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Infecciones causadas por micobacterias diferentes a las del complejo

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MICOBACTERIAS NO TUBERCULOSAS …

MICOBACTERIAS NO TUBERCULOSAS
MICOBACTERIAS ATÍPICAS
MICOBACTERIAS AMBIENTALES
DE CRECIMIENTO RAPIDO


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  • 1. UNIVERSIDAD NACIONAL DE COLOMBIA FACULTAD DE MEDICINA DEPARTAMENTO DE MICROBIOLOGIA ASPECTOS MICROBIOLOGICOS DE LAS MICOBACTERIAS 2013
  • 2. INFECCIONES CAUSADAS PORMICOBACTERIAS DIFERENTES A LAS DEL COMPLEJO M. tuberculosis Leonardo Favio Jurado Zambrano MICOBAC- UN 2013
  • 3. “MICOBACTERIAS NO TUBERCULOSAS”• M. kansassi• M. intracellulare• M. avium• M. scrofulaceum• M. marinumVIH / SIDA
  • 4. Clin Chest Med 23 (2002) 553– 567
  • 5. Clin Chest Med 23 (2002) 553– 567
  • 6. Clin Chest Med 23 (2002) 553– 567
  • 7. Clin Chest Med 23 (2002) 369–376
  • 8. Clin Chest Med 23 (2002) 553– 567
  • 9. Clin Infect Dis 1993;17:7– 20.
  • 10. MNT DE RAPIDO CRECIMIENTO Mycobacterium fortuitum Mycobacterium abscessus Mycobacterium chelonae Mycobacterium mucogenicum Mycobacterium inmunogenum Mycobacterium peregrinum Mycobacterium goodii Mycobacterium smegmatis Mycobacterium phlei Mycobacterium flavencens Mycobacterium peregrinum Mycobacterium alveiAm J Respir Crit Care Med Vol 175. pp 367–416, 2007 (…)
  • 11. Infect Dis Clin N Am 2002;16: 187–219
  • 12. Mycobacterium fortuitumMycobacterium fortuitum da Costa Cruz 1938, species. Type strain: strain ATCC 6841 = CCUG 20994 = CIP 104534 = DSM 46621 = IFO (now NBRC) 13159 = JCM 6387 = NCTC 10394. GenBank/EMBL/DDBJ accession number for the 16S rRNA gene sequence of the type strain: AY457066. Synonyms: "Mycobacterium giae" Darzins 1950, "Mycobacterium minetti" Penso et al. 1952. Etymology: L. neut. adj. fortuitum, casual, accidental, fortuitous. References: SKERMAN (V.B.D.), McGOWAN (V.) and SNEATH (P.H.A.) (editors): Approved Lists of Bacterial Names. Int. J. Syst. Bacteriol., 1980, 30, 225-420 [Da COSTA CRUZ (J.C.): Mycobacterium fortuitum um novo bacillo acidoresistance pathogenico para o homen. Acta Medica (Rio de Janeiro), 1938, 1, 297-301.]
  • 13. Mycobacterium fortuitum • No cromógena • Muy ambiental ( suelo y agua para consumo humano) • Generalmente produce infecciones cutáneas, tejido celular subcutáneo, hueso, articulaciones. Infecciones asociadas a dispositivos.J Clin Microbiol Infect Dis 1994;13:884–901
  • 14. Mycobacterium abscessusMycobacterium abscessus (Moore and Frerichs 1953) Kusunoki and Ezaki 1992, comb. nov. Type strain: strain Hauduroy L948 = TMC 1543 = ATCC 19977 = CCUG 20993 = CIP 104536 = DSM 44196 = JCM 13569 = NCTC 13031. GenBank/EMBL/DDBJ accession number for the 16S rRNA gene se quence of the type strain: AY457071. Basonym: Mycobacterium chelonae subsp. abscessus corrig. (Moore and Frerichs 1953) Kubica et al. 1972 (Approved Lists 1980). Other synonym: "Mycobacterium abscessus" Moore and Frerichs 1953. Etymology: L. gen. n. abscessus, of an abscess, referring to the ability of the organism to form abscesses. Reference: KUSUNOKI (S.) and EZAKI (T.): Proposal of Mycobacterium peregrinum sp. nov., nom. rev., and elevation of Mycobacterium chelonae subsp. abscessus (Kubica et al.) to species status: Mycobacterium abscessus comb. nov. Int. J. Syst. Bacteriol., 1992, 42, 240-245.
  • 15. Mycobacterium abscessus • Descrita en 1992 • No cromógena • Generalmente afecta hueso, piel y tejidos blandos. • Se asocia a heridas (trauma, cirugía) • De las mas frecuentes causantes de enfermedad pulmonar.J Clin Microbiol Infect Dis 1994;13:884–901 Am J Respir Crit Care Med Vol 175. pp 367–416, 2007
  • 16. Clin Chest Med 23 (2002) 369–376
  • 17. Caso M. abscessusChest radiograph of a 77-year-old female ex-smoker who presented with a chronic productive cough,intermittent hemoptysis, fatigue, and weight loss. Sputum smears were 4+ positive for acid-fast bacilli,and she grew M abscessus from many sputum specimens.
  • 18. Tipo de presentación patológica de infección pulmonar por MNT • TUBERCULOIDE / FIBROCAVITARIO • BRONQUIECTASICO • SARCOIDEDiagnostic Microbiology and Infectious Disease 68 (2010) 228–235
  • 19. TUBERCULOIDE
  • 20. BRONQUIECTASICO
  • 21. SARCOIDE
  • 22. Mycobacterium chelonaeMycobacterium chelonae corrig. Bergey et al. 1923, species. Type strain: strain CM 6388 = ATCC 35752 = CCUG 47445 = CIP 104535 = DSM 43804 = JCM 6388 = NCTC 946. GenBank/EMBL/DDBJ accession number for the 16S rRNA gene se quence of the type strain: AY457072. Etymology: Gr. n. khelone, a tortoise; N.L. gen. n. chelonae, of a tortoise. References: SKERMAN (V.B.D.), McGOWAN (V.) and SNEATH (P.H.A.) (editors): Approved Lists of Bacterial Names. Int. J. Syst. Bacteriol., 1980, 30, 225-420 [BERGEY (D.H.), HARRISON (F.C.), BREED (R.S.), HAMMER (B.W.) and HUNTOON (F.M.) (eds): Bergeys Manual of Determinative Bacteriology, 1st ed., The Williams & Wilkins Co, Baltimore, 1923, pp. 1-442.] Note: The original spelling, Mycobacterium chelonei (sic), has been corrected by Hill et al. 1984. Reference: HILL (L.R.), SKERMAN (V.B.D.) and SNEATH (P.H.A.): Corrigenda to the Approved Lists of Bacterial Names edited for the International Committee on Systematic Bacteriology. Int. J. Syst. Bacteriol., 1984, 34, 508-511.
  • 23. Mycobacterium chelonae • Descrito en 1923 en el manual Bergey • No cromógena • Primeros reportes clínicos en los años 70 • Se ha aislado de fuentes naturales de agua, sistemas de agua potable. • Comúnmente contamina material medico- quirurgico y de laboratorio. • Infecciones oculares, procedimientos esteticos, inyecciones con mala tecnica.J Clin Microbiol Infect Dis 1994;13:884–901
  • 24. CASO M chelonaeChest radiograph of a 70-year-old nonsmoking Asian man who presented with cough, hemoptysis, andweight loss. He had been treated many years earlier for tuberculosis. His respiratory specimens wereacid-fast bacilli smear negative, but he had repeatedly positive sputum cultures for M. chelonae.
  • 25. Clin Chest Med 23 (2002) 623–632
  • 26. Mycobacterium mucogenicumMycobacterium mucogenicum Springer et al. 1995, sp. nov. Type strain: strain MO76 = ATCC 49650. GenBank/EMBL/DDBJ accession number for the 16S rRNA gene sequenc e of the type strain: AY457074. Etymology: L. n. mucus, mucus, Gr. v. gennaio, to produce; L. neut. suff. - icum, suffix used with the sense of pertaining to; N.L. neut. adj. mucogenicum, intended to mean producing mucus, referring to the highly mucoid character of most strains on solid agar. Reference: SPRINGER (B.), BÖTTGER (E.C.), KIRSCHNER (P.) and WALLACE Jr. (R.J.): Phylogeny of the Mycobacterium chelonae-like organism based on partial sequencing of the 16S rRNA gene and proposal of Mycobacterium mucogenicum sp. nov. Int. J. Syst. Bacteriol., 1995, 45, 262-267. Note: Mycobacterium mucogenicum Springer et al. 1995 was previously designated as Mycobacterium chelonae-like organism (MCLO) by Silcox et al. 1981. Reference: SILCOX (V.A.), GOOD (R.C.) and FLOYD (M.M.): Identification of clinically significant Mycobacterium fortuitum complex isolates. J. Clin. Microbiol., 1981, 14, 686-691.
  • 27. Mycobacterium mucogenicum • El primer aislamiento se hizo de un caso de peritonitis asociada a dialisis. • Springer lo describió como especie en 1995. • No cromógena • Se ha encontrado en fuentes de agua potable • Raro en humanos • Se asocia a infecciones de heridas por trauma • Tto: Amika, claritro, doxi, TMP- S. Resist a R e I.Am J Respir Crit Care Med Vol 175. pp 367–416, 2007
  • 28. Mycobacterium immunogenumMycobacterium immunogenum Wilson et al. 2001, sp. nov. Type strain: strain BH29 = MC 779 = ATCC 700505 = DSM 45595. GenBank/EMBL/DDBJ accession number for the 16S rRNA gene sequence of the type strain: AJ812215. Etymology: N.L. neut. adj. immunogenum, eliciting an immune response. Reference: WILSON (R.W.), STEINGRUBE (V.A.), BÖTTGER (E.C.), SPRINGER (B.), BROWN-ELLIOTT (B.A.), VINCENT (V.), JOST Jr. (K.C.), ZHANG (Y.), GARCIA (M.J.), CHIU (S.H.), ONYI (G.O.), ROSSMOORE (H.), NASH (D.R.) and WALLACE Jr. (R.J.):Mycobacterium immunogenum sp. nov., a novel species related to Mycobacterium abscessus and associated with clinical disease, pseudo-outbreaks and contaminated metalworking fluids: an international cooperative study on mycobacterial taxonomy. Int. J. Syst. Evol. Microbiol., 2001, 51, 1751-1764.
  • 29. Mycobacterium immunogenum • Recientemente descrito • Infecciones asociadas a dispositivos • Frecuentemente casusa infecciones de piel • Tto: amika, claritro.Am J Respir Crit Care Med Vol 175. pp 367–416, 2007
  • 30. Mycobacterium peregrinumMycobacterium peregrinum (ex Bojalil et al. 1962) Kusunoki and Ezaki 1992, sp. nov., nom. rev. Type strain: strain ATCC 14467 = CCUG 27976 = CIP 105382 = DSM 43271 = JCM 12142 = NCTC 10264. GenBank/EMBL/DDBJ accession number for the 16S r RNA gene sequence of the type strain: AY457069. Synonym: "Mycobacterium peregrinum" Bojalil et al. 1962. Etymology: L. neut. adj. peregrinum, strange, foreign. Reference: KUSUNOKI (S.) and EZAKI (T.): Proposal of Mycobacterium peregrinum sp. nov., nom. rev., and elevationof Mycobacterium chelonae subsp. abscessus (Kubica et al.) to species status: Mycobacterium abscessus comb. nov. Int. J. Syst. Bacteriol., 1992, 42, 240-245
  • 31. Mycobacterium peregrinum • Propuesta como nueva especie en 1962- 1992 • No cromógena • En el hombre causa enfermedad localizada • Compromete pulmón, hueso y piel • Tto: minociclina por 28 semanas Case Rep Dermatol 2012; 4: 76 – 79.Am J Respir Crit Care Med Vol 175. pp 367–416, 2007
  • 32. Mycobacterium smegmatisMycobacterium smegmatis (Trevisan 1889) Lehmann and Neumann 1899, species. Type strain: strain ATCC 19420 = CCUG 21002 = CCUG 21815 = CIP 104444 = DSM 43756 = JCM 5866 = JCM 6386 = NCTC 8159 = NRRL B-14616 = VKM Ac-1239. GenBank/EMBL/DDBJ accession number for the 16S rRNA gene sequenc e of the type strain: AJ131761. Synonyms: "Bacillus smegmatis" Trevisan 1889, "Bacterium smegmatis" (Trevisan 1889) Migula 1900, "Mycobacterium paratuberculosis smegmatis" Bustinza 1951. Etymology: L. n. smegma -atis, an unguent (for making the skin smooth), a detergent, a cleansing medicine, and in biology the sebaceous humor; L. gen. n. smegmatis, of smegma. References: SKERMAN (V.B.D.), McGOWAN (V.) and SNEATH (P.H.A.) (editors): Approved Lists of Bacterial Names. Int. J. Syst. Bacteriol., 1980, 30, 225-420 [1TREVISAN (V.): I. Generi e le Specie delle Batteriacee, Zanaboni and Gabuzzi, Milano, 1889. 2 LEHMANN (K.B.) and NEUMANN (R.): Lehmanns Medizin, Handatlanter X. Atlas und Grundriss der Bakteriologie und Lehrbuch der speziellen bakteriologischen Diagnostik. 2 Aulf., JF. Lehmann, München, 1899, pp. 1-497.]
  • 33. Mycobacterium smegmatis• Descrito por Lustgarten en 1885• Se encuentra en suelo y agua• Infecciones de tejidos blandos y hueso• Infecciones de sitio operatorio, procedimientos estéticos, dispositivos médicos.• Tto: doxi, amika. No anti TB.
  • 34. Nat rev micro. nov 2012