Your SlideShare is downloading. ×
Immunology xv transfusion
Upcoming SlideShare
Loading in...5
×

Thanks for flagging this SlideShare!

Oops! An error has occurred.

×

Introducing the official SlideShare app

Stunning, full-screen experience for iPhone and Android

Text the download link to your phone

Standard text messaging rates apply

Immunology xv transfusion

291
views

Published on

Published in: Technology, Business

0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total Views
291
On Slideshare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
8
Comments
0
Likes
0
Embeds 0
No embeds

Report content
Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
No notes for slide

Transcript

  • 1. Transfusion immunology
  • 2.  
  • 3. Polyscacharide antigens of blood groups
    • Most important: ABO system.
    • Antigens may be present in sec r etions and on surface of many endothelial and epitelial cells.
    • H substance - is a core structure of ABO antigens. Extremely rare are patients of Bombay phenotype - no H substance is present.
    • Antibodies are of IgM isotype, they are present even without antigen stimulation .
    • Minor blood groups: MN and Ss
  • 4.  
  • 5.  
  • 6. Proteine antigens of blood groups
    • The most importa n t is Rh system
    • Antibodies are of IgG isotype. They develop only after antigenic stimulus .
    • “ Small“ protein blood groups: Kelly, Lewis, Duffy
  • 7.  
  • 8.  
  • 9.  
  • 10. Adverse reactions associated with tran s fusion
    • Hemolytic: headache, myalgia, nausea, fever. Hemoglobin casts are responsible for kidney failure. Shock may develop.
    • Febrile – antibodies against minor blood groups
    • Allergic: urticaria, sometimes bronchospasm, anaphylactic shock in the most severe cases.
    • TRALI syndrome: dyspnoea, cough soon after transfusion. Caused by thrombocyte aggregates in the lungs.