Cutaneous Presentation of
    Systemic Diseases
SBE (sub-acute bacterial
        endocarditis)
 Emboli trapped at the capillary beds show as micro-
hemorrhages or infarct...
Nail bed pathology
Differentiate from Hutchinson’s Sign for melanoma
          Superficial Spreading:   most        Clubbi...
Acute Leukemias                        (non-lymphoblastic)


Uncontrolled proliferation of hematopoietic cells with malign...
Acute Leukemias                                        (non-lymphoblastic)
Etiologies include chromosomal damage from radi...
Acute Leukemias                (non-lymphoblastic)
Degree of organ or marrow
involvement will dictate the
types of lesions...
Acute Leukemias            (non-lymphoblastic)

AMOL lesion (1)
                        1
ANLL leukemia cutis
(2)
Leukemic...
Acute Leukemias                                    (non-lymphoblastic)

• Sweet’s syndrome:            acute febrile neutr...
Acute Leukemias                        (non-lymphoblastic)



• Bone involvement:           acute
  leukemic infiltration ...
Acute Leukemias                         (non-lymphoblastic)




    AML-induced Pseudomonas pyocyanea
•
    infection at t...
Acute Leukemia            (lymphoblastic)


• B-cell lymphoma (Burkitt’s)




• T-cell (Sézary syndrome)
Graft vs. Host Disease
•   Acute leukemia therapy (allogenic
    bone marrow transplant) can result in
    morbidity/morta...
Chronic Leukemias
                                                     3
•   CLL (chronic lymphocytic leukemia)
    presen...
Chronic Leukemias
•   CML can present with
    hyperviscosity syndrome
    and hepato-
    splenomegaly. Note the
    sple...
Lichen Planus
•   Inflammatory, muccocutaneous condition with common
                                                     ...
Internal Malignancies
•        The most common benign             Other diseases:
         cutaneous lesions most likely t...
Dermatomyositis
•   Associated with internal neoplasia with a     •Diagnosis is a combination of muscle
    27% incidence ...
Acanthosis Nigicans
• Associated with GI
  cancer (adenocarcinoma
  is the most common)
• Also associated with
  Diabetes ...
Necrotic Migratory Erythema
• Associated with α-cell
  islet tumors, with 60%
  malignant
  (glucagonoma)
• Seen with Diab...
Herpes Zoster
• With disseminated,
  severe and ulcerative
  disease, may signal
  cancer in 75% to 80%
  of people
• Usua...
Xanthoma Planum
• Has a high
  association with
  Multiple Myeloma
• No lipid dyscrasias
  in these patients
Multiple Eruptive Seborrheic
            Keratoses
                                    •Most commonly associated with
• Be...
Erythroderma
• Usually seen in psoriasis,
  atopic dermatitis, drug-
  induced allergic reactions
• 15% of cases are with
...
Pemphigus Vulgaris
• Autoimmune disease with
  bullous lesions which rupture
  leaving a denuded patch called
  “Nikolsky’...
Erythema Gyratum Repens
• Wood grain pattern in the
  skin
• 90% associated with
  internal cancer
• Most commonly lung
• ...
Breast Cancer
• Cutaneous presentation seen
  in 1% of patient population.
• Can be direct extension of the
  tumor or of ...
Ovarian Cancer
• Malignant, cutaneous lesions
  indicative of systemic cancer are
  typically nodular with a firm
  consis...
Other Signs
•   Flushing, usually evident in the face and upper chest, most commonly
    accompanies carcinoid tumors of t...
Gonococcal Septicemia
• Seen with Disseminated
  Gonnococcal infection DGI
• Present with pyrexia,
  polyarthralgias and s...
Syphilis
•   Primary syphilis usually presents as a chancre    1
    with bilateral inguinal adenopathy which may
    pers...
Lupus
•   Tissues and cells are damaged by
    deposition of pathogenic antibodies
    and immune complexes
    β-cell hyp...
Meningococcal septicemia
•   30%-50% of those who develop
    meningococcal disease have
    bacteremia without meningitis...
Disseminated Fat Necrosis
•   When associated with pancreatic
    cancer can cause lesions (1) from
    release of pancrea...
Polyarteritis
• Inflammation of and
  damage to blood vessels,
  compromise of vessel
  lumen and resulting
  ischemia
• M...
Tuberculosis
• Lupus vulgaris is a
  granulomatous disease of
  the skin usually in long-
  standing, untreated disease
  ...
Diabetes
• Diabetic bullosis
• Necrobiosis
  lipoidica
  diabeticorum
Thank
You
Upcoming SlideShare
Loading in...5
×

Cutaneous Presentations Of Systemic Diseases

4,020

Published on

Published in: Health & Medicine
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total Views
4,020
On Slideshare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
0
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

Cutaneous Presentations Of Systemic Diseases

  1. 1. Cutaneous Presentation of Systemic Diseases
  2. 2. SBE (sub-acute bacterial endocarditis) Emboli trapped at the capillary beds show as micro- hemorrhages or infarcts.
  3. 3. Nail bed pathology Differentiate from Hutchinson’s Sign for melanoma Superficial Spreading: most Clubbing of nails can be seen in common and seen on back and trunk. pachydermoperiostosis syndrome Can become nodular (seen in lung cancer— bronchogenic or alveolar cell Nodular: vertical growth phase carcinoma Bazex’s syndrome (yellow nails Acrolentigenous: seen on digits with violaceous color of skin) seen and subungual areas, more common in lung cancer blacks Terry’s Nails (ground glass Lentigo Maligna: least common, appearance to nails) can be seen usually on face or other actinic in CHF exposure areas
  4. 4. Acute Leukemias (non-lymphoblastic) Uncontrolled proliferation of hematopoietic cells with malignant cells filling marrow and other tissue and with the reduced production of erythrocytes, granulocytes and megakaryocytes, anemia, infection and hemorrhage results. 80% incidence of ALL (acute lymphoblastic leukemia) in children 80% incidence of ANLL (acute non-lymphocytic leukemia) in adults Classification is via predominant neoplastic cell line (lymphoblastic or non-lymphoblastic [myeloblastic/monocytic]) Sub-classified by the FAB (French/American/British) group
  5. 5. Acute Leukemias (non-lymphoblastic) Etiologies include chromosomal damage from radiation, chemicals (e.g., benzene and alkylating agents used in therapy), congenital diseases (e.g., Down’s syndrome), and chronic bone marrow diseases (e.g., myeloid metaplasia), congenital predisposition, and congenital immunodeficiency syndromes (e.g., ataxia-telangiectasia). In acute leukemia, the uncontrolled proliferation of hematopoietic cells in the bone marrow and peripheral blood eventually replace the marrow and invade other tissues and organs. The manifestation of the disease results in diminished production of erythrocytes, granulocytes and megakaryocytes with resulting anemia, infection and hemorrhage. As the degree of marrow and other organ involvement progresses, symptoms of fatigue, ecchymosis, buccal lesions and infection increase. Peri-rectal infections are often seen in ANLL with skin and gum infiltrates seen an acute monocytic leukemia. Rheumatic symptoms occur commonly with ALL, as well as lymphadenopathy and hepatosplenomegaly. Patients with ANLL can have unusual masses in the soft tissue and nodal sites, as a precursor of overt marrow and peripheral blood invasion and may be mistaken for lymphoma. These are called myeloblastomas.
  6. 6. Acute Leukemias (non-lymphoblastic) Degree of organ or marrow involvement will dictate the types of lesions Skin and gum infiltrates are commonly seen in AML (Candida albicans) Leukemic infiltration of the gums in AMOL Peri-rectal infections are frequent in ANLL Joint swelling and bone pain with rheumatic symptoms is seen in ALL
  7. 7. Acute Leukemias (non-lymphoblastic) AMOL lesion (1) 1 ANLL leukemia cutis (2) Leukemic infiltrates at the eye (3) Acute leukemia at 4 2 the anterior shin (4) AML with petechial 3 hemorrhages (5) 5
  8. 8. Acute Leukemias (non-lymphoblastic) • Sweet’s syndrome: acute febrile neutrophilic dermatosis. Seen in AML or AMOL (acute monocytic leukemia). Seen here in ANLL (acute non-lymphocytic leukemia [1]) • Usually drug-induced or following a viral 3 illness in the young • 10% incidence of underlying cancer, most commonly myelocytic leukemia (1-3) 1 • Nonmyelocytic leukemia and lymphoma have been reported (4) • Other cutaneous presentations: 4 2 – Arm in AML (2) – Leg in AML (3) – Scalp in ANLL (4)
  9. 9. Acute Leukemias (non-lymphoblastic) • Bone involvement: acute leukemic infiltration with necrosis marked by yellow opacification of the marrow with surrounding hyperemic tissue.
  10. 10. Acute Leukemias (non-lymphoblastic) AML-induced Pseudomonas pyocyanea • infection at the foot and hand • Streptococcal cellulitis at the neck and face all induced by the neutropenia from the prior chemotherapy for AML
  11. 11. Acute Leukemia (lymphoblastic) • B-cell lymphoma (Burkitt’s) • T-cell (Sézary syndrome)
  12. 12. Graft vs. Host Disease • Acute leukemia therapy (allogenic bone marrow transplant) can result in morbidity/mortality. This is seen as a range from papulosquamous eruptions or desquamation of the skin, with the palmar and plantar areas most commonly involved, as in this patient with AML
  13. 13. Chronic Leukemias 3 • CLL (chronic lymphocytic leukemia) presenting as lymphadenopathy (1) • CLL converting to DLCL (diffuse large cell lymphoma) with trunk lesion which shows B-immunoblastic type diffuse large cell lymphoma or Richter’s syndrome (2) 4 1 • CLL-induced herpes zoster lesions (3) with buccal infection with Candida albicans (4) • CLL-induced pharyngeal tonsil enlargement (5) 2 5
  14. 14. Chronic Leukemias • CML can present with hyperviscosity syndrome and hepato- splenomegaly. Note the splenic infarct (white spot at the surface of the spleen
  15. 15. Lichen Planus • Inflammatory, muccocutaneous condition with common 1 morphology • Long-term oral mucosal lesions (1) have an increased risk of developing squamous cell carcinoma. Same with genital lesions. • Causes include drug eruptions and HCV infection, although most cases are idiopathic • Treatment includes oral and topical steroids, Soriatane, 2 PUVA and possibly Dapsone and Plaquenil • Usual presentation is a violaceous polygonal flat-top papule (2) and plaque with white scales (Wickham’s striae) • Variations include: – a hypertrophic version (3) 5 – Vesiculobullous (4) and actinic type (5) variants 4 – Nail and subungual presentation 3
  16. 16. Internal Malignancies • The most common benign Other diseases: cutaneous lesions most likely to –Multiple eruptive seborrheic keratoses be associated with internal –Sweet’s syndrome malignancy include: –Erythroderma 1. Dermatomyositis –Xanthoma 2. Acanthosis nigricans –Pemphigus vulgaris 3. Necrotic migratory erythema –Erythema gyratum repens 4. Herpes zoster
  17. 17. Dermatomyositis • Associated with internal neoplasia with a •Diagnosis is a combination of muscle 27% incidence rate. abnormalities and characteristic heliotrope rash (periorbital reddish-purple flush which • Prevalence in women predates the muscle weakness by weeks, • Ovarian, breast, lung, stomach and colon months or even years cancers are most often seen in association •A violaceous erythema appearing over the with dermatomyositis with the cutaneous knuckles, elbows and knees (Gottron’s sign) presentation identical regardless of cancer with raised, flat-topped papules on the type knuckles (Gottron’s papules) • Polymyositis appears clinically as dermatomyositis, but has none of the increased cancer risks. Heliotrope Rash
  18. 18. Acanthosis Nigicans • Associated with GI cancer (adenocarcinoma is the most common) • Also associated with Diabetes Mellitus and obesity
  19. 19. Necrotic Migratory Erythema • Associated with α-cell islet tumors, with 60% malignant (glucagonoma) • Seen with Diabetes Mellitus • Glossitis also often seen
  20. 20. Herpes Zoster • With disseminated, severe and ulcerative disease, may signal cancer in 75% to 80% of people • Usual association is with lymphoma and leukemia
  21. 21. Xanthoma Planum • Has a high association with Multiple Myeloma • No lipid dyscrasias in these patients
  22. 22. Multiple Eruptive Seborrheic Keratoses •Most commonly associated with • Benign neoplasms usually adenocarcinoma of the stomach • Abrupt onset associated with •Others include leukemia, underlying cancer is called the mycosis fungoides, hepatoma sign of Leser-Trélat and carcinoma of lung and breast
  23. 23. Erythroderma • Usually seen in psoriasis, atopic dermatitis, drug- induced allergic reactions • 15% of cases are with underlying malignant disorders such as Sézary syndrome or mycosis fungoides
  24. 24. Pemphigus Vulgaris • Autoimmune disease with bullous lesions which rupture leaving a denuded patch called “Nikolsky’s sign” • Can be associated with thymoma and myasthenia gravis • Paraneoplastic pemphigus is associated with cancer, most commonly non-Hodgkin’s lymphoma with 90% mortality due to sepsis or respiratory failure
  25. 25. Erythema Gyratum Repens • Wood grain pattern in the skin • 90% associated with internal cancer • Most commonly lung • Less commonly esophagus and breast
  26. 26. Breast Cancer • Cutaneous presentation seen in 1% of patient population. • Can be direct extension of the tumor or of local or distant metastasis • Direct extension most common with breast cancer and oral cancer
  27. 27. Ovarian Cancer • Malignant, cutaneous lesions indicative of systemic cancer are typically nodular with a firm consistency and are red, plum- colored or hyperpigmented • Ulceration of the lesions suggest an underlying cancer
  28. 28. Other Signs • Flushing, usually evident in the face and upper chest, most commonly accompanies carcinoid tumors of the intestine • Palmar erythema, usually associated with advanced liver failure, may also accompany primary or metastatic malignant liver disease • Direct extension of breast cancer to the skin may be accompanied by telangiectasia • Purpuric lesions may be a manifestation of disseminated intravascular coagulation induced by cancer. DIC can also cause acral gangrene in foot and hand. • Thrombophlebitis is usually migratory when associated with cancer
  29. 29. Gonococcal Septicemia • Seen with Disseminated Gonnococcal infection DGI • Present with pyrexia, polyarthralgias and skin lesions which may be papular, petechial, pustular, hemorrhagic or necrotic and usually found on the distal extremities
  30. 30. Syphilis • Primary syphilis usually presents as a chancre 1 with bilateral inguinal adenopathy which may persist for months • Secondary syphilis presents with skin lesions (1) which move from macules to papules and pustular erosions with the palms and soles often affected (2) 3 • Intertrigenous areas can manifest with papules enlarging to moist lesions called condyloma lata (3), which are highly infectious • Tertiary syphilis is neurosyphilis and presents largely as changes in mentation, with sensorium and autonomic deficit (demyelination of posterior columns), Charcot joint and Argyll Robertson pupils 2 (accommodation but not light response)
  31. 31. Lupus • Tissues and cells are damaged by deposition of pathogenic antibodies and immune complexes β-cell hyperactivity, production of autoantibodies with specificity for nuclear antigenic determinants and abnormalities in T-cell function occur
  32. 32. Meningococcal septicemia • 30%-50% of those who develop meningococcal disease have bacteremia without meningitis • Prodromal syndrome of tussis, cephalgia, with sudden spike of pyrexia with 75% developing petechia with distal necrosis sometimes developing • Waterhouse-Friderichsen syndrome in fulminant disease (10-20%)
  33. 33. Disseminated Fat Necrosis • When associated with pancreatic cancer can cause lesions (1) from release of pancreatic enzymes into the blood or lymph, causing distal necrosis • An acute panniculitis (2), causing 1 tender nodules in subcutaneous fat and may be suppurative (nodular fat necrosis) • As panniculitis may result from a variety of conditions, Weber- Christian disease is not a specific entity 2
  34. 34. Polyarteritis • Inflammation of and damage to blood vessels, compromise of vessel lumen and resulting ischemia • May be primary or manifestation of disease or secondary to another disease process
  35. 35. Tuberculosis • Lupus vulgaris is a granulomatous disease of the skin usually in long- standing, untreated disease elsewhere • Erythema nodosum may be present, although more common in other diseases
  36. 36. Diabetes • Diabetic bullosis • Necrobiosis lipoidica diabeticorum
  37. 37. Thank You
  1. A particular slide catching your eye?

    Clipping is a handy way to collect important slides you want to go back to later.

×