Roadmap for the
Trillion Sensor Universe
Dr. Janusz Bryzek
Chair, TSensors Summit
Vice President, MEMS and Sensing Solutio...
Self Introduction
•

Education
•
•

•

Warsaw University of Technology: MSEE and Ph.D.
Stanford University: Executive Mana...
NovaSensor
Selected MEMS Devices from my Companies

Acceleration sensor

Catheter tip pressure
sensor

Microwave power met...
Outline
•
•
•
•

Quick look at VC funding
Introduction to Abundance
Overview of Trillion Sensor Universe
The Amazing Word ...
Introduction: US VC Funding

https://www.pwcmoneytree.com/MTPublic/ns/index.jsp
5
Silicon Valley vs New York

6
Top Software VC Investments SV-NY, Q3/2013

7
Abundance* Vision
•

The biggest global problems, such as hunger, lack
of medical care, lack of clean water and lack of
en...
Abundance Enablers
Exponential technologies:
–
–
–
–
–
–
–
–

Biotechnology and bioinformatics
Medicine
Nanomaterials and ...
Abundance Aftershock*
•

Rapid market evolution is expected to replace 40% of current Fortune 500
companies within 10 year...
Why TSensors Movement
•

Abundance* movement is forecasting elimination of major global problems in
one generation, 20 to ...
TSensors Acceleration Approach
•

Invite visionaries to predict many of the new ultrahigh volume sensor based
applications...
Trillion Sensors (TSensors) Visions
•

•

Mobile sensor market for volumes not
envisioned by leading market research
organ...
Global Tides Driving Demand for Sensors
•

Global (somewhat overlapping) tides driving demand for smart
systems include:
•...
15
16
17
Global Tides will Ride on Smart Systems
•

Smart Systems are defined by Harbor Research* as a fusion of computing,
communi...
MEMS Migration into Mainstream
Growth Assumptions:
Period

Estimate

MEMS

SEMI

MEMS+
SEMI

20132018

Low

15%/y

3%/y

3...
Can We Afford Trillion Sensors?
•

2023 global GDP should be
around $100T.
IoT alone is forecasted by Cisco
and GE around ...
Jobs, Jobs, Jobs…
Assuming an average revenue per employee in developed countries at:
– $200,000/year for component compan...
Jobs Where?
•

Sensor based systems require a high-tech work force.
•

•

Majority of created jobs will likely be for know...
Challenges for TSensors
•
•
•
•

User adoption.
Cycle time for commercialization.
Standardization.
Development of algorith...
Software for TSensors
•

Sensors fusion
– E.g., Kalman filter merging data from acceleration, rate, magnetic and pressure
...
Incentives for TSensors Adoption
•

Cost reduction of medical care, currently growing out of control.
–

Insurance compani...
Incentives for TSensors Adoption
•

Government policies
•

Many countries already have mandated reduction of pollution of ...
Accelerating Development through Competition
•

$2.25M Nokia Sensing XChallenge
•

Nanobiosym Health Radar won $525,000 Gr...
TSensorsNext Step: Roadmap
•

TSensors Summits collected visions for the ultrahigh volume sensor
applications likely to em...
The Amazing Word of
Sensor Based Products

29

29
MEMS Studded Mobile Devices
$CAGR: 35%/year!

Yole 2012

30

Samsung Galaxy S4: MEMS usage
leader. Additionally, it has:
•...
Startup Studded Emerging Market

31
Sampler 1: Amazing Sensor Based Products

iSonea personal asthma
wheeze monitor

Hexoskin‟s sensor-packed Tshirt analyzing...
http://www.omsignal.com/

33

33
Sampler 2: Amazing Sensor Based Products

Nike‟s smart shoe insert with
8 sensors

Ultrasound scanner from
Mobisante
34

T...
Sampler 3: Amazing Sensor Based Products

EKG monitor from AliveCor

Uchek (MIT) detects 25 diseases,
such as diabetes, ur...
Cuffless Blood Pressure Measurement

Sotera Wireless‟ non-invasive
measures continuous blood
pressure, along with pulse
ra...
Noninvasive Glucose Monitoring

Integrity Applications‟
employs a combination
of ultrasound,
electromagnetic, and
thermal ...
Printed Paper Microfluidics
•

Lab-on-Chip can be multilayer printed
on paper.
Is low-cost, easy-to-use, disposable,
and e...
Blood Testing based on Lab on Chip
Palo Alto startup Theranos rolled out blood testing
(starting with Walgreens in Palo Al...
Intelligent Pills
Swallowable capsule includes:
–
–
–
–
–
–
–

Pump
Drug reservoir
Wireless radio.
Imaging chips.
µControl...
Chemical Sensors: the Next Revolution

41
Spectrometer: the Next Gyro-like Tornado?
Testing Sweetness of AAPL?

fresh milk vs. old milk
2fresh
alcohol samples
4 day...
Hyperspectral Imaging

43
44
Breath Diagnostics
•

Dogs are trained to detect medical problems
based on breath due to their extreme smell
sensitivity:
...
iBreath
A new product turns iPod into an alcohol
breathalyzer.
The $79 accessory plugs into the base of the iPod
and funct...
TI‟s IR Vein Viewer
Displays location of veins for nurses.
MEMS mirror controlled infrared light is converted to visible i...
THz Imaging
Terahertz radiation penetrates fabric, wood, plastic, and even clouds,
but not metal or water.

THz image
4 mm...
Finding a Bacteria in Blood
•

LoC separates bacteria (grey) from human blood
cells (red) for quick identification, while ...
Neurano
•

Multidisciplinary project to integrate carbon
nanotubes (CNT) with a multielectrode array
to develop an new gen...
PharmacoGenomics
•
•

Deals with the influence of genetic variation on drug response in patients.
Promises "personalized m...
Anti-Aging Revolution
•

Calorie restricted (CR) starvation diet was
shown to extend many species life span by a
30% to 40...
Playing the God?
•
•

A new form of life has been created in a laboratory!
J. Craig Venter Institute made a piece of DNA t...
Summary
•
•

Future will be more amazing than shown products sampler.
Creating New Future will trigger multiple market Tor...
Thank you
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Roadmap for the Trillion Sensor Universe -- a Gilt-hosted, Internet of Things talk by Dr. Janusz Bryzek

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Roadmap for the Trillion Sensor Universe -- a Gilt-hosted, Internet of Things talk by Dr. Janusz Bryzek

  1. 1. Roadmap for the Trillion Sensor Universe Dr. Janusz Bryzek Chair, TSensors Summit Vice President, MEMS and Sensing Solutions, Fairchild Semiconductor Gilt Tech New York, November 26, 2013
  2. 2. Self Introduction • Education • • • Warsaw University of Technology: MSEE and Ph.D. Stanford University: Executive Management Program Started 7 high-tech (MEMS) companies in Silicon Valley: 1982 Sensym 1982 IC Sensors 1985 NovaSensor 1995 Intelligent MicroSensor Technology 2000 Transparent Networks 2004 LV Sensors 2009 Jyve • (now Honeywell) (now Measurement Specialties) (now General Electric) (now Maxim) (now Intel) (now Atmel) (now Fairchild Semiconductor) Performed due diligence for local VC firms and work as Board Member or Advisor for over 40 startups. Recognized as “Entrepreneur of the Year” by Arthur Young in 1989. Recognized in the industry as Father of Sensors. Awarded the Lifetime Achievement Awards: • • • – By Sensors Magazine In 1994 and by MANCEF in 2003. My field: MEMS (micromechanics) and NEMS (nanomechanics). 2
  3. 3. NovaSensor Selected MEMS Devices from my Companies Acceleration sensor Catheter tip pressure sensor Microwave power meter First fusion bonded pressure sensor. Shipped so far over billion units First DRIE based hydrophone First DRIE pressure sensor 2 Axis Acceleration Sensor Pressure Sensor ASIC 1200 fiber block with lens array Integrated 2D mirror Tire pressure sensor Energy scavenger 3 Tire pressure sensor module Consumer inertial sensors Million pixel optical position detector 1000x1000 port optical switch
  4. 4. Outline • • • • Quick look at VC funding Introduction to Abundance Overview of Trillion Sensor Universe The Amazing Word of Sensor Based Products 4
  5. 5. Introduction: US VC Funding https://www.pwcmoneytree.com/MTPublic/ns/index.jsp 5
  6. 6. Silicon Valley vs New York 6
  7. 7. Top Software VC Investments SV-NY, Q3/2013 7
  8. 8. Abundance* Vision • The biggest global problems, such as hunger, lack of medical care, lack of clean water and lack of energy, can be solved in one generation (20 years) through: – Exponential technologies. • Networked sensors are one of eight exponential Global Goods and Services Demand Supply technologies. – DIY (Do-it-Yourself) revolution. 2013 2023 2033 2043 – Unrivaled in history technophilanthropic force. – The rising billion. * http://www.abundancethebook.com/ 8
  9. 9. Abundance Enablers Exponential technologies: – – – – – – – – Biotechnology and bioinformatics Medicine Nanomaterials and nanotechnology Networks and sensors (45 trillion networked sensors in 20 years). Digital manufacturing (3D printing) and infinite computing Computational systems Artificial intelligence Robotics DIY (Do-it-Yourself) revolution: – – Power of individual innovators capable of “impossibles”. E.g., flying into space (Burt Rattan) and sequencing human genome (Craig Venter). Unrivaled in history technophilanthropic force: – Funded by billionaires (Gates, Zuckenberg, Omidyars, Elon Musk, etc.). The rising billion: – Billion of the very poorest of the poor on earth is being plugged into global economy through a global transportation network, Internet, microfinance and wireless communication. 9
  10. 10. Abundance Aftershock* • Rapid market evolution is expected to replace 40% of current Fortune 500 companies within 10 years… By companies we didn‟t hear about yet. • * Peter Diamandis, November 2013 10
  11. 11. Why TSensors Movement • Abundance* movement is forecasting elimination of major global problems in one generation, 20 to 30 years. This will require (among others) 45 trillion sensors, many of which are not yet developed. Historical sensor development cycles from prototypes in academic labs to volume production were 30 years. Left to historical cycles, new sensor would delay Abundance. TSensors movement is aiming at acceleration of sensor development cycles, to accelerate Abundance. • • • • 11
  12. 12. TSensors Acceleration Approach • Invite visionaries to predict many of the new ultrahigh volume sensor based applications to generate an upfront development focus. – – • Ultrahigh volumes are required to enable global impact. 2013 TSensors Summit collected the first set of such visions. Convert visionary sensor applications into a limited number of TSensing Platforms. – • This will be a first step towards potential process standardization, maximizing the number of supported applications for each platform. Open the development challenges to crowd genius (global development community) • • Perhaps form dedicated development organizations (startups) with Board or Advisory Board including entrepreneurs with scars in sensor technology commercialization. Facilitate funding the development of TSensing Platforms • 12 Potentially include target customers, supply chain companies, crowdfunding, techno-philanthropic organizations, Governments, academia-Government-industry consortia, Cooptition and Incentive Competition (similar to XPrize Foundation‟s in multiple health sensing areas).
  13. 13. Trillion Sensors (TSensors) Visions • • Mobile sensor market for volumes not envisioned by leading market research organizations in 2007, grew exponentially 212%/y between 2007 and 2012. Several organizations created visions for a continued growth to trillion(s). • • • Market research companies don‟t yet see it. Explosion to trillion(s) is likely to be driven by new applications not yet envisioned by leading market research organization. Forecasting thus needs visionaries! 13
  14. 14. Global Tides Driving Demand for Sensors • Global (somewhat overlapping) tides driving demand for smart systems include: • Mobile market • Transitioning to unPad like infrastructure. • Wearable market • Bringing fitness, wellness and health monitoring to all of us. • Digital Health • Improving health diagnostics and therapeutics while reducing cost. • Internet of Things • Connecting devices around us through new network architecture to enable low latency control. • Context Computing • Deriving information about us (such as feelings) and around us. • • CeNSE, Central Nervous System for the Earth, building global environment monitoring. 5-in-5 • Five senses for computers in five years 14
  15. 15. 15
  16. 16. 16
  17. 17. 17
  18. 18. Global Tides will Ride on Smart Systems • Smart Systems are defined by Harbor Research* as a fusion of computing, communication and sensing. • • • Forecasted growth to trillions is for Smart Systems, not just sensors! Enable people, machines, devices, sensors, and businesses to interact. This enables new modes of collaboration and intelligence called “Smart Business”, thus: • • • Truly connected world of machines, people, video streams, maps, newsfeeds, and sensors. Convergence of physical & virtual worlds, thus enabling collective awareness, creativity, and better decision making capabilities. Many observers believe that this phenomenon will drive the largest growth opportunity in the history of business. • Largest bull market over the next 20 years? * http://harborresearch.com/ 18
  19. 19. MEMS Migration into Mainstream Growth Assumptions: Period Estimate MEMS SEMI MEMS+ SEMI 20132018 Low 15%/y 3%/y 3.6%/y High 30%/y 3%/y 5.9%/y Low 20%/y 6%/y 6.7%/y High 50%/y 6%/y 12.3%/y 20182023 19
  20. 20. Can We Afford Trillion Sensors? • 2023 global GDP should be around $100T. IoT alone is forecasted by Cisco and GE around $15T by 2020. • • • 15% of GDP! Networked sensor market was estimated by Cisco to reach $1T in 2020. • • Networked sensor cost $1. We can afford trillion sensors at the right price. 20 Global GDP could reach $100 trillion by 2023. (Historical Data (blue) from Wikipedia. Extrapolation (red-pink) by Bryzek). IoT forecast from Cisco and GE.
  21. 21. Jobs, Jobs, Jobs… Assuming an average revenue per employee in developed countries at: – $200,000/year for component companies – $500,000/year (equal to 2011 NASDAQ 100 average) for smart system companies. Assuming further, based on Cisco forecast: – Average selling price of the wireless smart sensor at $1. – Smart system selling price $15. Trillion smart system would thus represent in 2023: – 5 million new direct jobs in component industries. – 30 million new direct jobs in system industries. Assuming indirect jobs multiplier of 3, this would result in 105 million additional jobs, for a total of 140 million jobs. – Indirect job multiplier for knowledge workers has been between 2 and 4 (depending on region). – As a reference, the US created only 1.3M new jobs in the last 10 years, primarily in Government and medical sectors. 21
  22. 22. Jobs Where? • Sensor based systems require a high-tech work force. • • Majority of created jobs will likely be for knowledge workers. An example of a sensor based system could be Apple‟s iPhone 4s, which had the following breakdown of 2011 selling price: – 3% ($14) cost of assembly (China) – 32% ($178) cost of components (global) – 66% ($368) Apple‟s share (US) 100% ($560) selling price • Most of “sensor and smart systems” jobs will likely be in industrialized countries. Fortune Magazine 2011 22
  23. 23. Challenges for TSensors • • • • User adoption. Cycle time for commercialization. Standardization. Development of algorithms enabling derivation of useful information. Bandwidth sharing wireless communication. Battery/scavenger sources enabling power for life. Network architecture enabling low latency control. Scaling network size enabling processing of sensor generated data at the level of Brontobytes. Available funding. • • • • • 23
  24. 24. Software for TSensors • Sensors fusion – E.g., Kalman filter merging data from acceleration, rate, magnetic and pressure sensors. to improve accuracy and lower processing power. • Data fusion – E.g., merging data from inertial sensors, GPS and weather service. • Sensing services – E.g., providing oil location and its quantity based of underground explosions monitored by millions sensors. • Big data – E.g., collecting and processing 16 bit data from all sensors (e.g., 12) in all cellphones (e.g., 5 billion) with 100 Hz data rate (3 ZettaBytes/year) • Small data – Processed big data, e.g., you just exceeded your calorie intake for the day; stop eating. Multiple startups popped to address sensor generated data. 24
  25. 25. Incentives for TSensors Adoption • Cost reduction of medical care, currently growing out of control. – Insurance companies are already funding development of new technologies potentially reducing health care cost. • – Governments will be doing their share as well. • • E.g., IBM‟s Dr. Watson, http://www.sbwire.com/press-releases/2019-telemedicine-and-m-healthconvergence-market-shares-strategies-and-forecasts-worldwide-347599.htm). A recent example could be Massachusetts Life Science Commission funding projects across the state of Massachusetts universities at $240M, including Personalized Health Monitoring at UMass Amherst at $95M. Improved quality of medical care and prevention. • • • We will be personally monitoring our health, enabling us not only to do a better job based on measured data than doctor‟s office, but also able to detect many problems very early. This will be a strong incentive for users‟ adoption. Energy savings. • • For example, some estimate about 30% of office building HVAC energy cost reduction when smart HVAC systems are installed, a very short ROI. Fun • 25 As Intel presented last year, about 30% of trillion sensors will be changing our lifestyles, giving us more fun, thus easy adoption.
  26. 26. Incentives for TSensors Adoption • Government policies • Many countries already have mandated reduction of pollution of air, water, food, reduction of energy use, etc. • E.g., past Governments regulations in automotive industry, drove massive adoption of sensors improving fuel economy (pressure, flow, exhaust) and safety (acceleration, gyro) and pollution (pressure, flow, exhaust). – The compliance will require deployment of smart systems. • Motivations for academia, Governments and industry: – – – – 26 Emergence of very large market. Challenging problems to solve. Creation of new jobs. Acceleration of Abundance.
  27. 27. Accelerating Development through Competition • $2.25M Nokia Sensing XChallenge • Nanobiosym Health Radar won $525,000 Grand Prize award in 2013. • Enables testing of a drop of blood or saliva with a nanochip inserted into a mobile device. It detects the presence (or absence) of selected disease's pathogen in real-time, with gold standard accuracy. • $120,000 Distinguished Award winners demonstrated game-changing technology: • Elfi-Tech - Using advanced optics in a device smaller than a penny, non-invasively measures skin blood flow, velocity, coagulation and vascular health. • InSilixa - Using blood, saliva or urine, created a single CMOS chip that analyzes proteins and nucleic acids to detect diseases and health status. • MoboSens - Water and biofluids can be analyzed rapidly with smartphone-based sensor that reports on the presence of chemical contaminants and bacteria. • Owlstone - Using a "digital nose" sensor, can detect the presence of chemicals in concentrations down to parts per trillion. identifying disease from user's breath or body fluids. • Silicon BioDevices - Using blood drawn from a small finger stick, sensor diagnoses and transmits results to mobile devices or electronic medical record (EMR) systems. • Qualcomm‟s $10M Xprize competition to detect 15 most common diseases and 2014 Nokia competitions are still open. • 27 34 teams competing.
  28. 28. TSensorsNext Step: Roadmap • TSensors Summits collected visions for the ultrahigh volume sensor applications likely to emerge over the next decade. Next Steps: • • • 28 Conversion of applications into Sensing Platforms Characterizing technology options for each sensing platforms as TSensors Roadmap.
  29. 29. The Amazing Word of Sensor Based Products 29 29
  30. 30. MEMS Studded Mobile Devices $CAGR: 35%/year! Yole 2012 30 Samsung Galaxy S4: MEMS usage leader. Additionally, it has: • 3 microphones • Over 30 FBARs filters
  31. 31. Startup Studded Emerging Market 31
  32. 32. Sampler 1: Amazing Sensor Based Products iSonea personal asthma wheeze monitor Hexoskin‟s sensor-packed Tshirt analyzing movement, breathing and heart activity 32 Smart sock from Owlet Baby Care Breast lumps self-exams monitors infant‟s quality of sleep, blood (mammogram) sensor from Eclipse Breast Health Technologies oxygenation levels, and skin temperature Preventice „s smart bandage constantly tracks cardiac ECG and rhythm monitoring Fraunhofer‟s glucose, lactate and cholesterol sensors, pulse oximeter, and a fluorescence sensor for detecting biomarkers
  33. 33. http://www.omsignal.com/ 33 33
  34. 34. Sampler 2: Amazing Sensor Based Products Nike‟s smart shoe insert with 8 sensors Ultrasound scanner from Mobisante 34 Tatooed sensors from UCSD Breast cancer killing chip from Northwestern University Shake stabilized spoon for Parkinson disease patients from Lift Labs Mobile Xray station from Tribogenics
  35. 35. Sampler 3: Amazing Sensor Based Products EKG monitor from AliveCor Uchek (MIT) detects 25 diseases, such as diabetes, urinary tract infections, and pre-clampsia, levels of glucose, proteins, ketones, and more. 35 Lapka can detect radiation and organicity of food. Brainwaves driven ears from Necomimi express your emotional state before you start talking. Smart tennis racket from Babolat MUSE: The Brain-Sensing Headband that lets you control things with your mind
  36. 36. Cuffless Blood Pressure Measurement Sotera Wireless‟ non-invasive measures continuous blood pressure, along with pulse rate, skin temperature, electrocardiogram, blood oxygenation and respiration rate and temperature. 36 Cnoga‟s device spectrometrically measures noninvasively blood pressure, blood oxygen, and pulse. HealthStats watch measures blood pressure using applanation tonometry.
  37. 37. Noninvasive Glucose Monitoring Integrity Applications‟ employs a combination of ultrasound, electromagnetic, and thermal technologies to obtain blood glucose readings 37 Echo launched a noninvasive continuous glucose monitoring system based on proprietary skin permeation Biosensors „ approach is based on electromagnetic impedance spectroscopy (EIS) and electromagnetic impedance tomography (EIT). Cnoga‟s device measures glucose, heartbeat, skin resistance, quality of skin collagen, skin health and identifies nervous people based of color change of RGB lights passing through skin. C8 MediSensors developed Raman spectroscopy based glucose sensor, raised $43M in 2012 and closed in 2013 after finding measurement instability. Apple hired several of former employees
  38. 38. Printed Paper Microfluidics • Lab-on-Chip can be multilayer printed on paper. Is low-cost, easy-to-use, disposable, and equipment-free. Promising technology particularly relevant to improving the healthcare and disease screening in the no- or low infrastructure developing world. Applications: • • • Health diagnostics (e.g., urinalysis, saliva analysis, sputum analysis, pregnancy test, blood type) Biochemical analysis (e.g., enzyme activity) Environment monitoring Food quality control Forensic (e.g., detection of blood) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365319/#c19 38
  39. 39. Blood Testing based on Lab on Chip Palo Alto startup Theranos rolled out blood testing (starting with Walgreens in Palo Alto) after $100M+ funding: – 1000x reduced blood volume for about 200 blood tests. • Likely enabled by Lab on Chip with fluorescent tags. – Providing results in 4 hours – With increased accuracy. – At a fraction of lab cost. 39
  40. 40. Intelligent Pills Swallowable capsule includes: – – – – – – – Pump Drug reservoir Wireless radio. Imaging chips. µController. Temperature sensor. Battery. Delivery of drugs to treat digestive tract disorders directly to the location of the illness, enables smaller dose, reducing side effects. 40
  41. 41. Chemical Sensors: the Next Revolution 41
  42. 42. Spectrometer: the Next Gyro-like Tornado? Testing Sweetness of AAPL? fresh milk vs. old milk 2fresh alcohol samples 4 days 6 days Source: nanoLambda 42
  43. 43. Hyperspectral Imaging 43
  44. 44. 44
  45. 45. Breath Diagnostics • Dogs are trained to detect medical problems based on breath due to their extreme smell sensitivity: • • Low sugar level in diabetics or cancer. What can be smelled with chemical sensors: • • • • • • • • • • Cancer Cholesterol Asthma Lipid peroxidation Metabolism Neonatal jaundice, intestinal distress Cystic fibrosis/bronchitis Periodontal disease Infectious disease (flu) Etc. Source: Dr. J. Stetter, SRI 45
  46. 46. iBreath A new product turns iPod into an alcohol breathalyzer. The $79 accessory plugs into the base of the iPod and functions like a field sobriety test. – The person using the iBreath exhales into a retractable "blow wand" – Within two seconds, it displays the results on an LED screen. – A reading of 0.08 or above sets off an alarm, signaling a blood-alcohol level above the legal limit in all 50 states. • Developed by David Steele Enterprises Inc. in Newport Beach. http://www.latimes.com/business/la-fi-idrunk19-2008dec19,0,3073178.story 46
  47. 47. TI‟s IR Vein Viewer Displays location of veins for nurses. MEMS mirror controlled infrared light is converted to visible image through the foil. 47
  48. 48. THz Imaging Terahertz radiation penetrates fabric, wood, plastic, and even clouds, but not metal or water. THz image 4 mm Skin tumor and breast cancer detection Wallace et. al, Faraday Discuss. 126 (2004) 48 1 0 Tooth decay detection Arnone et. al, Physics World, April (2000) Mona Jarrahi , Berkeley Sensor and Actuator Center
  49. 49. Finding a Bacteria in Blood • LoC separates bacteria (grey) from human blood cells (red) for quick identification, while keeping both sets of cells alive. Red blood cells and bacteria separate as they are deflected to different extents by liquid introduced from a side channel. The cells' deflection can be tuned to direct particles of a certain size to specific collection chambers. LOC isolates bacteria directly without first needing to culture the samples, a time consuming process. • • • Red blood cells and bacteria (grey) separate as they are deflected to different extents by liquid introduced from a side channel Soft inertial microfluidics for high throughput separation of bacteria from human blood cells Zhigang Wu, Ben Willing, Joakim Bjerketorp, Janet K. Jansson and Klas Hjort, Lab Chip, 2009 49
  50. 50. Neurano • Multidisciplinary project to integrate carbon nanotubes (CNT) with a multielectrode array to develop an new generation of biochips to repair damaged central nervous system tissues. New CNT-based interface with state-of-theart stimulation of brain-machine is key to developing all types of neuroprostetics: • – – – – – – – Sight Sound Smell Motion Vetoing epileptic attacks Spinal bypasses Repairing and enhancing cognitive functions. http://www.neuronano.net/Home.aspx?section=1 50
  51. 51. PharmacoGenomics • • Deals with the influence of genetic variation on drug response in patients. Promises "personalized medicine“ • • Drugs and drug combinations optimized for each individual's unique genetic makeup. Emerged after the first complete sequencing of human genome in 2001. – Is considered the next fundamental development in human medicine: – Promises an era of individualized patient care and personal medicine. – Uses markers in individuals‟ genetic code to pinpoint underlying causes of disease. • Transforms medicine from prescribing treatment based on patient‟s symptoms, to therapies based on patient‟s genetics. Promises to cure diseases rather than alleviate symptoms. • 51
  52. 52. Anti-Aging Revolution • Calorie restricted (CR) starvation diet was shown to extend many species life span by a 30% to 40%. Around 2000, several biotech startups were formed to bring CR benefit with normal diet. • – Transformed the guessing game into drug development program. – Target to switch ON complex mechanism embedded in our genomes to postpone and possibly attenuate myriads of ills brought by aging. • Four Potential Breakthrough Drugs Rapamycin (derived from Easter Island soil bacteria): first compound to convincingly extend live in mammals. Resveratrol (derived from grape skin): somewhat less effective than rapamycin. Metformin (derived from French lilac plant): shows promise. Mannoheptulose (derived from avocados): a sugar with multiple CR like effects in rodents. Compounds capable of regulating key effects of CR in rodents have come to light. Soon to be available to humans… • Source: Fortune Magazine, June 14, 2010 52 52
  53. 53. Playing the God? • • A new form of life has been created in a laboratory! J. Craig Venter Institute made a piece of DNA that carries about 1,000 genes, from off-the-shelf laboratory chemicals. – First creature since the beginning of creatures that has no ancestor. – What it is, and how it lives, depends entirely on a design put together by and held on the institute‟s computers. • • The first of these artificial creatures showed that it could reproduce on its own: The age of artificial life has began… Science Magazine, May 20th, 2010 53
  54. 54. Summary • • Future will be more amazing than shown products sampler. Creating New Future will trigger multiple market Tornados, redefining global economies and providing room for many new companies. Byproducts of these Tornados: •        Abundance, eliminating major global problems. Medical diagnostic will become faster, cheaper, portable, wireless… personal. We will start curing diseases rather than alleviate symptoms. All of us will live longer and healthier, in less polluted and more energy efficient world. We will have more fun than ever. The biggest bull market in history? The first MEMS/NEMS/Bio Billionaires may emerge… 54
  55. 55. Thank you
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