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Cell Culture: The World Market for Media, Sera and Reagents, 2nd Edition

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  • 1.    Get more info on this report!Cell Culture: The World Market for Media, Sera and Reagents, 2nd EditionMay 1, 2009Cell culture is a major foundation of biopharmaceutical development, bioprocessing andmanufacturing. As the biopharmaceutical market grows, so should interest in the cellculture products market. Biopharmaceutical products are developed from large,complex protein molecules, which require equally complex manufacturing methods andan array of analytical techniques. As growing cells for biopharmaceutical production isslow, expensive and complicated, optimizing cell culture development is of paramountconcern to companies developing biopharmaceuticals.This report, Cell Culture represents the second time that Kalorama has focused onculture used in the research and production of biopharmaceuticals, analyzing the worldcell culture market and the major trends driving this market in three specific segments: • Media, • Sera, and • ReagentsIn addition to a thorough discussion of the technologies and techniques currentlyemployed and emerging in the cell culture area, the Kaloramas exhaustive reportprovides specific information on: • Market Size, growth, and forecasts of the segments through 2013 • Competitive Market Share by leading supplier as of 2008. • Estimated Market Share by Region (North America, Europe, U.S.) • Key Market Drivers and Restraints for suppliers, including discussions of biopharmaceutical pipelines, biomedical R&D directions, and the future of transgenic plant and animal production. • Review of the various expression systems (Bacteria, Yeast, Insect, and Mammal) and the biopharmaceutical product manufactured by these systems • Discussion of the preferences in media types vying for dominance in the market, including the following: o ADCF - animal derived component free media o CD - chemically defined media
  • 2. o CSFM - complete serum free medium o PF - protein free media o SF - serum free media o SFM - serum free medium • Major Trends Impacting the Market stem cell research (including plans of major companies)cell culture-based vaccine Production and generic bipharmaceuticals • Profiles of 27 Leading Suppliers and information about M&A activities in recent yearsThe information for this report was gathered using both primary and secondary researchincluding comprehensive research of secondary sources such as company literature,databases, investment reports, and medical and business journals. Telephoneinterviews and email correspondence were the primary method of gathering information.For the purpose of this study Kalorama Information conducted interviews with keyindustry officials, consultants, and government personnel. These sources were theprimary basis in gathering information specifically relating to revenue and market sharedata presented in this report. Specific interviews with pharmaceutical company and cellculture supply company representatives included marketing directors, divisionmanagers, and product representatives.Table of ContentsCHAPTER ONE: EXECUTIVE SUMMARY Scope and Methodology Cells for Biopharmaceutical Production Bacteria and Yeasts Systems Animal Cell Systems Insect Cell Systems Cell Lines and Cell Banks Fermentors and Bioreactors Stirred-tank Reactors Airlift Fermentors Packed Bed Reactors Hollow-fiber Reactor Disposable Systems Fermentation Processes Batch and Fed-Batch Fermentation Suspended vs. Anchored Cells Microencapsulation Cell Culture Environment Functions and Components of Basal Media pH and Osmotic Pressure Energy Sources Nutrients Cell Culture Media
  • 3. Lysogeny broth (LB) Classical Media Serum-free Media Protein-free Media Chemically Defined Media Specialty Media Sera Reagents Shifting Towards Non-animal Derived Reagents Addressing Reagent Safety Issues World Cell Culture Market Impact of Shift to Serum-free Products on Cell Culture Suppliers Impact of Shift to Serum-free Products on Research Impact of Shift Serum-free Products on Biopharmaceutical Manufacturers Cell Culture Market and Forecast Trends Impacting The Cell Culture MarketCHAPTER TWO: GENETICALLY MODIFIED CELLS FOR BIOPHARMACEUTICALDEVELOPMENT Growing Demand for Biopharmaceuticals Demand Increasing for Cell Culture Products A Brief History of Biotechnology Science of Genetic Manipulation From Petri Dish to Biopharmaceutical Upstream Bioprocessing: Cell Culture Expression Systems Cells for Biopharmaceutical Production Bacteria and Yeasts Systems Animal Cell Systems Insect Cell Systems Advantages/Disadvantages of Cell Culture Systems Cell Lines and Cell Banks Biopharmaceuticals Produced from Cell Culture Cell Culture Practices and Regulatory Guidelines Validation of Facilities Maintaining Sterilization StandardsCHAPTER THREE: CELL CULTURE TECHNOLOGY Introduction and Overview Milestones in Cell Culture Development Cell Lines for Bioproduction Predominant Cell Lines Chinese Hamster Ovary (CHO) SP2/0, and NS0 HEK 293 and PER. C6 Sources: Largest Collections of Cell Lines Fermentors and Bioreactors Types of Bioreactors/Fermentors
  • 4. Stirred-tank Reactors Airlift Fermentors Packed Bed Reactors Hollow-fiber Reactor Disposable Systems Fermentation Processes Batch and Fed-Batch Fermentation Suspended vs. Anchored Cells Microencapsulation Cell Culture Environment Functions and Components of Basal Media pH and Osmotic Pressure Energy Sources Nutrients Cell Culture Media Types of Media Lysogeny broth (LB) Classical Media Serum-free Media Protein-free Media Chemically Defined Media Specialty Media Sera Sources of Sera Bovine Serum Safety Issues and Regulations Shift to Serum-free Media Reagents Major Types of Biologic Reagents Amino Acids Growth Factors and Cytokines Albumin Transferrin Thrombin Growth Supplements Protease Inhibitor Attachment Factors Shifting Towards Non-animal Derived Reagents Addressing Reagent Safety IssuesCHAPTER FOUR: CELL CULTURE MARKET: CURRENT AND FUTURE TRENDS Overview Shift Away From Serum-Based Cell Culture Impact of Shift to Serum-free Products on Cell Culture Suppliers Impact of Shift to Serum-free Products on Research Life Technologies’ End Run Around the BSE Issue Cell Culture Market Market Drivers
  • 5. Cell Culture Market and Forecast Segment Analysis Media Sera Reagents Market Characteristics Market Share: Cell Culture Suppliers Trends Impacting The Cell Culture Market Stem Cell Research Life Technologies Sigma-Aldrich Millipore Corporation ThermoFisher Scientific Lonza Bioscience Cell Culture-based Vaccine Production Generic Biopharmaceuticals Transgenically Produced BiopharmaceuticalsCHAPTER FIVE: COMPANY PROFILES Advanced Biotechnologies, Inc History and Lines of Business Cell Culture Products and Services Amresco, Inc History and Lines of Business Cell Culture Products Analytical Biological Services Inc History and Lines of Business Cell Culture Products Mammalian Cell Culture Cell in Microtiter Plates for HTS Primary Cultures Insect Cell Culture Atlanta Biologicals, Inc History and Lines of Business Cell Culture Products Athena Enzyme Services History and Lines of Business Cell Culture Products BD Biosciences History and Lines of Business Cell Culture Products Financial Information Biochrom AG History and Lines of Business Cell Culture Products Cell Essentials, Inc History and Lines of Business
  • 6. Cell Culture ProductsCellGenix Technologie Transfer GmbHHistory and Lines of BusinessCell Culture Products and ServicesIrvine ScientificHistory and Lines of BusinessCell Culture ProductsJ R Scientific, IncHistory and DevelopmentCell Culture ProductsLife Technologies CorporationHistory and Lines of BusinessCell Culture ProductsFinancial InformationLonza BioscienceHistory and Lines of BusinessCell Culture Products and ServicesCulture Media DevelopmentCell Line CreationCell BankingFinancial InformationMediatech, IncHistory and Lines of BusinessCell Culture ProductsMillipore CorporationHistory and Lines of BusinessCell Culture ProductsFinancial InformationMP BiomedicalsHistory and Lines of BusinessCell Culture ProductsPAA laboratories, IncHistory and Lines of BusinessCell Culture ProductsPromoCell GmbHHistory and Lines of BusinessCell Culture ProductsQuality Biological, IncHistory and Lines of BusinessCell Culture ProductsR&D Systems, IncHistory and Lines of BusinessCell Culture ProductsSBH SciencesHistory and Lines of BusinessCell Culture Products
  • 7. Selexis SA History and Lines of Business Cell Culture Products SeraCare Life Sciences, Inc History and Lines of Business Cell Culture Products Financial Information Sigma-Aldrich Corporation History and Lines of Business Cell Culture Products Financial Information Thermo Fisher Scientific, Inc History and Lines of Business Cell Culture Products Financial Information USB Corporation History and Lines of Business Cell Culture Products Wisent, Inc History and Lines of Business Cell Culture ProductsAPPENDIX: A: COMPANY DIRECTORYAPPENDIX: B: PROFESSIONAL ORGANIZATIONSTABLE OF EXHIBITSCHAPTER ONE: EXECUTIVE SUMMARY Table 1-1: Worldwide Cell Culture Market Figure 1-1: Cell Culture World Market Share, by Region, 2008 (US, Asia/Pacific, EU)CHAPTER TWO: GENETICALLY MODIFIED CELLS FOR BIOPHARMACEUTICALDEVELOPMENT Table 2-1: Biopharmaceuticals Approved in the USA and/or the EU in 2007 Table 2-2: Approximate times from Introduced Gene to Protein Production at Useable Levels Table 2-3: Disadvantages/Advantages of Cell Culture Systems Table 2-4: Selected Biopharmaceuticals Produced from Bacteria, Yeast and Mammalian CellsCHAPTER THREE: CELL CULTURE TECHNOLOGY Table 3-1: Selected Products/Companies Offering Alternatives to Animal Sera Products for Hybridoma, Myeloma and CHO cell linesCHAPTER FOUR: CELL CULTURE MARKET: CURRENT AND FUTURE TRENDS
  • 8. Table 4-1: Selected Brandname Serum-Free Formulations of Cell Culture Products Currently on the Market Table 4-2: Worldwide Cell Culture Market Figure 4-1: Cell Culture World Market Share, by Region, 2008 (US, Asia, EU) Table 4-3: World Cell Culture Market by Segment: Media, Sera and Reagents Table 4-4: Cell Culture Market Share, 2008Available immediately for Online Download athttp://www.marketresearch.com/product/display.asp?productid=2091313  US: 800.298.5699UK +44.207.256.3920Intl: +1.240.747.3093Fax: 240.747.3004