Challenges of SLE and
pregnancy
Mahantesh Karoshi,
Consultant Obstetrician & Gynaecologist
Barnet General Hospital, London...
Systemic lupus erythematosus in
Pregnancy
•
• SLE is known to increase the risk of
spontaneous miscarriage; it can also ca...
Pre-pregnancy consultation
• The presence of anti-Ro/La
and antiphospholipid antibodies should be
determined.
• These anti...
• Antiphospholipid antibodies are present in
about 30% of women with SLE and
• are associated with arterial and venous
thr...
• Quiescent disease, without associated
antiphospholipid syndrome (APS),
hypertension or renal involvement the risks
of mi...
• The risk of miscarriage and stillbirth in
pregnancies complicated by lupus varies
from 6–35% and from 0–22%
• The great ...
• Patients should be advised not to conceive
during a period of active disease,
particularly with lupus nephritis, because...
• Counsel women with SLE for increased risk
of pre-eclampsia, preterm delivery and fetal
growth restriction
8
Pre-pregnanc...
• In active lupus nephritis with worsening
renal function, increasing proteinuria and
hypertension,it may be necessary to ...
• Pregnant women with active SLE/lupus
nephritis or anti- Ro/La/antiphospholipid
antibodies should be considered as a high...
• For patients with stable disease, 4-weekly
reviews of disease activity and regular
assessment of fetal growth, blood pre...
• For those women who are anti-Ro/La
positive the fetal heart rate should be
monitored and recorded at each visit and
feta...
• Women who have had a previous venous
thromboembolism should receive
thromboprophylaxis with low molecular
weight heparin...
• The risk of an SLE flare in pregnancy is
increased with active disease in the 3–6
months prior to conception, with the
ma...
• At every antenatal visit, measure the BP,
test the urine for proteinuria, and quantify
the proteinuria by PCR or 24 hour...
• The presence of hematuria or red cell casts
as well as a rise in anti-dsDNA titres or a
fall in complement levels help t...
• In cases of lupus nephritis that fail to
respond to increasing dosages of steroids
and azathioprine, and where there is ...
• Premature rupture of membranes is also
being more frequent in pregnancies
complicated by SLE; rates vary and are
general...
SLE and fetal risks
• Increased risks of congenital heart block,
fetal growth restriction and increased rates
of preterm d...
• Doppler studies can be used to estimate
placental function A uterine artery Doppler
should be first carried out at 20 wee...
• Congenital heart block is associated with maternal
anti-Ro/La autoantibodies. usual presentation is a
fixed fetal bradyca...
• Congenital heart block develops between
18– 28 weeks of gestation and fetal
echocardiography should be performed
around ...
Drug treatment in pregnant SLE
patient
• Glucocorticoids, mainly in the form of
prednisolone, are frequently but not
exclu...
• Immunosuppressants that are used and are
generally considered safe during pregnancy
include azathioprine and
hydroxychlo...
•To consider thromboprophylaxis
•Manage hypertension
25
Postpartum management
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Challenges of sle and pregnancy

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  • F The ideal method for hemorrhage control should be suitable for application by a lay-person with effective control of bleeding from a variety of sources within minutes, and it should be associated with a low complication rate. How much time do we have? 2 hours from Postpartum Haemorrhage 2 days from Obstructed Labor 6 days from Infection Initial fluid administration is to prevent peripheral damage Any bleeding with hypotension needs blood Average time to transfuse compatible blood :60 minutes First hour in shock management is the most important determinant
  • Challenges of sle and pregnancy

    1. 1. Challenges of SLE and pregnancy Mahantesh Karoshi, Consultant Obstetrician & Gynaecologist Barnet General Hospital, London, UK Blog : http://labourwardexperiences.blogspot.co.uk/2013/06/sleinpregnancy.html
    2. 2. Systemic lupus erythematosus in Pregnancy • • SLE is known to increase the risk of spontaneous miscarriage; it can also cause fetal growth restriction and increased rates of sudden intrauterine death, pre-eclampsia and preterm delivery 2
    3. 3. Pre-pregnancy consultation • The presence of anti-Ro/La and antiphospholipid antibodies should be determined. • These antibodies are associated with congenital heart block and neonatal cutaneous lupus syndrome. 3
    4. 4. • Antiphospholipid antibodies are present in about 30% of women with SLE and • are associated with arterial and venous thrombosis, recurrent miscarriage, fetal growth restriction, fetal loss and preterm • delivery due to uteroplacental insufficiency 4 Pre-pregnancy consultation 2
    5. 5. • Quiescent disease, without associated antiphospholipid syndrome (APS), hypertension or renal involvement the risks of miscarriage/stillbirth and fetal growth restriction are not significantly increased 5 Pre-pregnancy consultation 3
    6. 6. • The risk of miscarriage and stillbirth in pregnancies complicated by lupus varies from 6–35% and from 0–22% • The great concern are women with SLE and associated pulmonary arterial hypertension who wish to conceive: maternal mortality rates have been quoted as being as high as 33% 6 Pre-pregnancy consultation 4
    7. 7. • Patients should be advised not to conceive during a period of active disease, particularly with lupus nephritis, because of worse maternal and fetal outcomes 7 Pre-pregnancy consultation 5
    8. 8. • Counsel women with SLE for increased risk of pre-eclampsia, preterm delivery and fetal growth restriction 8 Pre-pregnancy consultation 6
    9. 9. • In active lupus nephritis with worsening renal function, increasing proteinuria and hypertension,it may be necessary to use treatments such as cyclophosphamide and mycophenolate mofetil, which are associated with congenital malformations if used in the first trimester, 9 Pre-pregnancy consultation 7
    10. 10. • Pregnant women with active SLE/lupus nephritis or anti- Ro/La/antiphospholipid antibodies should be considered as a higher risk group and managed in tertiary centre 10 Pre-pregnancy consultation 8
    11. 11. • For patients with stable disease, 4-weekly reviews of disease activity and regular assessment of fetal growth, blood pressure and proteinuria should be undertaken 11 Pregnancy consultation 1
    12. 12. • For those women who are anti-Ro/La positive the fetal heart rate should be monitored and recorded at each visit and fetal echocardiography assessments made at 18–20 and ~28 weeks of gestation 12 Pregnancy consultation 2
    13. 13. • Women who have had a previous venous thromboembolism should receive thromboprophylaxis with low molecular weight heparin throughout pregnancy and for 6 weeks postpartum 13 Pregnancy consultation 3
    14. 14. • The risk of an SLE flare in pregnancy is increased with active disease in the 3–6 months prior to conception, with the majority of flares occurring after the 20th weeks of pregnancy • Most flares are managed expectantly with medical management and adjustments to drug therapy 14 Pregnancy consultation 4
    15. 15. • At every antenatal visit, measure the BP, test the urine for proteinuria, and quantify the proteinuria by PCR or 24 hour urine proetein estimation. • The features of lupus nephritis include hypertension and proteinuria with or without haematuria and renal impairment 15 Pregnancy consultation 5
    16. 16. • The presence of hematuria or red cell casts as well as a rise in anti-dsDNA titres or a fall in complement levels help to distinguish this from pre-eclampsia 16 Pregnancy consultation 7
    17. 17. • In cases of lupus nephritis that fail to respond to increasing dosages of steroids and azathioprine, and where there is a deterioration of renal function and/or hypertension, other immunosuppressive drugs may be considered, such as mycophenolate mofetil or tacrolimus. Such management decisions should be undertaken in consultation with nephrologists and rheumatologists, 17 Pregnancy consultation 8
    18. 18. • Premature rupture of membranes is also being more frequent in pregnancies complicated by SLE; rates vary and are generally quoted at ~20% and is common in women who are on steroids 18 Pregnancy consultation 9
    19. 19. SLE and fetal risks • Increased risks of congenital heart block, fetal growth restriction and increased rates of preterm delivery • Scanning at least every 4 weeks to screen for fetal growth restriction in those women at risk is generally accepted and fetal echocardiography referral should be arranged for those with anti-Ro/La antibodie 19
    20. 20. • Doppler studies can be used to estimate placental function A uterine artery Doppler should be first carried out at 20 weeks and repeated 4 weeks later if any abnormality is found A raised pulsatility index or diastolic notching are associated with increased risk for developing pre-eclampsia, as they can indicate underlying placental dysfunction 20 SLE and fetal risks
    21. 21. • Congenital heart block is associated with maternal anti-Ro/La autoantibodies. usual presentation is a fixed fetal bradycardia of 60–80 beats per minute on ultrasound scan. It occurs in 2–3% of fetuses of women with the anti-Ro/La antibody CHB is associated with significant perinatal morbidity and mortality, with about half of infants requiring pacing by the first year of life. 21 SLE and fetal risks
    22. 22. • Congenital heart block develops between 18– 28 weeks of gestation and fetal echocardiography should be performed around this period to detect it. Hydrops fetalis can occur in utero and is thought to be due to the degree of endomyocardial fibrosis and associated myocarditis. 22 SLE and fetal risks
    23. 23. Drug treatment in pregnant SLE patient • Glucocorticoids, mainly in the form of prednisolone, are frequently but not exclusively used as one of the first-line treatments in pregnancy Women on moderate to high dosages of steroids should should be screened regularly for gestational diabetes. 23
    24. 24. • Immunosuppressants that are used and are generally considered safe during pregnancy include azathioprine and hydroxychloroquine. There is no need to discontinue them during pregnancy 24 Drug treatment in pregnant SLE patient
    25. 25. •To consider thromboprophylaxis •Manage hypertension 25 Postpartum management
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