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Lectures on Medical Bi o physics Department of Biophysics, Medical Faculty,  Masaryk University in Brno
Structure of living matter Lectures on Medical Bi o physics Department of Biophysics, Medical Faculty,  Masaryk University in Brno
Lecture outline ,[object Object],[object Object],[object Object],[object Object],[object Object]
Water Molecules of water are strongly polar. Between the oxygen and hydrogen atoms of neighbouring molecules,  hydrogen bonds  are formed. They join water molecules in aggregates – clusters.
Hydrogen bonds between water molecules Liquid water Pictures : http://cwx.prenhall.com/bookbind/pubbooks/hillchem3/medialib/media_portfolio/11.html Ice
Colloids ,[object Object],[object Object],[object Object],[object Object]
Weak chemical bonds ,[object Object],[object Object],[object Object]
Properties of colloids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Tyndall effect in micellar and molecular colloids -  In solution of gelatin (a protein) http://link.springer-ny.com/link/service/journals/00897/papers/0006002/620095mb.htm -  In solution of colloidal gold http://mrsec.wisc.edu/edetc/cineplex/gold/
Types of Colloids  - Biopolymers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Chemical composition of proteins ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Structure of proteins ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Structure of proteins ,[object Object],[object Object],[object Object],[object Object],Wavelength (nm) Molar absorption coefficient  
Structure of proteins ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object]
 -structure (pleated sheet – antiparallel model) http://www-structure.llnl.gov/Xray/tutorial/protein_structure.htm
Tr iple helix of collagen h ttp://cwx.prenhall.com/horton/medialib/media_portfolio/text_images/FG04_34.JPG
[object Object]
Structure of nucleic acids (NA) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object]
B-DNA http://cwx.prenhall.com/horton/medialib/media_portfolio/text_images/FG19_15aC.JPG
A-DNA – dehydrated, B-DNA – commonly present under physiological conditions, Z-DNA – in sequences rich on CG pairs
Superhelical structure of circular DNA   ,[object Object]
Structure of chromatin http://cwx.prenhall.com/horton/medialib/media_portfolio/text_images/FG19_23_00742.JPG, http://cwx.prenhall.com/horton/medialib/media_portfolio/text_images/FG19_25_00744.JPG
[object Object],[object Object],[object Object],Amino acid binding site Valine
Ribosom al  RNA http://www.imb-jena.de/cgi-bin/htmlit.pl?color=ffffff&id=GIF&src=1c2w.gif&name=Image%20Library%20Thumb%20Nail%201C2W
Conformation changes and denaturation of biopolymers ,[object Object],[object Object],[object Object]
Denaturation factors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Author:  Vojtěch Mornstein Content collaboration and language revision:  Carmel J. Caruana, Viktor Brabec Presentation design:  Lucie Mornsteinová Last revision: June 2009

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Structure oflivingmatter fin

  • 1. Lectures on Medical Bi o physics Department of Biophysics, Medical Faculty, Masaryk University in Brno
  • 2. Structure of living matter Lectures on Medical Bi o physics Department of Biophysics, Medical Faculty, Masaryk University in Brno
  • 3.
  • 4. Water Molecules of water are strongly polar. Between the oxygen and hydrogen atoms of neighbouring molecules, hydrogen bonds are formed. They join water molecules in aggregates – clusters.
  • 5. Hydrogen bonds between water molecules Liquid water Pictures : http://cwx.prenhall.com/bookbind/pubbooks/hillchem3/medialib/media_portfolio/11.html Ice
  • 6.
  • 7.
  • 8.
  • 9. Tyndall effect in micellar and molecular colloids - In solution of gelatin (a protein) http://link.springer-ny.com/link/service/journals/00897/papers/0006002/620095mb.htm - In solution of colloidal gold http://mrsec.wisc.edu/edetc/cineplex/gold/
  • 10.
  • 11.
  • 12.
  • 13.
  • 14.
  • 15.
  • 16.  -structure (pleated sheet – antiparallel model) http://www-structure.llnl.gov/Xray/tutorial/protein_structure.htm
  • 17. Tr iple helix of collagen h ttp://cwx.prenhall.com/horton/medialib/media_portfolio/text_images/FG04_34.JPG
  • 18.
  • 19.
  • 20.
  • 22. A-DNA – dehydrated, B-DNA – commonly present under physiological conditions, Z-DNA – in sequences rich on CG pairs
  • 23.
  • 24. Structure of chromatin http://cwx.prenhall.com/horton/medialib/media_portfolio/text_images/FG19_23_00742.JPG, http://cwx.prenhall.com/horton/medialib/media_portfolio/text_images/FG19_25_00744.JPG
  • 25.
  • 26. Ribosom al RNA http://www.imb-jena.de/cgi-bin/htmlit.pl?color=ffffff&id=GIF&src=1c2w.gif&name=Image%20Library%20Thumb%20Nail%201C2W
  • 27.
  • 28.
  • 29. Author: Vojtěch Mornstein Content collaboration and language revision: Carmel J. Caruana, Viktor Brabec Presentation design: Lucie Mornsteinová Last revision: June 2009