Capsule
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Capsule

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    Capsule Capsule Presentation Transcript

    • Slide 1 TOPIC NAME : CAPUSLE • Sumitted to: Dr.Khizar Hayyat Submitted By: Zulcaif Ahmad & Saqib Hafeez (696) (719)
    • Slide 2 • Developing and preparing the formulation and selecting the capsule size • Filling the capsule shells • Capsule sealing(optional) • Cleaning and polishing the filled capsules
    • Slide 3 Developing and preparing the formulation and selecting the capsule size uniform powder Diluent or filler Disintegrants Lubricant or Glidant Wetting and Solublizing agent Coating agent
    • Slide 4 000 00 o 1 2 3 4 5
    • Slide 5 Filling Hard Capsule Shells Punch method. • When filling a small number of capsules in the pharmacy • takes the precise number of empty capsules to be filled from the stock container. Machines • Machines developed for industrial use automatically separate the caps from empty capsules, fill the bodieS
    • Slide 6 Filling Hard Capsule Shells Punched vertically Hold capsule between the thumb and forefinger Mix with spatula Powder place on a clean paper or glass or porcelain plate Punch method Empty capsules
    • Slide 7
    • Slide 8 Filling Hard Capsule Shells  Hand-operated capsule filling machines or Feton capsule filling machine  Consist of a couple of plates are capable of producing about 200 to 2000capsules/hr.
    • Slide 9 OSAKA MODEL R-180 SEMI AUTOMATIC CAPSULE FILLING MACHINE
    • Slide 10
    • Slide 11 Capsule Sealing • that fuses the capsule cap to the body through the double wall thickness at their juncture The process results in a distinctive ring around the capsule where heat welded. Heat- welding process • that lowers the melting point in the contact areas of the capsule’s cap and body and then thermally bonds the two parts using low temperatures Liquid wetting agent
    • Slide 12 Capsule Sealing Heat-welding process Fuse the cap & body through double wall thickness at their juncture distinctive ring around the capsule where heat welded Liquid wetting agent lowers the melting point in contact areas thermally bonds two parts using low temperatures (40 C–45 C).
    • Slide 13 Cleaning and Polishing Capsules • On a small scale, capsules may be cleaned individually or in small numbers by rubbing them with a clean gauze or cloth. On small Scale • Many capsule-filling machines are affixed with a cleaning vacuum that removes any extraneous material from the capsules as they exit the equipment. industrial cleaning and polishing of filled hard capsules using the Accela-Cota apparatus. On large scale
    • Slide 14 Cleaning and Polishing Capsules On small scale Cleaned individually in small numbers Rubbing with a clean gauze or cloth. On large scale Cleaning vacuum affixed with filling machine cleaning and polishing by Accela-Cota apparatus.
    • Slide 15
    • Slide 16
    • Slide 17 CAPSULE POLISHING MACHINE AUTO MATIC CAPSULE ARRANGEMNT
    • Slide 18 Preparation of Soft Gelatin Capsules Preparation of Soft Gelatin Capsules Plate process Reciprocating die process
    • Slide 19 Molds Filling with gelatin and medicament on bottom plate Second sheet of gelatin is carefully placed on top of the medication Top plate of the mold is put into place Pressure & heat is applied to seal the capsules Washing
    • Slide 20
    • Slide 21
    • Slide 22 References:- • Pharmaceutical Dosage forms and Drug delivery Systems, Ansel’s, Chapter 7, Page 203-214, Ninth Edition, 2011, 2005 Wolters Kluwer / Lippincott Williams & Wilkins. • Martin’s physical pharmacy and pharmaceutical sciences, Patrick J. Sinko, Chapter No.22, Page No. 580-581, Sixth Edition 2011, 2006 Lippincott Williams & Wilkins, Wolters Kluwer Business. • Pharmaceutical preformulation and formulation , Mark Gibson, Page 451-453, 2004, Printed in USA, By Interpharm / CRC. • Pharmaceutics The design and manufacture of Mediicines, Michael E.Aulton, Third Edition. • Text book of Pharmaceutics, Bentley’s, Chapter 19 page 310- 314, Eight Edition, Edited by: E.A.Rawlins, Published by A.I.T.B.S
    • Slide 23