CHAPERONE ENZYME PROVIDES NEW CANCER TREATMENT TARGET & CANCER IN A SINGLE CATASTROPHE. <br />María Carolina Portela Ferná...
FOLDING: ANTERIOR VIEW<br />
FOLDING: POSTERIOR VIEW<br />
INTRODUCTION<br />
Chaperoneenzyme<br />Rad18<br />Escortsthe DNA polymerasePol eta<br />Repairssunlightinduceddamagepropperly<br />CHAPERONE...
Pol eta     <br />Other DNA polymerasesmaytakeits place<br />Therepairmechanisms are notaccurate<br />e.g.: XerodermaPigme...
CHAPERONE ENZYME PROVIDES NEW TARGET FOR CANCER TREATMENT<br />Essentialtopreventmutations in themost vulnerable cellcycle...
CHAPERONE ENZYME PROVIDES NEW TARGET FOR CANCER TREATMENT<br />CancercellshavehighCdc7levels<br />IncreasesPol eta+Rad18<b...
STUDENT’S OPINION<br />
CANCER IN A SINGLE CATASTROPHE: CHROMOSOMAL CRISIS COMMON IN CANCER CAUSATION<br />Theteamlookedfor DNA structuralchangesw...
CANCER IN A SINGLE CATASTROPHE: CHROMOSOMAL CRISIS COMMON IN CANCER CAUSATION<br />
CANCER IN A SINGLE CATASTROPHE: CHROMOSOMAL CRISIS COMMON IN CANCER CAUSATION<br />
CANCER IN A SINGLE CATASTROPHE: CHROMOSOMAL CRISIS COMMON IN CANCER CAUSATION<br />Mostcellsgointo apoptosis<br />Fewones ...
STUDENT’S OPINION<br />It would be interesting to do some research on the mechanisms that cause these catastrophes as a co...
MEDICAL UTILITY<br />
Cancer epidemic, humankind has tofightagainstit<br />Great interest in investigationsaboutitsmechanisms.<br />MEDICAL UTI...
Sciencemustdiscoverhowtoattackthem<br />Cancer’sdownfall<br />MEDICAL UTILITY<br />Downfall – James Murphy<br />
Medicalutility comes to<br />MEDICAL UTILITY<br />Howtosuccessfullytreatcancer?<br />Howdoesitbecomethemonster?<br />
MARTINEZ SÁNCHEZ, Lina María [y otros]. Biología molecular. 6 ed. Medellín: UPB. Fac. de Medicina, 2011. 292 p. <br />“Cha...
CHAPERONE ENZYME PROVIDES NEW CANCER TREATMENT TARGET & CANCER IN A SINGLE CATASTROPHE
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CHAPERONE ENZYME PROVIDES NEW CANCER TREATMENT TARGET & CANCER IN A SINGLE CATASTROPHE

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CHAPERONE ENZYME PROVIDES NEW CANCER TREATMENT TARGET & CANCER IN A SINGLE CATASTROPHE

  1. 1. CHAPERONE ENZYME PROVIDES NEW CANCER TREATMENT TARGET & CANCER IN A SINGLE CATASTROPHE. <br />María Carolina Portela Fernández<br />UPB’sSchool of HealthSciences, Faculty of Medicine<br />III SemesterStudent<br />
  2. 2. FOLDING: ANTERIOR VIEW<br />
  3. 3. FOLDING: POSTERIOR VIEW<br />
  4. 4. INTRODUCTION<br />
  5. 5. Chaperoneenzyme<br />Rad18<br />Escortsthe DNA polymerasePol eta<br />Repairssunlightinduceddamagepropperly<br />CHAPERONE ENZYME PROVIDES NEW TARGET FOR CANCER TREATMENT<br />
  6. 6. Pol eta <br />Other DNA polymerasesmaytakeits place<br />Therepairmechanisms are notaccurate<br />e.g.: XerodermaPigmentosum<br />CHAPERONE ENZYME PROVIDES NEW TARGET FOR CANCER TREATMENT<br />
  7. 7. CHAPERONE ENZYME PROVIDES NEW TARGET FOR CANCER TREATMENT<br />Essentialtopreventmutations in themost vulnerable cellcyclephase<br />
  8. 8. CHAPERONE ENZYME PROVIDES NEW TARGET FOR CANCER TREATMENT<br />CancercellshavehighCdc7levels<br />IncreasesPol eta+Rad18<br />BLOCK CHEMOTHERAPY AGENTS’ ACTION SUCH AS CIS-PLATINUM<br />
  9. 9. STUDENT’S OPINION<br />
  10. 10. CANCER IN A SINGLE CATASTROPHE: CHROMOSOMAL CRISIS COMMON IN CANCER CAUSATION<br />Theteamlookedfor DNA structuralchangeswithadvancedsequencingtechologies<br />
  11. 11. CANCER IN A SINGLE CATASTROPHE: CHROMOSOMAL CRISIS COMMON IN CANCER CAUSATION<br />
  12. 12. CANCER IN A SINGLE CATASTROPHE: CHROMOSOMAL CRISIS COMMON IN CANCER CAUSATION<br />
  13. 13. CANCER IN A SINGLE CATASTROPHE: CHROMOSOMAL CRISIS COMMON IN CANCER CAUSATION<br />Mostcellsgointo apoptosis<br />Fewones try tofixthemistake, causingcancer.<br />Mosthumancellsmaysufferone of thesecatastrophes<br />
  14. 14. STUDENT’S OPINION<br />It would be interesting to do some research on the mechanisms that cause these catastrophes as a contribution in the prevention of the cancer disease.<br />
  15. 15. MEDICAL UTILITY<br />
  16. 16. Cancer epidemic, humankind has tofightagainstit<br />Great interest in investigationsaboutitsmechanisms.<br />MEDICAL UTILITY<br />
  17. 17. Sciencemustdiscoverhowtoattackthem<br />Cancer’sdownfall<br />MEDICAL UTILITY<br />Downfall – James Murphy<br />
  18. 18. Medicalutility comes to<br />MEDICAL UTILITY<br />Howtosuccessfullytreatcancer?<br />Howdoesitbecomethemonster?<br />
  19. 19. MARTINEZ SÁNCHEZ, Lina María [y otros]. Biología molecular. 6 ed. Medellín: UPB. Fac. de Medicina, 2011. 292 p. <br />“Chaperoneenzymeprovides new target forcancertreatments” on ScienceDaily.com [available online at http://www.sciencedaily.com/releases/2011/01/110118143220.htm (January 30, 2011)] <br />“Cancer in a single catastrophe: Chromosome crisis common in cancercausation” on ScienceDaily.com [available online at http://www.sciencedaily.com/releases/2011/01/110106144735.htm (January 30, 2011)]<br />BIBLIOGRAPHY<br />
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