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DDT
Matthew Spicuzza
Outline
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•
•
•
•
•
•
•

What is DDT?
Structure of DDT
Rachel Carson
Dangers of DDT
MOA
How DDT “helped”
Conclusions
Quest...
What is DDT?
• In 1948 Paul Mueller was awarded the Nobel Prize in Medicine
• DDT is a pesticide
• Persistent Organic Poll...
Structure of DDT

• Dichlorodiphenyltrichloroethane
Rachel Carson

• Rachel Carson’s Silent Spring
DDT
• DDD
– 1,1-dichloro-2,2-bis[p-chlorophenyl] ethane

• DDE
– Dichlorodiphenyldichlolorethylene
– a degradation of DDT
...
Dangers of DDT
• Bioaccumulation
• POP
• Birds are major target species
MOA in Birds
• Inhibits Ca-dependent ATPases
• Egg shell thinning
• Increased risk of damage to eggs
Birds affected by DDT
• Osprey
• Brown Pelican
• Raptor
How DDT “helped”
• Boomerang Paradigm
• Increased awareness of ecotoxicity
Conclusions
• In conclusion, DDT is an insecticide that was used heavily from
the late 1930’s to the early 1970’s
• Throug...
References
• Casarett, Louis J., John Doull, and Curtis D. Klaassen. "Chapter
29/Ecotoxicology." Casarett and Doull's Toxi...
Questions?
DDT
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DDT

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Transcript of "DDT "

  1. 1. DDT Matthew Spicuzza
  2. 2. Outline • • • • • • • • What is DDT? Structure of DDT Rachel Carson Dangers of DDT MOA How DDT “helped” Conclusions Questions
  3. 3. What is DDT? • In 1948 Paul Mueller was awarded the Nobel Prize in Medicine • DDT is a pesticide • Persistent Organic Pollutant
  4. 4. Structure of DDT • Dichlorodiphenyltrichloroethane
  5. 5. Rachel Carson • Rachel Carson’s Silent Spring
  6. 6. DDT • DDD – 1,1-dichloro-2,2-bis[p-chlorophenyl] ethane • DDE – Dichlorodiphenyldichlolorethylene – a degradation of DDT – also dangerous to environment 7
  7. 7. Dangers of DDT • Bioaccumulation • POP • Birds are major target species
  8. 8. MOA in Birds • Inhibits Ca-dependent ATPases • Egg shell thinning • Increased risk of damage to eggs
  9. 9. Birds affected by DDT • Osprey • Brown Pelican • Raptor
  10. 10. How DDT “helped” • Boomerang Paradigm • Increased awareness of ecotoxicity
  11. 11. Conclusions • In conclusion, DDT is an insecticide that was used heavily from the late 1930’s to the early 1970’s • Throughout this time there were several populations of birds that declined rapidly • DDT has been one of the most widely influential pesticides to help gain the attention of the impact we have on the environment.
  12. 12. References • Casarett, Louis J., John Doull, and Curtis D. Klaassen. "Chapter 29/Ecotoxicology." Casarett and Doull's Toxicology: The Basic Science of Poisons. New York: McGraw-Hill, 2008. 1176-177. Print. • Michael, C. Newman. Fundamentals of Ecotoxicology, Third EditionMichael C. Newman. Fundamentals of Ecotoxicology, Third Edi: CRC, 2009. Print. • "DDT - A Brief History and Status | Pesticides | US EPA." EPA. Environmental Protection Agency, n.d. Web. 18 Nov. 2013. <http://www.epa.gov/pesticides/factsheets/chemicals/ddt-briefhistory-status.htm>. • Dr. Baer’s power points from clinical toxicology • Google images
  13. 13. Questions?
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