Surviving sepsis
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Surviving sepsis






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  • Tachypnea stratification happens in APACHE2 scoring
  • Hypoxemia due to lung problems.Tissue hypoxia and inadequate perfusion=shockDefinitions from American College of critical care medicine + ATS +
  • The epidemiology of sepsis in the United States from 1979 through 2000.AUMartin GS, Mannino DM, Eaton S, Moss MSON Engl J Med. 2003;348(16):1546.
  • Does ScvO2 measure SvO2In shock the hepatosplanchnic region gets more hypoxic possiblyAnaerobic glycolysis and the organs that handle pH
  • EARLY GOAL-DIRECTED THERAPY IN THE TREATMENT OF SEVERE SEPSISAND SEPTIC SHOCK- Emmanuel RiversMortality 30.5 vs 46.5Resuscitation End points: Values used to confirm that the changes in preload, afterload and heart contractilty, normalized values for mixed venous oxygen saturation,arterial lactate concentration, base deficit, and pHStandard of care involves hemodynamic optimization and assessment of disease.
  • CVP is right ventriclular EDVCVP: 500mL bolus every 30 minMAP:ScvO2: why? Can have adequate hemodynamic parameters w/o adequate oxygenation, often they will have a normal pressures.

Surviving sepsis Presentation Transcript

  • 1. (hopefully)
    Surviving Sepsis
    Understand sepsis
    Review the reasoning behind the current sespsis treatment guidelines
    Look at some new targets in sepsis treatment
  • 2. First some definitions
    Systemic Inflammatory Response Syndrome (SIRS)
    A constellation of signs and symptoms including:
    1. Tachycardia (>90 bpm)
    2. Tachypnea (risk stratification begins at >24 breaths/min) or hypocapnia (<32mm Hg CO2) or mechanical ventilation assistance
    3. Change in temperature (>38oC or <36oC)
    4. Change in WBCs (>12,000 cells/mL or <4,000 cells/mL or Left Shift= >10% immature band cells)
    Causes: Pancreatitis, Burns, Infection, Trauma, Blood Loss
  • 3. Sepsis = proven or suspected bacteremia/fungemia + 2 SIRS criteria
    Severe Sepsis = Sepsis + organ system dysfunction distant from site of infection(thrombocytopenia, oliguria, ARDS, AMS etc.)
    Septic Shock = Sepsis + hypotension despite fluid resuscitation resulting in tissue hypoxia
  • 4. What happens in sepsis
    Globlal tissue hypoxia is the key element leading to organ failure and death
    Inflammation/Cytokines Inadequate Oxygenation of Tissue Organ Failure/Death
    The goal in treatment is to achieve a balance between oxygen demand and delivery
  • 5. Sepsis Epidemiology
    Sepsis incidence is rising: Approximately 2% of hospitalized patients and 75% of ICU patients will have severe sepsis/septic shock.
    The mortality of severe sepsis/septic shock is decreasing: Estimates range from 20-50% mortality.
    Sepsis occurs in the emergency room, ICU, medical wards and is increasingly being managed outside the ICU.
  • 6. Finding out what works in Sepsis treatment Requires Measuring Oxygenation
    Mixed Venous Oxygen Saturation (SVO2)
    Measured with a pulmonary artery catheter.
    Normal values= ~75% (40 mm Hg)
    Central Venous Oxygen Saturation (SCVO2)
    Measured with a catheter inserted into the jugular or subclavian vein, catheter often ends up in right atrium. Cheaper, safer.
    SvO2/ScvO2 are surrogates for Cardiac Index (CO/body surface area.) and Oxygen Utilization
    Lactate, pH and base deficit: measurement of the amount of anaerobic glycolysis (and the organs that buffer pH changes)
  • 7. ER Presentation:
    SIRS + hypotension or lactate > 4 mmol/L
    Before ICU admission patient receives:
    6 hours of
    Early Goal Directed Therapy
    Standard of Care
  • 8. What is early goal directed therapy?
    EGDT is an algorithm for optimizing fluid resuscitation by responding to 4 parameters, i.e. making sure you’re pumping enough oxygenated blood so tissues receive adequate oxygenation
    Ventilation: via intubation and mechanical ventilation
    Mean Arterial Pressure: the perfusion pressure seen by organs of the body
    Central Venous Pressure: measures fluid returning to heart and thus preload
    Mixed Central Venous Oxygenation (SCVO2): central venous oxygenation, approximates CO.
  • 9. Why Early Goal Directed Therapy?
    Previous studies using pulmonary artery catheterization, immunotherapy or hemodynamic optimization all showed negligible changes in mortality
    How is EGDT different?
    It’s early. All previous studies had been initiated 72 hours or later after admission. EGDT is initiated as soon as sepsis is recognized: the golden hours of entering the emergency room
  • 10. Beginning steps in the algorithm
    1. Recognize Sepsis and obtain at least 2 blood cultures
    2. Start IV broad spectrum anti-biotics within the first hour.
  • 11. The algorithm
    Supplemental O2+ intubation & mechanical ventilation
    Central Venous & Arterial Catherization
    Sedation, paralysis (if intubated) or both
    CVP<8mm Hg
    Infusion 500mL/30min
    Do you have enough fluid?
    CVP 8-12mm Hg
    Vasoactive Agents – NE or Dopamine for vasoconstriction
    MAP <65
    (or >90)
    Are your organs being perfused?
    MAP >65 (and <90)
    RBCs until
    Hematocrit >30%
    Are you using the oxygen
    being delivered?
    Goals Achieved
    (hospital admission)
  • 12. Mortality Results for All Patients
    Standard Therapy: 59%
    EGDT Therapy: 39%
    P= 0.009
  • 13. New findings in sepsis
    “Experimental resultsclearly indicate that microcirculatory dysfunction lies at the centre of sepsis pathogenesis”
    AND SEPTIC SHOCK’ in-hospital deaths were stratified by cause:
    Cardiovascular collapseMultiorgan Failure
    Standard Therapy: 21% Standard Therapy: 21.8%
    EGDT: 10.3% EGDT: 16.2%
    P=0.02 p=0.27
    EGDT did not significantly impact MOF death rate
    Lehr HA, Bittinger F, Kirkpatrick CJ: Microcirculatory dysfunction in
    sepsis: a pathogenetic basis for therapy?
  • 14. Microcirculation
    …and dilate other arterioles to
    reduce shear stress and prevent
    one area stealing all the blood
    Is integrated: When one portion dilates in response to local hypoxia signals via endothelial cells are sent upstream…
  • 15. Microcirculation is a little more than hemodynamics
    Experimental evidence shows that at the same level of hypotension perfusion abnormalities are significantly less in hypovolemic shock than in septic shock
    Possible mechanism: bacterial toxins inhibits endothelial cell communication producing shunting when only those arterioles that can communicate dilate efficiently
  • 16. Is microcirculation malfunction causing organ failure?
    31 bed ICU: Microcirculation (orthogonal polarization spectral imaging device) was the only discriminant between those who survived vs. those who died from multiple organ failure after shock had resolved.
    Hemodynamic parameters were similar for both groups.
    Persistent Microcirculatory Alterations Are Associated With Organ Failure and Death in Patients With Septic Shock . Crit Care Med. 2004
  • 17. Guideline Updates
    Recombinant Activated Protein C (anticoagulant and anti-inflammatory) is now on the sepsis guidelines for those with a high risk of death, as are steroids for those who don’t respond to vasopressor
    A weak recommendation due to lack of clear evidence
  • 18. Future therapies
    Inducible Nitric Oxide Synthase knockout mice do not have the microperfusion abnormalities in response to sepsis. iNOS inhibitors may prevent the vasodilation and microcirculatory shunting causing hypoxia
    Microcirculation Monitoring: experimented with in cardiac surgeries with orthogonal polarization spectral imaging (OPS) to observe whole organ perfusion.