Result from impaired insulin function . (insulin resistance)
Constitutes 90-95% of DM
Specific causes of this form are unknown .
Risk factors : age, obesity, alcohol, diet, family Hx and lack of physical activity ..etc.
mild beta-cell depletion severe beta-cell depletion focal atrophy and amyloid deposits marked atrophy and fibrosis no insulitis insulitis early Islet Cells relative insulin deficiency severe insulin deficiency insulin resistance autoimmunity, immunopathologic mechanisms Pathogenesis No HLA association human leukocyte antigen (HLA)-D linked ketoacidosis rare ketoacidosis common Genetics no anti-islet cell antibodies anti-islet cell antibodies normal or increased blood insulin decreased blood insulin obesity normal weight onset >30 years onset <20 years Clinical Type 2 Type 1 Comparison