Loading…

Flash Player 9 (or above) is needed to view presentations.
We have detected that you do not have it on your computer. To install it, go here.

Like this document? Why not share!

am_cv_Feb2010_SOMS.docx - Curriculum vitae

on

  • 321 views

 

Statistics

Views

Total Views
321
Views on SlideShare
321
Embed Views
0

Actions

Likes
0
Downloads
0
Comments
0

0 Embeds 0

No embeds

Accessibility

Categories

Upload Details

Uploaded via as Microsoft Word

Usage Rights

© All Rights Reserved

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Processing…
Post Comment
Edit your comment

am_cv_Feb2010_SOMS.docx - Curriculum vitae am_cv_Feb2010_SOMS.docx - Curriculum vitae Document Transcript

  • Name:Andrew John Moorhouse<br />Date of birth:May 30th 1967<br />Citizenship:Australian<br />University education:Bachelor of Science (hons),<br />University of Sydney,<br />-1st class honours - 1989<br />- Pharmacology Distinction -1988<br />- Physiology Credit -1988<br />Doctor of Philosophy<br />University of Sydney,-1995<br />Current position:Senior Lecturer, (July, 2005 )<br />School of Medical Sciences,<br />University of New South Wales,<br />Sydney, Australia.<br />Previous Full-time Research and Academic positions:<br />i)Lecturer – 1/10/2002 31/06/2005<br />School of Medical Sciences,<br />University of New South Wales,<br />Sydney, Australia.<br />ii)NH&MRC Senior Research Officer - 01/01/1999 31/12/2001<br />Department of Physiology and Pharmacology,<br />University of New South Wales,<br />Sydney, Australia.<br />iii)NH&MRC Research Officer 13/05/1996 31/12/1998<br />Department of Physiology and Pharmacology,<br />University of New South Wales,<br />Sydney, Australia.<br />iv)Research Scientist (RS1A),26/9/1994 25/03/1996,<br />University Laboratory of Physiology,<br />Oxford, England. <br />Visiting Research Appointments:<br />JSPS Exchange Program Recipient (1999) and Research Scientist (2002)<br />Department of Cellular and Systems Physiology, School of Graduate Medical Sciences, Kyushu University, Fukuoka, Japan<br />Visiting Research Fellow (2002)<br />Division of Molecular Bioscience, John Curtin School of Medical Research,<br />Canberra, Australia<br />Visiting Professor (2005) and JSPS Visiting Research Fellow (2007)<br />National Institute for Physiological Sciences, Okazaki, Japan<br />Full papers in refereed journals<br />As of February, 2010, a total of thirty-two scientific papers since 1996 (+ two book chapters), with total citations at 624 (Science Citations Index, Feb. 17, 2010), and 41 citations for the 10 papers published since 2005. My h-index is 14.<br />1. Ammala C., Moorhouse A., Gribble F., Ashfield R., Proks P., Smith P.A., Sakura H., Coles B, Ashcroft S.J.H. and Ashcroft F.M.A. (1996) Promiscuous coupling between the sulphonylurea receptor and inwardly rectifying potassium channels. Nature ,379, pp 545-548. [citations, 137, IF 26.7]<br />2. Ammala C., Moorhouse A and Ashcroft F.M.A. (1996) The sulphonylurea receptor confers diazoxide sensitivity on the inwardly rectifying Kir6.1 expressed in human embryonic kidney cells. J. Physiol., 494.3, pp 709-714. [citations, 56, IF 4.4]<br />3. Tucker S.J., Pessia M., Moorhouse A.J., Gribble F., Ashcroft F.M.A., Maylie J. and Adelman J.P. (1996) Heteromeric channel formation and Ca2+-free media reduce the toxic effect of the weaver Kir 3.2 allele. FEBS Letters, 390, pp. 253-257. [citations, 21, IF 3.4]<br />4. Moorhouse A.J., Jacques, P., Barry, P.H. and Schofield, P.R. (1999) The startle <br />disease mutation Q266H, in the second transmembrane domain of the human glycine receptor, impairs channel gating. Molec. Pharmacol., 55 (2), pp 386-395. <br />[citations, 26, IF 4.5]<br />5. Smith, P.A., Proks, P. and Moorhouse, A. (1999) Direct effects of tolbutamide on <br />mitochondrial function, intracellular Ca2+ and exocytosis in pancreatic -cells. Pflügers Arch., 437, pp 577-588. [citations, 16, IF 4.8]<br />6. Keramidas, A., Kuhlmann, L., Moorhouse, A.J. and Barry, P.H. (1999) Measurement of the limiting equivalent conductivities and mobilities of the most prevalent ionic species of EGTA (EGTA2- and EGTA3-) for use in electrophysiological experiments. J. Neurosci. Meth., 89, pp 41-47. [citations, 2, IF 2.2]<br />7. Barry, P.H., Schofield, P.R. and Moorhouse, A.J. (1999) Glycine receptors: What gets in and why? Clin. Exp. Pharmacol. Physiol., 26, pp 935-936. [citations, 6, IF 1.8]<br />8. Qu, W., Moorhouse, A.J., Rajendra, S. and Barry, P.H. (2000) Very negative potential for half-inactivation of, and effects of anions on, voltage dependent sodium currents in acutely isolated rat olfactory receptor neurons. J. Memb. Biol., 175, pp 123-138<br />[citations, 7, IF 2.1]<br />9. Keramidas, A, Moorhouse, A.J., French, C.R., Schofield, P.R. and Barry, P.H. (2000) M2 pore mutations convert the glycine receptor channel from being anion- to cation-selective. Biophys. J., 79, pp 247-259. [citations, 61, IF 4.8]<br />10. Qu, W., Zhu, X.O., Moorhouse, A.J., Bieri, S., Cunningham, A.M. and Barry, P.H. (2000) Ion permeation and selectivity of wild-type recombinant rat CNG (rOCNC1) channels expressed in HEK293 cells. J. Memb. Biol., 178, 137-150. [citations, 5, IF 2.1]<br />11. Qu, W., Moorhouse, A.J., Cunningham, A.M. and Barry, P.H. (2001) Anomolous mole-fraction effects in recombinant and native cyclic-nucleotide-gated channels in rat olfactory receptor neurons. Proc. Royal Soc. Lond. B, 268, 1-9. [citations, 2, IF 3.6]<br />12. Kaur, R., Zhu, X.O., Moorhouse, A.J. and Barry, P.H. (2001) IP3-gated channels and their occurrence relative to CNG channels in the soma and the dendritic knob of rat olfactory receptor neurons. J. Memb. Biol., 181 (2), 91-105. [citations, 18, IF 2.1]<br />13. Keramidas, A, Moorhouse, A.J., Pierce, K.D., Schofield, P.R. and Barry, P.H. (2002) Cation-selective mutations in the M2 domain of the inhibitory glycine-receptor channel reveal determinants of ion charge selectivity. J. Gen. Physiol., 119, 393-410. [citations, 38, IF 5.0]<br />14. Moorhouse, A.J., Keramidas, A, Zaykin, A., Schofield, P.R. and Barry, P.H. (2002) Single-channel analysis of conductance and rectification in cation-selective mutant glycine-receptor channels. J. Gen. Physiol., 119, 411-425. [citations, 18, IF 5.0]<br />15. Akaike, N. and Moorhouse, A.J. (2003) Techniques: applications of the nerve-bouton preparation in neuropharmacology. TIPS., 24, 44-47. [citations, 53, IF 10.4]<br />16. Jeong, H.J., Jang, I.S., Moorhouse, A.J, and Akaike, N. (2003) Activation of presynaptic glycine receptors facilitates glycine release from presynaptic terminals synapsing onto rat spinal sacral dorsal commissural nucleus neurons. J Physiol., 550.2, 373-383. [citations, 16, IF 4.4]<br />17. Kubota, H., Katsurabayashi, S., Moorhouse, A.J., Murakami, N., Koga, H. and Akaike, N. <br />(2003) GABAB receptor transduction mechanisms, and crosstalk between protein kinases A and C, in GABAergic terminals synapsing on to rat nucleus basalis of Meynert's neurons. J Physiol., 551.1, 263-276. [citations, 17, IF 4.4]<br />18. Lee, D.J-S, Keramidas, A., Moorhouse, A.J., Schofield, P.R., Barry, P.H. (2003). <br />Contribution of P250 (P-2’) to ion selectivity and pore diameter in the human glycine receptor. Neurosci. Lett., 351, 196-200. [citations, 8, IF 2.1]<br />19. Keramidas, A., Moorhouse, A.J., Schofield, P.R. and Barry, P.H. (2004) Ligand gated ion<br />channels: Mechanisms underlying ion selectivity. Prog. Biophys. Molec. Biol., 86, 161-204. [citations, 39, IF 5.7]<br />20. Moorhouse, A.J., Li, S., Vickery, R.M., Hill, M.A. and Morley, J.W. (2004). A patch-clamp investigation of membrane currents in a novel mammalian retinal ganglion cell line. Brain Res., 1003, 205-208. [citations, 5, IF 2.3]<br />21.Katsurabayashi, S., Kubota, H., Moorhouse, A.J. and Akaike, N. (2004) Differential modulation of evoked and spontaneous glycine release from rat spinal cord glycinergic terminals by the cyclic AMP/protein kinase A transduction cascade. J Neurochem., 91, 657-666. [citations, 5, IF 4.3]<br />22. Carland, J.E., Moorhouse, A.J., Barry, P.H., Johnston, G.A. and Chebib, M. (2004) Charged residues at the 2' position of human GABAC rho 1 receptors invert ion selectivity and influence open state probability. J. Biol. Chem., 279, 54153-54160. [citations, 9, IF 5.8]<br />23. Qu W., Moorhouse, A.J., Lewis, T.M., Pierce, K.D. and Barry, P.H. (2005). Mutation <br />of the pore glutamate affects both cytoplasmic and external dequalinium block in the <br />rat olfactory CNGA2 channel. Eur. Biophys. J. , 34, 442-453. [citations, -, IF 1.8]<br />24. Qu, W., Moorhouse, A. J., Chandra, M., Lewis, T. M., Pierce, K. D. and Barry, P. H. (2006). A single P-loop glutamate point mutation to either lysine or arginine switches the cation-anion selectivity of the CNGA2 channel. J. Gen. Physiol., 127, 375-389. [citations, 2, IF 5.0]<br />25. Wake, H., Watanabe, M., Moorhouse, A.J., Kanematsu, K., Horibe, S., Matsukawa, N., Asai, K., Ojika, K., Hirata, M., and Nabekura, J. (2007) Early changes in KCC2 phosphorylation in response to neuronal stress results in functional downregulation. J. Neurosci., 27: 1642-1650. [citations, 18, IF 7.5]<br />26. Park, E.J., Choi, I.S., Cho, J.H., Nakamura, M., Lee, J.J., Lee, M.G., Choi, B.J., Moorhouse, A.J. and Jang, I.S. (2008) Zinc modulation of glycine receptors in acutely isolated rat CA3 neurons. Life Sci., 83: 5-6. [citations,1, IF 2.4]<br />27. Sugiharto, S., Lewis, T. M, Moorhouse, A. J, Schofield, P. R. and Barry, P. H. (2008) Anion-cation permeability correlates with hydrated counterion size in glycine receptor channels. Biophys. J. 95: 4698-4715. [citations -, IF 4.8]<br />28. Carland, J. E., Cooper, M. A., Sugiharto, S., Jeong, H. J., Lewis, T. M., Barry, P. H., <br />Peters, J. A., Lambert, J. J. and Moorhouse, A. J. (2009) Characterization of the effects of charged residues in the intracellular loop on ion permeation in alpha1 glycine receptor channels. J Biol Chem. 284(4): 2023-2030. [citations,-, IF 5.8]<br />29. Wake, H., Moorhouse, A.J., Jinno, S., Kohsaka, S. and Nabekura, J. (2009) Resting <br />microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J. Neurosci., 29: 3974-3980. [citations,-, IF 7.5]<br />30. Watanabe, M., Wake, H., Moorhouse, A.J. and Nabekura, J. (2009) Clustering of neuronal K+-Cl- cotransporters in lipid rafts by tyrosine phosphorylation. J Biol Chem.. J. Biol. Chem, 284, 27980-27988. [citations,-, IF 5.8] <br />31. Sugiharto S, Carland JE, Lewis TM, Moorhouse AJ, Barry PH‡. (2010) External divalent cations increase anion-cation permeability ratio in glycine receptor channels. Pflügers Arch. Accepted 20/1/2010. Online version available at: http://dx.doi.org/10.1007/s00424-010-0792-6. ERA A.<br />32. Barry PH‡, Sugiharto S, Lewis TM, Moorhouse AJ. (2010). Further analysis of counterion permeation through anion-selective glycine receptor channels. Channels 4:3, May/June. Accepted 23/12/2009. 8 journal pages. Online version available at: www.landesbioscience.com/journals/channels/article/11020. ERA C (IF=1.5)<br />Invited Book Chapters<br />33 Barry, P.H., Qu, W. and Moorhouse, A.J. (2008). Biophysics of CNG ion channels. In: Sensing with Ion Channels. Ed. B. Martinac, Springer-Verlag, Heidelberg, pp 176-200.<br />34. Moorhouse, AJ, Nabekura, J (2010) Cellular Mechanisms of Neuronal Cl- Homeostasis and its Modulation by Neuronal Injury. In Inhibitory Synaptic Plasticity. Eds. Maffei A, Woodin MA. Contemporary Neuroscience Series. Springer. In Press. Expected publication date June, 2010<br />Peer reviewed research grants:<br />Australian Research Council, (2005-2007)<br />Mechanisms of flavonoid actions on glycine receptors,<br />Moorhouse (CIA) & Barry (CIB), Aus$300,000<br />National Health & Medical Research Council of Australia (2005-2007)<br />Chloride channel blockers,<br />Johnston (CIA), Moorhouse (CIB), Duke (CIC), Aus$511,500<br />National Health & Medical Research Council of Australia (2003-2005)<br />Structure-function studies of ion permeation and selectivity in recombinant glycine receptor channels,<br />Barry (CIA), Moorhouse (CIB), Lewis (CIC) Aus$313,000<br />National Health & Medical Research Council of Australia (1999-2001)<br />Molecular structure-function study of ion permeation through GABA and glycine-gated ion channels,<br />Barry (CIA), Moorhouse (CIB) Aus$356,379<br />UNSW Goldstar (2009)<br />Functional characterisation of the intracellular M3-M4 loop in anionic cys-loop LGICs,<br />Moorhouse (CIA), Aus$40,000<br />UNSW Early Career Researcher Grant (2008)<br />Are Intracellular Portals a Conserved Feature of Cys-Loop Receptors?'<br />Carland JE (CI), Lewis TM (AI), Moorhouse AJ (AI), $30,000 <br />UNSW Goldstar (2007)<br />Molecular determinants of ion permeation and selectivity in the glycine receptor<br />Moorhouse (CIA), Barry (CIB) & Lewis (CIC), Aus$40,000<br />UNSW, Faculty Research Grant, (2005)<br />Investigating the role of intracellular portals in ion permeation in glycine receptor-channels,<br />Moorhouse (CIA), Lewis (AI), Barry (AI), Aus$ 40,000<br />UNSW, Faculty Research Grant, (2003)<br />The effects of flavonoids on the human glycine receptor,<br />Moorhouse (CIA), Barry (AI), Aus$20,000<br />Summary of Other Academic Contributions<br />Head of Neuroscience Research Group,<br />School of Medical Sciences, UNSW, Sydney Australia (2005-2007)<br />Invited speaker at:<br />10th Annual Conference of the Thai Neuroscience Society, Bangkok, 2004<br />International Symposium on Brain Function, Fukuoka, Japan, 2002<br />Australian Society for Biophysics meeting, Katoomba, 2001.<br />Australian Physiological and Pharmacological Society symposia (Ion Channel Workshop, 1996; Membrane Transport of Ions, 1997).<br />Brain Sciences Cellular Neuroscience Symposium, UNSW, 2009<br />Awarded an:<br />Australian Postgraduate Research Award (1990 - 1994)<br />Travel Fellowship from the Instituto Juan March de Estudios Investigaciones (to attend International Workshop on Ion Channels, Spain, Nov. – Dec., 1998)<br />Exchange program award from the Australian Academy of Science/Japan Society for the Promotion of Science (Aug. 1999 – Dec., 1999).<br />School of Medical Sciences, UNSW, “Best Paper Award”, 2002<br />School of Medical Sciences, “Citation Classic” award, 2006<br />Japan Society for the Promotion of Science Fellowship, 2007<br />Invited teacher for the:<br />1st Nation-wide Patch Clamp Workshop at the Dr. Panjwani Center For Molecular <br />Medicine And Drug Research, Karachi, Pakistan, November, 2008<br />5th International Brain Research Organisation (Asia-Pacific) Neuroscience School, Bangkok, Thailand, December, 2004<br />2nd International Brain Research Organisation (IBRO) Associate School of Neuroscience, Chongqing, China, May, 2004<br />8th Teaching and Research for Staff Development Programme; Department of Physiology, Srinakharinwirot University, Bangkok, Thailand, September, 1998.<br />Expert scientific reviewing for:<br />Biophysical Journal, Journal of Biological Chemistry, European Journal of Neuroscience, Neuroscience Letters, Today's Life Science, British Journal of Pharmacology, Neuropharmacology and Journal of Neurochemistry.<br />National (NH&MRC, ARC) and International (Wellcome Trust) grants<br />Summary of Other Academic Contributions (cont)<br />Consultantancy<br />(unpaid) to British Journal of Pharmacology Guide to Receptors and Channels, 2004, 2005, 2006, 2007<br />Invited university and/or research centre seminars at the:<br />University Laboratory of Physiology, Oxford, 1995<br />Department of Pharmacology, University of Sydney, 1996<br />Department of Physiology and Pharmacology, UNSW, 1996<br />Department of Physiology, University of Newcastle, 1997<br />Department of Physiology, Kurume University, 1999<br />Department of Cellular and Systems Physiology, Kyushu University, 1999<br />National Institute for Physiological Sciences, Okazaki, 1999<br />John Curtin School of Medical Research, Canberra, 2002<br />University of Texas Medical Branch, Galveston, 2003<br />Kumamoto Health Science University, Japan, 2005 & 2007<br />Hamamatsu University School of Medicine, Japan, 2005.<br />National Institutes for Physiological Sciences, Okazaki, Japan, 2007<br />School of Biomedical Sciences, University of Newcastle, 2008<br />Departments of Physiology and Biochemistry, University of Karachi, 2008.<br />PhD Examination<br />a total of 7 PhD students since 2003 (4 from the University of Sydney, 1 from the Australian National University, 1 from University of Queensland, 1 from the University of Newcastle)<br />Public Promotion of Science<br />UNSW Courses and Careers Day Medical Sciences Lecture, 2001, 2003, 2004<br />ABC National Radio Interview (July 2005), Interview for ABC Online (July 2005)<br />Cursive Summary of Research Contributions<br />My research has concentrated on the molecular physiology of ion channels. My early postdoctoral work at Oxford University investigated K+ channels involved in insulin secretion (with my main contribution from this time published in Nature, IF 30.4) while my subsequent studies at UNSW have made a substantial contribution to ion permeation in ligand-gated channels, including a delineation of the selectivity filter in both the glycine receptor and the cyclic nucleotide gated channels with unprecedented resolution enabling a biophysical and molecular description of ion selectivity, conductance and rectification in these channels. Our initial GlyR paper in Biophysics Journal (IF = 4.5) documented what, as one reviewer described, “will come to be recognized as one of the key experiments in the field of ionic selectivity pertaining to the family of ligand-gated ion channels”. Our subsequent research papers include publications in the Journal of General Physiology (IF 5.2), Journal of Membrane Biology (IF 3.6) and the Journal of Biological Chemistry (IF 8) with an invited review in Progress in Biophysics and Molecular Biology (IF 5.3). More recently, I have expanded my research interests into the modulation of neuronal excitability and synaptic transmission, and the pharmacology of recombinant and native receptor-channels, establishing collaborations in Japan and the United Kingdom, and resulting in publications in the Journal of Physiology (IF 4.7), the Journal of Neurochemistry (IF 4.8), the Journal of Neuroscience (IF 7.5 and an invited techniques review in Trends in Pharmacological Sciences (IF 13.3). I was awarded a JSPS/Australian Academy of Science Exchange Fellowship in 1999 and 2007, and appointed as a Visiting Research Professor at the National Institutes for Physiological Sciences in Japan in 2005. I am currently (since 2004) a consultant to the British Journal of Pharmacology’s Guide to Receptors and Channels. <br />My contributions to the field of patch clamping and ion channel research have been further recognised by my invitations to present at 2 international and 3 national conferences, and to present research seminars at 4 Australian and 7 overseas universities and research centres. I regularly review journal articles, including for the Journal of Biological Chemistry, Journal of Physiology, British Journal of Pharmacology and the Biophysics Journal. I have reviewed research grant applications for both national (NH&MRC, ARC) and international (Wellcome Trust) funding bodies. I have also examined a total of 7 PhD thesis, from the University of Sydney, Newcastle, Queensland and the Australian National University.<br />Cursive Summary of Recent Teaching Contributions<br />In addition to my research contributions described above, I have made substantial contributions to teaching and learning in both Science and Medicine undergraduate degrees. In the Bachelor of Science Program, I co-ordinate a 3rd year Physiology course at UNSW (Membrane and Cellular Physiology; 60 students), with further contributions to teaching in 2nd year Physiology (Excitable Cells, 400 students), and in 2nd and 3rd year Pharmacology.<br />UNSW has recently introduced a new Medical Degree Program and I have been heavily involved with curriculum design and implementation of this new program. I currently am a member of the Phase 1 (1st & 2nd yr) committee, the Health Maintenance Design and Implementation Group and am convenor of the Health Maintenance (HM) domain in Phase 1. The HM domain covers about 25% of the Phase 1 teaching with a student load of almost 500 students. In addition to taking responsibility for the organisation and running of the HM course, I am also heavily involved in the actual Physiology teaching content, for HM and other domains within the Med Program.<br />My teaching commitment in Science and Medicine typically involves about 150-220 direct student contact hrs / year (in addition to teaching co-ordination and administration) and encompasses lectures, practical classes and a range of different small group tutorials.<br />I have successfully co-supervised 8 honours students (6 with 1st class) and 2 PhD students, both of whom now hold postdoctoral appointments in scientific research. I have also contributed to postgraduate training in our region, being twice invited by the International Brain Research Organisation (IBRO) to teach in their Asia Pacific Neuroscience Schools, and twice being the principle teacher at the 1st Nation-wide and 1st National Patch Clamp Workshops at the Dr. Panjwani Center For Molecular Medicine And Drug Research, Karachi, Pakistan<br /> <br />