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  • We will have 4 speakers today and you will have a chance to ask a few questions after ea presentationDo not despair if you don’t have a chance to ask your qustion because we will bring all of the speakers back to the front for a Q&A panel session.Breal and lunch info
  • Genomics technically began in 1975 – fredsanger was the first to sequence and organisms entire genome using a clever technique that he developed (chain termination) sanger method20 years earlier he Also determined the amino acid sequence of insulin – very importantWas awarded Nobel prize for each of these accomplishments – 2 Nobel awardsIf you told someone you were in genomics between the time of sanger and start of the human genome project – 1990 they knew what you did.Since the human genome project that is no longer trueLike many ambitious endeavors the journey to the objective is often as fruitful or more so than the objective itselfCertainly true of HGP- the journey to the human genome has produced a wealth of data, technology and tools that is revolutionizing the field of biology.So today if you said you were in genomics – microbiology, developmental biology, evolutionary biology, medical research or even a physician.In fact genomics is spilling into other fields like computer science, statistics and informatics. A true renaissance. Genomics is changing the way we do research, changing the questions we ask and even changing the way we look at biology.Great time for students to explore the many fields of genomics as potential careers
  • As we were planning to move into this fabulous buildingWe were planning for the future of our research programs and wanted our scientists to have the opportunity to participate in cutting edge scienceSo we developed the CCG
  • What role does genomics play in natural history museums like the califacad of sciences?Our primary responsibility is to go into the field and observe & describe biodiversity and then use that information to protect that diversityThe most effective way to protect biodiversity is to know as much about biodiversity and the roles it plays in ecosystem as we can.Genomics not only tells us about ourselves with the human genomeSome of the new tools in genomics can greatly enhance our understanding of complex ecosystems andUltimately, genomics will play an essential role in helping us in make informed and intelligent decisions about the conservation and protection of our planet.
  • Transcript

    • 1. BioForumGenomics: Insights and Impacts Speakers Dr. Jeff Boore - Genome Project Solutions Dr. Katherine Pollard - Gladstone Institute, UCSF Dr. Jonathan Eisen – Genome Center, UCD Dr. Nadav Ahituv - Bioengineering and Therapeutic Sciences, UCSF Host Dr. Brian Simison – California Academy of Sciences
    • 2. BioForum – Genomics 9:00-9:30 Welcome and Introduction - Brian Simison 9:30-10:20 Dr. Jeff Boore - Genomics: Where have we come and where are we going? 10:20-10:40 Break 10:40-11:30 Dr. Katherine Pollard - What makes us Human? 11:30-12:20 Dr. Jonathan Eisen - Evolution of microbes and their genomes: a phylogenomic perspective 12:20-1:20 Lunch 1:20-2:10 Dr. Nadav Ahituv - Future Genomics 2:10-3:00 Panel Question & Answer Session 2
    • 3. 1975 – developed chain termination method for DNA sequencing. – Sequenced first complete genome (bacterial phage) 1955 – determined amino acid sequence of Insulin 2 Nobel awards!! Cycle Sequencing - Fred Sanger
    • 4. Center for Comparative Genomics 4 Standard DNA sequencing Population genetic studies Whole genome shotgun sequencing ABI 3130xl - 16-capillary sequencer Amersham Megabace 4500 - 384-capillary sequencer
    • 5. PhyloCluster 136-core Apple Xserve High Performance Computing Cluster Interactive web interface Computer Lab 4 powerful desktops (two 8-core Macs & two 4-core PCs) Center for Comparative Genomics
    • 6. CryoCollection cDNA libraries, Genomic DNA, BAC libraries, etc 2-d barcoded -80º collection Dynamically linked to tissue and specimen collections Center for Comparative Genomics
    • 7. Center for Comparative Genomics Jack Dumbacher – Evolution of Bird Viruses David Mindell – mitochondrial genomics & phylogenomics of bird viruses Brian Simison – evolution and origin of Mitochondrial genomes (mechanisms of gene order change). Genomics research
    • 8. Role of Genomics at California Academy of Sciences? The field of genomics is not only informing us about ourselves, but it is helping to better understand the living world around us so we can make informed decisions on how to protect that living world
    • 9. Dr Jeff Boore • B.S. - Penn State • Ph.D. - University of Michigan • NIH Postdoctoral Fellow – University of Minnesota • Visiting Researcher – University of Michigan • Head of Evolutionary Genomics at JGI • Adjunct Professor – UC Berkeley • Owner and CEO – Genome Project Solutions
    • 10. Dr.Jeff Boore 1980 to 2000 – served in US Navy & Air National Guard as a Naval Officer Attended Navy Flight School Lt. Colonel Jeff Boore
    • 11. Dr. Lt. Colonel Jeff Boore Genomics: Where have we come and where are we going?
    • 12. BioForumGenomics: Insights and Impacts Speakers Dr. Jeff Boore - Genome Project Solutions Dr. Katherine Pollard - Gladstone Institute, UCSF Dr. Jonathan Eisen – Genome Center, UCD Dr. Nadav Ahituv - Bioengineering and Therapeutic Sciences, UCSF Moderator Dr. Brian Simison – California Academy of Sciences
    • 13. Dr Katie Pollard • B.A. – Pomona College, CA - Anthropology & Mathematics • Watson Fellow – socio-political aspects of SIDS in New Zealand, Indonesia & Australia • Ph.D. – UC Berkeley – Biostatistics • Postdoctoral Fellow – UC Berkeley • Postdoctoral Fellow – UC Santa Cruz – Chimpanzee Genome project • Professor – UC Davis Genome Center & Dept. of Statistics • Professor & Investigator – UC Gladstone Institute & Div. of Biostatistics, UCSF
    • 14. Dr Katie Pollard What makes us Human?
    • 15. BioForumGenomics: Insights and Impacts Speakers Dr. Jeff Boore - Genome Project Solutions Dr. Katherine Pollard - Gladstone Institute, UCSF Dr. Jonathan Eisen – Genome Center, UCD Dr. Nadav Ahituv - Bioengineering and Therapeutic Sciences, UCSF Moderator Dr. Brian Simison – California Academy of Sciences
    • 16. Dr Jonathan Eisen • B.S. – Harvard • Ph.D. – Stanford – Evolution of DNA repair processes • Faculty – The Institute for Genomic Research (TIGR) • Professor – UC Davis Genome Center & Dept. of Medical Microbiology & Immunology, School of Medicine • Adjunct appt – Joint Genome Institute • Editor in Chief – PLoS Biology – an open access journal “… making the world’s scientific and medical literature a freely available public resource” • Phylogenomics and the Origin of Novelty in microorganisms
    • 17. Dr Jonathan Eisen Evolution of microbes and their genomes: A phylogenomic perspective
    • 18. BioForumGenomics: Insights and Impacts Speakers Dr. Jeff Boore - Genome Project Solutions Dr. Katherine Pollard - Gladstone Institute, UCSF Dr. Jonathan Eisen – Genome Center, UCD Dr. Nadav Ahituv - Bioengineering and Therapeutic Sciences, UCSF Moderator Dr. Brian Simison – California Academy of Sciences
    • 19. Dr Nadav Ahituv • B.S. – Tel-Aviv University – General Biology • Ph.D. – Tel-Aviv University - Human Genetics • Postdoctoral Fellow – Lawrence Berkeley National Labs - Genomics • Professor – UC San Francisco - Bioengineering and Therapeutic Sciences, Institute for Human Genetics & Department of Biopharmaceutical Sciences – determining the pharmacogenetics of membrane transport proteins that play a role in drug response pathways
    • 20. Dr Nadav Ahituv Future Genomics
    • 21. BioForumGenomics: Insights and Impacts Speakers Dr. Jeff Boore - Genome Project Solutions Dr. Katherine Pollard - Gladstone Institute, UCSF Dr. Jonathan Eisen – Genome Center, UCD Dr. Nadav Ahituv - Bioengineering and Therapeutic Sciences, UCSF Moderator Dr. Brian Simison – California Academy of Sciences

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