Presented by: <your name here> From Bench to Bedside An up-to-date look at HIV Vaccine Research and HIV drugs in the pipel...
HIV Globally 40 million infected with HIV worldwide Over 20 million have died since 1981 5 million were infected in 2004 6...
The World needs an HIV Vaccine <ul><li>AIDS kills more people than any other infectious disease </li></ul><ul><li>History ...
Is an AIDS vaccine really possible? <ul><li>In 1984 researchers predicted that a vaccine was right around the corner… </li...
What are the steps in Vaccine development? <ul><li>Phase I:  10-30 volunteers, 8-12 months </li></ul><ul><li>Phase II: 50-...
Progress toward AIDS vaccine since 2000 <ul><li>30 AIDS vaccines in small-clinical trials </li></ul><ul><li>Developing cou...
What are the animal models for HIV vaccines? Macaques Chimpanzees
What types of HIV vaccines are being tested? Peptide epitopes  (protein fragments) Status: In phase I trials Live attenuat...
What types of HIV vaccines are being tested? Recombinant Viral Proteins Status: Phase II and III trials Live bacterial vec...
What are the possible HIV vaccine outcomes? Sterilizing Immunity Transient Infection Long-term controlled infection Altrui...
Who is organizing the HIV vaccine trial movement? “ Our goal is to develop safe and effective preventive HIV vaccines that...
What are some of the current HIV vaccine trials? Phase I trial- Product:  AVX101 Company: Alphavax Inc. Safety of an HIV v...
What are some of the current HIV vaccine trials? Phase II Product: rgp 120 MN Company: VaxGen Study the immune system resp...
What are some of the current HIV vaccine trials? Phase III Products: ALVAC vCP1521/ AIDSVAX B/E Company: Aventis, VaxGen A...
Where are these vaccines being tested?
What needs to happen to actually have an HIV vaccine?
Imagine a world without AIDS <ul><li>No country, region or community is immune to HIV </li></ul><ul><li>All must play a ro...
What can you do to stay informed about HIV vaccines and HIV/AIDS? <ul><li>Join HPSAAN and stay informed! </li></ul><ul><li...
Go to  www.iavi.org/callforaction and sign-on !
Sources: <ul><li>International AIDS vaccine initiative </li></ul><ul><ul><li>http://www.iavi.org/ </li></ul></ul><ul><li>H...
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HIV Vaccine Research and HIV drugs in the pipeline HIV Vaccine Research and HIV drugs in the pipeline

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  • HIV Vaccine Research and HIV drugs in the pipeline HIV Vaccine Research and HIV drugs in the pipeline

    1. 1. Presented by: <your name here> From Bench to Bedside An up-to-date look at HIV Vaccine Research and HIV drugs in the pipeline
    2. 2. HIV Globally 40 million infected with HIV worldwide Over 20 million have died since 1981 5 million were infected in 2004 600 new infections every hour
    3. 3. The World needs an HIV Vaccine <ul><li>AIDS kills more people than any other infectious disease </li></ul><ul><li>History of Public Health Initiatives </li></ul><ul><li>Economics </li></ul>
    4. 4. Is an AIDS vaccine really possible? <ul><li>In 1984 researchers predicted that a vaccine was right around the corner… </li></ul>
    5. 5. What are the steps in Vaccine development? <ul><li>Phase I: 10-30 volunteers, 8-12 months </li></ul><ul><li>Phase II: 50-500 volunteers,18-24 months </li></ul><ul><li>Phase III: Thousands of volunteers, 3 or more years </li></ul>
    6. 6. Progress toward AIDS vaccine since 2000 <ul><li>30 AIDS vaccines in small-clinical trials </li></ul><ul><li>Developing countries taking a lead </li></ul><ul><li>Demonstration that large scale AIDS vaccine trials can be conducted </li></ul>
    7. 7. What are the animal models for HIV vaccines? Macaques Chimpanzees
    8. 8. What types of HIV vaccines are being tested? Peptide epitopes (protein fragments) Status: In phase I trials Live attenuated HIV Status: Non-human primates Whole, killed HIV Status: Not under study in primates Naked DNA Status: Phase I trials
    9. 9. What types of HIV vaccines are being tested? Recombinant Viral Proteins Status: Phase II and III trials Live bacterial vectors Status: Phase I trials Live Viral Vectors Status: Phase II trials Pseudovirions Status: Pre-clinical trials
    10. 10. What are the possible HIV vaccine outcomes? Sterilizing Immunity Transient Infection Long-term controlled infection Altruistic vaccine
    11. 11. Who is organizing the HIV vaccine trial movement? “ Our goal is to develop safe and effective preventive HIV vaccines that will work everywhere on the globe, against all strains of HIV, in all people.”
    12. 12. What are some of the current HIV vaccine trials? Phase I trial- Product: AVX101 Company: Alphavax Inc. Safety of an HIV vaccine in HIV uninfected volunteers in United States and South Africa
    13. 13. What are some of the current HIV vaccine trials? Phase II Product: rgp 120 MN Company: VaxGen Study the immune system response to vaccine in Brazil, Haiti, Trinidad and Tobago
    14. 14. What are some of the current HIV vaccine trials? Phase III Products: ALVAC vCP1521/ AIDSVAX B/E Company: Aventis, VaxGen Assessing immunogenicity and ability to prevent HIV infection in Thailand
    15. 15. Where are these vaccines being tested?
    16. 16. What needs to happen to actually have an HIV vaccine?
    17. 17. Imagine a world without AIDS <ul><li>No country, region or community is immune to HIV </li></ul><ul><li>All must play a role in vaccine development </li></ul>
    18. 18. What can you do to stay informed about HIV vaccines and HIV/AIDS? <ul><li>Join HPSAAN and stay informed! </li></ul><ul><li>www.amsa.org/global/hpsaan.cfm </li></ul><ul><li>Participate in an AIDS Vaccine Trial: </li></ul><ul><li>www.hvtn.org </li></ul>
    19. 19. Go to www.iavi.org/callforaction and sign-on !
    20. 20. Sources: <ul><li>International AIDS vaccine initiative </li></ul><ul><ul><li>http://www.iavi.org/ </li></ul></ul><ul><li>HVTN </li></ul><ul><ul><li>http://www.hvtn.org/index.html </li></ul></ul><ul><li>DNA vaccines </li></ul><ul><ul><li>http://people.ku.edu/~jbrown/dnavac.htm </li></ul></ul><ul><li>The Pipeline Project </li></ul><ul><ul><li>http://chi.ucsf.edu/vaccines/vaccines?page=vc-00-00 </li></ul></ul><ul><li>NIAID Division of AIDS </li></ul><ul><ul><li>http://www.niaid.nih.gov/daids/vaccine/overview.htm </li></ul></ul>

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