Research Tissue

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Research Tissue

  1. 1. Research Tissue Kate Truncale, MS Senior Scientist
  2. 2. Overview <ul><li>About MTF </li></ul><ul><li>Why Research Consent is Important </li></ul><ul><li>Research Tissue Avenues </li></ul><ul><li>Examples of Various Research Projects Utilizing Research Tissue </li></ul>
  3. 3. MTF Mission Statement MTF is a non-profit service organization dedicated to providing quality tissue through a commitment to excellence in education, research, recovery and care for recipients, donors & their families.
  4. 4. MTF Facts <ul><li>MTF was founded by leading academic orthopedic surgeons who identified an increasing need for high quality allograft tissue. </li></ul><ul><li>Since 1987, MTF has recovered over 60,000 donors and have distributed over 3 million grafts. </li></ul><ul><li>In 2007, MTF recovered over 6,300 donors resulting in more than 390,000 grafts to surgeons, hospitals, dentists and clinicians. </li></ul>
  5. 5. Why We Need Research Consent <ul><li>Honor & maximize the gift </li></ul><ul><ul><li>If donor is non-transplantable and does not have research consent it can’t be used! </li></ul></ul><ul><li>Improve current tissue forms & processes </li></ul><ul><li>Develop new tissue forms & processes </li></ul><ul><li>Broaden applications for tissue forms </li></ul><ul><li>Optimize donor criteria </li></ul>
  6. 6. Avenues for Research Tissue <ul><li>Internal MTF R&D Projects </li></ul><ul><li>MTF Research Tissue Program (Hospitals& Universities) </li></ul><ul><ul><li>Application process </li></ul></ul><ul><li>MTF Research Grant Program </li></ul><ul><ul><li>Directed research </li></ul></ul><ul><ul><li>Grant applications </li></ul></ul>
  7. 7. Fresh Osteochondral Allografts <ul><li>Application : Cartilage repair, eliminate pain and morbidity associated with autologous grafting </li></ul><ul><li>Study : Affect of storage media on cell viability of fresh refrigerated osteochondral allografts for articular cartilage repair </li></ul><ul><li>Result : Proprietary media developed to maintain cell viability, allowing introduction of living chondrocytes to the implant site </li></ul>
  8. 8. Acellular Dermis (Flex HD) <ul><li>Application : Hernia repair, pelvic floor reconstruction, urological incontinence, rotator cuff repair </li></ul><ul><li>Study : Develop a process to remove epidermal and dermal cells from donated skin producing acellular dermis matrix </li></ul><ul><li>Result : Matrix supports cellular repopulation and vascularization at the surgical site. Supplied pre-hydrated & stored at room temperature </li></ul>
  9. 9. Precision Spinal Allografts <ul><li>Application : cervical fusions, lumbar fusions & spinal corrections </li></ul><ul><li>Study : Develop machining methods to create intricate designs & consistent sizing </li></ul><ul><li>Result : Spinal fusion grafts including technique specific precision shapes capable of restoring spinal function, enhancing patients’ lives & eliminates donor site pain associated with autologous grafting </li></ul>
  10. 10. <ul><li>Application : ACL repair, eliminates pain associated with autologous grafting </li></ul><ul><li>Study : Collaboration with Dr. Charlie Gatt, MD - determine donor criteria for BTB grafts </li></ul><ul><ul><li>100 Hemi BTB Grafts </li></ul></ul><ul><ul><li>Age Range: 16 – 69, sex matched </li></ul></ul><ul><li>Result : No statistical difference between age and sex </li></ul>Bone –Tendon-Bone Allograft
  11. 11. AATB STAC Study on Fosamax <ul><li>Application : MTF currently rejects donors treated with Fosamax </li></ul><ul><ul><li>Affect on bone transplantation unknown </li></ul></ul><ul><ul><li># of donors treated with Fosamax continues to increase </li></ul></ul><ul><ul><li>Effects both male and female donors </li></ul></ul><ul><li>Study : 4 Major tissue banks providing research tissue (DBM) to test difference in quality </li></ul><ul><li>Result : Potentially broaden donor criteria increasing use of the gift </li></ul>
  12. 12. Non-standard Donors <ul><li>Application : MTF donor age limit for weight bearing tissues is 70 </li></ul><ul><li>Study : Evaluate differences in cortical bone from male donors 55-70 and 71-80 y/o </li></ul><ul><li>Result : Donors over 70 years of age are not acceptable for weight bearing applications </li></ul>* p < 0.05 * *
  13. 13. Research Tissue Program <ul><li>Prosthesis attachment for war veterans </li></ul><ul><ul><li>100 femurs </li></ul></ul><ul><ul><li>Development of fixation </li></ul></ul><ul><li>Development of a Device to Increase Proximal Femur Strength in Patients with Osteoporosis </li></ul><ul><ul><li>Hip fractures </li></ul></ul><ul><ul><li>Method reinforcement with PMMA cement to prevent repeat injury </li></ul></ul><ul><ul><li>Mechanical testing </li></ul></ul>
  14. 14. Research Tissue Contd. <ul><li>Geometric and material properties of ACL, Patella Tendons and Hamstring Tendons </li></ul><ul><ul><li>ACL graft failure risk factors </li></ul></ul><ul><ul><li>Male vs. female tissue </li></ul></ul><ul><ul><li>Dimensions and mechanical testing </li></ul></ul>
  15. 15. MTF Directed Research <ul><li>Effects of Aging on Bone </li></ul><ul><li>Evaluation of Bone Density Through Radiographic Techniques </li></ul><ul><li>Effects of Processing and Low Dose Radiation on Cortical Bone Grafts </li></ul>
  16. 16. MTF Grant Recipients <ul><li>Optimization of Novel Sterilization Methods for Soft Tissue Allografts PI: Michael Dunn, Ph.D. - UMDNJ-Robert Wood Johnson Medical School Amount Funded: $125,000 </li></ul><ul><li>Osteoprogenitor Cell Differentiation When Cultured on Allograft Bone PI: Stuart Goodman, M.D., Ph.D. - Stanford University </li></ul><ul><li>Amount Funded: $82,336 </li></ul><ul><li>Physiologic Loading for Long-Term Maintenance of Osteochondral Grafts in Culture PI: Clark Hung, Ph.D. - Columbia University </li></ul><ul><li>Amount Funded: $125,000 </li></ul>
  17. 17. Summary <ul><li>Research tissue plays an important role in our ability to : </li></ul><ul><ul><li>Honor & maximize the gift </li></ul></ul><ul><ul><li>Provide highest quality and innovative allografts </li></ul></ul><ul><ul><li>Support progression of external research </li></ul></ul><ul><li>Without research consent, non-transplantable donors can not be used </li></ul>
  18. 18. Thank You! Questions?

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