Integrative Medicine Yoga Meditation

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Integrative Medicine Yoga Meditation

  1. 1. INTEGRATIVE NEUROLOGY YOGA AND MEDIATION’S ROLE IN HEALTH SHRI KANT MISHRA, ABMS, MD, MS (ADMIN. MEDICINE) PROFESSOR OF NEUROLOGY /COORDINATOR INTEGRATIVE MEDICINE KECK USC SCHOOL OF MEDICINE, LOS ANGELES, CALIF DIRECTOR NEUROMUSCULAR PROGRAM VA GLA AND OLIVE VIEW UCLA MEDICAL CENTER
  2. 2. HISTORICAL BACKGROUND <ul><li>VARIOUS NATURAL MEDICINE REMEDIES IN EXISTENCE SINCE THE BEGINNING OF THE CIVILIZATION </li></ul><ul><li>VARIOUS ETHNIC MEDICINE HAS BEEN PRACTICED FOR AT LEAST 2,000-5,000 YRS </li></ul><ul><li>LIKE CHINESE, KOREAN, AYURVEDA (INDIAN SYSTEM OF MEDICINE) AMERICAN INDIAN MEDICINE </li></ul>
  3. 3. HISTORICAL BACKGROUND <ul><li>MANY OF THESE SYSTEMS OF MEDICINE ARE WELL ORGANIZED WITH RELATIVELY GOOD PHARMACOPEA BASIC PRINCIPLES AND TRETMENT MODALITIES. </li></ul><ul><li>MANY MODERN MEDICINES HAVE ORIGINATED FROM PLANT SOURCES AND FROM ETHENIC MEDS </li></ul><ul><li>EXAMPLE - RESERPINE, EPHEDRINE, ETC. </li></ul>
  4. 4. FACTS AND FIGURES <ul><ul><li>CAM VISITS </li></ul></ul><ul><ul><ul><li>1993 425 MILLION VISITS (NEJM) </li></ul></ul></ul><ul><ul><ul><li> THIS WILL DOUBLE BY 2010. </li></ul></ul></ul><ul><ul><ul><li>1997 625 MILLION VISITS (JAMA) </li></ul></ul></ul><ul><ul><li>EXPENDIETURE </li></ul></ul><ul><ul><ul><li>1997 $27 BILLION </li></ul></ul></ul><ul><ul><ul><li>2004 $35 BILLION </li></ul></ul></ul><ul><ul><ul><li>2010 $ DOUBLE “ David Isenberg, M.D.” </li></ul></ul></ul><ul><ul><li>EDUCATIONAL PROGRAMS </li></ul></ul><ul><ul><ul><li>90% MEDICAL SCHOOLS OFFER INTRODUCTORY COURSES. HARVARD,UCSF, UCLA , UCI , ETC. </li></ul></ul></ul><ul><ul><li>RESEARCH </li></ul></ul><ul><ul><ul><li>NCCAM STARTED IN 1994 - $5 MILLION BUDGET </li></ul></ul></ul><ul><ul><ul><li>BUDGET FY 2006 $200 MILLION </li></ul></ul></ul>
  5. 5. NCCAM /CLASSIFICATION <ul><li>SYSTEMS OF MEDICINE </li></ul><ul><li>MIND BODY MEDICINE </li></ul><ul><li>HERBAL MEDICINE </li></ul><ul><li>ELECTRO MAGNETIC MEDICINE </li></ul><ul><li>MANIPULATION </li></ul><ul><li>MASSAGE THERAPY </li></ul><ul><li>AROMATHERAPY </li></ul><ul><li>HOMEOPATHY </li></ul><ul><li>BIOLOGICAL BASED MEDICINE </li></ul><ul><li>DIET NUTRITION </li></ul><ul><li>LIFE STYLE CHANGES </li></ul>
  6. 6. <ul><li>MIND/BODY MEDICINE </li></ul><ul><li>TECHNIQUES INVOLVE EXPLORING THE MIND’S ABILITY TO AFFECT THE BODY. </li></ul><ul><li>BASED ON TRADITIONAL PRINCIPLES ON HOW THE MIND AND BODY ARE INTERLINKED. </li></ul><ul><li>YOGA </li></ul><ul><li>MEDITATION </li></ul><ul><li>MUSIC THERAPY </li></ul><ul><li>PRAYER THERAPY </li></ul><ul><li>PSYCHOTHERAPY </li></ul><ul><li>COUNSELING </li></ul><ul><li>HYNOTHERAPY </li></ul><ul><li>SPIRITUALITY </li></ul><ul><li>ART THERAPY </li></ul><ul><li>BIOFEEDBACK </li></ul><ul><li>RELAXATION TECHNIQUES </li></ul><ul><li>DANCE THERAPY </li></ul><ul><li>GUIDED IMAGERY </li></ul><ul><li>HUMOR THERAPY </li></ul><ul><li>SUPPORT GROUPS </li></ul>CLASSIFICATION
  7. 7. CAM MODALITIES USED IN NEUROLOGICAL DISORDERS <ul><li>AYURVEDA </li></ul><ul><li>YOGA </li></ul><ul><li>HOMEOPATHIC MEDICINE </li></ul><ul><li>TRANSCUTANEOUS ELECTRICAL NERVE STIMULATION (TENS) </li></ul><ul><li>VAGAL /TRIGEMINAL NERVE STIMULATION </li></ul><ul><li>CHINESE MEDICINE </li></ul><ul><li>ACUPUNCTURE </li></ul><ul><li>ACCUPRESSURE </li></ul><ul><li>ELECTRO ACUPUNCTURE (EA) </li></ul><ul><li>CHIROPRACTIC </li></ul><ul><li>TRAGER THERAPY </li></ul><ul><li>MASSAGE THERAPY </li></ul><ul><li>AROMATHERAPY </li></ul><ul><li>HERBAL THERAPY </li></ul>
  8. 8. THE ROLE OF CAM IN NEUROLOGICAL DISORDERS <ul><li>CNS </li></ul><ul><ul><li>DEMENTIA, INCLUDING ALZHEIMERS DISEASE </li></ul></ul><ul><ul><li>PARKINSON’S DISEASE </li></ul></ul><ul><ul><li>EPILEPSY </li></ul></ul><ul><ul><li>STROKE </li></ul></ul><ul><ul><li>HEADACHE </li></ul></ul><ul><ul><li>MULTIPLE SCLEROSIS </li></ul></ul><ul><li>PNS </li></ul><ul><ul><li>PERIPHERAL NEUROPATHY, CARPAL TUNNEL SYNDROME CHRONIC PAIN </li></ul></ul><ul><ul><li>MUSCLE DISORDERS </li></ul></ul><ul><ul><li>FIBROMYALGIA </li></ul></ul>
  9. 9. AYURVEDA <ul><li>ANCIENT MEDICAL DISCIPLINE OF INDIA </li></ul><ul><li>LITERAL MEANING: “SCIENCE OF LIFE” </li></ul><ul><li>DATES BACK THOUSANDS OF YEARS COMPREHENSIVE APPROACH TO HEALING PRINCIPAL </li></ul><ul><li>GOAL: </li></ul><ul><li>PRESERVATION AND PROMOTION OF HEALTH </li></ul><ul><li>EMPHASIS ON ENHANCEMENT OF NATURAL IMMUNITY </li></ul><ul><li>BASED ON 4 ELEMENTS, 3 HUMORS AND TISSUES </li></ul><ul><li>INDIVIDUAL CONSTITUTIONAL PROFILE. SIMILARITIES WITH TCM </li></ul>
  10. 10. YOGA <ul><li>PRACTICED IN INDIA FOR THOUSANDS OF YEARS </li></ul><ul><li>BY FAR THE BEST KNOWN AND MOST POPULAR EXERCISE REGIMEN. </li></ul><ul><li>1.69 MILLION PRACTICE IT REGULARLY. </li></ul><ul><li>COMES FROM SANSKRIT ROOT “YUJ” </li></ul><ul><ul><li>DEFINITION </li></ul></ul><ul><ul><ul><li>TO YOKE, TO JOIN AND TO DIRECT AND CONCENTRATE ONE’S ATTENTION. </li></ul></ul></ul><ul><ul><li>BASIC PRINCIPLES </li></ul></ul><ul><ul><ul><li>FOCUSES ON THE BODY’S MUSCULATURE POSTURE, </li></ul></ul></ul><ul><li>BREATHING MECHANISMS(PRANAYAMA) AND </li></ul><ul><li>CONSCIOUSNESS . </li></ul><ul><ul><li>EFFECTS ON NERVOUS SYSTEM </li></ul></ul><ul><ul><ul><li>REDUCTION IN CHRONIC PAIN AND BACK PAIN </li></ul></ul></ul><ul><ul><ul><li>CARPAL TUNNEL SYNDROME </li></ul></ul></ul>
  11. 11. TYPES OF YOGA <ul><li>KARMA Yoga </li></ul><ul><ul><li>YOGA OF ACTION </li></ul></ul><ul><li>BHAKTI YOGA </li></ul><ul><ul><li>THE PATH OF DEVOTION </li></ul></ul><ul><li>RAJ YOGA </li></ul><ul><ul><li>THE MOST COMPREHENSIVE YOGA </li></ul></ul><ul><ul><li>IT HAS 8 PARTS INCLUDING </li></ul></ul><ul><ul><ul><li>ASANAS </li></ul></ul></ul><ul><ul><ul><li>MORAL ETHICAL </li></ul></ul></ul><ul><ul><ul><li>PRANAYAMA </li></ul></ul></ul><ul><ul><ul><li>MEDITATION </li></ul></ul></ul>
  12. 12. PRANAYAMA <ul><li>PRANAYAMAS ARE SPECIALLY DEVELOPED BREATHING TECHNIQUES. </li></ul><ul><li>ALSO IMPROVES BRAIN FUNCTION (INTELLIGENCE AND MEMORY) INCREASING THE ELIMINATION OF TOXINS FROM THE SYSTEM. </li></ul><ul><li>THE TOTAL EFFECT OF YOGA ASANAS AND BREATHING IS TO PRODUCE A STATE OF HIGH VITALITY AND REJUVENATION </li></ul><ul><li>STUDIES HAVE SHOWN THAT IT INCREASES THE SEROTONIN LEVEL IN THE BRAIN WITH REGULAR PRANAYAMA </li></ul>
  13. 13. MEDITATION <ul><li>IT IS A SELF-DIRECTED PRACTICE FOR RELAXING THE BODY AND CALMING THE MIND. </li></ul><ul><li>MEDITATION IS A SAFE AND SIMPLE WAY TO BALANCE A PERSON'S PHYSICAL, EMOTIONAL, AND MENTAL STATES. </li></ul><ul><li>IT IS SIMPLE, BUT CAN BENEFIT EV ERY ONE </li></ul>
  14. 14. PROVEN SCIENTIFIC/SOCIAL STUDIES EFFECTS CAN BE DIVIDED INTO THREE PARTS <ul><li>HEALTH PROMOTION AND DISEASE PREVENTION </li></ul><ul><li>PHYSICAL ILLNESS </li></ul><ul><li>MENTAL ILLNESS </li></ul>
  15. 15. HEALTH PROMOTION AND DISEASE PREVENTION EFFECTS OF YOGA <ul><li>IMPROVES RESPIRATORY ENDURANCE, MUSCLE STRENGTH, AND OVERALL PHYSICAL FITNESS. </li></ul><ul><ul><li>GENERAL EFFECT </li></ul></ul><ul><ul><ul><li>MEDITATION AND BREATHING EXERCISES INCREASE PHYSICAL AND MENTAL WELL BEING. </li></ul></ul></ul><ul><ul><li>ENDOCRINE FUNCTION </li></ul></ul><ul><ul><ul><li>BLOOD CORTISOL LEVELS LOWER AFTER MEDITATION. </li></ul></ul></ul><ul><ul><li>CARDIOVASCULAR </li></ul></ul><ul><ul><li>STRESS MANAGEMENT </li></ul></ul><ul><ul><li>EFFECTS ON NERVOUS SYSTEM </li></ul></ul><ul><ul><li>MUSCLE TENSION </li></ul></ul>
  16. 16. PHYSICAL ILLNESS EFFECTS OF YOGA <ul><li>NERVOUS SYSTEM </li></ul><ul><ul><li>REDUCTION IN CHRONIC PAIN AND BACK PAIN. </li></ul></ul><ul><ul><li>QUALITY OF LIFE IMPROVED. </li></ul></ul><ul><ul><li>SEIZURE DISORDERS IMPROVE QUALITY OF LIFE AND BETTER SEIZURE CONTROL </li></ul></ul><ul><li>CARDIOVASCULAR DISEASE </li></ul><ul><ul><li>IMPROVES HYPERTENSION . </li></ul></ul><ul><ul><li>IMPROVES HYPERCHOLESTEROLEMIA. </li></ul></ul><ul><li>CANCER </li></ul><ul><li>RHEUMATOLOGICAL DISORDERS </li></ul><ul><li>RESPIRATORY DISORDERS (INCLUDING ASTHMA) </li></ul>
  17. 17. MENTAL ILLNESS/ PSYCHIATRIC DISORDERS EFFECTS OF YOGA <ul><li>HELPS COGNITIVE FUNCTION IN MENTALLY RETARDED CHILDREN. </li></ul><ul><li>REDUCE ANXIETY LEVELS. </li></ul><ul><li>BIPOLAR SYNDROME IS IMPROVED. </li></ul><ul><li>FOUND TO BE HELPFUL IN HEROIN AND OTHER DRUG ADDICTIONS. </li></ul>
  18. 18. BENEFITS OF MEDITATION <ul><li>REDUCE HEALTH CARE USE </li></ul><ul><li>INCREASES LONGEVITY AND QUALITY OF LIFE </li></ul><ul><li>REDUCES CHRONIC PAIN </li></ul><ul><li>REDUCES ANXIETY </li></ul><ul><li>REDUCES HIGH BLOOD PRESSURE </li></ul><ul><li>REDUCES POST-TRAUMATIC STRESS S YNDROME IN VIETNAM VETERANS </li></ul><ul><li>LOWERS BLOOD CORTISOL LEVELS INITIALLY BROUGHT ON BY STRESS . </li></ul>
  19. 19. STATISTICS <ul><li>PHYSICIANS, PSYCHOTHERAPISTS, AND OTHER PROFESSIONALS ARE INCREASINGLY ADDING MEDITATIVE TECHNIQUES TO THEIR PRACTICE. </li></ul><ul><li>OVER SIX THOUSAND PHYSICIANS HAVE BEGUN THE PRACTICE OF TRANSCENDENTAL MEDITATION AND REGULARLY RECOMMEND THE TM TECHNIQUE TO THEIR PATIENTS. </li></ul><ul><li>MANY PHYSICIANS CONSIDER MEDITATION A KEY ELEMENT OF AN INTEGRATED HEALTH PROGRAM. </li></ul>
  20. 20. CHINESE MEDICINE <ul><li>3,-4000 YEARS OLD HEALTH CARE SYSTEM </li></ul><ul><li>REQUIRES </li></ul><ul><ul><li>BALANCE OF BODY’S DIFFERENT ENERGIES (YIN AND YANG) </li></ul></ul><ul><ul><li>PROPER FLOW OF ENERGY </li></ul></ul><ul><ul><ul><li>CAN BE CORRECTED BY STIMULATING RELATED CHANNELS BY HERBAL REMEDIES, ACUPUNCTURE, ACUPRESSURE </li></ul></ul></ul>
  21. 21. HOMEOPATHIC MEDICINE <ul><li>SPECIALIZED, SCIENTIFIC FIELD OF ALTERNATIVE MEDICINE </li></ul><ul><li>STARTED IN LATE 18 TH CENTURY BY PHYSICIAN SAMUEL HAHNEMANN. </li></ul><ul><li>BASED ON PRINCIPAL OF SIMILARS </li></ul><ul><ul><li>HIGHLY DILUTED PREPARATIONS OF SUBSTANCES </li></ul></ul><ul><ul><li>STIMULATES HEALING IN PTS WHO HAVE SIMILAR SX’S WHEN ILL </li></ul></ul><ul><ul><li>USED IN HEADACHE,DEMENTIA,CHRONIC PAIN </li></ul></ul>
  22. 22. AROMA THERAPY <ul><li>ORIGINS </li></ul><ul><ul><li>TRACED BACK TO ANCIENT EGYPT AND INDIA </li></ul></ul><ul><ul><li>3,000 YEARS AGO, ESSENTIAL OILS WERE UTILIZED FOR HEALING, COSMETICS, PERFUMERY, AND RELIGIOUS RITES. </li></ul></ul><ul><li>BENEFITS </li></ul><ul><ul><li>REDUCES STRESS, ENHANCES RELAXATION, RELIEVE ANXIETY AND OTHER EMOTIONAL DISORDERS. </li></ul></ul>
  23. 23. ACUPUNCTURE <ul><li>ACUPUNCTURE (THE USE OF NEEDLES) </li></ul><ul><ul><li>ELECTRO ACUPUNCTURE (EA) </li></ul></ul><ul><ul><li>TRANSCUTANEOUS ELECTRICAL NERVE STIMULATION (TENS) </li></ul></ul><ul><li>ACUPRESSURE </li></ul><ul><ul><li>THE USE OF PRESSURE ON SPECIFIC POINTS </li></ul></ul>
  24. 24. <ul><li>FIFTY-FIVE PERCENT OF CAREGIVERS REPORTED THAT THEY HAD TRIED AT LEAST ONE ALTERNATIVE THERAPY TO IMPROVE THE PATIENT'S MEMORY. </li></ul><ul><li>TWENTY PERCENT OF CAREGIVERS TRIED THREE OR MORE UNPROVEN THERAPIES </li></ul><ul><li>VITAMINS WERE USED MOST FREQUENTLY (84%) </li></ul><ul><li>HEALTH FOODS (27%) HERBAL MEDICINES (11%) &quot;SMART PILLS&quot; (9%) AND HOME REMEDIES (7%) </li></ul>DEMENTIA COLEMAN LM, FOWLER LL, WILLIAMS ME. AM GERIATR SOC. 1995 JUL;43(7):747-50
  25. 25. DEMENTIA <ul><li>AYURVEDIC HERBAL TREATMENTS </li></ul><ul><ul><li>MEDHYA(MEMORY ENHANCER) </li></ul></ul><ul><ul><li>BRAHMI (BACOPA ) </li></ul></ul><ul><ul><li>SANKHPUSPI CONVOLULUS PLURICALIS </li></ul></ul><ul><ul><li>GOTUKOLA </li></ul></ul><ul><ul><li>CURCUMIN </li></ul></ul><ul><ul><li>WITHANIA SEMNIFORA ETC </li></ul></ul>
  26. 26. DEMENTIA <ul><li>GINKGO CONTROVERSIAL </li></ul><ul><ul><li>STUDIES SHOW: </li></ul></ul><ul><ul><li>SLOWS DEVELOPMENT OF 20% OF DEMENTIA BY 6-12 MONTHS </li></ul></ul><ul><ul><li>META ANALYSIS BARRY OKEN 1998, ARCHIVES OF NEUROLOGY </li></ul></ul><ul><ul><li>OVERALL THERE WAS A SIGNIFICANT EFFECT SIZE OF 0.40 (P<.0001). THIS MODEST EFFECT SIZE TRANSLATED INTO A 3% DIFFERENCE IN THE ALZHEIMER DISEASE ASSESSMENT SCALE-COGNITIVE SUBTEST . </li></ul></ul><ul><ul><li>SOLOMON JAMA 2002 NEGATIVE STUDY: TOTAL 26 TRIAL MAJORITY OF STUDIES NEGATIVE? </li></ul></ul>
  27. 27. MIGRAINE HEADACHE <ul><li>HOMEOPATHIC TREATMENT </li></ul><ul><ul><li>IN A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL ON 60 PTS SHOWED THAT 93% OF PATIENTS GIVEN AN INDIVIDUALIZED HOMEOPATHIC MEDICINE EXPERIENCED GOOD RESULTS. </li></ul></ul><ul><ul><li>ISOMETRIC NECK EXERCISE / BIOFEEDBACK A COMBINATION PRODUCT CONTAINING MAGNESIUM, RIBOFLAVIN, AND FEVERFEW; MELETONIN, GINGER AND GINKO </li></ul></ul><ul><ul><li>TRAGER THERAPY </li></ul></ul>
  28. 28. TREATMENT OF PATIENTS WITH CHRONIC HEADACHES IN A HOSPITAL FOR TRADITIONAL CHINESE MEDICINE IN GERMANY <ul><li>A RANDOMISED, WAITING LIST CONTROLLED TRIAL SHOWED PATIENTS WITH MIGRAINE AND A COMBINATION OF MIGRAINE AND EPISODIC TENSION-TYPE HEADACHES HAD LASTING IMPROVEMENTS MORE THAN PATIENTS WITH OTHER HEADACHES, WITH TREATMENT OF TRADITIONAL CHINESE MEDICINE IN KOTZTING </li></ul>MELCHART D, HAGER S, MUNICH, GERMANY .
  29. 29. ACUPUNCTURE FOR PATIENTS WITH MIGRAINE <ul><li>ACUPUNCTURE IS WIDELY USED TO PREVENT MIGRAINE ATTACKS. </li></ul><ul><li>THE PROPORTION OF RESPONDERS (REDUCTION IN HEADACHE DAYS BY AT LEAST 50%) WAS 51% IN THE ACUPUNCTURE GROUP, 53% IN THE SHAM ACUPUNCTURE GROUP, AND 15% IN THE WAITING LIST GROUP. </li></ul><ul><li>ACUPUNCTURE AND SHAM ACUPUNCTURE IN REDUCING MIGRAINE HEADACHES ALTHOUGH BOTH INTERVENTIONS WERE MORE EFFECTIVE IN REDUCING MIGRAINE HEADACHES THAN A WAITING LIST CONTROL. </li></ul>LINDE K, STRENG A, MUNICH, GERMANY
  30. 30. MULTIPLE SCLEROSIS <ul><li>ACUPUNCTURE </li></ul><ul><ul><li>MAIL SURVEY INCLUDED 217 PATIENTS </li></ul></ul><ul><li>RESULT </li></ul><ul><ul><li>37 HAD REDUCED PAIN </li></ul></ul><ul><ul><li>34 DECREASED SPASTICITY </li></ul></ul><ul><ul><li>14 IMPROVED BLADDER AND BOWEL DYSFUNCTION </li></ul></ul><ul><ul><li>34 IMPROVED WALKING AND MOBILITY </li></ul></ul><ul><ul><li>48 EXPERIENCED ELEVATED ENERGY LEVEL AND REDUCED FATIGUE </li></ul></ul><ul><ul><li>YOGA AND MS >MEDITATION </li></ul></ul>
  31. 31. AYURVEDIC HERBS IN NEURODEGENERATIVE DISEASES <ul><li>AYURVEDIC PLANTS USED FOR THE MANAGEMENT OF N EURODEGENERATIVE DISEASES SUCH AS: </li></ul><ul><ul><li>PARKINSON'S, ALZHEIMER'S, LOSS OF MEMORY </li></ul></ul><ul><ul><li>DEGENERATION OF NERVES AND OTHER NEURONAL DISORDERS </li></ul></ul><ul><li>GENERALLY POSSESSES STRONG ANTIOXIDANT ACTIVITY. </li></ul>
  32. 32. AYURVEDA IN PARKINSON'S DISEASE . <ul><li>CLINICAL PROSPECTIVE STUDY, OF AYURVEDA TREATMENT (A CONCOCTION IN COW'S MILK OF POWDERED MUCUNA PRURIENS AND HYOSCYAMUS RETICULATUS SEEDS WITHANIA SOMNIFERA AND SIDA CORDIFOLIA ROOTS) </li></ul><ul><li>IN 18 CLINICALLY DIAGNOSED (WITH A MEAN HOEN AND YAHR VALUE OF 2.22) PARKINSONIAN PATIENTS SHOWED: </li></ul>
  33. 33. PARKINSON’S DISEASE <ul><li>HP - 200 </li></ul><ul><ul><li>DERIVED FROM MUCUNA PRURIENT(AYURVEDIC HERB) </li></ul></ul><ul><ul><li>A CLINICAL TRIAL OF 60 PATIENTS SHOWED THAT HP-200 MAY HAVE SOME BENEFITS. (BALA MANYAM PI) </li></ul></ul>
  34. 34. AYURVEDA IN PARKINSON'S DISEASE . <ul><li>RESULTS </li></ul><ul><ul><li>SIGNIFICANT IMPROVEMENT IN ACTIVITIES OF DAILY LIVING (ADL) AND ON MOTOR EXAMINATION AS PER UPDRS RATING. SYMPTOMATICALLY, THEY EXHIBITED GOOD RESPONSE IN TREMOR, BRADYKINESIA, STIFFNESS AND CRAMPS. </li></ul></ul>
  35. 35. CURCUMIN AND ALZHEIMER DISEASE <ul><li>CURCUMIN, IN VITRO, INCUBATED WITH ABETA 40 AND A BETA42, SIGNIFICANTLY DECREASES AMYLOID AGGREGATION ( GREG COLE ET AL ). </li></ul><ul><li>CAPABLE OF INDUCING THE DISAGGREGATION OF PRE-AGGREGATED AMYLOID. </li></ul><ul><li>SIGNIFICANTLY REDUCES ABETA OLIGOMERS FORMATION. </li></ul><ul><li>INHIBITED THE CELL TOXICITY OF AMYLOID OLIGOMERS. </li></ul><ul><li>POSSESSES POTENT ANTI-AMYLOIDOGENIC ACTIVITY, IN ALZHEIMER AGED APP TRANSGENIC MICE TG2576. </li></ul><ul><li>RATIONALE FOR CURCUMIN USE IN CLINICAL TRIALS PREVENTING OR TREATING IN AD ,WHICH IS UNDERWAY AT UCLA </li></ul><ul><li>EPIDEMEOLOGICAL STUDY IN INDIA GANGULI ETAL </li></ul>
  36. 36. CURCUMIN AND ALZHEIMER DISEASE <ul><li>THE INHIBITION OF EGR-1 DNA-BINDING ACTIVITY BY CURCUMIN WAS DEMONSTRATED, IN VITRO, IN HUMAN THP-1 MONOCYTES AND HUMAN PERIPHERAL BLOOD MONOCYTES. </li></ul><ul><li>INHIBITION RESULTED IN A DECREASE IN MRNA EXPRESSION OF CYTOKINES (TNFALPHA AND IL-1BETA) AND CHEMOKINES (MCP-1, IL-8 AND MIP-1BETA). </li></ul><ul><li>CURCUMIN COULD THUS AMELIORATE INFLAMMATION. </li></ul><ul><li>CURCUMIN DID NOT AFFECT THE VIABILITY OF CELLS. </li></ul>
  37. 37. MEDITATION IN NEUROLOGICAL DISORDERS <ul><li>ACCORDING TO STUDIES CONDUCTED BY HERBERT BENSON, M.D., [HARVARD MEDICAL SCHOOL] </li></ul><ul><li>MEDITATION PROCESS COUNTERACTED THE EFFECTS OF THE SYMPATHETIC NERVOUS SYSTEM. </li></ul><ul><li>WHEREAS THE SYMPATHETIC SYSTEM DILATES THE PUPILS AND GETS THE HEART RATE, RESPIRATION, AND BLOOD PRESSURE UP, THE PARASYMPATHETIC SYSTEM, ACTIVATED WHEN WE MEDITATE, DOES JUST THE OPPOSITE. </li></ul>
  38. 38. ALS AND CURCUMIN <ul><li>FAMILIAL FORMS OF ALS DEMONSTRATE UP-REGULATION OF TUMOR NECROSIS FACTOR ALPHA (TNFALPHA). </li></ul><ul><li>CURCUMIN ANTAGONIZED TNF ALPHA, IN VITRO, IN THE MICROGLIAL CELL LINE, DERIVED FROM MOUSE WALKER EOC-20 CELLS. </li></ul><ul><li>ANTAGONISM WAS POSSIBLY DUE TO THE INHIBITION OF 5LOX. </li></ul><ul><li>CURCUMIN COULD THUS BE USED FOR CLINICAL BENEFIT IN ALS. ( WEST ET AL ) </li></ul>
  39. 39. EPILEPSY ALTERNATIVE TREATMENTS <ul><li>VAGUS NERVE STIMULATION </li></ul><ul><li>DEEP BRAIN STIMULATION </li></ul><ul><li>CORTICAL STIMULATION </li></ul><ul><li>TRIGEMINAL NERVE STIMULATION </li></ul><ul><li>FISH OIL </li></ul>
  40. 40. BACKGROUND <ul><li>THE TRIGEMINAL NERVE PROJECTS TO THE NUCLEUS TRACTUS SOLITARIUS (NTS), THE LOCUS CERULEUS, AND THE VAGUS NERVE. </li></ul><ul><ul><li>Stimulation of NTS reduces seizures induced by amygdala stimulation. </li></ul></ul><ul><li>STIMULATION OF LC SUPPRESSES COBALT AND PENICILLIN INDUCED EPILEPTIC DISCHARGES. </li></ul><ul><ul><li>Lesioning the LC blocks the effect of vagus nerve stimulation. </li></ul></ul><ul><li>TRIGEMINAL NERVE STIMULATION BLOCKS PTZ INDUCED SPIKES AND SEIZURES IN RATS </li></ul><ul><ul><li>Fanselow, Nicolelis, et al 2000 </li></ul></ul>
  41. 41. SUDDEN DEATH IS A MAJOR PROBLEM IN EPILEPSY <ul><li>SUDDEN DEATH RATES ARE SIGNIFICANTLY HIGHER IN EPILEPSY THAN AGE MATCHED POPULATION </li></ul><ul><ul><li>SPERLING </li></ul></ul><ul><ul><li>ANNEGERS </li></ul></ul>
  42. 42. STROKE <ul><li>AYURVEDIC SPICE : TURMERIC </li></ul><ul><ul><li>INHIBITS PLATELET AGGREGATION AND MODULATES EICOSANOID BIOSYNTHESIS </li></ul></ul><ul><ul><li>AYURVEDIC OIL MASSAGE </li></ul></ul><ul><li>ACUPUNCTURE </li></ul><ul><ul><li>A CLINICAL TRIAL ON 118 PTS: SHORTER DURATIONS OF HOSPITAL STAY FOR REHAB </li></ul></ul><ul><li>YOGA </li></ul><ul><li>MASSAGE THERAPY </li></ul>
  43. 43. SUB ACUTE LOW-BACK PAIN <ul><li>PROTOCOL </li></ul><ul><ul><li>RANDOMIZED CONTROLLED TRIAL COMPARED COMPREHENSIVE MASSAGE THERAPY(CMT) TO SOFT-TISSUE MANIPULATION (STM), REMEDIAL EXERCISE, AND PLACEBO. </li></ul></ul><ul><li>RESULTS (1 MONTH FOLLOW-UP) </li></ul><ul><ul><li>% OF PATIENTS WHO REPORTED NO PAIN </li></ul></ul><ul><ul><ul><li>CMT: 63% </li></ul></ul></ul><ul><ul><ul><li>STM: 27% </li></ul></ul></ul><ul><ul><ul><li>PLACEBO: 0% </li></ul></ul></ul><ul><li>CHIROPRACTIC MANUPULATION AND ACUPUNCTURE USEFUL IN NIH CONCENSOUS PANEL REPORT </li></ul>
  44. 44. CHRONIC PAIN <ul><li>TENS </li></ul><ul><li>STUDY OF 482 PATIENTS WITH CHRONIC PAIN OF VARIOUS ORIGINS. GOOD RESPONSE </li></ul><ul><li>PROBLEMS WITH STUDY </li></ul><ul><ul><li>INDIVIDUAL DIFFERENCES IN PTS RESPONSE </li></ul></ul><ul><ul><li>HIGH DROP OUT RATE IN LONG-TERM TREATMENT </li></ul></ul>
  45. 45. PERIPHERAL NEUROPATHY <ul><li>YOGA / CARPAL TUNNEL SYNDROME </li></ul><ul><ul><li>RANDOMIZED SINGLE-BLIND CONTROLLED TRIAL 42 PTS WITH CTS </li></ul></ul><ul><ul><li>RESULT: YOGA-BASED REGIMEN MORE EFFECTIVE THAN WRIST SPLINTING OR NO TX IN RELIEVING SOME S/SXS OF CTS </li></ul></ul><ul><ul><li>PHALEN SIGN IMPROVEMENT IN 12 PTS WITH YOGA TX VS. 2 PTS IN CONTROL </li></ul></ul>
  46. 46. YOGA <ul><li>YOGA'S ROLE IN THE MANAGEMENT OF DEPRESSION HAS BEEN INVESTIGATED AND REPORTED TO BE BENEFICIAL FOR COLLEGE STUDENTS WHO EXHIBIT A HIGH LEVEL OF DEPRESSIVE SYMPTOMS. </li></ul><ul><li>CASE REPORT DESCRIBING AN APPLICATION OF YOGA THERAPEUTICS TO A PATIENT WITH PARKINSON DISEASE. </li></ul><ul><li>RELAXATION MAY PROMOTE POSITIVE EFFECTS ON CAROTID ATHEROSCLEROSIS, HYPERTENSION, DIABETES, AND CORONARY ARTERY DISEASE, WHICH ARE IDENTIFIED AS RISK FACTORS ASSOCIATED WITH STROKE OCCURRENCE OR REOCCURRENCE </li></ul>
  47. 47. YOGA AND MS <ul><li>DR. OKEN HYPOTHESIS: </li></ul><ul><ul><li>YOGA MIGHT BE BENEFICIAL IN TERMS OF COGNITIVE FUNCTION IN MULTIPLE SCLEROSIS, WHERE THERE ARE SIGNIFICANT COGNITIVE PROBLEMS, SUCH AS DIFFICULTY CONCENTRATING. </li></ul></ul><ul><ul><li>COGNITIVE FUNCTION WAS THE PRIMARY OUTCOME MEASURE IN THE STUDY, AND ALL THE QUALITY OF LIFE MEASURES SUCH AS FATIGUE AND MOOD WERE SECONDARY OUTCOME MEASURES </li></ul></ul>
  48. 48. FUTURE INVESTIGATIVE POTENTIALS <ul><li>YOGA CAN BE USED TO PREVENT AND CURE VARIOUS INDIVIDUAL, COMMUNITY, AND SOCIETAL ILLNESSES. </li></ul><ul><li>INDIVIDUAL DEVELOPMENT TO UPLIFT ONESELF IS CRUCIAL AND NEEDS TO BE STUDIED. </li></ul><ul><li>YOGA WITH AYURVEDA AND MODERN MEDICINE CAN BE APPLIED TO AGING, DEMENTIA, STRESS ADAPTATION, G.I. DISORDERS, HIV/AIDS, AUTOIMMUNE DISORDERS, AND MANY OTHER AILMENTS. </li></ul>
  49. 49. W. SOMNIFERA IN MUSCLE SARCOPENIA <ul><li>PRELIMINARY TRIAL ON 28 HEALTHY VOLUNTEERS (22 MALES) AND (6 FEMALES) BETWEEN 60 TO 75 YEARS WAS CONDUCTED. </li></ul><ul><li>THE HERB W. SOMNIFERA MAY HAVE THE POTENTIAL TO IMPROVE MUSCLE STRENGTH AND ENDURANCE FOR THE AGED SUBJECTS. </li></ul><ul><li>SHOWED POTENTIAL EFFECT IN IMPROVING MUSCLE FUNCTIONING AND MUSCLE STRENGTH TESTING </li></ul><ul><li>FUNCTIONAL MEASUREMENT UP AND GO TEST </li></ul><ul><li>NO SIDE EFFECT WAS OBSERVED FOR THE HERB AT 500 MG (BID) FOR THE AGED SUBJECTS FOR CONTINUOUS PERIOD OF 3 MONTHS. </li></ul><ul><li>MISHRA ETAL 2002 </li></ul>
  50. 50. FIBROMYALGIA <ul><li>CLINICAL SURVEY SHOWS 98% PERCENT OF THE PATIENTS USE SOME TYPE OF CAM THERAPY. </li></ul><ul><li>MOST FREQUENTLY USED CAM TREATMENTS: </li></ul><ul><ul><li>EXERCISE FOR A SPECIFIC MEDICAL PROBLEM (48%), </li></ul></ul><ul><ul><li>SPIRITUAL HEALING (PRAYERS) (45%), </li></ul></ul><ul><ul><li>MASSAGE THERAPY (44%), </li></ul></ul><ul><ul><li>CHIROPRACTIC TREATMENTS (37%), </li></ul></ul><ul><ul><li>VITAMIN C (35%), VITAMIN E (31%), MAGNESIUM (29%), VITAMIN B COMPLEX (25%), GREEN TEA (24%), AND </li></ul></ul><ul><ul><li>WEIGHT-LOSS PROGRAMS (20%). </li></ul></ul><ul><ul><li>ACUPUNCTURE 20% </li></ul></ul><ul><li>CONCLUSION: CAM USE IS COMMON IN PATIENTS REFERRED TO A FIBROMYALGIA TREATMENT PROGRAM. . </li></ul>WAHNER-ROEDLER DL, MAYO CLINIC COLLEGE OF MEDICINE, ROCHESTER, MINN 55905, USA
  51. 51. FUTURE OF CAM <ul><li>TM/CAM WILL UNDER GO RIGOROUS SCRUTINY AND WILL BE MORE EVIDENCE BASED </li></ul><ul><li>EFFICACY, QUALITY--- WILL BE INCORPORATED IN TM </li></ul><ul><li>SCIENTIFIC INTEGRATION OF TM/MODERN ALLOPATHIC MEDICINE </li></ul><ul><li>A PARADIGM SHIFT in HEALTH CARE </li></ul><ul><li>COST EFFECTIVE, EASILY ACCESIBLE </li></ul><ul><li>QUALITY HEALTH CARE WILL EVOLVE </li></ul><ul><li>WHO IS HELPING CAM / TM ?? </li></ul>
  52. 52. SUMMARY <ul><li>CAM IS CONSIDERED AS ANCIENT, TRADITIONAL HEALTHCARE DISCIPLINE PRACTICED FOR THOUSANDS OF YEARS </li></ul><ul><li>IN RECENT DECADES INCREASING AMOUNT OF INTEREST IN CAM IN WESTERN COUNTRIES, ESPECIALLY IN FIELD OF NEUROLOGY. </li></ul><ul><li>PROPER EDUCATION FOR MODERN HEALTH CARE PRACTITIONERS </li></ul><ul><li>INCREASING AMOUNT OF EVIDENCE-BASED RESEARCH BEING PERFORMED. </li></ul><ul><li>THERE IS NEED FOR FURTHER RESEARCH IN NEUROLOGICAL DISORDERS </li></ul>

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