Results case 4Product amount Period 1 Period 2Doxycyclin 100% 1kg 2 2Trim/sulfa 80/420 5kg 12 2Ampicillin 100ml 204 114Draxxin 50ml 23 18Powerflox 100ml 30 12Florkem 100ml 15 10Oxytetracyclin 100% 5kg 17 0ADD 46 7
  48. 48. Improvement of general farm management• Very important, not only health-management also total farm-management• Without good management every veterinary therapy is useless• Labour hours will be decreasing (more hours to spent for other subjects such as fertility)• Employees have a higher labour moral
  49. 49. Improvement of general farm managementStructural changes in housing systems;• continuous productionsystems vs fixed week production system (poultry)• no mixing up animals from different origins• animals of same age• all in all out• strictly 1 to 1• multisite production
  50. 50. ADD fixed week production system57
  51. 51. Improvement of general farm management• Stock density!! Many farms +10-20%• SPF monitoring system (Denmark)• Eradication of diseases (auj, prrs, mhyo, app)• New farms start SPF
  52. 52. Agenda• 1 introduction• 2 reduction of antibiotics; why? how much?• 3 reduction of antibiotics; how? results• 4 moment of consideration• 5 conclusions
  53. 53. 4 moment of consideration• vetcis: reduction about 32 %• Sda gives ddy (sows+piglets 20, fatteners 13)• No more preventive medication (poor management)• Discussion quinolones, cephalosporines (01-01-2012)• No antibiotic mixing at feedmill (01-09-2011)• Political discussion about split (vetclinic/pharmacy)• Veterinarian most involved person at farm (farmspecific healthplan, welfare, control zoonotic diseases and art 1 diseases) 1 to 1 contract with farmer.• Income; margin drugs? and hourly fee ? Contract ? Sector? Ministry ?
  54. 54. teteten
  55. 55. 62
  56. 56. Challenge• New decrease 20% (with swine sector)• Veterinarian becomes “health” director at farmlevel (1 on 1 relation) with help from government to act independant• System higher health and pig pass• Sustainable swine production• More alternatives (vaccines, feed additives, antioxydantia, herbs, toxin binders...........)• Partner for financial returns Lintjeshof, 30 maart 2011
  57. 57. Another challenge:Big ChallengeTEAM LINTJESHOF
  58. 58. Threats?• Therapeutic bandwidth• Are certain problems without antibiotics kept under control (e.g. strep. suis)• Unable to go to higher health (density of farms and animals)• Cost price meat in W. Europe? International competition• Is consumer willing to pay for better and safer meat ?• Will the vet be sufficiently paid for advice to keep his quality and know how Lintjeshof, 30 maart 2011
  59. 59. Agenda• 1 introduction• 2 reduction of antibiotics; why? how much?• 3 reduction of antibiotics; how? results• 4 moment of consideration• 5 conclusions
  60. 60. Conclusions• Profitability in swine production strongly influenced by farm health status• Food producers (decrease of antibiotics)• Reduction of ab strongly depending on farm health status• End 2012 50% ab reduction (32% is obtained)• Alternatives for antibiotics………….• Strong improvement general management and sector structure• In the end a higher return on investment at farmlevel• Swineproducers need to improve their competitiveness
  61. 61. Thank you for your attention
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