T he clinical hallmark of CVI is distal venous hypertension, which follows the development of valvular incompetence, reflux, and/or venous obstruction.
At the cellular level there is abnormal metabolism of the connective tissue matrix of the vein wall with a marked increase in fibrouse tissue and abnormal deposition of collagen in both the vein wall and the skin.
T here is a proliferation of the dermal capillaries and fibrosis on subcutaneous tissue
It is a combination of:
VENOUS LEG ULCERS Large scale studies suggest that about 1% of the population develop a chronic leg ulcer at some point in their live. Most of the ulcers have chronic venous origin. Venous disease is identified as the most common predisposing risk factor.
However, their chronic course, unpredictable behavior, morbidity, the associated economic burden have to led to a renewed interest in the development of new approaches to improve the speed of healing, the quality of live and work productivity.