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From  macro to micro in hodgkin lymphoma sept 2013 eng.ppt [compatibility mode]
From  macro to micro in hodgkin lymphoma sept 2013 eng.ppt [compatibility mode]
From  macro to micro in hodgkin lymphoma sept 2013 eng.ppt [compatibility mode]
From  macro to micro in hodgkin lymphoma sept 2013 eng.ppt [compatibility mode]
From  macro to micro in hodgkin lymphoma sept 2013 eng.ppt [compatibility mode]
From  macro to micro in hodgkin lymphoma sept 2013 eng.ppt [compatibility mode]
From  macro to micro in hodgkin lymphoma sept 2013 eng.ppt [compatibility mode]
From  macro to micro in hodgkin lymphoma sept 2013 eng.ppt [compatibility mode]
From  macro to micro in hodgkin lymphoma sept 2013 eng.ppt [compatibility mode]
From  macro to micro in hodgkin lymphoma sept 2013 eng.ppt [compatibility mode]
From  macro to micro in hodgkin lymphoma sept 2013 eng.ppt [compatibility mode]
From  macro to micro in hodgkin lymphoma sept 2013 eng.ppt [compatibility mode]
From  macro to micro in hodgkin lymphoma sept 2013 eng.ppt [compatibility mode]
From  macro to micro in hodgkin lymphoma sept 2013 eng.ppt [compatibility mode]
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From macro to micro in hodgkin lymphoma sept 2013 eng.ppt [compatibility mode]

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Just a quick view of combining two techniques to go a little deeper into the research of this disease

Just a quick view of combining two techniques to go a little deeper into the research of this disease

Published in: Health & Medicine, Technology
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  • 1. José Miguel Vicente Gomila, jmvicent@ingenio.upv.es Co-fundador de TRIZ XXI y Profesor Asociado de la Universidad Politécnica de Valencia A Combination tech mining – semantic TRIZ About Hodgkin lymphoma With help of de ISI WOS; Search tech's VantagePoint e IHS GoldFire
  • 2. ©2013, triz XXI todos los derechos reservados <informa@triz.es>, www.triz.es Nota sobre el “copyright” de esta documentación: La presente documentación no puede ser reproducida por ningún medio. Cualquier otro destino queda sujeto a la autorización expresa por triz XXI. Todo el resto de derechos reservados por Triz XXI. triz XXI S.L. © 2013 Ap. Co. 12 122, E-46080 Valencia. (España) Tfno.: 34-96 3890513 Fax 34-96 3692190
  • 3. ©2013, triz XXI todos los derechos reservados <informa@triz.es>, www.triz.es With increasing quasi exponential appearance of research articles, how do we know what is occuring specially in the surroundings of our research speciality? New therapies, new substances still with little presence, new cobinations, synergies, etc? This is a first incursion into the world of Hodgkin Lymphoma, open to the contribution of willing researchers First come a macro view and afterward we go little in deep
  • 4. ©2013, triz XXI todos los derechos reservados <informa@triz.es>, www.triz.es Soruce ISI WOS all years; term: lymphoma. 20.206 arts. analyzed Main authors and their weight.
  • 5. ©2013, triz XXI todos los derechos reservados <informa@triz.es>, www.triz.es Main Institutions y their weight Source ISI WOS all years; term: lymphoma. 20.206 arts. analyzed
  • 6. ©2013, triz XXI todos los derechos reservados <informa@triz.es>, www.triz.es Source ISI WOS all years; term: lymphoma. 20.206 arts. analyzed Large domains of research
  • 7. ©2013, triz XXI todos los derechos reservados <informa@triz.es>, www.triz.es But to go to the concret, ¿Who is more active with Rituximab? 20.206 arts. analyzed
  • 8. ©2013, triz XXI todos los derechos reservados <informa@triz.es>, www.triz.es
  • 9. ©2013, triz XXI todos los derechos reservados <informa@triz.es>, www.triz.es
  • 10. ©2013, triz XXI todos los derechos reservados <informa@triz.es>, www.triz.es Main substances used to treat HL and their trend by years
  • 11. ©2013, triz XXI todos los derechos reservados <informa@triz.es>, www.triz.es Some of the substances are new but show a good increase in use: are they disruptive substances?
  • 12. ©2013, triz XXI todos los derechos reservados <informa@triz.es>, www.triz.es Biology del Linfoma Hodgkins a partir de varias fuentes (ver debajo) inform reduces proliferate express activate proliferate produce induce express inhibit defense functions produce release secrete stimulate activate stimulate increase presence stimulate impair availability activate stimulate increase presence stimulate help survive recruit help survive activate attract help survive attract help survive attract attract secrete secrete produce prevent apoptosis become secrete stimulate passivate passivate activate degradate phosphorilate activate associate activate activate control carry carry stimulate include produce kill impair induce signal destroy induce produce attack silence signalling phosphorylate express activate detect lymphocyte T-cell JAK2 Stat3 Reed Stenberg cells NF-kB (NEMO, IKK beta, IKK alfa apoptopic protein cell surface receptors including DDR2, MSPR, TRKA y TRKB Epstein- Barr virus and TNFAIP3 TRAF RIP IKB alfa and beta TNFAIP3 cytokine antigen activated B cell dark zone of the germinal centre CCL5 and CCL22 eosinophils basophils mast cells T-Lymphocyte High Plasma glucose concentrations insulin ascorbic acid IGF1 Inflammatory cytokine IL-10, IL7 CD40, CD30 and CD15 Notch 1 jagged 1 treg cells HLA Systemic view of biology of Hodgkin lymphoma based on the following sources:The Biology of Hodgkin's Lymphoma; Ralf Küppers, www.webmd.com; Hodgkin lymphoma ; Fields P, Wrench D, Medicine 41:5; The microenvironment in classical Hodgkin lymphoma: an actively dhaped and essential tumor component; Liu Y. et al ; Seminars in cancer biology 2013 (art in press) Springer Articles : From Basics to Disease Jak-Stat Signaling, ISBN: 978-3-7091-0890-1; US-20120004169 A1 ; The EMBO Journal (2002) 21, 2159 – 2167 doi:10.1093/emboj/21.9.2159; Acute Myelogenous Leukemia Editors: Judith E. Karp MD ISBN: 978-1-58829-621-4 ; 2012 Nutrition, Diet and Cancer Editors: Sharmila Shankar, Rakesh K. Srivastava ISBN: 978-94-007-2922-3 Done with the help of IHS GoldFire
  • 13. ©2013, triz XXI todos los derechos reservados <informa@triz.es>, www.triz.es Example: in the previous system, cytokine secretion activates JAK2 and this contributes to cancer: How to prevent cytokine secretion? Done with the help of IHS GoldFire Substances or méthods to prevent citokynes
  • 14. ©2013, triz XXI todos los derechos reservados <informa@triz.es>, www.triz.es As Bendamustine is being used, what is people using bendamustine for? Done with the help of IHS GoldFire

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