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2. Tiered approaches
 

2. Tiered approaches

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The second lecture on modelling exposure for a course held in Norway 2011

The second lecture on modelling exposure for a course held in Norway 2011

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  • A similar substance is defined as possessing similar physico-chemical properties relevant for exposure (e.g. vapour pressure, dustiness). To be on the safe side, a more “critical” similar substance has to be used for analogous/surrogate data. As an example, the use of toluene data for a xylene exposure assessment could be appropriate, since toluene is more volatile than xylene and thus results in a conservative exposure estimate.
  • Figure 1 compares the proportion of exposure measurements inside the randomly selected range with the corresponding value derived from the expo- sure range allocated by EASE. The data in this graph show the 52 scenarios for 28 different end-points. The bottom right hand area on the graph shows data sets where EASE was more successful than the random allocation of exposure and the top left area where the random allocation was better than EASE. Ideally, we would have liked to have seen most of the points in the former area, although in fact there is no indication that EASE is substantially better than a random allocation of exposure range. In 39% of the end-points the EASE prediction was better than the random allocation, whereas there were 22% of end-points where the random allocation produced a better agreement with the measured exposures. In the remainder of instances the EASE and randomly allocated exposure end- points were equally good (or poor) in the assessment of exposure.

2. Tiered approaches 2. Tiered approaches Presentation Transcript

  • Tiered approaches to exposure assessment
    John Cherrie
  • Summary…
    Exposure scenarios – what’s their purpose and how should they be specified?
    Measurements and models
    The tiered approach and available tools
    EASE – the rise and fall
    Sons of EASE – Tier 1 tools
    ECETOC TRA
    MEASE
    Stoffenmanager
    The next step – a Tier 2 tool
    ART
  • Exposure scenarios…
    Key concept in developing exposure estimates
    Environment
    Consumer 1
    Occupation 1
    Occupation 2
  • http://www.arbeidshygiene.nl/UserFiles/File/symposium06/1H%20Reach%20Hans%20Marquart%20proceedings.pdf
    ES…
  • Measurements and models…
    REACH allows the use of both measurement sand models
    Measured data for the actual substance
    Measured data for analogous/surrogate substances/activities
    Modelled estimates.
    Presumption that measurements are “better”
    Assessment should be conservative
  • Measurement quality
    High quality
    median or 90th percentile from 26 personal sampling measurements under conditions representative of the ES
    Intermediate quality
    mean from 3 measurements with personal sampling for the ES
    Lower quality
    a value given only as a mean – no details of number of measurements etc, especially if it is not fully representative of the activity described in the ES
  • Measurements and models…
    Where does a model sit in relation to measurement quality?
    How can we maximise the approach of modelling and measurement?
  • Tiered approach to models…
    Tier 1
    Very conservative
    With limited work to underpin their validity
    Tier 1+
    Slightly more refined models
    Better validity
    Tier 2
    Should provide a reliable assessment
    With good level of validity
  • Available tools…
    ECETOC TRA (EASE)
    EMKG Exposure Assessment Tool (COSHH-Essentials)
    MEASE (EASE)
    Stoffenmanager (Cherrie et al model)
    RISKOFDERM calculator
  • EASE…
    “Estimation and Assessment of Substance Exposure”
    Rule-based “expert” system
    Generic tool
    Developed for the pre-REACH regulatory risk assessment systems in Europe
    Inhalation and dermal exposure
    Based on the UK National exposure Database (NEDB)
    Tickner et al. The development of the EASE model. The Annals of Occupational Hygiene (2005) vol. 49 (2) pp. 103-10
  • Validity?
    Cherrie and Hughson. The validity of the EASE expert system for inhalation exposures. The Annals of Occupational Hygiene (2005) vol. 49 (2) pp. 125-34
  • Validity of dermal exposure
    Hughson and Cherrie. Comparison of measured dermal dust exposures with predicted exposures given by the EASE expert system. The Annals of Occupational Hygiene (2005) vol. 49 (2) pp. 111-23
  • ECETOC TRA…
    Based heavily on…
    Form of substance – solid, liquid
    Fugacity
    Indoor/outdoor
    Local ventilation
    PPE
    % substance in preparatoins
  • TRA…
  • TRA output
  • The Advanced REACH Tool…
    Being developed piecemeal by a group of research institutes – TNO, HSL and IOM
    Many experts originally skeptical
    Originally supported by governments and only latterly by industry and others
    Based on the premise of maximising the use of data by combining measurements and model estimates in a Bayesian framework
  • Summary…
    EASE and its successor tools dominate Tier 1 model options
    Tool applicability scope is always limited
    They are likely to typically be highly conservative but not in all situations
    There are a range of tools available but little information about their comparability and validity
    BaUA intend to commission a study of Tier 1 tool validity in 2011
    For Tier 2 it makes sense to use all available information – measurements and model data