Acne

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acne - brief review

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Acne

  1. 1. ACNEBreif Review
  2. 2. Acne Vulgaris - Treatment Based on Pathogenesis• A disease of the pilosebaceous unit of the skin• start appearing in adolecence• Pathogenesis is multifactorial• It causes social, and psychological quality of life impairment
  3. 3. Pathogenesis of Acne• Abnormal follicular keratinization• More sebum production• Proliferation of Propionobacterium acnes• Hormonal factors• Host immune response
  4. 4. Primary Lesions of Acne• Closed comedones• Open comedones• Red papules• Pustules• Nodules or some times Cysts• Scars
  5. 5. Primary Lesions of Acne• Closed comedo• Open comedo• Red papule• Pustule• Nodule or Cyst• Scar
  6. 6. • Acne in 4th and 5th Grade Girls is Correlated with increased DHEAS during adrenarche
  7. 7. The Comedokeratinaceous debris, that blocks the orifice of pilocebaceousunit
  8. 8. Acne Therapies Principles• Correct altered follicular keratinization• Modulate host immune response• Reduce sebum production• Decrease androgenic effects• Inhibit the growth of P. acnes
  9. 9. Acne Treatments• For comedonal lesions - topical retinoids – Tretinoin (Retin-A) – Adapalene (Differin) – Tazarotene (Tazorac)• Add benzoyl peroxide 2.5% to 5% if few papules are present too. (Bleaches clothes)• Or add azelaic acid
  10. 10. Systemic therapies for acne– Isotretinoin (Accutane™, Sotret etc.)– DHEAS, free testosterone, 17 OH-P– Ortho Tri-cyclen, Yasmin, Allese– Spironolactone

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