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This article is a historical review of the important role that Mexico and international NGOs have played in developing food security issues since World War II. It was in Mexico where NGO funded researchers discovered new hybrids that became the basis of the 1970s Green Revolution that increased yields and saved millions from famine. Written in 1999, this article reviews how hybridization evolved into gene-modified crops as part of a historical process. It forecasts that in the 21st century, agricultural technologies will increasingly be the subject of international relations.