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Oral herpes paper presentation
Oral herpes paper presentation
Oral herpes paper presentation
Oral herpes paper presentation
Oral herpes paper presentation
Oral herpes paper presentation
Oral herpes paper presentation
Oral herpes paper presentation
Oral herpes paper presentation
Oral herpes paper presentation
Oral herpes paper presentation
Oral herpes paper presentation
Oral herpes paper presentation
Oral herpes paper presentation
Oral herpes paper presentation
Oral herpes paper presentation
Oral herpes paper presentation
Oral herpes paper presentation
Oral herpes paper presentation
Oral herpes paper presentation
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Oral herpes paper presentation

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  • 1. • ‘HERPES’ – most common viral infection in oral cavity .• The term ‘herpes simplex’ –herpes labialis(cold sores) & herpes progenital(genital herpes), fever blisters
  • 2. • Herpes viridae family includesI. HSV-1II. HSV-2III. Varicella zosterIV. Epstein –Barr virusV. CytomegalovirusVI. HHV-6VII. HHV 7VIII. HHV 8IX.Herpes virus simian
  • 3. • HSV-1 (oral herpes) - permanent infection , very infectious• Oral herpes simplex virus infection(HSV 1) – herpes simplex virus(HSV)
  • 4. Structure:• VIRION - > double stranded - DNA genome,icosahedral protein cage - capsid ,lipid bilayer –envelope ,envelope joined to capsid – tegument .•HSV1 & HSV2 – 74 genes within genome .• DNA core – control replication & infectivity of thevirus .
  • 5. • Ballooning degeneration, contain intranuclear inclusions known as Lipschitiz bodies.• Cytoplasm of the infected cell forms giant cells .
  • 6.  Types of HSV –> HSV 1 - >physical contact in oral cavity .• HSV 2 ->’new epidemic disease’ -contracted through sexual contact . HSV 1 &2 occurs as:1. Primary infection2. Recurrent infection – milder than primary infection
  • 7. Susceptible host Virus primary infection Recurrent manifestationClinical Subclinicaldisease 1% disease 99% Excitants Carries (70% -80% of population) Antibodies & virus presist
  • 8. • Primary infection• Incubation period –> 1-26 days.• Prodromal Symptoms –( fever ,headache ,loss of appetite , tiredness , irritation .)• Appearance- group of small red bumps that blister, begin to dry , form yellow crust - preceded by itching &burning -10 to14 days• Red swollen , bleeding gums or sore throat and enlarged lymph node• Gingivastomatitis - in infant from mother• HSV -latent infection in trigeminal ganglion
  • 9. • Severe in immunodeficient & neonates .• Complication – meningoencephalitis and keratoconjuctivis
  • 10. • Impetigo• Aphthous ulcers• Hand foot & mouth disease
  • 11.  Clinical Lab test:• Smear test• Tissue culture• Biopsy
  • 12.  Antiviral• Acyclovir -> orally- 400mg -800mg .• injection-10mg/kg body weight .• Famciclovir -> 250mg & 500mg .• Valacyclovir -> 500mg & 1gm Antibiotic- (secondary infection like bacteria )• Always keep the infected area dry
  • 13. VIRAL THYMIDINE KINASECELLULAR KINASE
  • 14. ACYCLOVIR• Used to treat herpes group of virus• Pharmacokinetics – poor biocompatibility 20%• widely distributed• Excreted- mainly in urine ,renal impairment dose reduction• Effective in normal as well as deficient immune status• Adverse effect – tiredness ,rashes ,hypotension• Toxicity ->1. Decrease in Glomerular filtration rate &produces reversible neurological manifestation to higher doses
  • 15. FAMCYCLOVIR• Ester prodrug of guanine nucleoside –penciclovir• Good oral biocompatibility ,prolonged intracellular t ½ active triphosphate metabolite• Treat ->Herpes zoster(shingles)->500mg every 8 hours HSV2 ->250mg 5 days Herpes labialis (immunodeficient patients)- >1500mg oral dose• Toxicity is more in famciclovir especially in bone marrow
  • 16. VALACYCLOVIR• VALACYCLOVIR –herpes simplex• Prodrug ->esterases ->aminoacid valine->via hepatic first pass metabolism,greater biocompatibility(55%) than acyclovir(10-20%)• Dosage –Valtrex ->500mg & 1mg /day• Adverse effect –Vertigo ,edema ,arthralgia
  • 17. • Avoid touching the affected area .• Vaccines – under research• HSV 2 – condoms can be used

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