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Immunology viii malt

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  • 1. Mucosal immune system (MALT)
  • 2. MALT (Mucous Associated Lymphoid Tissue)
    • GALT (Gut Associated Lymphod tissue)
    • BALT (Bronchi Associated Lymphoid Tissue)
    • Immune stissues of the urinary tract, genital tract, conjunctiva, middle ear…
    • Includes also brest gland!
  • 3. Anatomy of MALT
    • Diffuse tissue containing lymphocytes and other cells of the immune system in submucosa.
    • Specialized organs:
      • Waldeyer´s ring
      • Payer´s patches
      • Appnedix
  • 4. Mucosal immune system (MALT)
    • Antigenic stimulation in one part of MALT leads to immune response also in other compartments of MALT.
    • IgA is a predomina n t immunoglobulin secreted through the epitelial cells.
    • Oral administration of antigens frequently leads to induction of immune tolerance.
    • Intraepitelial lymphocytes - CD8+, restricted antigenic specifi ci ty.
  • 5. Common Immune System of Mucous Membranes
  • 6. Střevo novorozence krevní oběh Mléčná žláza sliznice a žlázy střevo matky bakterie a potrava lymfatické uzliny mízovod Společný imunitní systém sliznic
  • 7. Homing of Lymphocytes
    • The directed migration of subsets of circulating lymphocytes into particular tissue sites.
    • Regu lated by se l ective expression of adhesion molecules called homing receptors on lymphocytes.
    • Tissue speciphic endothelial ligands are called addressins.
  • 8. High endotelial venules
    • Specialized venules. The site where lymphpocytes leave the blood stream and migrate into lymph nodes, spleen, organs of MALT.
    • Adhesion molecules enable selective attachment of various types of lymphocytes.
  • 9. Downloaded from: StudentConsult (on 15 July 2006 09:09 AM) © 2005 Elsevier Circulation of lymphocytes
  • 10. Downloaded from: StudentConsult (on 20 July 2006 11:29 AM) © 2005 Elsevier
  • 11. Intraepitelial T-lymphocytes
    • TCR  or 
    • Extrathymic differentiation
    • First line of specific immune response
    • Predominantly CD8+
    • Low antigenic specificity of TCR
  • 12. M-cells
    • Speciali z ed enterocytes responsible for transport of antigens from the gut towards the immunocompe tent cells inside the Payer´s patches.
    • Transport in mediated by transcytosis.
  • 13. Lymphocyte circulation in GALT www.prn.org/.../hiv_1_gastrointestinal_galt_267