Acne
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Acne

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acne - brief review

acne - brief review

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    Acne Acne Presentation Transcript

    • ACNEBreif Review
    • Acne Vulgaris - Treatment Based on Pathogenesis• A disease of the pilosebaceous unit of the skin• start appearing in adolecence• Pathogenesis is multifactorial• It causes social, and psychological quality of life impairment
    • Pathogenesis of Acne• Abnormal follicular keratinization• More sebum production• Proliferation of Propionobacterium acnes• Hormonal factors• Host immune response
    • Primary Lesions of Acne• Closed comedones• Open comedones• Red papules• Pustules• Nodules or some times Cysts• Scars
    • Primary Lesions of Acne• Closed comedo• Open comedo• Red papule• Pustule• Nodule or Cyst• Scar
    • • Acne in 4th and 5th Grade Girls is Correlated with increased DHEAS during adrenarche
    • The Comedokeratinaceous debris, that blocks the orifice of pilocebaceousunit
    • Acne Therapies Principles• Correct altered follicular keratinization• Modulate host immune response• Reduce sebum production• Decrease androgenic effects• Inhibit the growth of P. acnes
    • Acne Treatments• For comedonal lesions - topical retinoids – Tretinoin (Retin-A) – Adapalene (Differin) – Tazarotene (Tazorac)• Add benzoyl peroxide 2.5% to 5% if few papules are present too. (Bleaches clothes)• Or add azelaic acid
    • Systemic therapies for acne– Isotretinoin (Accutane™, Sotret etc.)– DHEAS, free testosterone, 17 OH-P– Ortho Tri-cyclen, Yasmin, Allese– Spironolactone