Genetic Skin Health


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The health of your skin and genetics

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Genetic Skin Health

  1. 1. Ginny Bank Brief Bio Ginny Bank is the Director of Product Education and Technical Support for GeneWize Life Sciences. Ms. Bank has significant experience in the dietary supplement and functional food industries and began her career as a natural products chemist with a research company (Hauser, Inc.) which focused on developing natural product extracts and purified plant compounds for the dietary supplement, pharmaceutical and food industries. She is considered an industry expert in antioxidant research and throughout her career has been researching and developing plant-based functional ingredients for a variety of nutritional supplement applications. Ms. Bank holds four U.S. patents pertaining to antioxidants and their applications and is a contributing editor for Prepared Foods /NutraSolutions Magazine. She received her bachelor’s degree in Chemistry and a Master’s Degree in Science Education from the University of Colorado, Boulder.
  2. 2. LifeMap Me™ Skin Repair Serum Formula An Overview • The LifeMap Me™ Skin Repair Serum Formula is a scientifically-proven antiwrinkle firming formulation customized just for you based on your own (genetically-determined) skin-care needs. • The Genelink®’s Healthy Skin Aging DNA Assessment measures for variations in 6 key skin aging genes that are very important to your skin’s overall skin health and appearance and are based on your genetic propensity for:     Collagen breakdown Photo-aging Wrinkling, skin aging and slackening Skin’s ability to tolerate environmental pollutants • The LifeMap Me™ Skin Repair Serum formulas are customized based on the Genelink®’s Healthy Skin Aging DNA Assessment . – Base formula - Foundational blend of skin care ingredients – SNPActives™ - Contain active ingredients that specifically help treat and control problems areas identified by the DNA skin profile.
  3. 3. The Science – Base Serum Base Serum contains a proprietary blend of skin care ingredients for all skin types • Aloe - moisturizer • Soy Protein - antioxidant, anti-inflammatory, collagen stimulating • Skin Health Vitamins (A, C, B5 and E) • Cereal Grain Extracts – Oat Extract (Hydrolyzed Glycosaminoglycans) to increase hydration in the cell layers of the skin – Corn Extract (source of Sodium Levulinate) to condition the skin. – Rice Extract (source of sodium phytate) to improve skin color – Barley Extract as a good source of antioxidants
  4. 4. The Science – Base Serum • Plants and Plant Extracts – Balm Mint (Melissa officinalis) Extract - soothing tonic for skin. – Konjac Mannan fiber– Moisturizing and water-binding activity – Green Tea Extract • • • • – – – – Antioxidant Anti-inflammatory Reduce UV damage Prevent collagen breakdown Milk Thistle Extract - protect against UV-damage Cabbage Leaf Extract - reduce swelling Cat’s Claw Extract - antioxidant and anti-inflammatory Super Fruit Extracts (Açai, Goji Berry, Mangosteen, pomegranate) - anti-aging/antioxidant – Tomato Extract (Lycopene) - protects against UV-damage
  5. 5. SNPActives™ ADDED SUPPORT MAXIMUM SUPPORT Optimal Genetic Function +- ++ -- Heterozygous Disadvantaged : Homozygous Disadvantaged: Homozygous Advantaged : One chromosome carries the SNP Both chromosomes carries the SNP Neither chromosome carries the SNP • Amount of SNPActive™ in each individual formula is dependent upon results of the Genelink®’s Healthy Skin Aging DNA Assessment . – Heterozygous disadvantaged receive Added support from SNPActive™ – Homozygous disadvantaged receive Maximum support from SNPActive™ • Individual SNPActive™ formulations were designed to address each (enzymatic) genetic marker identified in the Genelink®’s Healthy Skin Aging DNA Assessment. • Each SNPActive™ was tested in vitro and demonstrated enhancement or diminishment of the enzymatic activity pertinent to the appropriate genetics marker
  6. 6. The Science – EPHX SNPActive™ • Human microsomal Epoxide Hydrolase (EPHX) is a phase-I xenobiotic metabolizing enzyme that detoxifies potentially toxic epoxides • Xenobiotics are foreign substances (e.g. pollutants, pesticides) which can cause skin irritation • In vitro test showed upregulation of EPHX enzyme Test Material SNP-Related Enzyme Activity (Compared to Untreated Control) Analysis Method EPHX SNPActive™ Microsomal epoxide hydrolase Enhanced  Flouresence EPHX SNPActive™ provides ingredients to:  Protect the skin from toxins  Promote skin cells growth after damage by toxins  Prevent irritation causes by environmental toxin exposure
  7. 7. The Science - EPHX SNPActive™ • N-Acetylcysteine – Neutralizes toxins – Increases glutathione peroxidase activity – Protects against UV radiation • Fennel Extract – antioxidant compounds to protect skin from the detrimental effects of the environment – Anti-inflammatory • Trimethylglycine – Anti-irritant – Increase skin moisturization, elasticity and hydration • Folic Acid – Contributes to healthy skin cell division – Replenishes skin cells for younger, firmer looking skin
  8. 8. The Science – GPX1 SNPActive™ • GPX1 is the most abundant antioxidant enzyme in the Glutathione Peroxidase family with specific activity against hydrogen peroxide. Hydrogen peroxide is produced: – During exposure to sunlight – Stimulation of acne bacteria • • • • Hydrogen peroxide plays a major role in both chronological and photo-aging of skin because it is the most common source of oxidative stress SNP on GPX1 gene may show a reduced function in quenching hydrogen peroxide in skin cells. GPX1 enzyme contains selenium in its protein structure and therefore how much GPX1 a person produces is dependent on their selenium levels In vitro test showed upregulation of GPX1 enzyme Test Material SNP-Related Enzyme Activity (Compared to Untreated Control) Analysis Method GPX1 SNPActive™ Glutathione peroxidase Enhanced  Colormetric GPX1 SNPActive™ provides     Ingredients that protect the body against hydrogen peroxide damage Extra selenium Ingredients that increase glutathione peroxidase activity Ingredients to help heal acne
  9. 9. The Science – GPX1 SNPActive™ • N-Acetylcysteine – increases glutathione peroxidase activity and protects against UV radiation • Amino acids Glutamine & Glycine – – antioxidants – wound-healing (acne) activity • Plant Extracts (grape, aloe leaf and fennel) – – anti-inflammatory – antioxidant activity against hydrogen peroxide • Saccharomyces/Selenium Ferment – Ingredient created by the fermentation of the Saccharomyces yeast with the mineral selenium. – This anti-aging ingredient that protects against hydrogen peroxide damage and boosts SPF – Provides added selenium to skin
  10. 10. The Science – MMP-1 SNPActive™ • • MMP-1 (collagenase) is an enzyme that degrades collagen Collagen is the main protein of skin – Collagen is constantly synthesized and broken down in an ongoing cycle to form new tissue. – Collagen degradation is the major factor in aging of skin • Wrinkles • Loss of elasticity • • • MMP-1 enzyme production is increased with age and exposure to sunlight SNPs in the MMP-1 gene causes increased rates of collagenase production leading to more collagen breakdown In vitro test showed downregulation of MMP-1 enzyme Test Material MMP1 SNPActive™ SNP-Related Enzyme Matrix metalloproteinase Activity (Compared to Untreated Control) Analysis Method Diminished  ELISA MMP-1 SNPActive™ provides ingredients to:  Strengthen collagen  Protect collagen against free radical damage
  11. 11. The Science – MMP-1 SNPActive™ • Saccharomyces cerevisiae (yeast) – – – – Improves skin moisture Improves skin microrelief Increases skin microcirculation Antioxidant to protect against free radical damage to collagen • Polyglucan – helps preserve, strengthen and protect collagen • Panthenol – Pro-Vitamin B5 – Helps diminish wrinkles by infusing moisture deeper into skin layers – Anti-inflammatory – Stimulates cell growth Normal Skin microrelief Oily Skin microrelief Dry Skin microrelief
  12. 12. The Science – SOD2 SNPActive™ • SOD2 gene encodes for Superoxide Dismutase (SOD), is an antioxidant enzyme which helps neutralize superoxide radicals in the skin cells, produced by: – UV exposure – Acne bacteria • • • SNPs on the SOD2 gene can lead to a damaging build-up of the superoxide radicals. The skin's enzymatic antioxidant defense - copper-zinc superoxide dismutase (CuZnSOD), manganese SOD (MnSOD) - have are modulated by UVB and UVA irradiation In photo-aged skin, a significant depletion of antioxidant enzyme expression is observed within the stratum corneum and in the epidermis • In vitro test showed upregulation of SOD2 enzyme Test Material SNP-Related Enzyme Activity (Compared to Untreated Control) Analysis Method SOD2 SNPActive™ Superoxide dismutase Enhanced  Colormetric SOD2 SNPActive™ provides:  Antioxidant ingredients with specific activity against the superoxide radical  Superoxide dismutase
  13. 13. The Science – SOD2 SNPActive™ • Superoxide dismutase – topical treatment with SOD has been shown to – – – – Counteract the reduced expression of SOD by UV light Protect skin proteins (collagen and ellastin) from oxidation Protects skin against inflammation caused by acne Protect skin against photodamage • Saccharomyces (Yeast)/Manganese ferment and Copper Ferment – Antioxidant to quench superoxide radical – Promote would healing – Firms and rejuvenates the skin
  14. 14. The Science – TNF-α SNPActive™ • Tumor Necrosis Factor- alpha (TNF-α) is a chemical messenger which mobilizes white blood cells to fight infections and other invaders. • TNF-α has been found at elevated levels in patients with psoriasis, acne and other inflammatory skin diseases • Toxins and UV light are potent inducers of TNF-α release from the epithelial cells that comprise skin • SNPs on the TNF-α gene may result in an over-reactive inflammatory response and a predisposition to acne and other skin conditions • In vitro test showed downregulation of TNF-α Test Material SNP-Related Enzyme Activity (Compared to Untreated Control) Analysis Method TNF-α SNPActive™ Tumor necrosis alpha Diminished  ELISA TNF-α SNPActive™ provides ingredients to:  Reduce inflammation  Reduce irritation
  15. 15. The Science – TNFα SNPActive™ • Red algae extract – Reduces concentration of nitric oxide, which causes skin inflammation – Reduces skin irritation • Clover leaf extract – – – – Skin regenerating activity Antioxidant-rich Contains isoflavones, which help prevent skin photo-damage Helps treat psoriasis and acne
  16. 16. The Science – NQ01 SNPActive™ • The coenzyme Q10 reductase (NQO1) converts CoQ10 (ubiquinone) to its reduced form, ubiquinol, which scavenges free radicals in the mitochondria and lipid membranes. • Individuals with a SNP in the NQO1 gene have reduced ability to make this conversion from ubiquinone to ubiquinol, resulting in very low blood and tissue levels of this key antioxidant. • CoQ10-depleted skin tissue may be particularly more prone to the damage by free radicals because of its constant exposure environmental oxidants such as sunlight and pollution. • Research has shown that CoQ10 may inhibit the production of epidermal cell interleukin-6, which stimulates fibroblasts in the dermis and contributes to protecting dermal fiber components from degradation, leading to rejuvenation of wrinkled skin. NQ01 SNPActive™ provides:  Ubiquinol (Red and Yellow)  Ubiquinone (Green)
  17. 17. Clinically-proven 8-week double-blind randomized (half-face) study OVERALL IMPROVEMENT ALL PARAMETERS • LifeMap Me™ significantly out-performed the placebo for all areas in both qualitative and 5 4 3 quantitative measurements PRODUCT 2 CONTROL • 1 0 DAY 14 28 62% reported substantial reduction in appearance of wrinkles after 14 days of treatment 54 • • FINE LINES IMPROVEMENT After 56 days the number rose to 70% Similarly, after 14 days, 56% reported improved skin firmness 0.5 PRODUCT 0 CONTROL -0.5 DAY 14 28 56 • After 8 weeks 70% indicated improved skin firmness
  18. 18. Thank You!