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National and Affiliate Research Programs of the American Heart ...

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  • 11/23/10

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  • 1. National and Affiliate Research Programs of the American Heart Association Rajini Reddy Mudhasani, PhD Type of Award: Postdoctoral Fellowship
  • 2.
    • Mission and Goal
  • 3. Mission
    • Building healthier lives, free from cardiovascular diseases and stroke
    Michaela Gagne Miss Massachusetts and AHA Volunteer I truly appreciate how fortunate I am to have escaped potential fatality. It’s because of American Heart Association-funded research that I am alive, well and physically active today. It’s also the reason I’m doing everything in my power to motivate others to support the heart association’s cause and lead a heart healthy life.
  • 4. Goal of the AHA Research Programs
    • The goal of the American Heart Association Research Programs is the acquisition of new knowledge broadly related to the normal function of the cardiovascular system and the causes, prevention, treatment or control of cardiovascular diseases and stroke.
  • 5.
    • Milestones in AHA Research
  • 6.
    • 1985 . Drs. Joseph Goldstein and Michael Brown , funded by the Association in 1972, '73 and '75, are awarded the Nobel Prize in Physiology or Medicine for their research on the role of low-density lipoprotein receptors in controlling blood cholesterol levels.
    Their research provides new insights into the ways cholesterol enters body cells and why cholesterol levels may become too high.
  • 7.
    • 1992 . Drs. Edwin Krebs and Edmond Fischer win the Nobel Prize in Physiology or Medicine for their discovery of how proteins are switched on to perform functions within cells.
    Dr. Krebs, whose research was supported in part by the American Heart Association, received the Association's Research Achievement Award in 1987.
  • 8.
    • 1998 . Three Americans are awarded the Nobel Prize in Physiology or Medicine for their discovery of nitric oxide, a colorless gas that makes blood vessels dilate by relaxing the vessels' smooth muscle. The American Heart Association funded one of the awardees, Dr. Robert Furchgott , from 1952 to 1954.
  • 9.
    • 2003 . Dr. Peter Agre is awarded the Nobel Prize in Chemistry for his discovery of aquaporins, proteins that govern the movement of water in and out of cells.  Dr. Agre received American Heart Association Established Investigator funding from 1987-92.
  • 10.
    • The Importance of AHA Research
  • 11. The AHA’s Investment in Research Compared to Other Major Health Agencies In 2007, the AHA invested more in research funding than any other health agency. Organization 2007 Research Expense A American Heart Association 147,500,000 B American Cancer Society 146,933,000 C Juvenile Diabetes Research Foundation 146,614,000 D American Diabetes Association 54,341,000 E National Multiple Sclerosis Society 50,940,905 F March of Dimes (includes research and medical support) 46,323,000 G Alzheimer’s Association 37,593,000 H Muscular Dystrophy Association 37,313,847 Source: Respective Health Agencies’ 2007 Annual Reports
  • 12. Life Cycle of a Research Application Hmm… Yea! Application submitted An idea begins Peer Review Committee E-mail notification Research completed Reports Published Findings translated Assigned to reviewers Critique developed Rank-ordered list Research Committee $ Funded
  • 13.
    • The AHA Research Program
    • Today
  • 14.
    • To avoid losing a generation of scientists, the AHA now awards about two-thirds of its research dollars to early career investigators.
    • Successful early career investigators then go on to secure NIH and other grants.
    Zoltan Ungvari, M.D., Ph.D. Type of Award: Scientist Development Grant
  • 15. Our Science Focus
    • The AHA funds research broadly related to cardiovascular function and disease and stroke, or to related basic science, clinical science, bioengineering or biotechnology, and population science. The association encourages research that will further our understanding of specific risk factors, diseases, or populations.
  • 16. Types of Research: Basic
    • Basic Research is a synonym for fundamental research, which is the study of life processes that are universal in their application to scientific knowledge.
      • Example of Basic Research on Childhood Obesity:
        • Early life determinants of metabolic syndrome in animal models: interaction of perinatal environment and genetic predisposition
  • 17. Types of Research: Clinical
    • Clinical Research addresses important questions of normal function and disease using human subjects.
      • Example of Clinical Research on Childhood Obesity:
        • Binge Eating, Purging, and Cardiovascular Risk in Adolescents ; The Effect of Weight-Loss Diets Varying in Protein and Carbohydrate Content on Markers of Cardiovascular Risk
  • 18. Types of Research: Population Health
    • Population Health Research is the science of studying the distribution and determinants of health status as influenced by social, economic and physical environments, human biology, health policy and services and of preventing disease, prolonging life and promoting health at the population levels.
      • Example of Population Health Research on Childhood Obesity:
        • Walking School Bus Approach to Increase Physical Activity And Attenuate BMI of Elementary School Children
  • 19. Our National and Affiliate Investigator-Initiated Research Programs
    • Investigator-Initiated Research investigates a question or hypothesis that the researcher has defined. The AHA's publicly donated dollars are used to support this type of research.
    Joseph M. Miano, PhD Type of Award: Grant-in-Aid
  • 20. Greater Southeast Affiliate Research Programs 2 years to the institution $13,500/year Predoctoral health sciences students Health Science Student Fellowship 2 years $66,000/year 1st Faculty/Staff appt. through Asst. Prof. Beginning Grant in Aid 2 years $82,000/year Faculty/Staff pursuing independent research Grant in Aid 2 years $75,000/year MA, MD, DO or PhD not yet independent Clinical Research Program* * New in 2009 2 years Sliding scale, $35,568 - $51,036 year stipend PhD, MD students, not yet independent Postdoctoral 2 years $21,770/year stipend PhD, MD students Predoctoral Duration Annual Minimum Target Audience Program
  • 21. Success Rates GSA- July 08
    • Grant-in-Aid 18.89%
    • Beginning Grant-in-Aid 14.29%
    • Postdoctoral Fellowship 20.39% Predoctoral Fellowship 34.92%
    • Health Sciences Fellowship 100.00%
    • Total for Greater Southeast Affiliate $11,341,448.00 22.63%
  • 22. National Investigator-Initiated Research Programs 2 years $100,000 ($50,000/ year) To encourage early career investigators who have appropriate and supportive mentoring relationships to engage in high quality introductory and pilot clinical studies that will guide future strategies for reducing cardiovascular disease and stroke while fostering new research in clinical and translational science, and encouraging community- and population-based activities Clinical Research Program 5 years $593,000 over 5 years To provide funding for beginning physician-scientists with outstanding potential for careers in cardiovascular and stroke research Fellow-to- Faculty Transition Awards Duration Award Amount Description Program
  • 23. National Investigator-Initiated Research Programs 5 years $500,000 ($100,000/ year, project support) To support mid-term investigators with unusual promise, a rapidly growing research career and an established record of accomplishments; candidates have a demonstrated commitment to cardiovascular or cerebrovascular science as indicated by prior publication history and scientific accomplishments Established Investigator Awards 4 years $308,000 ($77,000/ year) To support highly promising beginning scientists in their progress toward independence; bridges the gap between completion of research training and readiness for completion as an independent investigator Scientist Development Grants Duration Award Amount Description Program
  • 24. National Investigator-Initiated Research Programs 2 years $150,000 ($75,000/ year) To support highly innovative, high-risk, high-reward research that could ultimately lead to critical discoveries or major advancements that will accelerate the field of cardiovascular and stroke research. Innovative Research Grant Duration Award Amount Description Program
  • 25. Success Rates AHA National- Jan 09
    • Scientist Development Grant 21.33%
    • Established Investigator Grant 14.78%
    • Clinical Research Program 25.58%
    • Innovative Research Grant 2.90%
    • Total AHA National Research Program $30.56 Million 11.12%
  • 26. AHA Affiliates Pacific Mountain Western States Midwest South Central Greater Southeast Great Rivers Mid-Atlantic Founders
  • 27. AHA Research Consortia The AHA’s peer review system is divided into four regional consortia. Consortia are groups of funding compo-nents that conduct peer review together. Individual consortium review committees review applications in specific science areas.
  • 28. Peer Review
    • Formal process for reviewing and ranking applications
    • Peer Reviewers volunteer their time and expertise
    • At least 12 reviewers on each peer review committee
  • 29. Funded and Unfunded Meritorious Grants
    • All reviewed applications are scored and ranked.
    • We would fund all applications deemed highly meritorious (above the 30 th percentile) if we had the resources to do so.
    Satoshi Komatsu, PhD (right) Type of Award: Scientist Development Grant
  • 30. All the Information You Want
    • Extensive information about our Research Program can be found on our website. The website also offers a glossary of the types of research that we fund.
  • 31. Questions