CDE innate response for targets webinar

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  • 1. Centre Defence Enterprise for Themed Competition Webinar
  • 2. © Crown copyright 2013 Dstl 20 May 2014
  • 3. The aim of CDE Technology Best providers Barriers
  • 4. 20 May 2014 Funding research
  • 5. Two routes to funding Enduring Themed
  • 6. Themed competition Requirements Bounded Specific
  • 7. CDE themed competition Innate response targets for therapy
  • 8. Enduring challenge competition Perpetual Radical £3M per year
  • 9. Dstl is part of the Ministry of Defence UNCLASSIFIED / For Public Release Centre for Defence Enterprise www.science.mod.uk/enterprise cde@dstl.gov.uk Crown Copyright Dstl 2012 Enduring challenges • protection • situational awareness • power • communications • data • lethality • mobility • human performance • lower cost of ownership • new capabilities
  • 10. Online bid submission CDE Portal Only route Low overhead
  • 11. Dstl is part of the Ministry of Defence UNCLASSIFIED / For Public Release Centre for Defence Enterprise www.science.mod.uk/enterprise cde@dstl.gov.uk Crown Copyright Dstl 2012 Read available information Start with – Quick Start Guide CDE Portal
  • 12. Intellectual property
  • 13. Dstl is part of the Ministry of Defence UNCLASSIFIED / For Public Release Centre for Defence Enterprise www.science.mod.uk/enterprise cde@dstl.gov.uk Crown Copyright Dstl 2012 Register now
  • 14. CDE Innovation Network
  • 15. Innate response targets for therapy CDE themed competition March 25 - June 5 2014 20 May 2014
  • 16. Key dates • Competition launches today • Presentation to follow • Opportunity for Q&A • Webinar Tuesday 1 April • Deadline for applications Thursday 5 June 2014 at 17:00 hrs via Centre for Defence Enterprise Portal • Funding decisions to be made July 2014 • Notifications end July © Crown copyright 2014 Dstl 20 May 2014
  • 17. Background: biothreat agents • Pathogenic for man or animals • Very low infectious dose • Infectious via the inhalational route • Cause endemic disease around world • Usually are zoonotic diseases • Lethal or incapacitating © Crown copyright 2014 Dstl 20 May 2014
  • 18. © Crown copyright 2014 Dstl 20 May 2014 Defence against biothreats • Many potential biothreat agents • How to defend against them? • Impossible to make a vaccine/therapy for every potential agent • Require generic therapy
  • 19. Generic approach to therapy • By influencing the host response • Requires an understanding of the host response to pathogen & safe ways to influence it • Requires identification of relevant targets or pathways in the host 20 May 2014 © Crown copyright 2014 Dstl
  • 20. Innate (host) response targets for therapy • Objective of this competition is to look broadly across research and development to identify host cell targets and pathways • Using data derived from diverse infection models • Respondents to competition do not need to work directly with biothreat agents • Ultimate aim is to apply the most innovative approaches to biothreat agents 20 May 2014 © Crown copyright 2014 Dstl
  • 21. CDE themed competition specifics • Seeking innovative proposals for short projects (<1year); £30- 80k guide; (£500k total budget) • Show proof-of-concept for your proposal; there is funding allocated for follow-on work for successful projects • Competition divided into 3 challenges • Respondents need to address 1 of the challenges, may address >1, do not have to address all 3 • Challenges described fully in the competition document • Bids must be ethical and compliant with UK government legislation 20 May 2014 © Crown copyright 2014 Dstl
  • 22. Challenge 1 © Crown copyright 2014 Dstl 20 May 2014 Identification of new cellular or host pathway targets
  • 23. Identification of new cellular or host pathway targets • In host-pathogen model of your choice – Does not need to be a biodefence pathogen – Does not need to be in vivo • Conditioning of cells ex vivo eg to profile responses or prior to adoptive transfer • Targeting cells in situ eg – to refocus them – to activate them – to induce them to traffic – to redirect them © Crown copyright 2014 Dstl 20 May 2014
  • 24. Identification of new cellular or host pathway targets May involve the identification of eg • immuno stimulants • modulators • transfection factors • chemokines, cytokines or the induction (or blockade) of these • cytokine/chemokine/growth factor receptors and application of these to modulate host responses © Crown copyright 2014 Dstl 20 May 2014
  • 25. Identification of new cellular or host pathway targets • Some of these may be exogenous and some endogenous factors • Some endogenous natural regulators /regulatory pathways may be exploited • to reduce inflammation and to restore homeostasis © Crown copyright 2014 Dstl 20 May 2014 Normal OveractiveUnderactive
  • 26. Possible outcomes Proposals for – identification of new cellular targets /pathways – new applications of manipulating known cellular targets/pathways – demonstration that targets may be influenced beneficially, for example to: • prevent cytotoxicity • prevent/reduce microbial invasion • reduce microbial load • restore normal cell function © Crown copyright 2014 Dstl 20 May 2014
  • 27. Challenge 2 Identification of new candidate therapies © Crown copyright 2014 Dstl 20 May 2014
  • 28. Identification of new candidate therapies Exploit appropriate cellular targets and pathways to identify new therapies by, for example: • enhancing cell-mediated immunity • investigating novel combinations • identification and manipulation of significant transcription factors • micro RNA-directed therapies or antagonists © Crown copyright 2014 Dstl 20 May 2014
  • 29. Possible outcomes • Candidate therapies should be druggable and generic • Proposals should show proof-of-concept • Does not exclude the re-purposing or augmentation of existing therapies © Crown copyright 2014 Dstl 20 May 2014
  • 30. Challenge 3 Identification of new platform technologies © Crown copyright 2014 Dstl 20 May 2014
  • 31. Identification of new platform technologies For assessing therapeutic benefit • Novel technologies such as: • non-invasive methods of in-vivo/ex-vivo analysis eg bio-imaging or tracking • Transcriptomics including micro RNA analysis • In-silico modelling of host responses • Novel assays to monitor the host immune response © Crown copyright 2014 Dstl 20 May 2014
  • 32. Possible outcomes • New technologies which may facilitate the identification and development of candidate therapies • Proposals should demonstrate the impact of the technology on therapeutic development © Crown copyright 2014 Dstl 20 May 2014
  • 33. What we want • Highly innovative approaches that are significantly different from existing technologies • Generally technology readiness level (TRL) ≤ 3 • Generic approaches (not pathogen specific) • Approaches applicable to intracellular pathogens where appropriate • Approaches that will lead to a feasible clinical product © Crown copyright 2014 Dstl 20 May 2014
  • 34. What we don’t want Proposals that concern: • high technology readiness level (TRL) capability • serological targets only (rather than cellular) • antibody-based therapies (but antibodies as a targeting mechanism are acceptable) • existing solutions or technology already tested and found to have limited utility • a paper study or review or similar • pre-exposure therapies or therapeutics • topical therapies for wounds © Crown copyright 2014 Dstl 20 May 2014
  • 35. Successful proposals • Each will be assigned a Technical Partner – Provides interface between project and defence community – If project successful, potential routes to exploitation developed © Crown copyright 2014 Dstl 20 May 2014
  • 36. Summary • Competition launches today • Webinar Tuesday 1 April • Closes on Thursday 5 June 2014 at 17:00 hrs • Short proof-of-concept proposals • If successful, potential for follow-on funding • May include additional research to develop technology for MOD • Competition information available on CDE website www.science.mod.uk © Crown copyright 2014 Dstl 20 May 2014
  • 37. Questions? © Crown copyright 2014 Dstl 20 May 2014
  • 38. Dstl is part of the Ministry of Defence UNCLASSIFIED / For Public Release Centre for Defence Enterprise www.science.mod.uk/enterprise cde@dstl.gov.uk Crown Copyright Dstl 2012 e: cde@dstl.gov.uk w: www.science.mod.uk @dstlmod #dstlcde LinkedIn group – search ‘Centre for Defence Enterprise’ Keep in touch