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Put a Little Color in Your Life - Botanical Research Center

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    Put a Little Color in Your Life - Botanical Research Center Put a Little Color in Your Life - Botanical Research Center Presentation Transcript

    • Natural History of Type 2 Diabetes
      Progressive Pancreatic Failure
      Pancreas function
      Insulin “efficiency”
      “Pre-diabetes”
      “Metabolic Syndrome”
      Insulin secretion
      PLASMA GLUCOSE
      Normal:99 mg/dlor less
      Pre-Diabetes:100-125 mg/dl)
      Diabetes>126 mg/dlfasting); >200 mg/dl )(PostPrandial)
      Post-Meal glucose
      Fasting glucose
      Years from
      diagnosis
      0
      10
      5
      15
      -10
      -5
      Onset
      Diagnosis
      Pre-diabetes
      Type 2 diabetes
      Ramlo-Halsted BA, Edelman SV. Prim Care. 1999;26:771-789 Nathan DM. N Engl J Med. 2002;347:1342-1349
    • Diabetes
      5.02
      3.64
      3.19
      2.4
      Cardiovascular Risk in Pre-diabetes
      Non-Diabetic
      7
      6
      5
      4
      Relative Risk of MI or Stroke
      3
      2
      1.0
      1
      0
      NondiabeticThroughout
      10-14.9 YrBefore Dx
      >15 YrBefore Dx
      <10 YrBefore Dx
      DiabeticThroughout
      Pre-Diabetes
      Hu FB, et al. Diabetes Care. 2002;25:1129-1134.
    • Insulin “Efficiency”
      Pre-diabetes
      Plasma membrane
      Insulin receptor
      Chemical Signals
      Glucose (“sugar”)
      carriers
      Insulin
      Glucose carriers move
      to the surface
      Carriers insert into cell surface
      Blood Sugar
      Blood Sugar enters body
      GLUT4=glucose transporter 4
    • “Metabolic” Syndrome
      Physical
      Inactivity
      Aging
      Insulin Efficient (“resistance”)
      High
      Cholesterol
      Heart Disease
      Blood Vessel
      Dysfunction
      Elevated
      Blood Pressure
      High Blood Sugar
      Obesity
      Modified from S. Grundy MD
    • High Waist/Hip
      (0.95 in men)
      (0.80 in women)
      Body Shape Matters!!!“Central” obesity
      An Index of Abdominal vs Peripheral Obesity
      Low Waist/Hip
      (<0.95 in men)
      (<0.80 in women)
    • 25
      20
      15
      10
      5
      0
      Waist Measurement and Diabetes Risk
      Upper 10% WHR
      Lower 10% WHR
      Risk (%)
      54
      55
      56
      57
      58
      59
      60
      61
      62
      63
      64
      65
      66
      67
      Age
      Risk of diabetes mellitus during 13 years in relation to WHR at baseline.
      Comparison between these in upper and lower 10% of WHR distribution.
      Larsson. Acta Med Scand Suppl. 1988;723:45-51.
    • Waist/Hip Ratio and Risk
      Men: waist size >40 vs <37 inches
      Women: waist size >34 vs <31 inches
      ~4-fold greater risk for type 2 diabetes
      ~3- to 4-fold greater risk for major cardiovascular event
      Lean et al. Lancet. 1998;351:853-856.
    • 15
      YES
      10
      NO
      5
      0
      2
      6
      8
      12
      4
      0
      10
      Death Increases with Metabolic Syndrome
      Heart Disease Deaths
      Metabolic Syndrome:
      Cumulative hazard (%)
      Follow-up (y)
    • Visceral Fat Distribution: Normal vs Type 2 Diabetes
      Type 2 Diabetes
      Normal
    • To diabetes
      Diabetes
      Metabolic
      Syndrome
      ?
      R. Heine MD
    • Type 2 DiabetesPredicted Treatment Paradigm
      Insulin
      Combination (two) Medications
      Other Injected meds
      Single Medication
      Nutritional Preventive
      Strategies
      Diet and exercise
      Increased Heart
      Disease
      Years from
      diagnosis
      10
      0
      5
      15
      -10
      -5
      Onset
      Diagnosis
      Type 2 diabetes
      Pre-diabetes
    • NIH Funded Botanical Research Centers
      “Your Tax Dollars at work”
      • Botanical Center for Age-Related Disease
      Purdue University/UAB
      • Botanical Dietary Supplements for Women’s Health
      University of Illinois at Chicago
      • Botanical and Lipids (Cholesterol)
      Harvard and Wake Forest Universities
      • Botanicals and Cancer
      Memorial Sloan-Kettering Cancer Center/
      Rockefeller University
      • Botanicals and Metabolic Syndrome
      PBRC-LSU/Rutgers
    • Russian tarragon
      Tarragon and Diabetes
      Extract of Artemisia dracunculus with antidiabetic properties
      Produced from hydroponically grown plants under controlled conditions
    • Clinical Research:
      BENCH to BEDSIDE!
      Years 1-4
      Animal Testing to monitor
      Safety and effectiveness
      Human Testing in
      Several Phases
      Years 1-3
      Years 3-5
      Cells tested with
      Experimental
      Intervention
    • Are Claims for “over the counter” supplements real?
    • Botanicals Studied
      “Eat and Drink the Rainbow”