The UNM Research Enterprise: Translating Science to Medical Cures

The UNM Research Enterprise: Translating Science to Medical Cures Richard S. Larson, M.D., Ph.D. HSC VP for Translational Research SOM Sr. Associate Dean for Research

Overview
Goal/Vision
Growth
Strategy & Organization
Scientific Highlights
Commercialization Effort

Goal/Vision
The goal of the UNM HSC is to accelerate the translation of scientific discovery to improved health.
We will achieve this by creating a platform that transforms research at UNM into a continuum extending investigation from discovery into practice, thereby linking even the most basic research to practical improvements in human health.

Strategies:
Programmatic Grants
Clinical Trials growth
Diversification of Portfolio

Year UNM HSC Research Funding (Percent of 1990 Dollars) Growth of UNM HSC Research Funding Compared to Growth of NIH Research Funding 1995 1990 2005 2000 1990: $25 Million 2008: $134 Million UNM NIH Source for NIH Data: http://www.aaas.org/spp/rd/cht9005a.pdf

Translating Discovery into Medical Practice
6 Signature Research Programs
Brain and Behavioral Illnesses
Cancer
Cardiovascular and Metabolic Diseases
Environmental Health
Infectious Diseases and Immunity
Child Health Research
Bench Bedside Community Conceptual Process of Bench to Bedside to Practice Research

P & U Submissions & Received Data FY 2006 FY 2007 FY 2008 FY 2009 U - Submissions 20 25 39 6 U - Received 18 32 32 11 P - Submissions 6 5 8 1 P - Received 5 5 7 2

Recent programmatic grants
Infectious Disease & Immunity
Pulmonary Responses to Bioweapon Category A Pathogens
Hantavirus Ecology and Disease in Chile and Panama
Cancer
University of New Mexico Cancer Center Support
University of New Mexico Center for Molecular Discovery
Environmental Health Sciences
Genetics of Kidney Disease in Zuni Indians
Children’s Health
Prevention Research Center
Treating Children to Prevent Exacerbations of Asthma (TREXA)
Brain & Behavioral Illnesses
Integrative Program in CNS Pathophysiology Research
Fetal Ethanol-induced Behavioral Deficits: Mechanisms, Diagnoses, and Interventions
Diabetes Prevention Program Outcomes study
INBRE

BRAIN AND BEHAVIORAL ILLNESS SIGNATURE PROGRAM
Brain injury
Stroke
Trauma
Immune-mediated brain disorders
Dementia, movement disorders, epilepsy, critical care neurology
Addictive behavior
Alcohol and substance abuse
Schizophrenia
Neurodevelopmental disorders
Fetal alcohol spectrum disorder
Autism spectrum disorders
Heavy metal exposure
Cerebral palsy
Technology Development
Advanced MRI technologies: spectroscopic imaging, metabolite diffusion, real-time fMRI
Magnetoencephalography
Continuous cerebral blood flow measurement in the ICU
Brain slice electrophysiology and combined fluorescence imaging

Mission - To enhance the opportunities for research in Cardiovascular and Metabolic Diseases at the University of New Mexico by facilitating collaborative inter-disciplinary scientific interactions and discussions, supporting the study of new ideas and fostering the development of new investigators.
Strategic organization to address national trends - Areas of research include basic science, clinical and translational studies focusing on:
Cardiovascular Disease (Leading cause of death in NM residents; 11.7% of population nationally diagnosed with CV disease)
Diabetes (9% of the NM population has diabetes compared to 7% nationally; 2-3X higher incidence in Native Americans and Hispanics)
Obesity (57% of NM adults are considered overweight or obese compared to 32% nationally)
Alignment with Training programs
Cardiovascular Biology Training Grant for graduate students and postdoctoral fellows (17th year of funding)
CTSC pilot projects and scholars program
Integration of basic, clinical and translational Sciences - Numerous collaborative interactions exist. i.e. Studies of cytokine-induced protein catabolism in vitro subsequently examined in patients with chronic kidney disease leading to studies examining the effectiveness of blocking cytokine activation in dialysis patients. examining the effectiveness of blocking cytokine activation in dialysis patients.
Leveraging between HSC and UNM programs - i.e.Studies of cytokine-induced protein catabolism in vitro subsequently examined in patients with chronic kidney disease leading to studies examining the effectiveness of blocking cytokine activation in dialysis patients.
Partnerships
Lovelace Respiratory Research Institute collaborative studies on vascular disease
Sandia National Laboratory nanotechnology programs for detection of disease markers
Numerous Pharma relationships for clinical trials and product testing and development

Infectious Diseases and Immunity
Mission – To develop and enhance collaborative programs among researchers, physicians and businesses in New Mexico to address the threat of infectious and immunologically mediated diseases in New Mexican populations and the world by characterizing epidemiologic issues, studying basic host-pathogen mechanisms, developing new vaccines, therapeutics, and diagnostics, and testing the preventive, therapeutic and diagnostic efficacy of these discoveries in clinical trials.
Strategic organization to address national trends
CIDI nationally known for Biodefense
CIDI has outstanding emerging infections research: Hantavirus, tuberculosis, West Nile Virus
Alignment with Training programs
Ninth year of T32 Infectious Disease and Inflammation training program
Funds grad students and postdocs
Center for Biomedical Research Excellence (COBRE) submitted 2007
Integration of basic,clinical and translational Sciences
Vaccine preclinical development- Papilloma virus research
Tularemia vaccine development team
Translating genetically based predisposition to infections into drugs ( deCode project)
Leveraging between HSC and UNM programs
Clinical and Translational Research Center
Center for Biomedical Engineering
Department of Computer Science
School of Pharmacy
Partnerships - Lovelace Respiratory Research Institute, Sandia National Labs, Multiple Biotechnology companies ( deCoded Genetics, Rules Based Medicine , Exagen Inc

Cancer
Mission
T he UNM Cancer Research & Treatment Center, is dedicated to curing cancer by conducting world class research, reducing cancer health care disparities in our NM population, educating the next generation of cancer researchers and healthcare professionals, and delivering state of the art cancer treatment to all New Mexicans.
Achieve designation and federal funding from NCI as nations newest NCI designated cancer center
One of Americas top 50 cancer hospitals (US News and World Report)
Alignment with training programs
T35 for minority students
Integration of basic, clinical and translational Sciences
Awarded NCI designation
Nanoparticle imaging projects, genomic studies, clinical trials
Integrates College of Pharmacy, multi-departments and School of Medicine
Partnerships
Lovelace Respiratory Research Institute
Sandia National Laboratories
Los Alamos National Labs
New Mexico’s Universities
New Mexico’s biotechnology industry
New Mexico Department of Health
Pueblo’s, Tribe’s and Indian Nations
Senior Scientific, Inc.

Environmental Health Sciences
Mission
Studies potential environmental causes of airway inflammation, asthma, kidney disease, cancer and other environmental diseases
Funded by NIEHS for $4.2M 4/03 – 3/07 (renewal planned 3/08)
Integration of basic, clinical and translational sciences
Clinicians, applied and basic scientists as well as key community partners
Strong collaborations between SOM and COP
Partnerships
Lovelace Respiratory Research Institute
UNM Advanced Research Cooperation in Health (ARCH) Grant between UNM (RIU) and University of Texas, El Paso (MSU)
Border Health Collaborations
Numerous native communities directly involved as collaborators in projects
Sandia National Laboratories

NMCIM Progress on Research and Economic Development
$1.03M Keck grant (Sklar, PI with UNM CRTC) enabled NMCIM to develop a unique and advanced small animal imaging resource (KUSAIR) in association with the UNM CRTC for micro-PET imaging and NanoSPECT/CT Imaging; an industrial partnership has been established with Bioscan, Inc
The State of New Mexico Technology Research Consortium (TRC) committed $350K in funds to develop a Germanium-68 (Ge 68 ) generator to produce Gallium-68 (Ga 68 ) a 68 min half life PET imaging agent that can be linked to targeting molecules; we are in-line for more State and Federal funds
Ga 68 Generators will be developed in collaboration with industrial partners: production of Ga 68 imaging agents will allow radiopharmaceuticals to be prepared independent of cyclotrons and will produce superior imaging quality with less radiation exposure
First generation Ga 68 -DOTA imaging agents will be prepared to target somatostatin receptors and EGF receptors
Future applications for estrogen receptors and LFA will utilize NanoSPECT/CT

General Clinical Research Center (GCRC)
Year 32 of funding with an annual budget from NCRR of approximately $3M
An essential resource for enabling physician-scientists to compete nationally
All 78 GCRC’s will be phased out by 2010 beginning this year
To provide state-of-the-art infrastructure support for NIH funded and developing clinical and translational researchers, including space, inpatient, outpatient and pediatric nursing, bionutrition, clinical laboratory, biostatistics, biomedical informatics, and pharmacy services.

Clinical and Translational Science Center Enhanced Vision of healthcare and clinical research
NIH initiative to transform the way in which clinical research and training is done
Designed to integrate clinical, translational and basic science research
Infrastructure to support integrated research structure
Educational component: New MSCR, PhD programs
Increase support to community and practice based research
40-50 will be awarded by 2010 - assures that UNM will be in top 40-50 of HSCs in the country
$25 million over 5 years
Tobacco Settlement funds allocated for clinical trials within CTSC in FY08 and FY09
Conceptual Process of Bench to Bedside to Practice Research

New Model of Health Care Improvement: Linking Research and Clinical Care
Identify community health priorities (liaisons, HEROs, Community Engagement Council, web page, database)
Direct clinical trials and other interventions to community and local health care providers
Find approaches that most effectively address health issues
Establish education and dissemination processes that improve care in New Mexico communities

New Biotechnologies
Biosensor
One-handed Needle
Screening Center

Molecular Libraries Network HyperCyt Discovery Platform Discovery and Innovation MLSCN Partnership Logos Biotech Economic Dev. Translation: Imaging Diagnostics Repurposing The University of New Mexico Division of B IOCOMPUTING Burnham Scripps Emory U Penn U Pitts Vanderbilt Columbia Southern Research UNM

Building a Biomedical Research Corridor in New Mexico Visualizing these partners within the Biomedical Research Corridor represents the meeting of our scientific expertise and intellectual property with commercialization of research results for the public good. Our faculty provide the intellectual property, expert consultation, and cutting edge business knowledge to make these startup companies and alliances a unique contribution to the State of New Mexico and the City of Albuquerque. Not only does the UNM Biomedical Research Corridor contribute to the public good by introducing exciting new products to the marketplace, it also makes a significant impact on the economic development of the state by providing jobs and generating tax dollars. These partners and affiliates are examples of entrepreneurial efforts that exist, in part, due to the presence of the UNM Health Sciences Center.

Summary
HSC has growing research enterprise that is disease-focused
HSC seeks partners for commercialization and clinical application

The UNM Research Enterprise: Translating Science to Medical Cures

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