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"Overview of the Harvard Catalyst Imaging Program"

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  • 1. Overview of the Harvard Catalyst Imaging program Randy Gollub,MD,PhD; Valerie Humblet,PhD http://catalyst.harvard.edu April 28, 2009
  • 2. Institutions participating in Harvard CTSC
    •   Academic Healthcare Centers
    • Beth Israel-Deaconess Medical Center
    • Brigham and Women’s Hospital
    • Massachusetts General Hospital
    • Children’s Hospital Boston
    • Specialty Hospitals and Institutes
    • Dana-Farber Cancer Institute
    • Forsyth Dental Institute
    • Joslin Diabetes Center
    • Massachusetts Eye and Ear Infirmary
    • McLean Hospital
    • Schepens Eye Research Institute
    • Massachusetts Institutes of Technology
    • Harvard University
    • Faculty of Arts and Sciences
    • Harvard Business School
    • Harvard School of Dental Medicine
    • Harvard Divinity School
    • Graduate School of Design
    • Graduate School of Education
    • Kennedy School of Government
    • Harvard Law School
    • Harvard Medical School
    • Harvard School of Public Health
    • Harvard School of Engineering
    • Community Healthcare Institutions
    • Cambridge Health Alliance
    • HMS Department of Ambulatory Care and Prevention at Harvard Pilgrim Healthcare
    Yearly budget: $38 million (23 NIH + 15 matching)
  • 3. Harvard Catalyst
    • Programs (Selected list)
      • Development of Novel C/T Methodologies
      • Biomedical Informatics
      • Research Education, Career Development
      • Pilot studies
      • Community Engagement
      • Design and Biostatistics
      • Diversity and Health Disparities Research
      • Ethics
      • Linkages across the institutions
      • Regulatory Knowledge and Support
  • 4. Imaging Consortium Team Bruce Rosen, Director Randy Gollub, Co-Director Gordon J. Harris, Site Co-Director Robert Lenkinski, Site Co-Director Neil Rofsky, Site Co-Director Clare Tempany, Site Co-Director Ron Kikinis, Site Co-Director Gordon Williams, PI for CTSC Translational Technologies Stephan Voss, Site Co-Director Simon Warfield, Site Co-Director Annick D. Van den Abbeele, Site Co-Director Jeff Yap, Site Co-Director Gordon J. Harris, Site Co-Director Annick D. Van den Abbeele, Site Co-Director William Hanlon, Core Manager Valerie Humblet, Imaging Liaison Yong Gao, XNAT Engineer
  • 5. Mission of the Imaging Consortium
    • Expand imaging in clinical research
      • Build infrastructure (software, image analysis and visualization tools, cross-site acquisition tools)
      • Provide expert consultation in the use of imaging as part of clinical translational research
      • Educate and advise about available imaging and image processing capabilities in the Harvard environment.
      • Provide education at the local and national level (participation in RSNA education program)
  • 6. Image Consortium Consultation Service
  • 7. Technologies and Expertise
    • Cancer imaging, MRI, PET, CT, fMRI, US, pediatric imaging, neuroimaging.
    • Focused on assisting with planning and design of research proposals and/or methods for image analysis.
    • Consultation is available for the preparation of a grant or IRB submission.
    • We do not (yet) provide ongoing support for the implementation of new studies or the analysis of data from existing studies.
  • 8. Examples of Imaging Consultation
    • Standardization of physiologic monitoring system for MRI.
      • Deployed at 6 institutions (MGH, BWH.BIDMC, CHB, MIT, Harvard)
      • Creation of a biomedical engineer working group
  • 9. Examples of Imaging Consultation
    • Development of lingual nerve imaging (MGH-BIDMC)
      • MGH maxillofacial surgeon contacted us regarding pre-op imaging of lingual nerve
      • Bob Lenkinski (BIDMC) had expertise in MRI nerve imaging
      • Healthy volunteer was scanned at BIDMC
      • Head and neck radiologist (BIDMC) will help with reading of images
  • 10. Examples of Imaging Consultation
    • Study of brain-development in premature infants (new collaboration: CHB-BWH-MGH)
    Slicer (BWH): quantitative tractography ( Gilmore, 2007 AJNR) CHB : new Fetal-Neonatal Neuroimaging and Developmental Science Center Optical Imaging of Cerebral Oxygenation in Infants ( MGH )
  • 11. Medical Imaging Informatics
    • Examples:
      • Clinical:
        • Ruling out appendicitis based on CT scans. Are there metrics that can be found by analyzing clinical data?
        • Quantitative output from Freesurfer for Alzheimer disease
      • Research:
        • Helping TIMC get easier access to PACS system for clinical trials
  • 12. Medical Imaging Informatics
    • IT Catalyst infrastructure:
      • i2b2: scalable computational framework to help translation of genomic findings.
      • BIRN: XNAT imaging informatics platform: large collections of images and study-specific metadata to be managed by image-driven clinical translational research groups.
      • NA-MIC:robust, open source solutions for medical image analysis, visualization and management software tools by the creation of a “desktop” version of XNAT. Key image analysis software tools: Slicer, Freesurfer.
  • 13. Medical Imaging Informatics Data Repository (CRC) File Repository Identity Management Ontology Management Correlation Analysis De - Identification Of data Natural Language Processing Annotating Genomic Data #1 Project Management Workflow Framework Annotating Genomic Data #2 PACS PACS i2b2 HIVE Dr X Desktop Pediatric rare disease Dr Y Desktop Alzheimer Dr Z Desktop Chronic pain management Dr W Desktop Quantitative cancer biomarkers XNAT Enterprise
  • 14. Educational Program
    • Mission: Provide lectures, tutorials, and educational materials promoting the use of imaging to junior investigators and associated research staff
    • Tailored lectures: Host on-site and based on discipline (oncology, neuro, cardiology, pediatrics, etc)
    • Generic imaging modules: Basic principles of imaging, quantitative methods, clinical trial design with imaging endpoints, imaging risks and considerations for informed consent forms
    • Dissemination: through national networks (CTSA, RSNA, IRAT, SNM)
  • 15. Pilot funds
    • Eligibility: All Harvard faculty are eligible to apply, regardless of degree or institutional affiliation.
    • First round: 62 projects funded (out of 602)
    • Funds: Pilot Grants will be awarded in the amount of $50,000, with an award period of one year. (80 grants expected)
    • Deadlines: Letter of intent: May 13, 2009
    • Full application: June 12, 2009
    • Contact: Harvard Catalyst Research Navigators 617 432-7800
  • 16. http://catalyst.harvard.edu [email_address] www.na-mic.org/Wiki/index.php/Collaboration:Harvard_CTSC

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