This document summarizes the process of mast cell activation. When an antigen binds to IgE antibodies on the surface of a mast cell, it activates anaphylatoxin receptors. This leads to the release of various inflammatory mediators including vasoactive amines, enzymes, leukotrienes, prostaglandins, and cytokines. These mediators cause smooth muscle contraction, increased vascular permeability, chemotaxis of eosinophils, platelet activation, and protease effects. Ultimately, this results in physiological effects associated with anaphylaxis.

1. Activation by
Coplement peptides
Anaphytatoxin
receptors
Release of:
• Vasoactive amines (histamine)
• Eosinophil chemotactic factor
• Platelet activating factor
• Enzymes
• Leukotrienes C,D,E
• Prostaglandin PG𝐷2 , thromboxane
• Smooth muscle contraction
• Increased vascular
permeability
• Chemotactic attraction of
eosinophils
• Platelet activation
• Protease effects,
kininogenases
Effects:
lgE antibody
Antigen
Anaphylactic activation
Arachidonic
acid products
C3a
C5a
Secretory
events
Ca2-
Receptor-Ligand
Coupling
Metabolic
Responses
Mast cell

2. Mast cell – With Labels Removed

3. Mast cell – With Highlighted Part
Download this awesome diagram.
Bring your presentation to life.
Capture your audience’s
attention. Pitch your ideas
convincingly. Bring your
presentation to life. Capture your
audience’s attention. All images
are 100% editable in PowerPoint.
Download this awesome diagram.
Pitch your ideas convincingly.
Download this awesome diagram.
Bring your presentation to life.
Antigen

4. Mast cell – With Highlighted Part
Download this awesome diagram.
Bring your presentation to life.
Capture your audience’s
attention. Pitch your ideas
convincingly. Bring your
presentation to life. Capture your
audience’s attention. All images
are 100% editable in PowerPoint.
Download this awesome diagram.
Pitch your ideas convincingly.
Download this awesome diagram.
Bring your presentation to life.
Anaphytatoxin receptors

5. " Add your Own Lables and Highlight Any section"

6. This image is 100% editable in PowerPoint

7. Add Text
1) Open the PowerPoint Slide in which you have to insert the Text Box. Then click on the “Insert
Tab’ in the Ribbon and then inside the Insert Tab, in the ‘Text’ category click on the “Text Box”
icon.
2) Now to insert the Text box, click on the Portion of the Slide where you want the Text box to be
inserted. Once you click, the Text box will be inserted. You can change the size and the shape of
the Text box as per your requirements.
3) Now click on the Text box to enter data into it.
1 2
3

8. 1. Select the shape to change the color and Right click the object( click any object which you
want to change color)
2. Choose Format Shape in the dialog box.
3. Choose “Fill” in the Format Shape box then “Solid” or “Gradient” depending on the
appearance of the object. Change colour as shown in the picture.
Change Color
1
2 3

9. 1. Select the shape to change the size.
2. Click the mouse in the corner of the shape and drag the mouse.
Change Size
1
2