Junyu Ma CV*Ph.D*Biotech/Medical device

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Seeking for opportunities which utilize innovative and technical skills in the biotechnology/medical devices area

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Junyu Ma CV*Ph.D*Biotech/Medical device

  1. 1. Junyu Ma, Ph.D Curriculum Vitae Columbus, OH 43202 junyuma@gmail.com (803)-586-2871
  2. 2. Objective Results-oriented and self-motivated biomedical engineering professional seeking R&D position in Biotech/Medical Device industry Key Qualifications •Over 10 years solid professional experience in­­ cell culture, target drug delivery and cancer diagnosis device development • In­depth knowledge of using principle of cell biology, molecular biology, materials science and engineering to solve biotechnology problems • Excellent hands on skills of cell culture, cell based assay, polymer synthesis, drug loaded nanoparticle preparation and medical device fabrication • Strong analytical, problem solving and multitasking skills coupled with ability to work both independently and as part of a multidisciplinary team • Eligible to working for any employers in USA without sponsorship
  3. 3. Education 2006~2011 Ph.D. in Chemical Engineering, University of South Carolina, Columbia, SC 2003~06 M.S. in Biochemical Engineering, Dalian Institute of Chemical Physics. P.R. China 1999~2003 B.S. in Life Sciences, University of Science and Technology of China
  4. 4. Technical Skills Cell Biology Techniques: mammalian and bacteria cell culture, cell-based toxicity test, bacteria transformation, cell transfection, flow cytometry, fluorescent microscopy, confocal microscopy Immunology Techniques: immunostaining, ELISA development Molecular Biology Techniques: RNA and DNA Extraction, PCR, DNA Gel Analysis, Western Blotting Animal Manipulation: handling and breeding, primary cells generation, injection, blood withdrawal, survival surgery and post-operative care of rodents GPC, HPLC, LC-MS, NMR, SEM, spectrophotometry Analytical Techniques:
  5. 5. Professional Experience Postdoctoral Researcher, The Ohio State University, Department of Chemical& Biomolecular Engineering May 2011-present •• Develop a non-invasive detection method, tethered Develop a non-invasive detection method, tethered cationic lipoplex nanoparticles biochip, to simultaneously captures cationic lipoplex nanoparticles biochip, to simultaneously captures and characterize tumor biomarkers such as circulating tumors cells and characterize tumor biomarkers such as circulating tumors cells and exosomes. and exosomes. •• Successfully generated induced neuron from embryonic and adult Successfully generated induced neuron from embryonic and adult fibroblast cells with nonviral method, achieving low tumorgenicity fibroblast cells with nonviral method, achieving low tumorgenicity and mutation compared with traditional viral method and mutation compared with traditional viral method •• Fabricated a multifunctional device by combining release chamber Fabricated a multifunctional device by combining release chamber and cell microencapsulation for therapeutic and pharmaceutics and cell microencapsulation for therapeutic and pharmaceutics applications, such as treating diabetics and monitoring inflammation applications, such as treating diabetics and monitoring inflammation
  6. 6. Professional Experience Research Assistant August 2006-May 2011 University of South Carolina, Department of Chemical Engineering “Tissue engineered bone regeneration in a biodegradable osteoinductive scaffold” “Tissue engineered bone regeneration in a biodegradable osteoinductive scaffold” •• Studied methods for synthesis of complex organic molecules, such as macromers and peptides Studied methods for synthesis of complex organic molecules, such as macromers and peptides •• Implemented chemical variations to polymers to introduce functionality Implemented chemical variations to polymers to introduce functionality •• Studied techniques for culture, differentiation, and analysis of bone marrow stromal cells Studied techniques for culture, differentiation, and analysis of bone marrow stromal cells •• Characterized the biocompatibility and osteogenic potential of scaffolds in vivo (subcutaneous Characterized the biocompatibility and osteogenic potential of scaffolds in vivo (subcutaneous implantation, implantation, critical femoral defect of rats, and others )) critical femoral defect of rats, and others ““
  7. 7. Professional Experience Research Assistant August 2006-May 2011 University of South Carolina, Department of Chemical Engineering “Multi-functional nanoparticles for drug delivery in vitro and in vivo study” “Multi-functional nanoparticles for drug delivery in vitro and in vivo study” •• Conjugated and encapsulated rhBMP-2 in NPs for differentiation of bone marrow stromal Conjugated and encapsulated rhBMP-2 in NPs for differentiation of bone marrow stromal cells cells •• Encapsulated Paclitaxel in biodegradable self-assembled core-shell poly(lactide-coEncapsulated Paclitaxel in biodegradable self-assembled core-shell poly(lactide-coglycolide ethylene oxide fumarate) nanoparticles for targeted anti-tumor drug delivery glycolide ethylene oxide fumarate) nanoparticles for targeted anti-tumor drug delivery ““
  8. 8. Professional Experience Research Assistant August 2003May 2006 Dalian Institute of Chemical Physics • Fabricated artificial pancreas based on cell • Fabricated artificial pancreas based on cell microencapsulation technology to treat diabetes microencapsulation technology to treat diabetes • Transplanted alginate-chitosan-alginate • Transplanted alginate-chitosan-alginate microencapsulated bovine chromaffin cells to mice microencapsulated bovine chromaffin cells to mice intraperitoneal cavity, achieving long term analgesic intraperitoneal cavity, achieving long term analgesic effect effect • Immobilized endostatin secreting CHO cells in • Immobilized endostatin secreting CHO cells in microcapsules and optimized production of endostatin microcapsules and optimized production of endostatin in bioreactors in bioreactors
  9. 9. • • • • • • • • Publications 1. J. Ma, X. He, E. Jabbari. “Osteogenic Differentiation of Marrow Stromal Cells on Random and Aligned Electrospun Poly(L-lactide) Nanofibers”. Annals of Biomedical Engineering. 2011, 39(1): 14-25 2. X. He, J. Ma, E. Jabbari. “Migration of marrow stromal cells in response to sustained release of stromal-derived factor-1α from poly(lactide ethylene oxide fumarate) hydrogels”. International Journal of Pharmaceutics. 2010, 390(2):107116 3. W. Xu, J. Ma, X. He, E. Jabbari. “Material properties and osteogenic differentiation of marrow stromal cells on fiber-reinforced laminated hydrogel nanocomposites”. Acta Biomaterialia. 2010, 6(6):1992-2002 4. A.E. Mercado, J. Ma, X. He, E. Jabbari. “Release characteristics and osteogenic activity of recombinant human bone morphogenetic protein-2 grafted to novel selfassembled poly(lactide-co-glycolide fumarate) nanoparticles”. J. Control. Release. 2009, 140: 148-156. 5. X. He, J. Ma, A. E. Mercado, W. Xu, E. Jabbari. “Cytotoxicity of Paclitaxel in Biodegradable Self-Assembled Core-Shell Poly(Lactide-Co-Glycolide Ethylene Oxide Fumarate) Nanoparticles”. Pharm. Res. 2008, 25(7):1552-1562. 6. X. He, J. Ma, E. Jabbari. “Effect of grafting RGD and BMP-2 protein-derived peptides to a hydrogel substrate on osteogenic differentiation of marrow stromal cells”. Langmuir. 2008, 24 (21): 12508–12516 7. S. Moeinzadeh, S. Khorasani, J. Ma, X. He, E. Jabbar. “Synthesis and gelation characteristics of photo-crosslinkable star Poly(ethylene oxide-co-lactideglycolide acrylate) macromonomers”. Polymer. 2011,52(18): 3887–3896 8. J. Zhou, Y. Zhang, W. Wang, J. Ma, H. Zhang, X. Guo, X. Ma. “The Effect of
  10. 10. • • • • • • • • Publications 1. J. Ma, X. He, E. Jabbari. “Osteogenic Differentiation of Marrow Stromal Cells on Random and Aligned Electrospun Poly(L-lactide) Nanofibers”. Annals of Biomedical Engineering. 2011, 39(1): 14-25 2. X. He, J. Ma, E. Jabbari. “Migration of marrow stromal cells in response to sustained release of stromal-derived factor-1α from poly(lactide ethylene oxide fumarate) hydrogels”. International Journal of Pharmaceutics. 2010, 390(2):107116 3. W. Xu, J. Ma, X. He, E. Jabbari. “Material properties and osteogenic differentiation of marrow stromal cells on fiber-reinforced laminated hydrogel nanocomposites”. Acta Biomaterialia. 2010, 6(6):1992-2002 4. A.E. Mercado, J. Ma, X. He, E. Jabbari. “Release characteristics and osteogenic activity of recombinant human bone morphogenetic protein-2 grafted to novel selfassembled poly(lactide-co-glycolide fumarate) nanoparticles”. J. Control. Release. 2009, 140: 148-156. 5. X. He, J. Ma, A. E. Mercado, W. Xu, E. Jabbari. “Cytotoxicity of Paclitaxel in Biodegradable Self-Assembled Core-Shell Poly(Lactide-Co-Glycolide Ethylene Oxide Fumarate) Nanoparticles”. Pharm. Res. 2008, 25(7):1552-1562. 6. X. He, J. Ma, E. Jabbari. “Effect of grafting RGD and BMP-2 protein-derived peptides to a hydrogel substrate on osteogenic differentiation of marrow stromal cells”. Langmuir. 2008, 24 (21): 12508–12516 7. S. Moeinzadeh, S. Khorasani, J. Ma, X. He, E. Jabbar. “Synthesis and gelation characteristics of photo-crosslinkable star Poly(ethylene oxide-co-lactideglycolide acrylate) macromonomers”. Polymer. 2011,52(18): 3887–3896 8. J. Zhou, Y. Zhang, W. Wang, J. Ma, H. Zhang, X. Guo, X. Ma. “The Effect of

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