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Chapter25 endopart1marieb

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  • effect that RHs and IHs released from the hypothalamus go immediately without dilution to their target.
  • Transcript

    • 1. Chapter 25 The Endocrine System
      • Compare the basic organization and function of the ES and the NS
      • Describe the structural and functional organization of the hypothalamus and the pituitary and explain their relationship
      • Discuss the locations and structures of the thyroid, parathyroid, and adrenal glands as well as the thymus and the endocrine part of the pancreas.
      • List the hormones (and their function) produced by these glands.
      • Briefly review examples of abnormal hormone production
    • 2. Endocrine System Overview
      • Ductless glands produce hormones
      • Secreted into the bloodstream (endocrine)
        • Except the thyroid
      • Gland may be entire organ:
        • Pituitary, thyroid, parathyroid, pineal, adrenal
      • or bits of tissue interspersed within an organ
        • Gonads, kidneys, many others
    • 3.  
    • 4. Classes of Hormones (p 754)
      • Chemical classification of hormones
        • Amino Acid Derivatives
          • Proteins (longer)
          • Peptides (shorter)
        • Steroids (from cholesterol)
        • Eicosanoids (from arachidonic acid)
      • Target tissues are identified by specific receptors (on target cells). The effects may be stimulatory or inhibitory, depending on the receptors.
    • 5. Control of Hormone Secretion
      • Humoral
        • BP and the kidney’s JG apparatus
      • Neural
        • Recall the adrenal medulla
        • Hypothalamic Releasing Factors
      • Hormonal
        • Pituitary Releasing Hormones, e.g., FSH
    • 6. Hypothalamus
      • Control Center for internal environment
      • Regulates nervous and endocrine systems via 3 mechanisms:
        • ANS centers exert nervous control on adrenal medulla
        • ADH and Oxytocin production
        • Regulatory hormone production (RH and IH) controls pituitary gland directly and all other endocrine glands indirectly
          • These regulatory hormones are released from neurons, thus we have neuroendocrine cells.
      Fig 25.3
    • 7. Pituitary Gland (= Hypophysis) p 755
      • Structure:
        • Located at the base of the brain, surrounded by the Circle of Willis
        • Infundibulum - connection to hypothalamus
        • In the sella turcica of the sphenoid bone
        • Two parts with separate embryonic origins:
          • Anterior Pituitary
          • Posterior Pituitary
    • 8. Pituitary Gland (= Hypophysis) p 755 Fig 25.3
      • Anterior Pituitary (= adenohypophysis)
        • AKA pars distalis
        • production of 7 peptide hormones
          • 4 are tropic hormones, stimulating other endocrine glands
        • Pars intermedia and pars tuberalis secrete MSH and some gonadotropins.
    • 9. Pituitary Gland (= Hypophysis) p 755 Fig 25.3
      • Posterior Pituitary (= neurohypophysis)
        • AKA pars nervosa
        • Storage reservoir for ADH and Oxytocin (produced in ?)
    • 10. Pituitary Gland (= Hypophysis) Review Table 25.1
    • 11. Hypophyseal Portal System
      • Review: Three sites of capillary portal systems: liver, kidney, and pituitary
      • Portal systems : two capillary networks in serial arrangement
      • Portal veins : blood vessels that link two capillary networks
    • 12.  
    • 13. Control of the Adenohypophysis
      • Hypothalamus has neurons that produce
        • Releasing , e.g., GnRH, or
        • Inhibiting Hormones
      • Into a capillary plexus
      • Down the infundibulum in portal veins
      • Into a second capillary plexus
        • Receptors in pituitary
      • Hormones then released into the circulation
      Fig 25.4
    • 14. Neurohypophysis = PP
      • Neurons originate in the Supraoptic and Paraventricular Nuclei
      • Extend down the infundibulum
      • Release Oxytocin and Antidiuretic Hormone (ADH or vasopressin) into the circulation
    • 15. Superior view Anterior Pituitary Posterior Pituitary Infundibulum
    • 16.  
    • 17. Pituitary MRI, contrast enhanced
    • 18. Thyroid Gland
      • Anterior surface of trachea just inferior of thyroid cartilage (or Adam’s apple)
      • Two lobes connected by isthmus
      Fig 25-7
    • 19. More Thyroid
      • Thyroid follicular cells (simple cuboidal epithelium) produce and store thyroglobulin in thyroid follicles
        • Iodine then added to produce thyroxine (T 4 ) and triiodothyronine (T 3 ) inside the follicles
        • The thyroglobulin is reabsorbed by the follicular cells, cleaved, and the thyroid hormone (T3 and T4) are released into the bloodstream
        • Note that this is the only extracellular storage of hormones
      • C (chief) Cells : (AKA parafollicular cells) produce calcitonin
        • Interspersed between thyroid follicles
        • Lower blood Calcium
    • 20. Classic Negative Feedback Loop
    • 21. C-Cells
    • 22. Thyroid Disease
      • Hyper-
        • Cardiovascular
          • Increased BP
          • Tachycardia
          • Palpitations
        • Neuromuscular
          • Emotional lability
          • Insomnia
          • Weakness
          • Hand Tremor
      • Hypo-
        • Weakness
        • Dry, coarse Skin
        • Lethargy, Slow Speech
        • Feel cold
        • Less Sweat
        • Eyelid and Facial Edema
    • 23. Four Parathyroid Glands
      • Parathyroid hormone (PTH; sometimes also called parathormone)
      • Function:
        • (raises blood [Ca 2+ ])
        • antagonist to Calcitonin
      4 tiny glands embedded in the posterior aspect of the thyroid (superior and inferior)
    • 24.  
    • 25.