BWF Programs and Priorities
January 23, 2008
U.S. Veterans Administration
Office of Research and Development
Research Cybe...
Outline
• Funding for Biomedical Research
• About Burroughs Wellcome Fund
• Mission and Strategy
• Award Programs
0
50
100
150
200
250
300
1965 1970 1975 1980 1985 1990 1995 2000 2005
Recessions in green: 1969–70; 1973–75; 1980; 1981–82...
•
GIVING BY FOUNDATIONS, 1965–2005
($ in billions)($ in billions)
Data: The Foundation CenterData: The Foundation Center
30....
Environment
and animals
$8.86
3.4%
Foundations
$21.70
8.3%
Human services
$25.36
9.7%
International
affairs
$6.39
2.5%
Art...
0
20
40
60
80
100
120
140
1996 1998 2000 2002 2004 2006
Year
Funding,$inBillions
Medical Device Firms
Biotechnology Firms
...
The Two
Translational Blocks
Translation from
basic science to
human studies
Translation of
new knowledge
into clinical pr...
Funding the Health
Research Continuum
Basic
Biomedical
Research
Clinical
Science
and
Knowledge
Block
1
Block
2
Goal:
Impro...
Under what conditions should
philanthropy support biomedical research?
Under what conditions should
philanthropy support b...
Silas Mainville Burroughs (1880 photo) started his
career as a pharmaceutical sales representative in
Philadelphia and mov...
1955 Burroughs Wellcome Fund (BWF) created as the
corporate foundation of the U.S. company
1993 The Wellcome Trust sells t...
Top 10 U.S. Foundations Awarding Grants
for Medical Research, 2005*
Foundation Amount, US $ No. of
Grants
Bill and Melinda...
Burroughs Wellcome Fund
“To advance the biomedical sciences by
supporting research and other scientific
and educational ac...
• Career development of outstanding
young scientists
• Development of investigators in
targeted areas of science that are
...
Independent private foundation
Endowment of ~ $800 million
Award ~$40 million annually
in US & Canada
~ 85% of our grants ...
BWF Board of Directors
• J. Michael Bishop, M.D.
University of California at San
Francisco
• Enriqueta C. Bond, Ph.D.
Burr...
 Basic Medical Sciences
 Interfaces in Science
 Infectious Disease
 Translational Research (bench to bedside)
 Scienc...
Competitive Program Matrix
Eligible applicants
Institutions Postdoctoral
fellows
University
Faculty
Type of
science
K-12 e...
Hitchings Elion Fellowship
Biomedical Sciences
Wellcome Research Travel Grants
1978
Evaluation:
Annual Advisory Committee ...
Basic Medical Sciences
Target D.D.S., D.V.M., M.D., or M.D.-Ph.D. degree
Working in any basic biomedical science, with not...
Interfaces in Science:
Physical/mathematical/computational science and biology
Institutional Awards at the
Scientific Inte...
Interfaces in Science
Target - Ph.D. degree in physical/mathematical/
computational sciences
- Working to address biologic...
Interfaces in Science
U.S. or Canadian citizens or
permanent residents
Career Awards at the Scientific Interface (CASI)
Fo...
BWF/WT Joint program
Infectious Diseases
Scholars in Molecular Parasitology
Field Development:
Woods Hole Parasitology cou...
Infectious Disease
Target - M.D. or Ph.D.
- Assistant Professor with record of
independent research
Amount $500,000 over f...
TRANSLATIONAL RESEARCH
Scholar Awards
in
Experimental
Therapeutics
Clinical Scientist Awards in
Translational Research
Fie...
Translational Research
Target - M.D. or M.D.-Ph.D. degree
- late Assistant Professor or
early Associate Professor
Amount $...
PHYSICIAN SCIENTISTS AT BWF
Career Awards
in the
Medical Sciences Clinical Scientist Awards in
Translational Research
Fiel...
Bridges between the Population and
Laboratory based Sciences
Field Development:
Epidemiology
Econometrics
Computer Modelin...
Population Sciences
Target Degree-granting institutions in the US and
Canada
Amount $500,000 per year for five years
Insti...
BWF Science Education
North Carolina Program
UNC Fast
Track
Student Enrichment
Public Policy
NC Network of
Education
Funde...
Science Education
Target non-profit organizations in North Carolina
Amount Up to $180,000 over three years
Student Science...
Science & Philanthropy
Target Non-profit organizations
Amount Varies
Noncompetitive “Complementary” Grants
Deadline Receiv...
Award Programs
Grants Awarded* by Focus Area: FY 2006
Interfaces in
Science
13%
Infectious
Disease
23%
Translational
Resea...
Is this how it works?Is this how it works?
Info for Applicants
The Selection Process
Application by Nominated Candidates
Review by Scientific Advisory Committee
Init...
♦ Primarily to degree-granting institutions on
behalf of researchers, who must be . . .
♦ Secondarily to non-profit organi...
www.bwfund.org
919-991-5100
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Burroughs Wellcome Fund Programs and Priorities

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    Figure 5: need legend, updated from Moses et al JAMA 2005
  • One issue on which we agreed after our last national meeting came through consideration of the continuum of health research. Many of us have historically funded research that is positioned firmly at the left side of this continuum, however in the last ten years it has become clear that there is a bottleneck that prevents translation of basic discoveries into clinical knowledge. So many of us began to focus our efforts at this point. Our goalhowever, is not just to reach the point where one of our investigators publishes something in the NEJM– it is for that knowledge to be translated into changed clinical practice and ultimately better health. There is a recognition that collaboration and integration across this whole spectrum is needed. So we made a small but philsophically significant change in our name/
  • One issue on which we agreed after our last national meeting came through consideration of the continuum of health research. Many of us have historically funded research that is positioned firmly at the left side of this continuum, however in the last ten years it has become clear that there is a bottleneck that prevents translation of basic discoveries into clinical knowledge. So many of us began to focus our efforts at this point. Our goalhowever, is not just to reach the point where one of our investigators publishes something in the NEJM– it is for that knowledge to be translated into changed clinical practice and ultimately better health. There is a recognition that collaboration and integration across this whole spectrum is needed. So we made a small but philsophically significant change in our name/
  • Our mission …….clearly defines our role yet allows for broader reaches in partnering with others as appropriate
  • The overview that follows clearly indicates how we are continuing to support programs that follow our grantmaking strategy to ……….
  • Burroughs Wellcome Fund Programs and Priorities

    1. 1. BWF Programs and Priorities January 23, 2008 U.S. Veterans Administration Office of Research and Development Research Cyber Seminar Nancy Sung, Ph.D.
    2. 2. Outline • Funding for Biomedical Research • About Burroughs Wellcome Fund • Mission and Strategy • Award Programs
    3. 3. 0 50 100 150 200 250 300 1965 1970 1975 1980 1985 1990 1995 2000 2005 Recessions in green: 1969–70; 1973–75; 1980; 1981–82; 1990–91; 2001 Inflation-adjusted dollarsInflation-adjusted dollars Current dollarsCurrent dollars ($ in billions)($ in billions) TOTAL GIVING, 1965–2005 Steep growth 1996-2000 Source: Giving USA, 2007
    4. 4.
    5. 5. GIVING BY FOUNDATIONS, 1965–2005 ($ in billions)($ in billions) Data: The Foundation CenterData: The Foundation Center 30.00 24.58 1.90 10.56 7.23 1.13 1.65 2.81 4.90 27.88 13.53 10.80 5.99 8.89 6.667.01 9.56 1965 1970 1975 1980 1985 1990 1995 2000 2005 Current dollars Inflation-adjusted dollars •Tripling of foundation giving from 1995-2005 •Number of foundations nearly doubled, now over 71,000 (50/week) •Foundation assets in 2006: over $550 billion •Foundation payout in 2006: $40.7 billion
    6. 6. Environment and animals $8.86 3.4% Foundations $21.70 8.3% Human services $25.36 9.7% International affairs $6.39 2.5% Arts, culture, and humanities $13.51 5.2%Public-society benefit $14.03 5.4% Unallocated giving $16.15 6.2% Health $22.54 8.7% Religion $93.18 35.8%Education $38.56 14.8% WHERE DID THE $260.28 BILLION GO? Grants for biomedical, translational and clinical research account for about 4% of the total
    7. 7. 0 20 40 60 80 100 120 140 1996 1998 2000 2002 2004 2006 Year Funding,$inBillions Medical Device Firms Biotechnology Firms Pharmaceutical Firms Private Funds State & Local Govt. Federal Support Other than NIH National Institutes of Health Funding the Biomedical Research Enterprise Total investment tripled since 1996 Majority funded by industry Proportion from private, non-profit unchanged Source: JAMA 2005; 294:1333-1342; Hamilton Moses, Alerion 2007
    8. 8. The Two Translational Blocks Translation from basic science to human studies Translation of new knowledge into clinical practice Basic Biomedical Research Clinical Science and Knowledge Block 1 Block 2 Goal: Improved Health Adapted from IOM Clinical Research Roundtable This is not the goal! Adapted from IOM Clinical Research Roundtable, 2002
    9. 9. Funding the Health Research Continuum Basic Biomedical Research Clinical Science and Knowledge Block 1 Block 2 Goal: Improved Health Adapted from IOM Clinical Research Roundtable NIH AHRQ PHARMA VHAs: ACS, AHA, ADA, CFF HHMI, DDCF BWF RWJF Health Foundations?
    10. 10. Under what conditions should philanthropy support biomedical research? Under what conditions should philanthropy support biomedical research? “[Foundations should] concentrate resources on problems that are not being dealt with by governments or for-profit organizations. Being constrained by neither voters nor shareholders, they can take risks to find pioneering new solutions that can then be adopted on a larger scale by governments or for-profit firms” The Business of Giving: A Survey of Wealth and Philanthropy, The Economist, 2006.
    11. 11. Silas Mainville Burroughs (1880 photo) started his career as a pharmaceutical sales representative in Philadelphia and moved to London in 1878 as an agent for a U.S. drug firm. Henry Wellcome enrolled in the Chicago College of Pharmacy in 1872 and finished his education at the Philadelphia College of Pharmacy, where me met Silas Burroughs.
    12. 12. 1955 Burroughs Wellcome Fund (BWF) created as the corporate foundation of the U.S. company 1993 The Wellcome Trust sells the company and endows BWF with $400 million; Burroughs Wellcome Co. contributes $30 million to give BWF complete independence 2008 Endowment grows to $800 million History of the Burroughs Wellcome Fund
    13. 13. Top 10 U.S. Foundations Awarding Grants for Medical Research, 2005* Foundation Amount, US $ No. of Grants Bill and Melinda Gates Foundation 270,976,718 26 The Starr Foundation 33,075,000 14 Burroughs Wellcome Fund 25,804,239 83 Flight Attendant Medical Research Institute, Inc. 20,461,776 143 Avon Foundation 16,216,577 16 The Dana Foundation 15,506,843 50 W.M. Keck Foundation 14,970,000 16 The Picower Foundation 13,198,221 8 Eli & Edythe L. Broad Foundation 12,689,219 45 The Robert A. Welch Foundation 10,960,000 37 *Based on grants of $10,000 or more awarded by a national sample of 1010 larger U.S. foundations. Source: JAMA 2005; 294:1333-1342
    14. 14. Burroughs Wellcome Fund “To advance the biomedical sciences by supporting research and other scientific and educational activities.”
    15. 15. • Career development of outstanding young scientists • Development of investigators in targeted areas of science that are undervalued or underfunded Grantmaking Strategies
    16. 16. Independent private foundation Endowment of ~ $800 million Award ~$40 million annually in US & Canada ~ 85% of our grants are made through competitive peer- reviewed award programs Each program has an Advisory Committee ~ 15% of our grants are catalytic and adhoc ~ Engage in “Terrain” Mapping every five years About BWF. . .
    17. 17. BWF Board of Directors • J. Michael Bishop, M.D. University of California at San Francisco • Enriqueta C. Bond, Ph.D. Burroughs Wellcome Fund • Carlos J. Bustamante, Ph.D. University of California-Berkeley • Geoff Gerber, Ph.D. TWIN Capital Management • Phil Gold, M.D., Ph.D. (chair) McGill University • I. George Miller, M.D. Yale University School of Medicine • Mary-Lou Pardue, Ph.D. Massachusetts Institute of Technology • Jerome F. Strauss, III, M.D. Virginia Commonwealth University • Judith Swain, M.D. University of California-San Diego • Philip R. Tracy, Esq. Smith, Anderson, Blount, Dorsett, Mitchell & Jernigan, L.L.P.
    18. 18.  Basic Medical Sciences  Interfaces in Science  Infectious Disease  Translational Research (bench to bedside)  Science Education  Population Laboratory-based biological sciences  Science and Philanthropy Focus Areas
    19. 19. Competitive Program Matrix Eligible applicants Institutions Postdoctoral fellows University Faculty Type of science K-12 education Student Science Enrichment Program Physician scientists Career Awards in the Medical Sciences Clinical Scientist Awards in Translational Research Investigators in Pathogenesis of Infectious DiseaseInfectious disease investigators Interdisciplinary science New population/basic science program Career Awards at the Scientific Interface
    20. 20. Hitchings Elion Fellowship Biomedical Sciences Wellcome Research Travel Grants 1978 Evaluation: Annual Advisory Committee reviews Academic Medicine 78:177-186, 2003 Comparative MS Complete Career Development: Awardee Conferences Informal Awardee Updates Lab Management Course Help with Individual Issues Lab Manual Career Development Pieces on website Field Development: Professional Society Support Support for outside studies and Initiatives Preterm Birth Initiative Training Programs: Frontiers in Reproduction AAOGF RSDP 1992 1995 2007 Career Awards at the Biomedical Sciences Career Awards for Medical Scientists 20061999
    21. 21. Basic Medical Sciences Target D.D.S., D.V.M., M.D., or M.D.-Ph.D. degree Working in any basic biomedical science, with not more than 120 months past most recent doctorate Disease-oriented, translational or molecular, genetic or pharmacological epidemiology research Amount $700,000 over five years Career Awards in the Medical Sciences (CAMS) Deadline October 1 Goal To bridge advanced postdoctoral training, or fellowship & the first years of faculty service
    22. 22. Interfaces in Science: Physical/mathematical/computational science and biology Institutional Awards at the Scientific Interface (IASI) 1996 2000 2001 2008 Career Awards at the Scientific Interface (CASI) Evaluation: Progress report review 2003: Science 301:1485 2007: Trainee Outcomes project Career Development: Lab management course Faculty offer analysis Awardee convening events Innovation Awards in Functional Genomics Field Development: “Bridging the Sciences” initiative Support for professional societies Disseminating experience at NIH, NSF, HHMI, NAS Training Programs: MBL Modeling Course MBL Physiology Course KITP Programs
    23. 23. Interfaces in Science Target - Ph.D. degree in physical/mathematical/ computational sciences - Working to address biological questions - With at least 12 months, but not more than 48 months of postdoctoral training Amount $500,000 over five years Career Awards at the Scientific Interface (CASI) Deadline April 15 Goal To bridge advanced postdoctoral training & the first years of faculty service
    24. 24. Interfaces in Science U.S. or Canadian citizens or permanent residents Career Awards at the Scientific Interface (CASI) Foreign scientists who present evidence that lawful immigration status has been granted & will extend through award duration Eligibility Exception (only one such nominee per institution)
    25. 25. BWF/WT Joint program Infectious Diseases Scholars in Molecular Parasitology Field Development: Woods Hole Parasitology course Societies Woods Hole Mycology IOM Microbial Threats Forum NIAID Fungal Workshops Support for small meetings Investigators in Pathogenesis of Infectious Diseases BWF/ASTMH ID Fellowships Field Development: Aspergillus genomes C.albicans genome Cryptococcus genome PlasmoDB Tri-tryps genomes Malaria genomes Malaria Next Steps New tools for work on Metazoan Parasites Career Development: Communicating Science Grant writing course Network Building Awardee Meetings Lab Management Book International Lab Management Book 1981 1990 1995 1999 2000 2005 New Investigators in Molecular Parasitology Scholars in Mycology New Investigators in Mycology
    26. 26. Infectious Disease Target - M.D. or Ph.D. - Assistant Professor with record of independent research Amount $500,000 over five years Investigators in Pathogenesis of Infectious Disease Deadline November 1 Goal To provide new opportunities for accomplished investigators at the Asst. Professor level to study pathogenesis
    27. 27. TRANSLATIONAL RESEARCH Scholar Awards in Experimental Therapeutics Clinical Scientist Awards in Translational Research Field Development: IOM Clinical Research Roundtable, Drug Forum Other IOM, AAMC studies Support for professional societies Clinical research ethics, conflict of interest Health Research Alliance Career Development: Awardee/trainee convening events AAMC, APM initiatives on clinical investigator career track Drug Development course AAAS website for physician scientists 1997 2007
    28. 28. Translational Research Target - M.D. or M.D.-Ph.D. degree - late Assistant Professor or early Associate Professor Amount $750,000 over five years Clinical Scientist Awards in Translational Research Deadline October 1 Goal To foster the development of established independent physician-scientists whose work bridges gap between “bench and bedside”
    29. 29. PHYSICIAN SCIENTISTS AT BWF Career Awards in the Medical Sciences Clinical Scientist Awards in Translational Research Field Development: IOM Clinical Research Roundtable, Drug Forum Other IOM, AAMC studies Support for professional societies Clinical research ethics, conflict of interest Health Research Alliance Career Development: Awardee/trainee convening events AAMC, APM initiatives on clinical investigator career track Lab management course AAAS website for physician scientists Postdocs Early faculty Mid career faculty Investigators in Pathogenesis of Infectious Disease Externally managed programs: ASTMH fellowships ACOG/ AAOGF fellowships MBL courses
    30. 30. Bridges between the Population and Laboratory based Sciences Field Development: Epidemiology Econometrics Computer Modeling Evolutionary Biology Public Health and more! Bridges between the Population and Laboratory based Sciences Field Development: Advanced Courses Societies Awardee Trainee Gatherings Networking with existing BWF family Support for small meetings Field Development: Trainee movement across institutions Program Evaluation Crosstalk with non-biological fields
    31. 31. Population Sciences Target Degree-granting institutions in the US and Canada Amount $500,000 per year for five years Institutional Program Unifying Population and Laboratory-based Sciences Deadline Letter of intent: March 3 Full application (invitation only) May 15 Goal The programs supported by these awards will develop young researchers who will be equally at home with the ideas, approaches, and insights generated at the molecular scale and at the population scale.
    32. 32. BWF Science Education North Carolina Program UNC Fast Track Student Enrichment Public Policy NC Network of Education Funders Convene Awardees Evaluation Workshops Sustainability Workshops Proposal Writing NC Grassroots Museum Collaborative NC School of Science and Math Education Future Center Institutional Capacity Partnership Building K-12 Outreach Conference NC SMT Education Center Teacher Development NSRC LASER 1996 2007 Student Science Enrichment Program Institute for Educational Policymakers
    33. 33. Science Education Target non-profit organizations in North Carolina Amount Up to $180,000 over three years Student Science Enrichment Program (SSEP) Deadline April 10 Goal To support creative inquiry-based science enrichment activities for elementary, middle and high school students
    34. 34. Science & Philanthropy Target Non-profit organizations Amount Varies Noncompetitive “Complementary” Grants Deadline Received all year Goal To support activities that are closely related to our targeted areas and are intended to improve the general environment for science
    35. 35. Award Programs Grants Awarded* by Focus Area: FY 2006 Interfaces in Science 13% Infectious Disease 23% Translational Research 19% Science Education 12% Science & Philanthropy 1% Biomedical Sciences 32% *Millions of dollars Total Grants Awarded $39.6 M
    36. 36. Is this how it works?Is this how it works?
    37. 37. Info for Applicants The Selection Process Application by Nominated Candidates Review by Scientific Advisory Committee Initial Scoring Leads to Finalists Advisory Committee Interviews All Finalists Recommend Awardees to Board of Directors Board Approval
    38. 38. ♦ Primarily to degree-granting institutions on behalf of researchers, who must be . . . ♦ Secondarily to non-profit organizations conducting activities to improve the environment for science Grants are made . . . Info for Applicants • Nominated by their institution • Citizens or permanent residents of the US or Canada * * An exception is made for one program
    39. 39. www.bwfund.org 919-991-5100

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