0
Jeanne-Marie Guise, M.D., M.P.H.
Director, Oregon BIRCWH and Comparative Effectiveness K12 Programs
Cynthia Morris, PhD, M...
Predoctoral Individual NRSA (F31)
Predoctoral Individual MD/PhD NRSA (F30)
T32: Postdoctoral Institutional Training Grant
...
K Support
• Salary Support
– Low (supplement clinically)
– 75% time (50% for some specialties)
– For training
– For conduc...
Institutional K vs. Independent K
vs. R01
Independent K
• Higher probability of
funding (vs. R01)
• Your previous track
re...
Institutional Ks
• BIRCWH (Dorsa,Guise) – Building Interdisciplinary
Research Careers in Women’s Health (NICHD)
Basic, Tra...
Independent Ks
• K01: Mentored Research Scientist
• K02: Independent Scientists Award
• K08: Mentored Clinical Scientist
•...
CD 7
NUMBER OF ENTRY LEVEL RESEARCH CAREER AWARDS
0
250
500
750
1,000
1,250
1998 1999 2000 2001 2002 2003 2004 2005 2006 2...
CD 8
SELECT RESEARCH CAREER DEVELOPMENT AWARDS
APPLICATIONS, AWARDS, AND SUCCESS RATES
0%
20%
40%
60%
80%
100%
1998 1999 2...
CD 9
NUMBER OF INDIVIDUAL RESEARCH CAREER AWARDS
BY INSTITUTES AND CENTERS
2007
NCMHD
NCCAMFICNIBIBNLM
NHGRI
NIGMSNINR
NIE...
CD 10
K01 APPLICATIONS AND AWARDS
BY PARTICIPATING INSTITUTES AND CENTERS
FY 2007
0
20
40
60
80
100
120
NIDDK
NIMH NCI
NIA...
CD 11
K08 APPLICATIONS AND AWARDS
BY PARTICIPATING INSTITUTES AND CENTERS
FY 2007
0
25
50
75
100
125
NHLBI
NIAID NCI
NIDDK...
CD 12
K23 APPLICATIONS AND AWARDS
BY PARTICIPATING INSTITUTES AND CENTERS
FY 2007
0
20
40
60
80
100
120
NIMH
NHLBI
NIA
NID...
CD 13
K24 APPLICATIONS AND AWARDS
BY PARTICIPATING INSTITUTES AND CENTERS
FY 2007
0
5
10
15
20
25
NIDDK
NIMH
NHLBI
NICHD
N...
NICHD Independent K Award
Success Rates 2005-2009
OCTRI Education and
Career Development
Cynthia Morris, Director
Educational Platform
Health Professional
Students, Predoctoral
Students
Clinical and
Postdoctoral Fellows
OHSU and
KP facu...
Clinical Research Education at OHSU
Master of Clinical Research
• Certificate program (2 years)
• Focused education in inf...
Core Competencies
• Identify major clinical or public health problems and
relevant research questions.
• Identify, interpr...
Core Competencies, continued
• Employ effective information management.
• Identify, evaluate, and minimize risks to resear...
HIP Capstone
• This mentored project pairs one or more
mentors with trainee
• End product: NIH R01 or K grant (or equivale...
HIP Buffet
• An informal forum to lean about practical
topics for research
• Alternate Tues/Weds at noon
• Examples:
– Dev...
OCTRI SCHOLARS PROGRAM
Who can participate?
• Anyone at OHSU or VA who is applying for a
career development award or first...
OCTRI SCHOLARS: What is available?
• Educational program
• Support of the scholar through
supplemental mentoring activitie...
• Support to maximize odds of research success
– OCTRI Design Studio
– Career Development Award (CDA) Library
– Targeted i...
Grow from Within to Excellence
A Mentoring Initiative
• Lead Mentor Program (cohort of 15-18)
– Take responsibility for de...
OHSU Clinical & Translational
Research Resources
Darlene Kitterman
Program Director, OCTRI Investigator
Support & Integrat...
Accessing OHSU Research Resources
• Women’s Health Research Unit (WHRU): Single point of
contact to coordinate resources f...
OCTRI Research Navigator Program
• Gateway to OCTRI Resources: Single point-of-contact for OCTRI services
• Facilitates ac...
OHSU resources for all stages of
translational research
Design and
planning
Funding
application
Pre-study
and start-up
Car...
Design and Planning
• Finding collaborators
– Ob/gyn, OHSU & Kaiser Permanente
• Statistical support
– Design
– Sample cal...
Funding Application
• Statistical support
• Grant development
– Writing/editing
– Budget development (grant and industry)
...
Pre-study & Start-Up
• Compliance submission services
– Protocol development
– IRB submissions (OHSU, KPCHR, VA)
– IND/IDE...
Implementation Stage
• Research space
– OCTRI CTRC inpatient (MPV2SE)
– Outpatient
• WHRU MPV
• OCTRI CTRC: HRC & CHH
• Re...
Analysis & Publication
• Statistical services
– Data analysis
– Manuscript preparation
Design and
planning
Funding
applica...
Resources for Funding at OHSU
Rachel Dresbeck, Ph.D.
Research Funding & Development Services
Funding landscape at OHSU
OHSU researchers brought in
$392 million in FY 2010
Research Funding & Development Services
Rachel Dresbeck, Ph.D.
Director
Currently Hiring
Program Manager
Katie Wilkes
Admi...
Research Funding & Development Services
RFDS
Grant Funding
Proposal
Development
Research
Communications
Grant Funding
• Funding Database
• Weekly Funding Alerts
• Limited Submission Program
• Presidential Bridge Funding
• Inte...
Proposal Development
• Help with grant writing
• Workshops
– Specific Aims Workshop
– NIH Format Change Workshop
• Funding...
Research Communications
• Research News blog
• Email updates
Where to get help
Research Funding and Development Services
www.ohsu.edu/xd/research/administration/research-
funding-deve...
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  • OHSU Researchers brought in $392 million in FY 2010. That’s a lot of research! There are over 1,000 Principle Investigators at OHSU, working on about 3,000 different research projects.
  • RFDS is made up of a staff of three. It is a program that falls within the Office of the Vice President for Research. RFDS also work very closely with other Research Administration offices, including the RGC and SPA.
  • RFDS began with two goals: (1) help researchers find funding opportunities, (2) help those researchers develop the best possible proposals for those grant opportunities. Over time, we’ve also become the lead on Research Communications at OHSU, which means we help disseminate important information about research both internally (faculty, postdocs, etc.), and externally (other institutions, general public).
  • RFDS is here to help you find money for your research. We maintain a database of private funding opportunities (from foundations, professional society’s, etc.) all over the world. We also send out a weekly email that includes plenty of NIH and other government funding opportunities. If you’re new to grant writing, or are looking for something specific, RFDS is a great place to start. Our department also coordinates the Limited Submission process at OHSU, and manages the Presidential Bridge Funding program. Visit the Funding Portal on our website to get started.
  • RFDS offers help on a wide range of topics. From how to write your first grant, to how to handle the latest NIH policy change, contact RFDS and we’ll do our best to help you. If we don’t know the answer, we’ll point you in the direction of someone who can.RFDS also sponsors a monthly brown bag seminar series that addresses topics important to OHSU researchers. Plus, the Director of RFDS, Rachel Dresbeck, teaches a science writing course four times a year, to help investigators improve their writing skills.
  • If you’re a researcher at OHSU, visit the Research News blog, bookmark it, and check back often. RFDS tries to limit the number of emails you receive in your inbox each day, but you can easily set up an RSS feed of the blog. We post information about funding opportunities, upcoming events, and changes in NIH policy.In the event something important does happen, we may also send out a targeted email to certain groups at OHSU.
  • Transcript of "Slide 1"

    1. 1. Jeanne-Marie Guise, M.D., M.P.H. Director, Oregon BIRCWH and Comparative Effectiveness K12 Programs Cynthia Morris, PhD, M.P.H. Director, OCTRI Education and Career Development Core Darlene Kitterman, MBA Director, OCTRI Investigator Support and Integration Services Rachel Dresbeck, Ph.D. Director, Research Development and Communication Services October 2010 Institutional Resources to Help With Research
    2. 2. Predoctoral Individual NRSA (F31) Predoctoral Individual MD/PhD NRSA (F30) T32: Postdoctoral Institutional Training Grant F32: Postdoctoral Individual NRSA Small Grant (R03) Research Project Grant (R01) K02: Independent Scientist Award K05: Senior Scientist Award Fellowships & Career Awards GRADUATE/ MEDICAL STUDENT POST- DOCTORAL FACULTY Predoctoral Institutional Training Grant (T32) K01: Mentored Research Scientist Development Award K08: Mentored Clinical Scientist Development Award K23: Mentored Patient-Oriented RCDA K24: Midcareer Investigator Award in Patient-Oriented Research Exploratory/ Developmental Grant (R21) Training and Career Development Pathway TrainingIndependent Research Grants Transition K99/R00: NIH Pathway to Independence (PI) Award K22: NIAAA Career Transition Award Research Center Grant (U and P series)
    3. 3. K Support • Salary Support – Low (supplement clinically) – 75% time (50% for some specialties) – For training – For conducting research • Research funding – Up to $25,000 per year for research and training expenses (e.g. tuition, books, supplies) • Training is an expected part of Ks – Must describe a training plan in the proposal
    4. 4. Institutional K vs. Independent K vs. R01 Independent K • Higher probability of funding (vs. R01) • Your previous track record can be slim • Limited research funding • Can get an R01 later • Requires NCR yearly R01 • More difficult to get funding • Rating depends in part on PI experience • No limit on research funding • Cannot get a K later • Requires NCR yearly Institutional K • Highest probability of funding • Your previous track record can be slim • Limited research funding • Can get an independent K or R01 later • Requires annual update of information & competitive renewal after 2nd year
    5. 5. Institutional Ks • BIRCWH (Dorsa,Guise) – Building Interdisciplinary Research Careers in Women’s Health (NICHD) Basic, Translational, Clinical, Behavioral 4 slots • OCTRI KL2 (Morris)– Designed for Career Development in Translational Research 6 slots • Child Health Research Center K12 ( Nicholson,Marks) 3 slots • Comparative Effectiveness K12 (Guise,Morris) 4 slots
    6. 6. Independent Ks • K01: Mentored Research Scientist • K02: Independent Scientists Award • K08: Mentored Clinical Scientist • K22: Career Transition award – Postdoctoral fellows in transition to a faculty position • K23: Mentored Patient Oriented Research Career Development • K24: Mid Career Investigator Award in Patient Oriented Research • K25: Mentored Quantitative Research Career Development • K99/R01 Pathway to Independence Award – 1-2 years mentored 3 years independent (intended for postdocs)
    7. 7. CD 7 NUMBER OF ENTRY LEVEL RESEARCH CAREER AWARDS 0 250 500 750 1,000 1,250 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 K08 K23 K01 K25 K99 Fiscal Year NumberofAwards
    8. 8. CD 8 SELECT RESEARCH CAREER DEVELOPMENT AWARDS APPLICATIONS, AWARDS, AND SUCCESS RATES 0% 20% 40% 60% 80% 100% 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 Fiscal Year SuccessRate K01 K02 K08 K23 K24
    9. 9. CD 9 NUMBER OF INDIVIDUAL RESEARCH CAREER AWARDS BY INSTITUTES AND CENTERS 2007 NCMHD NCCAMFICNIBIBNLM NHGRI NIGMSNINR NIEHS NCRRNEI NIDCR NIDCD NIAAA NIAMS NICHDNIANIDA NINDS NIAID NIDDKNCI NIMH NHLBI 0 100 200 300 400 500 600 Fiscal Year NIH Institutes and Centers NumberofAwards 199819992000200120022003200420052006 N C M H D N C C AM FIC N IBIB N LM N H G R I N IG M S N IN R N IEH S N C R R N EI N ID C R N ID C D N IAA A N IAM S N IC H D N IA N ID A N IN D S N IAID N ID D K N C I N IM H N H LBI 0 100 200 300 400 500 600
    10. 10. CD 10 K01 APPLICATIONS AND AWARDS BY PARTICIPATING INSTITUTES AND CENTERS FY 2007 0 20 40 60 80 100 120 NIDDK NIMH NCI NIA NIDA NHLBI NIAMS NINDS NICHD NIAID NINR NCRR NIAAA NIBIB NCCAM NIEHS NIDCD NIGMS FIC Participating NIH Institutes and Centers NumberofApplications/Awards Applications Awards
    11. 11. CD 11 K08 APPLICATIONS AND AWARDS BY PARTICIPATING INSTITUTES AND CENTERS FY 2007 0 25 50 75 100 125 NHLBI NIAID NCI NIDDK NINDS NIAMS NIMH NICHD NIA NIDCR NIGMS NIDA NEI NIDCD NIAAA NIBIB NIEHS NCCAM Participating NIH Institutes and Centers NumberofApplications/Awards Applications Awards
    12. 12. CD 12 K23 APPLICATIONS AND AWARDS BY PARTICIPATING INSTITUTES AND CENTERS FY 2007 0 20 40 60 80 100 120 NIMH NHLBI NIA NIDDK NICHD NINDS NCI NIAID NIDA NCRR NIAMS NIDCR NCCAM NEI NIDCD NIAAA NINR NIEHS NIGMS Participating NIH Institutes and Centers NumberofApplications/Awards Applications Awards
    13. 13. CD 13 K24 APPLICATIONS AND AWARDS BY PARTICIPATING INSTITUTES AND CENTERS FY 2007 0 5 10 15 20 25 NIDDK NIMH NHLBI NICHD NCI NIAID NIA NIDA NINDS NCRR NIAMS NIAAA NEI NCCAM NIDCD NIDCR NINR Participating NIH Institutes and Centers NumberofApplications/Awards Applications Awards
    14. 14. NICHD Independent K Award Success Rates 2005-2009
    15. 15. OCTRI Education and Career Development Cynthia Morris, Director
    16. 16. Educational Platform Health Professional Students, Predoctoral Students Clinical and Postdoctoral Fellows OHSU and KP faculty Educational Platform HIP Curriculum HIP Symposium, Seminars Master of Clinical Research Certificate in Human Investigations T32 OSLER program OCTRI KL2 program
    17. 17. Clinical Research Education at OHSU Master of Clinical Research • Certificate program (2 years) • Focused education in informatics, epidemiology, biostatistics, basic sciences • Mentored capstone Certificate in Human Investigations • Required didactic coursework (2 years) • Mentored capstone Non-degree • Attend courses in C/T research
    18. 18. Core Competencies • Identify major clinical or public health problems and relevant research questions. • Identify, interpret, and critique the state of knowledge regarding a question. • Design and write a research proposal. • Identify appropriate study methods (study design) for a research question considering feasibility, efficiency, and bias-free inference. • Evaluate the reliability and validity of measures. • Use appropriate sample size, power and apply basic statistical principles.
    19. 19. Core Competencies, continued • Employ effective information management. • Identify, evaluate, and minimize risks to research subjects. • Effectively communicate orally and in writing with colleagues and the public. • Work effectively with the diverse community. • Work effectively within a multidisciplinary research team. • Manage a research project (personnel, budget)
    20. 20. HIP Capstone • This mentored project pairs one or more mentors with trainee • End product: NIH R01 or K grant (or equivalent) • End product: Manuscript suitable for publication. Trainee must have designed project, implemented study, directed or conducted statistical analysis, written manuscript
    21. 21. HIP Buffet • An informal forum to lean about practical topics for research • Alternate Tues/Weds at noon • Examples: – Developing a research budget – Finding funding for your study – Time management – Organizing your references – Creating a publication strategy
    22. 22. OCTRI SCHOLARS PROGRAM Who can participate? • Anyone at OHSU or VA who is applying for a career development award or first R01. – “Temporary OCTRI Scholar” status during application • Anyone at OHSU or VA who receives a career development award or first R01 • This includes VA CDA, NIH K awards, and lookalike career development awards
    23. 23. OCTRI SCHOLARS: What is available? • Educational program • Support of the scholar through supplemental mentoring activities. – An informal, monthly noon seminar – A smaller, intensive group who commit to meet biweekly for manuscript and grant development • Support of career development award research through research support. – Talk with research navigator
    24. 24. • Support to maximize odds of research success – OCTRI Design Studio – Career Development Award (CDA) Library – Targeted information dissemination via listserv on funding opportunities, seminars and conference • Support to improve mentoring quality – Participation in an electronic "learning community" for mentors and mentees – Participation in OHSU institutional programs that deliver workshops and seminars targeted to mentors and mentees. OCTRI SCHOLARS: What is available?
    25. 25. Grow from Within to Excellence A Mentoring Initiative • Lead Mentor Program (cohort of 15-18) – Take responsibility for developing mentoring programs within dept or organization. – Mentors share best practices, learn new strategies • Career & Mentoring Series – Seminars and workshops on mentoring • Work-life balance; Coaching through active listening; Mentoring across differences • Mentoring website (www.ohsu.edu/mentoring)
    26. 26. OHSU Clinical & Translational Research Resources Darlene Kitterman Program Director, OCTRI Investigator Support & Integration Services (ISIS)
    27. 27. Accessing OHSU Research Resources • Women’s Health Research Unit (WHRU): Single point of contact to coordinate resources for ob/gyn students and faculty. – Access to WHRU departmental research resources – Triage to OHSU institutional research resources • Oregon Clinical & Translational Research Institute (OCTRI) • Institutional core resources • Navigate research administration – Assist investigators in finding collaborators • Contact – Tracy Lawson, WHRU Administrative Manager – 4-0111 – lawsontr@ohsu.edu
    28. 28. OCTRI Research Navigator Program • Gateway to OCTRI Resources: Single point-of-contact for OCTRI services • Facilitates access to OCTRI and Kaiser Permanente resources: – Resource availability and suitability for the research – Resource costs – OCTRI scientific review process, when applicable • Studies using more than one OCTRI program and; • The study has not received scientific review (Knight Institute, NIH, FDA) or a career development award – OCTRI support for new investigators: some services may be free or subsidized – OCTRI letters of support • Assists investigators in finding collaborators at OHSU and Kaiser Permanente • Contacts – Navigator Service staff • Navigation Manager: Joanne Price • Navigation assistants: Sunitha Jagannathan and Cynthia Malain – Call 503-418-9790 or email OCTRI@ohsu.edu
    29. 29. OHSU resources for all stages of translational research Design and planning Funding application Pre-study and start-up Carrying out the research Analysis and publications
    30. 30. Design and Planning • Finding collaborators – Ob/gyn, OHSU & Kaiser Permanente • Statistical support – Design – Sample calculations – OCTRI free Drop-in sessions: Wednesdays, 4-5pm, HRC14D80 • Patient population feasibility – OCTRI virtual data warehouses (OHSU & KP) – ResearchMatch.org: Julie Mitchell, OCTRI BMIP • Guidance in community and practice-based research Design and planning Funding application Pre-study and start-up Carrying out the research Analysis and publications
    31. 31. Funding Application • Statistical support • Grant development – Writing/editing – Budget development (grant and industry) • Regulatory assistance – Human subject regulation guidance – IND/IDE requirements guidance – Data & Safety Monitoring Plan development Design and planning Funding application Pre-study and start-up Carrying out the research Analysis and publications
    32. 32. Pre-study & Start-Up • Compliance submission services – Protocol development – IRB submissions (OHSU, KPCHR, VA) – IND/IDE submissions to FDA • OCTRI informatics solutions: – Database development: • REDCap: Free basic access – Database: online, webbased data forms and database – Survey: Sophisticated online, webbased survey tool • Free REDCap Tutorials: 1st Tuesday/3rd Monday, 2-4pm, HRC10D03 – Scannable forms – Virtual Data Warehouse: Data from Epic (OHSU & Kaiser) Design and planning Funding application Pre-study and start-up Carrying out the research Analysis and publications
    33. 33. Implementation Stage • Research space – OCTRI CTRC inpatient (MPV2SE) – Outpatient • WHRU MPV • OCTRI CTRC: HRC & CHH • Research nursing services • Study coordinator pool • OCTRI bionutrition services – Dietitian consultations – Patient meals and snacks • Energy expenditure and body composition procedures • OCTRI core laboratory services – Assays – Sample processing and shipping – Genetic analyses Design and planning Funding application Pre-study and start-up Carrying out the research Analysis and publications • Limited OCTRI funding to support costs of OHSU hospital tests and pharmacy services • Regulatory services – IND/IDE annual updates to FDA – GCP monitoring for IND/IDEs • Data & Safety Monitoring Board coordination • OCTRI Biolibrary (OHSU & KP) – Sample access – Sample banking
    34. 34. Analysis & Publication • Statistical services – Data analysis – Manuscript preparation Design and planning Funding application Pre-study and start-up Carrying out the research Analysis and publications
    35. 35. Resources for Funding at OHSU Rachel Dresbeck, Ph.D. Research Funding & Development Services
    36. 36. Funding landscape at OHSU OHSU researchers brought in $392 million in FY 2010
    37. 37. Research Funding & Development Services Rachel Dresbeck, Ph.D. Director Currently Hiring Program Manager Katie Wilkes Administrative Coordinator Contact us: funding@ohsu.edu
    38. 38. Research Funding & Development Services RFDS Grant Funding Proposal Development Research Communications
    39. 39. Grant Funding • Funding Database • Weekly Funding Alerts • Limited Submission Program • Presidential Bridge Funding • Internal funding opportunities • Visit the funding portal on our website! – http://www.ohsu.edu/xd/research/administration /research-funding-development/
    40. 40. Proposal Development • Help with grant writing • Workshops – Specific Aims Workshop – NIH Format Change Workshop • Funding Focus and other forums – Sample topics: Grant Writing 101, Foundation Funding, NIH Public Access Policy, and more! • Vollum Writing Class
    41. 41. Research Communications • Research News blog • Email updates
    42. 42. Where to get help Research Funding and Development Services www.ohsu.edu/xd/research/administration/research- funding-development/index.cfm Email us: funding@ohsu.edu Research Development & Administration www.ohsu.edu/xd/research/administration/index.cfm
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