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Review of Biomedical Research Grants by the US
Review of Biomedical Research Grants by the US
Review of Biomedical Research Grants by the US
Review of Biomedical Research Grants by the US
Review of Biomedical Research Grants by the US
Review of Biomedical Research Grants by the US
Review of Biomedical Research Grants by the US
Review of Biomedical Research Grants by the US
Review of Biomedical Research Grants by the US
Review of Biomedical Research Grants by the US
Review of Biomedical Research Grants by the US
Review of Biomedical Research Grants by the US
Review of Biomedical Research Grants by the US
Review of Biomedical Research Grants by the US
Review of Biomedical Research Grants by the US
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Review of Biomedical Research Grants by the US

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  • This slide represents our dramatic shift in program philosophy, where there are limited funds for traditional awards and Ideas are the highest priority for investment.
    What is an IDEA award?
    The vision of an IDEA project: creative, innovative, novel research that explores untested, unattempted or unrecognized avenues of investigation that may lead to a breakthrough.
    Despite the inherent risk-taking nature of Ideas, successful submissions must demonstrate solid scientific judgment.
    What does the pyramid represent?
    This pyramid illustrates the sense of IDEA awards in the larger context of science. There is an upward “flow” of new developments into applied research outcomes.
    Most funding agencies, including ours in past years, focus at the mid-level traditional awards. Our intent this year is to develop a strategy for science that complements and provides impetus to the traditional process rather than duplicating it...to fortify the foundation of scientific “exploration” and speed the flow of innovation up the developmental pyramid. Higher risk IDEA projects are the “seeds” or “spawning ground” of innovation that feeds and invigorates traditional development stages further up. The primary intent of our 96 program is to promote this novel IDEA GENERATION that will impact the harvest of research outcomes in the future. It is our vision that the work we fund now will invigorate the mid-level development by the year 2000.
    The apex of the pyramid
    The ultimate goal is to funnel development to the top of the pyramid...to translate research outcomes into all aspects of clinical practice and cancer prevention. This area represents investment in the best bets that have a high probability of translating into advances in all aspects of breast cancer detection, treatment & prevention.
    Given recent advances in the field, there is an unprecedented opportunity to bring well-developed ideas to fruition on behalf of women with breast cancer. Our FY 96 strategy supports such efforts with a $15 M investment.
  • Additional information about the Ovarian Cancer Research Program and other CDMRP Programs is available on our website. Program Announcements for upcoming CDMRP Programs will be available on the website when they are released.
    Abstracts of funded proposals are available on the website. This year’s ovarian cancer research abstracts will be posted there after contracts with the PI’s institutions have been finalized.
    A workbook on consumer participation in proposal review is also available.
  • Transcript

    • 1. 1 of 15 Department of Defense Congressionally Directed Medical Research Programs U.S. Army Medical Research & Materiel Command Congressionally Directed Medical Research Programs (CDMRP) Presented to National Institutes of Health Peer Review Advisory Committee Presented by Janet Harris, Ph.D., R.N. Colonel, US Army Nurse Corps Director 23 January 2006 US Army Medical Research and Materiel Command (USAMRMC)
    • 2. 2 of 15 Department of Defense Congressionally Directed Medical Research Programs U.S. Army Medical Research & Materiel Command CDMRP Philosophy Vision: Find and fund the best research to eradicate diseases and support the warfighter for the benefit of the American public Mission: We provide hope by promoting innovative research, recognizing untapped opportunities, creating partnerships, and guarding the public trust. THE CENTRAL THEME IS INNOVATION
    • 3. 3 of 15 Department of Defense Congressionally Directed Medical Research Programs U.S. Army Medical Research & Materiel Command CDMRP History 1992: Grassroots advocacy heightened political awareness of breast cancer 1993: Congress appropriated $210M to the Department of Defense (DOD) budget for breast cancer research, managed by the CDMRP, after consultation with the Institute of Medicine (IOM) in fiscal year 1993 (FY93) and re-reviewed the program in FY97. 1996-2002: Additional research programs added: 1996: Neurofibromatosis 1997: Prostate Cancer and Ovarian Cancer 1999: Peer Reviewed Medical Research Program 2002: Prion, Tuberous Sclerosis, and Chronic Myelogenous Leukemia. These and other programs are managed by the CDMRP
    • 4. 4 of 15 Department of Defense Congressionally Directed Medical Research Programs U.S. Army Medical Research & Materiel Command Funds added to the DOD budget by Congress [generally as DHP(RDT&E)]* Respond to targeted guidance from Congress Two-tier formal review of proposals – IOM Model Consumer advocate participation throughout process Vision is adapted yearly to facilitate rapid change and address research gaps Highly flexible management processes CDMRP Unique Features *Defense Health Program (Research Development, Test and Evaluation)
    • 5. 5 of 15 Department of Defense Congressionally Directed Medical Research Programs U.S. Army Medical Research & Materiel Command 0 50 100 150 200 250 300 350 400 FY92 FY 93-94 FY95 FY96 FY97 FY98 FY99 FY00 FY01 FY02 FY03 FY04 FY05 Institutionally Based Programs Osteoporosis Research Program Defense Women's Health Res. Prog. National Prion Research Program Cooperative DOD/VA Medical Res. Prog. Tuberous Sclerosis Research Program Myeloproliferative Disorders Research Chronic Myelogenous Leukemia Res. Prog. Ovarian Cancer Research Program Neurofibromatosis Research Program Peer Reviewed Medical Res. Prog. Prostate Cancer Research Program Breast Cancer Research Program CDMRP Funding History 0 50 100 150 200 250 300 350 400 FY92 FY 93-94 FY95 FY96 FY97 FY98 FY99 FY00 FY01 FY02 FY03 FY04 FY05 Institutionally Based Programs Osteoporosis Research Program Defense Women's Health Res. Prog. National Prion Research Program Cooperative DOD/VA Medical Res. Prog. Tuberous Sclerosis Research Program Myeloproliferative Disorders Research Chronic Myelogenous Leukemia Res. Prog. Ovarian Cancer Research Program Neurofibromatosis Research Program Peer Reviewed Medical Res. Prog. Prostate Cancer Research Program Breast Cancer Research Program Awards 26 445 366 313 524 435 661 746 664 726 721 566 ~650
    • 6. 6 of 15 Department of Defense Congressionally Directed Medical Research Programs U.S. Army Medical Research & Materiel Command Training and Research Resources Innovation-Based Research Clinical Research Traditional Research (e.g., R01-, P50-type awards) FY06 Investment Strategy Translational Research
    • 7. 7 of 15 Department of Defense Congressionally Directed Medical Research Programs U.S. Army Medical Research & Materiel Command Program Cycle Vision Setting Release of Program Announcement Proposal Receipt Peer Review Programmatic Review Candidate Award List Congressional Appropriation Receipt of Funds CG Approval Integration Panel Science evaluation Budget evaluation Programmatic relevance Budget evaluation
    • 8. 8 of 15 Department of Defense Congressionally Directed Medical Research Programs U.S. Army Medical Research & Materiel Command Electronic Proposal/Grant Management CDMRP eReceipt System Web-based proposal submission system Includes modules for Principal Investigators and Office of Sponsored Research Representatives Information collected in fields, text boxes, and PDF files Program and Peer Review Management Information System™ (P²RMIS™) Proprietary web-base system owned and used by Constella Health Sciences, our peer review contractor Electronic Grants System Custom designed, state of the art database and business system for the paperless management of medical research proposals and grants.
    • 9. 9 of 15 Department of Defense Congressionally Directed Medical Research Programs U.S. Army Medical Research & Materiel Command Advantages of Electronic Processes Reduced Applicant Cost: Uploading PDF files is less costly than copying and shipping proposal Reduced Program Cost: Reduction in labor during receipt and savings in reviewer shipping exceed cost of printing proposal copies Increased Communication: Reviewers, Chairperson, and Scientific Research Administrator can review critiques in advance of the meeting Time Savings: Compliance (administrative review), referral, and summary statement writing all streamlined through use of web-based tools Increased Efficiency: Allows for collaboration between organizations by implementing electronic workflows and virtual files Allows for real-time data transfer, multiple users, standardization of processes and unprecedented secure access to data
    • 10. 10 of 15 Department of Defense Congressionally Directed Medical Research Programs U.S. Army Medical Research & Materiel Command Standard Peer Review Scoring Criteria Global Adjectival 10, 9 1.0 - 1.5 Outstanding 8,7 1.6 - 2.0 Excellent 6, 5 2.1 - 2.5 Very good 4,3 2.6 - 3.5 Good 2,1 3.6 - 5.0 Fair
    • 11. 11 of 15 Department of Defense Congressionally Directed Medical Research Programs U.S. Army Medical Research & Materiel Command Regular (Idea Awards) Concept Era of Hope Innovator Clinical Trial Award Referral Discipline-Focused Discipline-Focused Mechanism- Focused Mechanism-Focused Distribution Paper/CD-ROM P²RMIS™ (Web) Paper Paper/CD-ROM Collection Critique and Preliminary Scores Brief Comment and Score Nothing Critique and Preliminary Scores Pre-Meeting Panel-Wide Access to Comments None None Panel-Wide Access to Comments Meeting Traditional Discussion None Comparative Discussion Dual Discussion: Proposal & Protocol Global Score Numeric: 1.0 – 5.0 Adjectival Only: Outstanding - Fair None Single Numeric Global Score Evaluation Criteria 10 – 1 None Text Only: No Scoring Separate Criteria for Proposal and Protocol Summary Statements Concatenated; Sent to Applicants Sequential; Internal Use Only Text Only: No Scoring Separated Sections for Proposal and Protocol Peer Review Processes
    • 12. 12 of 15 Department of Defense Congressionally Directed Medical Research Programs U.S. Army Medical Research & Materiel Command Correlations Between Final Global Scores and Final Criteria Scores for Idea Awards Scores Correlated with Final Global Score Pearson’s R Correlation (Interval by Interval) Research Strategy -0.886 Relevance -0.820 Innovation -0.876 Investigator -0.701 Environment -0.639
    • 13. 13 of 15 Department of Defense Congressionally Directed Medical Research Programs U.S. Army Medical Research & Materiel Command Lessons Learned Consumers are integral to peer review Efficiencies of cradle to grave electronic management Need to maintain dynamic flexible processes Tailor peer review processes to: Mechanism goals Time constraints Funding limitations
    • 14. 14 of 15 Department of Defense Congressionally Directed Medical Research Programs U.S. Army Medical Research & Materiel Command Ongoing Challenges Identifying Innovation Keeping Peer Reviewers engaged during panel discussions Congruency among narrative, criteria scores, and global score Optimizing panel size, reviewer workload, and length of panel discussion Meeting needs of multiple end users of critique Programmatic Review Applicant
    • 15. 15 of 15 Department of Defense Congressionally Directed Medical Research Programs U.S. Army Medical Research & Materiel Command Web Site – http://cdmrp.army.mil

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