Immunology xv transfusion

503 views

Published on

Published in: Technology, Business
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total views
503
On SlideShare
0
From Embeds
0
Number of Embeds
5
Actions
Shares
0
Downloads
11
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

Immunology xv transfusion

  1. 1. Transfusion immunology
  2. 3. Polyscacharide antigens of blood groups <ul><li>Most important: ABO system. </li></ul><ul><li>Antigens may be present in sec r etions and on surface of many endothelial and epitelial cells. </li></ul><ul><li>H substance - is a core structure of ABO antigens. Extremely rare are patients of Bombay phenotype - no H substance is present. </li></ul><ul><li>Antibodies are of IgM isotype, they are present even without antigen stimulation . </li></ul><ul><li>Minor blood groups: MN and Ss </li></ul>
  3. 6. Proteine antigens of blood groups <ul><li>The most importa n t is Rh system </li></ul><ul><li>Antibodies are of IgG isotype. They develop only after antigenic stimulus . </li></ul><ul><li>“ Small“ protein blood groups: Kelly, Lewis, Duffy </li></ul>
  4. 10. Adverse reactions associated with tran s fusion <ul><li>Hemolytic: headache, myalgia, nausea, fever. Hemoglobin casts are responsible for kidney failure. Shock may develop. </li></ul><ul><li>Febrile – antibodies against minor blood groups </li></ul><ul><li>Allergic: urticaria, sometimes bronchospasm, anaphylactic shock in the most severe cases. </li></ul><ul><li>TRALI syndrome: dyspnoea, cough soon after transfusion. Caused by thrombocyte aggregates in the lungs. </li></ul>

×