Metabolismo Fosforo Calcio

METABOLISMO FOSFORO CALCIO Dr. Eduardo Faure Servicio de Endocrinología Complejo Médico PFA Churruca-Visca Buenos Aires

Desarrollo: ,[object Object],[object Object],[object Object],[object Object],[object Object]

Introducción ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Introducción: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Metabolismo del Calcio ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Absorción Intestinal del Ca ++ ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Manejo Renal del Calcio: ,[object Object],[object Object],[object Object]

Manejo Renal del Ca ++ ,[object Object],[object Object],[object Object],[object Object],[object Object]

Calcio óseo ,[object Object],[object Object],[object Object],[object Object]

Balance General del Ca ++ ,[object Object]

125 mg jugos intestinales Eliminación por Heces 825 mg Absorción intestinal 1000 mg Absorción neta: 175 mg Absorbe del LEC 500 mg/día Vuelca al LEC 500 mg/día Balance Cero Filtra 10000 mg /día Reabsorbe 9700-9900 mg/ día Elimina 100-300 mg /día

Sangre: 500 mg/dia 8-10.5 mg/dl 50%forma iónica 40% unido proteínas 10% ligado lactato, fosfato, sulfato METABOLISMO DEL CALCIO

Metabolismo del fósforo: ,[object Object],[object Object],[object Object],[object Object],[object Object]

Fosforo en sangre: VN: 2,5-5 mg/dl

Absorción Intestinal del P: ,[object Object],[object Object],[object Object]

Manejo Renal del P ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Fosfato Oseo ,[object Object],[object Object]

Balance General de Fosfatos ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Metabolismo del Magnesio ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Absorción intestinal del Mg ,[object Object],[object Object],[object Object]

Magnesio óseo ,[object Object],[object Object],[object Object]

Manejo Renal del Mg ,[object Object],[object Object]

Manejo Renal del Mg: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Balance General del Mg ,[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],HORMONAS QUE INTERVIENEN EN LA REGULACION DEL METABOLISMO MINERAL

Ca iónico extracelular Sensor Ca++ Sensor Ca++ Cel. Paratiroidea Receptor PTH Túbulo Renal Mecanismo Endocrino PTH PTHrP PTHrP Mecanismo Autocrino-Paracrino Receptor PTH Hueso 1,25(OH) 2 D Luz duodenal Sangre y otros fluidos EC Cartílago y cel. Target PTHrP en otros tejidos

Introducción ,[object Object],[object Object],[object Object],Ca ++ LEC

Biosíntesis de la PTH ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],RER Golgi Granulo de Secreción

Secreción de PTH ,[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Mecanismo de acción ,[object Object],[object Object],[object Object],[object Object]

Regulación de la proliferación de células paratiroideas ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Metabolismo de la PTH ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Acciones de la PTH en el riñón ,[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object]

Acciones de la PTH en el hueso ,[object Object],[object Object],[object Object],[object Object]

OBL/Cel. Estroma Precursor OCL

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Proteína relacionada con la PTH (PTHrP) ,[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Síntesis de Vit D ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Metabolismo de la Vit D ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Regulación de la 1 α hidroxilasa ESTIMULA INHIBE PTH FGF 23 HIPOFOSFATEMIA HIPERFOSFATEMIA IGF 1 1,25 OH vitamina D PROLACTINA GH HIPOCALCEMIA

Piel 7-dehidrocolesterol Vitamina D3 Hígado Vitamina D2 Intestino 25 (OH) D 1,25 (OH)2 D Valores Normales de P y PTH 24,25 (OH)2 D P ↓ PTH ↑

Mecanismo de acción ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Mecanismos de Acción ,[object Object],[object Object]

Acciones en el hueso ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],ACCIONES SOBRE EL INTESTINO ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Conclusiones ,[object Object],[object Object],[object Object]

- Es una hormona peptídica, compuesta por 32 aa, secretada por las células C parafoliculares de la glándula tiroides. -Se desconoce una región biológicamente activa. Metabolismo: La vida media es de pocos minutos. Se degrada en hígado, hueso, tiroides. Uso como droga: Enfermedad de Paget. Hipercalcemia tumoral. Osteoporosis.

[object Object],[object Object],[object Object],[object Object]

Receptor de Calcitonina ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Acciones fisiológicas ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Secreción ,[object Object],[object Object],[object Object]

ACCION DE OTRAS HORMONAS SOBRE EL METABOLISMO FOSFOCALCICO:

Metabolismo Fosforo Calcio

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