Protein Folding: Understanding the Dance of              the Chaperones    and New Insights to the Function of           M...
FOLDING
FOLDING
INTRODUCTION Chaperones to work   need a previous    function trigger  factor ensure that  the protein is not          bad...
PROTEIN FOLDING:UNDERSTANDING THA   DANCE OF THE   CHAPERONES.     Science daily      may. 8, 2012
PROTEIN FOLDING: UNDERSTANDING THA DANCE OF THE CHAPERONES.                • chaperones are a class of                  pr...
PROTEIN FOLDING: UNDERSTANDING     THA DANCE OF THE CHAPERONES. chaperones have different families,  these classification...
PROTEIN FOLDING: UNDERSTANDING THA DANCE OF THE CHAPERONES.If not found GroEL, unfolded proteins accumulate, they        g...
OBSERVATION    I think the next step is to   investigate the subtypes in  humans, we might have somemore different than in...
NEW INSIGHTS THEFUNCION OF MOLECULAR     CHAPERONES      sCIENCE daily       Aug. 24, 2012
NEW INSIGHTS THE FUNCION OF  MOLECULAR CHAPERONES                   Chaperones act after                synthesis, but imm...
NEW INSIGHTS THE FUNCION OF        MOLECULAR CHAPERONES   prepares the trigger  factor for subsequent       protein foldin...
NEW INSIGHTS THE FUNCION OF       MOLECULAR CHAPERONES The trigger factor also has a component repair, if a proteinsynthes...
OBSERVATION  More important that these chaperones, the trigger is the   determinant factor in the maturation of proteins i...
Medical utility
MEDICAL UTILITY            PROTEIN FOLDING:      UNDERSTANDING THE DANCE         OF THE CHAPERONES        know that the c...
MEDICAL UTILITYPROTEIN FOLDING: UNDERSTANDING THE DANCE OF THECHAPERONESIn neurodegenerative diseases (Alzheimer and Parki...
MEDICAL UTILITY  NEW INSIGHTS TO THE FUNCTION OF MOLECULAR      CHAPERONES.   before a pathology level chaperones should...
Biologia molecular CHAPERONAS
Biologia molecular CHAPERONAS
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Biologia molecular CHAPERONAS

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Laura Segura Muñoz
3er semestre
Universidad Pontificia Bolivariana
Facultad de Medicina
Medellin, agosto 27, 2012

Published in: Health & Medicine, Technology
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Biologia molecular CHAPERONAS

  1. 1. Protein Folding: Understanding the Dance of the Chaperones and New Insights to the Function of Molecular Chaperones Laura Segura Muñoz Medicine student 3er semester UPB Teacher: Lina Mariia Martinez Sanchez Aug. 27, 2012 Medellin
  2. 2. FOLDING
  3. 3. FOLDING
  4. 4. INTRODUCTION Chaperones to work need a previous function trigger factor ensure that the protein is not bad.Chaperones are not justa class, there is a varietythat is more specialized GroEL (E. coli)
  5. 5. PROTEIN FOLDING:UNDERSTANDING THA DANCE OF THE CHAPERONES. Science daily may. 8, 2012
  6. 6. PROTEIN FOLDING: UNDERSTANDING THA DANCE OF THE CHAPERONES. • chaperones are a class of proteins that perform the folding of proteins after their synthesis, three- dimensional structure give.
  7. 7. PROTEIN FOLDING: UNDERSTANDING THA DANCE OF THE CHAPERONES. chaperones have different families, these classifications are called chaperonins, GroEL is the one, and was discovered in E. Coli. Chaperones GroEL helps when any protein can not fold while the folds 700 chaperone protein, GroEL alone the 1.
  8. 8. PROTEIN FOLDING: UNDERSTANDING THA DANCE OF THE CHAPERONES.If not found GroEL, unfolded proteins accumulate, they generate long-term problems, particularly neurodegenerative diseases.
  9. 9. OBSERVATION I think the next step is to investigate the subtypes in humans, we might have somemore different than in the E. Colieasier to find related pathologies accumulation of unfolded proteins.
  10. 10. NEW INSIGHTS THEFUNCION OF MOLECULAR CHAPERONES sCIENCE daily Aug. 24, 2012
  11. 11. NEW INSIGHTS THE FUNCION OF MOLECULAR CHAPERONES Chaperones act after synthesis, but immediately after synthesis acts trigger factor.
  12. 12. NEW INSIGHTS THE FUNCION OF MOLECULAR CHAPERONES prepares the trigger factor for subsequent protein folding chaperones by, besides avoiding premature folding during thesynthesis, making proteins restricting erroneous.
  13. 13. NEW INSIGHTS THE FUNCION OF MOLECULAR CHAPERONES The trigger factor also has a component repair, if a proteinsynthesis and ends has a premature folding factor reverses it, to make way for the chaperones for proper maturation.
  14. 14. OBSERVATION More important that these chaperones, the trigger is the determinant factor in the maturation of proteins in theprotein deficiency diseases andcould be the point of treatment to improve the condition.
  15. 15. Medical utility
  16. 16. MEDICAL UTILITY  PROTEIN FOLDING: UNDERSTANDING THE DANCE OF THE CHAPERONES know that the chaperones have the assistance of chaperonins like GroEL, is one possible way to classify diseases related to protein maturation, but still need to do research to determine the classes of chaperones in humans and to investigate much more about them as they can that the variation between human and E. Coli can be bigger.
  17. 17. MEDICAL UTILITYPROTEIN FOLDING: UNDERSTANDING THE DANCE OF THECHAPERONESIn neurodegenerative diseases (Alzheimer and Parkinson diseases) should assess the role of chaperonins like GroEL of E. Coli, if there is a deficiency of said chaperonin proteins accumulate which could not be folded by the chaperone protein level causing cerebral plaques.
  18. 18. MEDICAL UTILITY  NEW INSIGHTS TO THE FUNCTION OF MOLECULAR CHAPERONES.  before a pathology level chaperones should be assessed first trigger factor, because without chaperones would not work, so they were structurally well.
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