6.26. Indian Council of Medical Research
6.26.1. The Indian Council of Medical Research (ICMR), an apex body responsible f...
premonitory signs of impending disease epidemics and prediction of disease epidemic through application of
remote sensing ...
a Wastage Multiplication Factor (WMF) of 1.17 of OPV which is well below the present assumption of 25%
wastage and a multi...
as compared to control area. The following were found to be risk factors: disaster injury, occurrence of disaster
deaths i...
6.26.34. The Bioinformatics Centre of the Council set up in June, 1999 continued to publish information available
with and...
6.27.5. Patient management services: The clinical wing, the Clinical Research Centre (CRC) continued to provide
diagnostic...
aspects of methylxanthines; Studies on the mechanism of INH neurotoxicity and its modulation by drugs; Research
on stress ...
Clinical studies including drug trials are proposed to be carried out to develop better management strategies. The
researc...
6.28.9. Proposal for Next Year: The 1999 issue of the annual publication " Health Information of India" is
proposed to be ...
orienting them in screening of blood for hepatitis C. These training courses were organized all over the country
through 2...
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6.26. Indian Council of Medical Research 6.26.1. The Indian ...

  1. 1. 6.26. Indian Council of Medical Research 6.26.1. The Indian Council of Medical Research (ICMR), an apex body responsible for the planning, organization, implementation and coordination of medical research in the country promotes biomedical research through a network of its 21 permanent Institutes and 6 Regional Medical Research Centres ( Annexure (ix) distributed throughout the country and also through grants-in-aid given to projects in non-ICMR Institutes. The Governing Body of the Council is presided over by the Union Health Minister. The Council receives grants-in-aid from the Ministry of Health & Family Welfare for meeting its normal expenditure and finance its plan activities. The following provision exists during 2000-2001 in the budget for paying grant-in-aid to the Council: Plan - Rs.86 Crore and Non-Plan Rs.65 Crore. 6.26.2. Communicable Diseases: India is undergoing an epidemiologic, demographic and health transition. Though the expectancy of life has increased, but consequent rise in degenerative diseases of ageing and life- styles, communicable diseases are still dominant and constitute major public health issues. 6.26.3. In tuberculosis, the results of a study demonstrated the need for user-friendly attitude of public functionaries and involvement of private providers in Revised National Tuberculosis Control Programme(RNTCP). The studies to examine the feasibility of shortening the duration of treatment for smear positive pulmonary tuberculosis patients from the present 6-8 months to 3-5 months with regimens using ofloxacin are progressing. The Council's Tuberculosis Research Centre (TRC), Chennai in collaboration with the Tamil Nadu State TB Programme has established a Model Centre for DOTS implementation, tuberculosis control training and research. 6.26.4. Follow up of paucibacillery (PB) cases treated with a six monthly regimen comprising of dapsone, clofazimine and rifampicin has confirmed that the patients treated with this regimen have less residual activity, low reactions rates and no relapses during the first 3.5-4 years of follow-up. Gene probes have been developed for detection of early forms of leprosy in histopathological sections by insitu hybridization and the data confirm that this method is promising and would be able to detect suspicious and indeterminate cases efficiently. 6.26.5. A molecular epidemiological study in diarrhoea revealed clonal diversity among V.cholerae 0139 strain and emergence of new epidemic clone as evidence by the change in the structure, organization and location of the CTX prophages. Two DNA probes of the size of 0.2 kb and 0.3 kb were identified and developed for diagnosis of giardiasis. The Council's National Institute of Virology (NIV), Pune modified the ELISA test for rota virus and the new rapid test has been standardized. The test can now be completed in 2-3 hours. A Task Force project is currently in progress to study the disease burden due to leptospirosis. 6.26.6. For the control of malaria, the strategies of bioenvironmental interventions developed under the Integrated Disease Vector Control (IDVC) have been launched in Panji (Goa) and Ahmedabad (Gujarat) by the respective city corporations with the technical support of Malaria Research Centre (MRC), Delhi. The Konkan railway project and Marimugo port authorities have accepted strategy on bioenvironmental control in India. The distribution of Malaria Vector A dirus mapped by the CIS analysis was compared with reported distribution and was found to be correct. 6.26.7. For elimination of filariasis, a LYMFASIM model developed for predicting the required duration of intervention showed that a minimum of 13 years of vector control is required for 80% reduction in man biting rate of mosquito vectors. Mass DEC fortified salt programme showed gradual decline in the rate in the mf fiiariasis. 6.26.8. Research for the development of DNA/RNA diagnostic probe for its possible use in epidemiological studies on leishmanasis carried out at Rajendra Memorial Research Institute (RMRI), Patna. Other activities include establish- ment of Leishmania Parasite Bank. Clinical trial studies using different combinations of existing anti- kala-azar drugs have been carried out to optimize the drug dosages and associated side reactions. Epidemiological studies are ongoing to assess infection dynamics in population, transmission indicators to understand the PREVIOUS
  2. 2. premonitory signs of impending disease epidemics and prediction of disease epidemic through application of remote sensing technique. 6.26.9. In Japanese encephalitis, B and T cell epitopes of JE virus have been identified and a chimeric peptide has been synthesized with the aim of developing a cocktail vaccine in future. Role of Anopheles subpictus in Japanese encephalitis virus transmission in South Arcot district.Tamil Nadu has now been elucidated. Being mainly zoophagic, An.subpictus_appears to play a role in zoonotic cycle of JE transmission. 6.26.10. Cases of acute flaccid paralysis were investigated for poliovirus infection during the year 2000 in Mumbai. The virological studies indicate that the historical hot spots of wild poliovirus transmission have been completely eliminated by the OPV immunization. Wild polioviruses were detected in cases from almost all large states of the country. Wild poliovirus type 3 predominated throughout north India. However, wild polio viruses appears to be under control in southern states of the country. Discrepant results in Vaccine Vial Monitoring (WM) color reading and vaccine potency tests have been detected in some field samples called for a large-scale evaluation of WM. 6.26.11. An IgM capture ELISA for hepatitis A has been commercialised. Presence of a new Transfusion Transmitted Virus (TTV) has been detected in voluntary blood donors and in 'high risk' individuals. 6.26.12. ICMR research activities have provided the first reliable estimates of incidence of HIV infection in a cohort study of high-risk population and identified the behavioral and biological risk factors associated with acquiring HIV infection. Studies on acute pathogenesis and intervention of HIV/AIDS are ongoing using this cohort. Studies have revealed high prevalence of hepatitis B in STD patients in Pune and hepatitis C and D among HIV seropositive intravenous drug users. A strain of SRV has been isolated from langur peripheral blood mononuclear cells (PBMCs); this being the first report from India.The basic research including developmental aspects is given special importance for extensive virological and immunologieal studies. 6.26.13. Reproductive Health and Nutrition: The Institute for Research in Reproduction, Mumbai continued to focus on research in basic reproductive biology. A human sperm antegen , 80k Da , has been identified from human sperm extract and efforts are ongoing to develop this peptide as an immunogen for developing an antifertility vaccine. The research is ongoing to develop integrin as a clinical marker to assess the fertility potential in men, resazurin test for evaluation of semen quality and Onapristone (ZK 98.299) as a postpartum contraceptive. To understand the role of oviduct in gamete transport, sperm maturation, fertilisation and early embryonic development, a cDNA clone for monkey oviduct has been achieved and to test their role, a rodent model wherein the environment of oviduct could be altered with the use of antihormones- a eromatage inhibitor is being developed. The Council is coordinating with different agencies for production of all the raw material required for manufacturing indigenous CuT200 IUD . NorplantR (6 capsules) was offered as one of the contraceptive choices at the Council's 31 Human Reproduction Research Centres (HRRCs). The interim results indicated high efficacy and good continuation of the method upto five years of use. The main reason for discontinuation was menstrual irregularities in the initial 3 years and planning pregnancy after 3 years of use. A study has been initiated in 31 HRRCs to assess the knowledge and demand of emergency contraception. Phase HI clinical evaluation of indigenously developed male intravasal long term contraceptive RISUG (styrene maleic anhydride dissolved in dimethyl sulphoxide) has been initiated in a multicentre study. 6.26 14. Evaluation of the feasibility of using pregnancy kits for early detection of pregnancy at the field level revealed that paramedical workers can use the kits effectively in the field, A study on the management practices of meconium stained amniotic fluid (MSAF) and meconium aspiration syndrome (MAS) in the newborn, major obstetric and neonatal complications , is ongoing in 31 HRRCs. The interim results indicated that about 10% of children born to mothers with MSAF develop MAS. 6.26.15. The study carried out at the request of Ministry of Health & Family Welfare to assess the Vaccine Wastage during Pulse Polio Immunization (PPI) Programme has shown an overall wastage of 14.7 % doses and
  3. 3. a Wastage Multiplication Factor (WMF) of 1.17 of OPV which is well below the present assumption of 25% wastage and a multiplication factor of 1.33. 6.26.16. An Expert Group on Neonatal Health has been constituted to address neonatal mortality and related issues. Project proposals on innovative approaches for home-based management of sick neonates and other thrust areas identified by the Group have been developed. An Indo-US agreement on bilateral collaboration in maternal and child health research has been signed by both the countries. The Council will be acting as a nodal agency to steer this programme. 6.26.17. Nutrition: The Council identified certain priority areas for research for finding out effective, practical, economically viable and sustainable solutions for the plethora of nutrition related problems affecting people and to prepare project proposals in a multicentre mode, The areas identified include development of simple biochemical tests for detection of micronutrient deficiencies, the development of a nutritional surveillance system, identification of foods rich in micronutrients, nutritional problems of aged such as osteoporosis, development of intervention strategies to control undemutrition in children up to 2 years of age, and prevalence of low birth weight babies and interventions for their growth and development. The indigenous sandwich ELISA method, developed at National Institute of Nutrition, Hyderabad, for the assay of Serum transferrin receptor (STfR) was found to be a good indicator of iron status. Gaiactomannan, a soluble dietary fibre present in the fenugreek seeds, when incorporated into the diets of obese rats was shown to reduce plasma glucose as well as cholesterol levels significantly. Similarly, sesame lignans were shown to potentiate the antioxidant properties of tocopherols and contribute to their beneficial role as dietary antioxidants. Plums, papaya and guava were shown to have higher content of linolenic acid as compared to other fruits. This observation highlights their usefulness in the prevention of coronary heart disease and other chronic diseases. The existing primate facility at NIN Hyderabad has been strengthened so as to make it a state-of-the-art facility of international standard. 6.26.18. Non-Communicable Diseases: The Institute of Cytology and Preventive Oncology, New Delhi, carried out studies on etiology of cancers of breast, cervix and reproductive tract infections especially HPV. The National Cancer Registry Programme continued data collection on cancer occurrence in selected parts of the country and analyzed data with regards to its magnitude and trends over time. Inputs were provided for planning of tobacco control programmes for the country. 6.26.19. A multicentric case control study to identify risk factors for acute myocardial infarction was continued during the year. The Jaivigyan Mission Mode Project on Control of RF/RHD in India has been initiated. This project has four components namely epidemiology of streptococcal infection, Registries for RF/RHD, vaccine development and advanced studies. 6.26.20. The multicentric project on epidemiology of glaucoma was continued during the year to collect data on this important cause of blindness. Data have been collected from two rural blocks and one urban block. Preliminary analysis revealed a prevalence of around 4 per thousand. 6.26.21. An epidemiological study of childhood and adolescent psychiatric disorders in rural and urban areas was completed. The project has also generated data on psychosocial correlates of childhood psychiatric disorders and on felt treatment needs of the community. 6.26.22. The Centre for Advanced Research on Health Consequences of Earthquake Disaster completed its longitudinal studies in earthquake affected Marathwada region with special reference to mental health. The baseline study found excess psychiatric morbidity in disaster affected area as compared to control area. The excess psychiatric morbidity in disaster affected area was constituted by the following type of disorders: depressive episode, post traumatic stress disorders, other reactions to severe stress. The remission of psychiatric morbidity in stress related disorders was observed at follow up (after 5 years of earthquake), but it was still higher
  4. 4. as compared to control area. The following were found to be risk factors: disaster injury, occurrence of disaster deaths in the family, trapping experience, dissatisfaction with social support. 6.26.23. Field studies and applied research with reference to environmental monitoring of cotton dust in textile industries, silicosis in agate industry, occupational health programmes in chlor-alkali plants, exposure to benzidine based dyes and study on occupational cancer are continuing at the Council's National Institute of Occupational Health, Ahmedabad. 6.26.24. Basic Medical Sciences: Pathology: In the area of leishmaniasis, the study on identification of stage specific genes of Leishmania donovani has detected gene that codes for a centrin protein expressed mainly in promastigotes. 6.26.25. Mutation analysis of BRCA 1 and 2 genes have revealed 2 mutations in BRCA 1 and 10 mutations in BRCA 2 in Indian breast cancer patients. These are being matched against the previously described mutations from other part of the world. In the area of prostate cancer, results of histochemistry for p53 protein, RAS oncoprotein are being correlated with apoptosis and tumour grades in a group of 50 cases. 6.26.26. Haematology: Prenatal diagnosis of B-thalassaemia in the first and second trimester of pregnancy has been established successfully. Work is in the progress on the development of non-invasive method of prenatal diagnosis using maternal blood. 6.26.27. Monoclonal antibodies to Haemoglobin F and Factor VIII have been successfully developed which will be very useful as important tools for investigations in haemoglobinopathies and hemophilia respectively. Studies under the project on alloantigen in Indian population and detection of neonatal alloimmune thrombocytopenic purpura [NAITP] by allele specific amplification indicate that 1% of the female population of voluntry blood donors and those attending antenatal clinic under this study are at risk of developing alloimmunisation and alloimmune thrombocytopenia. This will help in definitively diagnosing cases of NAITP .Fluorescent in situ hybridisation [FISH] technique has been established for study of various haematological disorders. 6.26.28. Pharmacology: The Council has established Pre-clinical Toxicology Unit at National Institute of Nutrition, [NIN], Hyderabad and Clinical Pharmacology Unit at Tuberculosis Research Centre, Chennai. 6.26.29. Human Genetics: Task force study on Handigodu Syndrome has been initiated . The Council sponsored Training Programme on Genetic Counselling is in progress at Sanjay Gandhi Post Graduate Institute of Medical Science [SGPGIMS], Lucknow. 6.26.30. Traditional Medicines: Studies are in progress under multicentric flexible dose double blind randomised clinical trial on an Ayurvedic drug Vijayasar on Diabetes. 6.26.31. Ethical Guidelines: A comprehensive document entitled "Ethical Guidelines for "Biomedical Research on Human Subjects" has been released. 6.26.32. Publication, Information and Communication: The Council continued to publish its periodicals - the Indian Journal of Medical Research, the ICMR Bulletin and ICMR Patrika. A number of popular lectures, group discussions, open houses, workshops, seminars and symposia, exhibitions/displays were organized for dissemination of health information. The Council also participated in the 14th New Delhi World Book Fair and Swadeshi Vigyan We/a in February, 2000. 6.26.33. The ICMR-NIC Centre for Biomedical Information continued to provide biomedical information services from the MEDLARS databases of the National Library of Medicine, USA. A number of training programmes were conducted on online searching of bibliographic databases in different cities of the country. A Workshop on Biomedical Research and the Internet was organized in September, 2000.
  5. 5. 6.26.34. The Bioinformatics Centre of the Council set up in June, 1999 continued to publish information available with and generated by ICMR institutes on the web, to work as a platform to publish information from other key institutes on the web, to provide internet access to ICMR Institutes and other key institutes and to establish communication links with Bioinformatics Centre of DBT, other key institutions and funding agencies. The ICMR web site (http://www.icmr.nic.in) has been hosted from a server in National Informatics Centre, New Delhi. The site gives highlights of ICMR activities and achievements. 6.26.35. As part of the evaluation of biomedical research carried out by the Council the global impact of published research was analyzed. It was found that the average impact of Council's publications is showing an increasing trend with more papers being published in high impact journals. 6.26.36. In the area of human resource development a Workshop on IEC in Biomedical Research was held in Hyderabad in December, 1999; and a Workshop on Scientific Communication will be held in Manipal in December, 2000. 6.26.37. Indo-Foreign Collaboration: (i) During the year 2000-2001, the Indo-Foreign Cell (IFC) facilitated (with financial support) the organization of one Indo-German Workshop on tuberculosis, held at Braunschweig, Germany in September, 2000. (ii)The IFC coordinated ICMR-NIH Biomedical Research Policy Forum meeting held at New Delhi from October 18-20, 2000 and also arranged a number of visits by scientists to and from India under bilateral programmes in the field of biomedical sciences and public health such as Indo-Russian Workshop on Biomedical Technology/Biomolecular and Biomedical Research held in Moscow in June, 2000. Queries from Indian scientists from various parts of the country were answered, particularly on procedures/methods required to be followed for international collaboration. (iii)Being the Secretariat for the Health Ministry's Screening Committee (HMSC) Indo- Foreign Cell organised a meeting under the Chairmanship of Health Secretary, in 6th July, 2000 and another meeting will be held on 8h December, 2000. (iv) IFC has been rendering assistance to ICMR Institutes/Centres in obtaining financial support, organizing training programmes and award of fellowships from country budget of WHO. (v) The IFC represented ICMR on various national and international agencies. 6.27. Vailabhbhai Patel Chest Institute 6.27.1. The Vailabhbhai Patel Chest Institute (VPCI) established in 1949 is a National Institute for teaching & research in chest and allied diseases. The institute is maintained by the University of Delhi under ordinance XX(ii) administered by a Governing Body constituted by Executive Council of the University. The Institute is wholly financed by Grant-in-Aid from the Ministry of Health & Family Welfare, Govt. of India. 6.27.2. Highlights of Major Activities 1999-2000:The major activities of the Vailabhbhai Patel Chest Institute included research of fundamental and clinical aspects of chest diseases, development of new diagnostic technology and its dissemination in the country, training of post-graduates in tuberculosis and respiratory diseases as well as allied subjects. In addition, specialized clinical and laboratory reference diagnostic and treatment services were provided to thousands of patients visiting from all over India and abroad. 6.27.3. The budgetary allocation during 2000-01 is as given below: - Non-plan : Rs. 6.88 crore; Plan: Rs. 1.34 crore. 6.27.4. Major activities and achievements of the Institute during 1999-2000:Golden Jubilee Foundation day celebrations. The foundation stone of the Institute was laid on 6th April 1949 by Sardar Vailabhbhai Patel, then Deputy Prime Minister of India. The Institute celebrated the golden jubilee of its foundation on 6th April 1999. As part of the celebrations, a scientific programme consisting of seminars on Tuberculosis and HIV, Non-tubercular infections of the chest and Cellular and Molecular aspects of lung function was conducted. Eminent speakers in these areas from other institutions and from the Institute delivered talks. The first VPCI oration was instituted and was delivered by Prof. NK Ganguli, Director-General, Indian Council of Medical Research. A cultural programme was organized for the entertainment of the employees and their families followed by dinner.
  6. 6. 6.27.5. Patient management services: The clinical wing, the Clinical Research Centre (CRC) continued to provide diagnostic and management services to patients of various respiratory diseases referred to the Institute. A total of 7750 new cases were registered and 31662 previously registered patients were followed up. The in-patient services were utilized to the maximum. 700 patients were admitted for treatment during the year. A 24-hour Respiratory Diseases Emergency service was started. Emergency room management was provided to 6481 patients and 551 were admitted to the emergency ward. The clinical services were augmented during the year. The sleep laboratory became fully functional. A new computerized lung function equipment was installed. Mechanical ventilator and other items for starting an intensive care unit have been obtained and the ICU is expected to start in near future. 6.27.6. Diagnostic services were provided for the patients by different departments of the Institute. These included fiberoptic bronchoscopy including bronchoveolar lavage, bronchial aspiration and bronchial biopsy, respiratory polysomnography, lung function tests (spirometry, bronchodilator responsiveness, lung volumes, diffusion studies, arterial blood gas and acid-base analysis, exercise testing, body plethysography), skin tests for type-l hypersensitivity, X-rays and ultrasonography, microbiological investigations (sputum analysis, BAL fluid, bronchial aspirate, pleura! fluid, spleen/tissue biopsy, pus, pleural biopsy, stool, urine, blood, throat swabs cultures, antituberculosis drug susceptibility studies), mycological investigations (sputum and serology) and biochemical investigations (blood biochemistry). 6.27.7. Research: Research on different aspects of respiratory diseases is a major activity of the Institute. The following projects were carried out. 6.27.7(i) Assessment of quality of life in asthma and rhinitis patients; Case studies in Allergic bronchopulmonary aspergillosis; Antigenic and allergenic cross reactivity in curvularia; Genetic predisposition studies asthma in Indian population; Role of cyanobacteria in allergy; Effect of domestic fuels on respiratory system of women, Peripheral airway construction in rhinitis; Comparison of beclomethasone dipropionate, budesonide and fluticasone in asthma; Evaluation of various diagnostic modalities in tubercular lymphadenopathy; Comparison of two drug regimens (2RHZ/4RH and 2RHZE/4RH in category-l pulmolnary tuberculosis. Effect of orthostatic stress on cardiovascular system in anaesthetized dogs. Comparative study of hemodynamic effects of ionophore, monensin and dopamine on experimental hemorrhage in dogs; Endothelial dysfunction in experimentally induced atherosclerosis; Role of oxygen free radicals in acute haemorrhage-induced hemodynamic changes; Effects of hypoxia and cold environment on isolated airway smooth muscle, Reflex responses produced by lactic acid administration into the pulmonary and systemic circulations; Antituberculosis drug susceptibility (prevalence, comparison between proportion method and E-test); Biochemical identification of non-tuberculous mycobacteria (NTM); Isolation, purification and cloning of a MAC plasmid recovered from a clinical isolate; Genetic basis for heterogeneity of the drug-resistant Mycobacterium tuberculosis isolates; Role of Nitric Oxide (NO) in pathogenesis of pulmonary tuberculosis; Molecular analysis of mycobacterium complex isolates by using RFLP and PCR typing; Role of natural extracts from a medicinal plant as a bactericidal agent; Isolation, identification and plasmid profiling of mycobacterial strains from soil and water; Evaluation of rRNA restriction fragment analysis (ribotyping) for typing clinical isolates of Klebsiella pneumoniae; Evaluation of different. restriction enzymes for ribotyping of clinical isolates of Kpneumoniae; Ribotyping of clinical isolates of K.pneumoniae, Randomly amplified polymorphic DNA (RAPD) analysis of clinical isolates of K.pneumoniae; Isoenzyme profile of protein kinase C; Serum IgE and IL-1 levels in asthmatic patients, Immunophenotypic and molecular characterisation and viral association of acute lymphoblastic leukemia; Respiratory syncytial virus in lower respiratory tract infection; Role of influenza virus in acute exacerbation in asthma patients and in experimetnal guinea pigs; Environmental studies on the pathogenic fungi; Prevalence of mycotic and actinomycotic infections In immunocompromised patients; Oropharyngeal carriage of Candida dubliniensis; In vitro interactions between yeast-like fungi and aspergilli; Prevalence of various airborne fungal allergens in Delhi; Studies on retention of allergenic and antigenic activities of some clinically important allergen extracts; Immunochemical quantification and characterization of airborne allergens including insect allergens; Studies on shared/specific allergens in rice dust and rice weevil extracts; Suppression of histamine-induced skin reactions by some commonly used antihistamines; Prevalence of Type-1 hypersensitivity reactions to inhaled allergens in childhood bronchial asthma; Pharmacological and toxicological
  7. 7. aspects of methylxanthines; Studies on the mechanism of INH neurotoxicity and its modulation by drugs; Research on stress (immunopharmacological, biochemical and neuropharmacological aspects), Bronchial C fibre receptors; possible central effects. 6.27.8. Teaching: The Institute conducted the MD programmes of the University of Delhi in Tuberculosis and Respiratory Diseases (5 seats), Physiology, Biochemistry, Microbiology and Pharmacology (1 each) and a Diploma in Tuberculosis and chest Diseases (10 seats). Regular teaching programmes including lectures, seminars, journal dubs, demonstrations and case discussions, and bedside teaching, were continued. Research scholars (JRF/SRF) are enrolled for Ph.D. in various disciplines under the Faculty of Medical Sciences and carry out their work under the supervision of faculty members of different departments. The Ph.D. programmes in different specialities were continued. Altogether students were enrolled in MD programmes while continued their Ph.D research. Besides the above-mentioned degree courses, annual workshop in Diagnosis and Management of Respiratory Allergy Disorders was held. This workshop has been a regular feature since 1975. 6.27.9. Seminars/Conferences of national international significance held: 6.27.9 (i) Seminars on Tuberculosis and HIV, Non-tubercular infections of the chest and Cellular and Molecular aspects of lung function, Golden Jubilee Foundation day celebrations, VP Chest Institute, 6th April Delhi. 6.27.9 (ii) Indian Association of Medical Microbiology, Delhi Chapter Meeting at VPCI, 9th October 1999. 6.27.9 (iii) Symposium on "Targets for New Drug Development : Into the New millennium" VPCI, Delhi, 3rd November 1999. 6.27.9 (iv) 11t h Physiological Society of India Conference, VPCI, Delhi 29th November, 1999. 6.27.9(v) 27th Workshop on "Respiratory allergy diagnosis and management" jointly organized by the VP Chest Institute and Centre for Biochemical Technology, Delhi. 1-7 March 2000. 6.27.10. Publications: The Institute published "The Indian Journal of Chest Diseases and Allied Sciences" a leading national periodical, which has a wide circulation and is abstracted in Biological Abstracts, Chemical Abstracts, Excerpta Medica, Index Medicus, Medline, etc. The faculty of the Institute continued to manage the publication of the Indian Journal of Allergy & Applied Immunology, which is a biannual publication of the Indian College of Allergy & Applied Immunology. 6.27.11. Based upon research studies conducted during the year 1999-2000 more than 50 papers were published in international and national journals by the VPCI faculty. In addition, a number of papers were presented and abstracted in the proceedings of various international and national conferences, symposia, etc. 6.27.12. A number of distinguished scientists from abroad have visited VPCI for collaborative research work and/or discussions as well as for delivering lectures on fundamental and clinical aspects of respiratory diseases. 6.27.13. Research programmes for 2000-01: The Institute has got a vision to visualize the future aspects and to attune itself to meet the challenges lying ahead in the next millennium. Proper, prompt and accurate diagnosis of a disease is essential for its effective management. With this objective in mind, it is proposed to add several advanced investigation facilities, which include spiral CT scanning. Echocardiography and Treadmill testing besides developing a BACTEC 460 TB system and PCR based rapid diagnostic service for tuberculosis. Identification of newer causative aeroallergens and standardization of allergenic extracts for diagnosis and management of respiratory allergy are also to be taken up. 6.27.14. Epidemiological surveys also throw light on prevalence of a disease among various strata of society. It is, therefore, planned to study respiratory morbidity in different occupational groups and to find out the incidence of "Mycoplasma pneumoniae" and "Chlamydia pneumoniae" in patients of chronic obstructive pulmonary disease.
  8. 8. Clinical studies including drug trials are proposed to be carried out to develop better management strategies. The research programmes on different aspects of respiratory diseases will be continued in various departments of the Institute. 6.27.15. In general, each department has already set its goals and strategies for future research activities, the details of which are available in the Institute's Compendium of activities, 1949-99 and the latest Annual Report (1999- 2000) 6.28. Central Bureau of Health Intelligence 6.28.1. The Central Bureau of Health Intelligence (CBHI) is the Health Intelligence Wing of the Directorate General of Health Services. At national level, it is the sole organisation which deals with the collection, compilation, analysis and dissemination of the information on health conditions in the country covering various aspects of health including health status, health resources, utilisation of the health facilities etc. 6.28.2. Epidemic Intelligence: The obligations under the International Health Regulations are being observed. The morbidity and mortality figures in respect of internationally quarantinable diseases (Cholera) were received by CBHI every week from the States/Union Territories as well as from major seaports and airports. Based on the figures, Weekly Epidemiological reports were prepared and sent to WHO every week. 6.28.3. Principal Communicable Diseases: Data on number of institutional cases and deaths for principal Communicable Diseases was compiled on the basis of the monthly reports received from States/Union Territories in the prescribed proforma. These annual figures are regularly published in this bureaus' annua! publication " Health Information of India". 6.28.4. Field Survey Units: The six field survey units of CBHI located at Bangalore, Bhubaneswar, Patna, Jaipur, Lucknow and Bhopal (in the office of the Regional Directors Health and Family Welfare) conduct local surveys on priority health issues and monitoring of health programmes. 12 studies have been conducted during 1999-2000. 6.28.5. Training Programmes: In service training programmes for the personnel engaged in health statistics and medical records are organised regularly as described in the following two paragraphs. 6.28.6. Training Programmes in Medical Record Science: Medical Record Officer (MRO) training and Medical Record Technician (MRT) training are conducted through the Training Centre for medical records at Safdarjung Hospital, New Delhi and Jawahar Lal Institute of Post Graduate Medical Education and Research (JIPMER), Pondicherry, MRO programme is of one year duration conducted once in a year during July to June and MRT programme is of 6 months duration conducted twice a year during January to June and July to December. During 1999-2000, a total of 4 candidates for MRO and 17 for MRT were trained. 6.28.7. . Training Programmes in General and Health Statistics: The Bureau's two training centres i.e. the Model Vital Health Statistics Unit, Nagpur and Regional Health Statistics Training Centre, Chandigarh conduct 10weeks course on General and Health Statistics (twice a year), 12weeks course on medical coding(twice a year) and 2 weeks demonstration course for Medical Officers. During 1999-2000, 11 candidates in General and Health Statistics and 5 candidates in Medical Coding were trained in these centres. 6.28.8. Publication(s): CBHI has brought out the following publications: (i) Health Information of India (annual) publication - 1995 &1996(combined issue for 2 years) (ii) Health Map of India - 1998 (ad-hoc publication). The manuscript of the annual publication " Health Information of India 1997 and 1998 (combined issue)" is currently under printing.
  9. 9. 6.28.9. Proposal for Next Year: The 1999 issue of the annual publication " Health Information of India" is proposed to be published by next year. It is also proposed to bring out two ad-hoc publications (i) Directory of Hospitals in India (ii) Directory of Medical, Dental and Pharmacy Institutions in India. 6.28.10. Web Site for CBHI: With financial assistance from WHO, CBHI is working towards launching its WEB SITE containing important health statistics. 6.29. North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shiliong 6.29.1. It is an Autonomous institute established by Government of India in 1987 under the Meghalaya Registration of Societies Act 1983, It has been designed as a Postgraduate Medical Institute in the lineage of AIIMS, New Delhi and PGIMER, Chandigarh. It has been the first and the only Postgraduate Medical Institute in the North Eastern Region and Third in the country established by Ministry of Health and Family Welfare, Government of India. The Hon'ble Prime Minister, Shri Atal Behari Vajpayee declared NEIGRIHMS as a National Institute on 22nd January, 2000 and included in the package for North Eastern Region, namely, Agenda for the Socio-economic development of N.E. Region. 6.29.2. NEIGRIHMS will be an Institute with 500 bedded referral hospital integrated with 35 post-graduate teaching Departments and other ancilliary services in 306 acres of land at Mawdiangdiang, Shiliong. The C.C.E.A has approved the project at an estimated cost Rs. 422.60 crore. The project is to be completed by the year 2005. When completed, the project besides producing medical manpower in specialities and super-specialities will render high tech health care services, high standard of research particularly focussing on preventive medicine and to bring relief to thousands of ailing poor people in the North East. This will also provide adequate employment opportunies to the people of the entire North East Region. 6.29.3. The interim hospital facilities with 30 bedded hospital in the super-specialities of Cardiology and Gastroenterology have been established which started functioning on 20th August, 1998. Since then, these super- speciality facilities are giving satisfactory service to hundred of ailing people. The attendance in two OPD departments has been very encouraging. Average monthly attendance was 1923 for the year 1999 and 1427 for first half of 2000. 6.30. National Institute of Biologicals 6.30.1. The National Institute of Biologicals (NIB) is an autonomous institution of Ministry of Health & Family Welfare that is being set up to assure quality of biologicals including vaccines, diagnostic reagents, blood products, blood reagents and new biotechnological products that may enter Indian market. A new campus of NIB is being set up at Institutional Area of NOIDA, UP. Till March 2000, NIB was operating from its interim facility at Central Delhi. It shifted to permanent facility during April 2000. The permanent facility is located in an area of 74,000 sqm in institutional area of NOIDA on the outskirts of Delhi. A state-of-art main laboratory and animal house, that has been designed with inputs from National Institute of Health, USA, shall be constructed in near future. NIB is anticipated to be fully functional by 2004-05 at a cost of Rs. 269.24 crore. This was given CCEA approval in Feb. 2001. 6.30.2. This institute has already started supporting national regulatory agency in assuring quality of immunodiagnostic kits for HIV/AIDS, hepatitis B and hepatitis C; reagents required for blood grouping and oral polio vaccine through six of its laboratories. All the imported and indigenously produced kits for HIV/AIDS and hepatitis B and C are now first evaluated at NIB before these are released for use. Similarly, the blood grouping reagents (ABO, Rh and minor groups) are evaluated by this institute before the Drugs Controller General of India permits their use. Field samples of oral polio vaccine collected from the medical facilities of Uttar Pradesh are evaluated by virology laboratory to ascertain the efficacy of cold chain under the EPI. 6.30.3. NIB is also supporting National AIDS Control Organization in promoting safety of blood. During March to July 2000, NIB organized 93 training courses for medical officers and technicians of blood banks for
  10. 10. orienting them in screening of blood for hepatitis C. These training courses were organized all over the country through 23 Regional Training Centres. 6.30.4. NIB is in the process of defining standards for various biologicals. Expert group meetings are being organized to develop national consensus on acceptance criteria for various products that are in use in India. 6.30.5. The annual budget for 2000-01 is Rs 30 crore in the BE 2000-01 NEXT

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