CURRENT CV

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CURRENT CV

  1. 1. CURRICULUM VITAE Jeffrey Keith Smith, M.D., Ph.D. PERSONAL INFORMATION: PRESENT POSITION: Associate Professor of Radiology Residency Program Director, Diagnostic Radiology Clinical Director, High Field MRI Research Center Quality and Safety Officer, UNC Biomedical Research Imaging Center WORK ADDRESS: University of North Carolina Department of Radiology, Neuroradiology Section Old Infirmary Building, CB 7510 Chapel Hill, NC 27599-7510 PHONE #: 919.966.2885 office 919.966.1994 fax 919.347.1786 pager EMAIL ADDRESS: jksmith@med.unc.edu MEDICAL LICENSES: North Carolina: 1993 Texas: 1991 (inactive) Louisiana: 1987 (inactive) EDUCATION: BOARD CERTIFICATION: The American Board of Radiology Diagnostic Radiology, June 15, 1993 Neuroradiology, November 3, 1997 Neuroradiology, recertification 2007 FELLOWSHIP TRAINING: Neuroradiology: The University of North Carolina at Chapel Hill July 1, 1993 to June 30, 1995 RESIDENCY TRAINING: Diagnostic Radiology: The University of Texas Health Science Center, Houston, Texas, July 1, 1989 to June 30,1993 GRADUATE SCHOOL: Louisiana State University Medical School, Shreveport, LA, Department of Physiology: Ph.D. June 30, 1989 Updated on January 29, 2015 1
  2. 2. MEDICAL SCHOOL: Louisiana State University Medical School Shreveport, LA: M.D. May 30, 1987 COLLEGE: Louisiana State University-Baton Rouge, Louisiana: Major in Biochemistry, Minor in Computer Science September 1, 1980 to May 30, 1983 PROFESSIONAL EXPERIENCE: 2007-present: Residency Program Director, Diagnostic Radiology University of North Carolina Department of Radiology 2004-present: Associate Professor of Radiology University of North Carolina Department of Radiology 1998-2004: Assistant Professor of Radiology University of North Carolina Department of Radiology 1995-98: Mid-Carolina Radiology Associates, P.A. 115 S. Gulf Street, P.O. Box 1007 Sanford, North Carolina 27330 (919) 775-2234 office774-2360 hospital774-2399 fax 1991-93: Lyndon B. Johnson General Hospital 5656 Kelley, Department of Radiology Houston, Texas 77026 (713) 636-5440 Hermann Hospital The University of Texas Health Science Center 6431 Fannin, Room 2.132 MSMB Houston, Texas 77030 (713) 792-5230 Department of Radiology Pasadena General Hospital, P.O. Box 2002 Pasadena, Texas 77501 (713) 473-1771 Department of Radiology Southmore Hospital, 901 E. Curtis Pasadena, Texas 77502 (713) 475-5865 Updated on January 29, 2015 2
  3. 3. HONORS AND AWARDS: Faculty: School of Medicine Teaching Scholar 2007-2008, University of North Carolina at Chapel Hill School of Medicine Fellowship: Cum laude citation at the annual meeting of the Radiological Society of North America, November 27-December 2, 1994 Chicago, Illinois. For: SMITH JK, Castillo MC, Merten DF. Imaging of the CNS in child abuse: Computer-aided program. Cum Laude award. SCATLIFF JH, CASTILLO MC, GREEN JJ, SUZUKI K, CHANCELLOR K, SMITH JK. Postmortem MR imaging of lobar infarction with pathologic correlation. Radiological Society of North America Meeting, 1994 Residency: RSNA/AUR/ARRS “Introduction to Research” program participant Graduate School: Proctor and Gamble Professional Opportunity Award, March, 1989 Graduate student representative to the LSUMC executive council Medical School: AOA - Selected as a Junior Student Class Rank 1 out of 88 Bernstein Scholarship - Based on Academic Achievement LSUMC School Yearbook Editor 1985 and 1986 Editions College: PHI KAPPA PHI Honor Society Dean's List - Overall GPA 4.0/4.0 National Merit Scholarship Recipient LSU Alumni Federation Scholarship Recipient Circle K Service Organization Member LSU Yearbook Photographer 1981, 1982, and 1983 Editions Updated on January 29, 2015 3
  4. 4. BIBLIOGRAPHY: Articles Submitted to Refereed Journals: (underlined authors are students or trainees) 1. MARKS BL, KATZ LM, SMITH JK Exercise And The Aging Mind: Buffing The Boomer’s Body And Brain (Physician and Sports Medicine in press 2009 16 pages) 2. BULLITT E, FN RAHMAN, JK SMITH, E KIM, D ZENG, LM KATZ, BL MARKS. The Effect of Exercise on the Cerebral Vasculature of Healthy Aged Subjects as Visualized by Magnetic Resonance Angiography (Accepted, 2009, AJNR Am J Neuroradiol, 26 pages). Articles Published in Refereed Journals: (underlined authors are students or trainees) 3. GAO W, ZHU H, GIOVANELLO KS, SMITH JK, SHEN D, GILMORE JH, LIN W. Evidence on the emergence of the brain's default network from 2-week-old to 2-year-old healthy pediatric subjects. Proc Natl Acad Sci USA. 2009 Apr 21;106(16):6790-5. Epub 2009 Apr 7. PMID: 19351894 4. ESCOLAR ML, POE MD, SMITH JK, GILMORE JH, KURTZBERG J, LIN W, STYNER M. Diffusion Tensor Imaging Detects Abnormalities in the Corticospinal Tracts of Neonates with Infantile Krabbe Disease AJNR Am J Neuroradiol 2009 May;30(5):1017- 21. Epub 2009 Apr 22. PMID: 19386732 www.ajnr.org 5. CHEN Y, AN H, ZHU H, STONE T, SMITH JK, HALL C, BULLITT E, SHEN D, LIN W. White matter abnormalities revealed by diffusion tensor imaging in non-demented and demented HIV+ patients. Neuroimage. 2009 Apr 17. [Epub ahead of print] PMID: 19376246 6. MUKHERJEE N, KANG C, WOLFE HM, HERTZBERG BS, SMITH JK, LIN W, GERIG G, HAMER RM, GILMORE JH. Discordance of Prenatal and Neonatal Brain Development in Twins. Early Hum Dev. 2009 Mar;85(3):171-5. Epub 2008 Sep 19. PMID: 18804925 7. GAO W, LIN W, CHEN Y, GERIG G, SMITH JK, JEWELLS V, GILMORE JH. Temporal and Spatial Development of Axonal Maturation and Myelination of White Matter in the Developing Brain. AJNR Am J Neuroradiol. 2009 Feb;30(2):290-6. Epub 2008 Nov 11. PMID: 19001533 8. LIN W, ZHU Q, GAO W, CHEN Y, TOH CH, STYNER M, GERIG G, SMITH JK, BISWAL B, GILMORE JH. Functional connectivity MR imaging reveals cortical functional connectivity in the developing brain. AJNR Am J Neuroradiol. 2008 Nov;29(10):1883-9. Epub 2008 Sep 10. PMID: 18784212 Updated on January 29, 2015 4
  5. 5. 9. GILMORE JH, SMITH L, WOLFE H, HERTZBERG B, SMITH JK, CHESCHEIR N, EVANS D, KANG C, HAMER RM, LIN W, GERIG G. Prenatal Mild Ventriculomegaly Predicts Abnormal Development of the Neonatal Brain. Biol Psychiatry. 2008 Dec 15;64(12):1069-76. Epub 2008 Oct 2. PMID: 18835482 10. KNICKMEYER RC, GOUTTARD S, KANG C, EVANS D, WILBER K, SMITH JK, HAMER RM, LIN W, GERIG G, GILMORE JH A Structural MRI Study of Human Brain Development from Birth to Age 2. J Neurosci. 2008 Nov 19;28(47):12176-82. PMID: 19020011 11. HORTON AL, SMITH JK, STRAUSS RA Recurrence of Galloway Mowat syndrome and associated prenatal imaging findings. Prenat Diagn. 2009 Mar;29(3):280-2. PMID: 19177459 12. BULLITT E, ZENG D, MORTAMET B, GHOSH A, AYLWARD SR, LIN W, MARKS BL, SMITH JK. The effects of healthy aging on intracranial blood vessels visualized by magnetic resonance angiography NeurobiolAging (2008), PMID 18471935 doi:10.1016/j.neurobiolaging.2008.03.022. 13. CHRIS BUCKLE, J. KEITH SMITH Choroid Plexus Papilloma of the Third Ventricle Pediatric Radiology 37(7); p 725 July, 2007. Epub 2007 Apr 27. No abstract available. PMID: 17464502 14. IRVIN W, MACDONALD G, SMITH JK, KIM WY Dexamethasone-induced posterior reversible encephalopathy syndrome. JCO Journal of Clinical Oncology, 2007 Jun 10;25(17):2484-6. PMID: 17557962 15. BULLITT E, REARDON DA, SMITH JK. Brain Tumor Malignancy and Treatment Monitoring: A Review of Micro and Macro MR Vascular Imaging (Lecture Notes in Computer Science Proceedings- MICCAI- in press 2007, 10 pages). 16. BULLITT E, REARDON DA, SMITH JK. A review of micro- and macrovascular analyses in the assessment of tumor-associated vasculature as visualized by MR NeuroImage. 2007;37 Suppl 1:S116-9. Epub 2007 Apr 25. PMID: 17512217 Available online at http://dx.doi.org/10.1016/j.neuroimage.2007.03.067, and made available for public access: http://www.pubmedcentral.gov/articlerender.fcgi?artid=2292206 17. GILMORE JH, LIN W, COROUGE I, VETSA YS, SMITH JK, KANG C, GU H, HAMER RM, LIEBERMAN JA, GERIG G. Early Postnatal Development of Corpus Callosum and Corticospinal White Matter Assessed with Quantitative Tractography AJNR Am J Neuroradiol 2007 Oct;28(9):1789-95. Updated on January 29, 2015 5
  6. 6. 18. BULLITT E, LIN NU, SMITH JK, ZENG D, WINER EP, CAREY LA, LIN W, EWEND MG Blood vessel morphologic changes depicted with MR angiography during treatment of brain metastases: a feasibility study. Radiology 245:824-830 published online before print October 22, 2007, DOI:2453061889 **Article chosen to be featured on the journal cover and in "This Month in Radiology," which highlights articles from original research appearing in that issue.** 19. KWOCK L, SMITH JK, CASTILLO M, EWEND, MG, COLLICHIO F, MORRIS DE, BOULDIN TW, CUSH S. Clinical Role of Proton Magnetic Resonance Spectroscopy in Oncology: Brain, Breast and Prostate Cancer. Lancet Oncolo 2006;7:859-868. 20. BARNWELL JD, SMITH JK CASTILLO M Utility of Navigator-Prospective Acquisition Correction Technique (PACE) for Reducing Motion in Brain MR Imaging Studies. AJNR Am J Neuroradiol Apr 2007; 28: 790 - 791 21. BULLITT E, LIN NU, EWEND MG, ZENG D, WINER EP, CAREY LA, SMITH JK. Tumor Therapeutic Response and Vessel Tortuosity: Preliminary Report in Metastatic Breast Cancer. Lecture Notes in Computer Science, Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv. 2006;9(Pt 2):561-8. PMID: 17354817. 22. GILMORE JH, LIN W, PRASTAWA MW, LOONEY CB, VETSA YS, KNICKMEYER RC, EVANS DD, SMITH JK, HAMER RM, LIEBERMAN JA, GERIG G. Regional gray matter growth, sexual dimorphism, and cerebral asymmetry in the neonatal brain. J Neurosci. 2007 Feb 7;27(6):1255-60. PMID: 17287499 23. LOONEY CB, SMITH JK, MERCK LH, WOLFE HM, CHESCHEIR NC, HAMER RM, GILMORE JH. Intracranial hemorrhage in asymptomatic neonates: prevalence on MR images and relationship to obstetric and neonatal risk factors. Radiology 2007 Feb;242(2):535-41. Epub 2006 Dec 19. PMID: 17179400 24. SPAMPINATO MV, SMITH JK, KWOCK L, EWEND M, GRIMME JD, CAMACHO DLA CASTILLO M. Cerebral Blood Volume Measurements and Proton MR Spectroscopy in Grading of Oligodendroglial Tumors. Am. J. Roentgenol. Jan 2007; 188: 204 - 212. 25. BULLITT E, ZENG D, GERIG G, AYLWARD S, JOSHI S, SMITH JK, LIN W, EWEND MG Vessel tortuosity and brain tumor malignancy: A blinded study. Academic Radiology 2005; Oct;12(10):1232-40. PMID: 16179200 * This paper was selected as the recipient of the 2006 Herbert M. Stauffer Award for Best Clinical Paper 2005 by the Association of University Radiologists. * 26. BRUBAKER LM, SMITH JK, LEE YL, LIN W,·CASTILLO M,· Hemodynamic and Permeability Changes in Posterior Reversible Encephalopathy Syndrome Measured by Dynamic Susceptibility-Weighted MR Imaging. AJNR Am J Neuroradiol 2005, 26:825 – 830. Updated on January 29, 2015 6
  7. 7. 27. TUCKER KA. ROBERTSON KR, LIN W, SMITH JK, AN H, CHEN Y, AYLWARD SR, HALL CD. Neuroimaging in human immunodeficiency virus infection. Journal of Neuroimmunology 2004; 157:153-62. 28. PARIKH AH, SMITH JK, EWEND MG, BULLITT E Correlation of MR Perfusion Imaging and Vessel Tortuosity Parameters in Assessment of Intracranial Neoplasms. Technology in Cancer Research and Imaging 2004; Dec;3(6):585-90. PMID: 15560716. 29. SMITH JK, MATHEUS MG, CASTILLO M, Imaging Manifestations of Neurosarcoidosis. AJR American Journal of Roentgenology 2004;182:289-295. 30. BULLITT E, EWEND MG, AYLWARD S, LIN W, GERIG G, JOSHI S, JUNG I, MULLER K, SMITH JK Abnormal Vessel Tortuosity as a Marker Of Treatment Response of Malignant Gliomas: Preliminary Report. Technology in Cancer Research and Imaging 2004 Dec;3(6):577-84. PMID: 15560715. 31. GILMORE JH, ZHAI G, WILBER K, SMITH JK, LIN W, GERIG G. 3 Tesla magnetic resonance imaging of the brain in newborns Psychiatry Research: Neuroimaging, 2004; 132(1): 81-85. 32. CAMACHO DLA, SMITH JK, GRIMME JD, KEYSERLING HF, CASTILLO M. Atypical MRI perfusion in developmental venous anomalies. AJNR Am J Neuroradiol. 2004; 25:1549-1552. 33. BULLITT E, JUNG I, MULLER K, GERIG G, AYLWARD S, JOSHI S, SMITH JK, LIN W, EWEND M. Determining Malignancy of Brain Tumors By Analysis of Vessel Shape. Lecture Notes in Computer Science, Medical Image Computing and Computer- Assisted Intervention – MICCAI 2004: 7th International Conference, Saint-Malo, France, September 26-29, 2004. Proceedings, Part II 3217:645 – 653 DOI: 10.1007/b100270, Online Date: September 2004. 34. MATHEUS MG, CASTILLO M, EWEND MG, SMITH JK, KWOCK L, CUSH S, MORRIS D. CT and MR Imaging after Placement of the Gliasite Radiation Therapy System to Treat Brain Tumor: Initial Experience. AJNR Am J Neuroradiol 2004, 25:1211-1217. 35. MATHEUS MG, CASTILLO M, SMITH JK, ARMAO D, TOWLE D, MUENZER J. Brain MRI findings in patients with mucopolysaccharidosis types I and II and mild clinical presentation. Neuroradiology. 2004 Aug;46(8):666-72. Epub 2004 Jun 17. 36. BULLITT E, GERIG G, AYLWARD S, JOSHI S, SMITH K, EWEND M, LIN W, Vascular Attributes and Malignant Brain Tumors. Lecture Notes in Computer Science Volume 2878 / 2003 Proceedings of the Sixth Annual International Conference Medical Image Computing and Computer-Assisted Intervention - MICCAI 2003 pp. 671 – 679 DOI: 10.1007/b93810, Online Date: October 2003. Updated on January 29, 2015 7
  8. 8. 37. LONDOÑO A, CASTILLO M, LEE YZ, SMITH JK. ADC measurements in the hippocampi in patients with temporal lobe seizures. AJNR Am J Neuroradiol 2003, 24: 1582-1586. 38. THANANOPAVARN P, SMITH JK, CASTILLO M, On The AJR Viewbox: MR Imaging of Angiosarcoma of the Calvarium. AJR American Journal of Roentgenology 181(5):1432-3 November 2003. 39. KEYSERLING H, SMITH JK, CASTILLO M. Cranial Fasciitis of Childhood: A Case Report, AJNR Am J Neuroradiol 24(7):1465-7 2003. 40. CAMACHO DLA, SMITH JK, CASTILLO M. Differentiation between toxoplasmosis and lymphoma in AIDS patients using apparent diffusion coefficients. AJNR Am J Neuroradiol 24:633-637, April 2003. 41. DROSSMAN DA, RINGEL Y, VOGT B, LESERMAN J, LIN W, SMITH JK, WHITEHEAD W Alterations of Brain Activity Associated with Resolution of Emotional Distress and Pain in a Case of Severe IBS. Gastroenterology 2003;124:754-761. 42. KHAN R, SMITH JK, CASTILLO M. Case Report: False Negative Contrast MRA in the Setting of Carotid Artery Dissection Emergency Radiology 2002, 9:320-322. 43. SMITH JK, CASTILLO M, KWOCK L. Proton MR spectroscopy of brainstem lesions. Neuroradiology 2002; 44:825-829. Published online first (http://link.springer- ny.com/link/service/journals/00234/contents/tfirst.htm). 44. KWOCK L SMITH JK, CASTILLO M, et al. Clinical applications of proton MR spect- roscopy in oncology. Technology in Cancer Diagnosis and Treatment 2002; 1(1): 1-10. 45. RUMBOLDT Z, CASTILLO M, SMITH JK. CT and MRI of the palatovaginal canal. AJR American Journal of Roentgenology 2002; 179: 267-272. 46. RUMBOLDT Z, SMITH JK, CASTILLO M. Triple blowout orbital fracture. Emergency Radiology 2001; 8: 341-343. 47. CASTILLO M, SMITH JK, KWOCK L. Proton MR spectroscopy in patients with acute temporal lobe seizures. AJNR Am J Neuroradiol 2001; 22: 152-157. 48. BULLITT E, AYLWARD S, SMITH JK, MUKHERJI SM, JIROUTEK M, MULLER K. Symbolic Description of Intracerebral Vessels Segmented from MRA and Evaluation by Comparison with X-Ray Angiograms. Medical Image Analysis 5: 157-169, 2001. 49. CASTILLO M, SMITH JK, KWOCK L, WILBER K. Apparent diffusion coefficients in the evaluation of high-grade cerebral gliomas. AJNR Am J Neuroradiol 2001; 22: 60-64. 50. CASTILLO M, SMITH JK, KWOCK L. Correlation of myoinositol levels and grading of cerebral astrocytomas. AJNR Am J Neuroradiol 2000; 21: 1645-1649. Updated on January 29, 2015 8
  9. 9. 51. CASTILLO M, MUKHERJI SK, ISAACS D, SMITH JK. Cerebral infarctions: evaluation with single axis versus trace diffusion-weighted MR imaging. AJR American Journal of Roentgenology 2000; 174: 853-857. 52. SMITH JK, KWOCK L, CASTILLO M. Effects of gadolinium-DTPA on single volume proton MR spectroscopy. AJNR Am J Neuroradiol 2000 Jun-Jul;21(6):1084-9. 53. CASTILLO M, ARBELAEZ A, SMITH JK, FISHER LL. Diffusion-weighted MR imaging in vertebral metastatic disease. AJNR Am J Neuroradiol. 2000 May;21(5):948- 53. 54. SMITH JK, ARMAO DM, SPECTER BB, CASTILLO M. Danger space infection: infection of the neck leading to descending necrotizing mediastinitis. Emergency Radiology 1999; 6: 129-132. 55. CASTILLO M, ARBELAEZ A, FISHER LL, SMITH JK, MUKHERJI SK. Diffusion- weighted imaging in patients with cervical spondylosis: initial observations. International Journal of Neuroradiology 1999: 5: 79-85. 56. SMITH JK, ARMAO DM, KHAIRI SA, GANTT CB, CASTILLO M. Dermoid tumor of the spine with rupture. Case of the Week, eAJR American Journal of Roentgenology 1999, 172:(e4). 57. GREEN C, SMITH JK, CASTILLO M. Imaging of head trauma in child abuse victims. Emergency Radiology 3:34-42, 1996. 58. SMITH JK, MAH JK, CASTILLO M. Brain MR imaging findings in two patients with Alpers’ syndrome. Clinical Imaging 20:235-237, 1996. 59. CASTILLO M, SCATLIFF JH, KWOCK L, GREEN JJ, SUZUKI K, CHANCELLOR K, SMITH JK. Postmortem MR imaging of lobar infarction with pathologic and in vivo Correlation. Radiographics 16:241-250, 1996. 60. SMITH JK, CASTILLO M, WILSON JD. MR characteristics of low-flow facial vascular malformations in children and young adults. Clinical Imaging 19:109-117, 1995. 61. CASTILLO M, SMITH JK. Imaging features of acute head and spine injuries secondary to difficult deliveries. Emergency Radiology 2(1):7-12, 1995. 62. CASTILLO M, SMITH JK, MUKHERJI SK. MR appearance of cerebral cortex in children with and without a history of perinatal anoxia: preliminary observations. AJR American Journal of Roentgenology 164:1481-1484, 1995. 63. SMITH JK, CASTILLO M. Internet-accessible radiology teaching file. Emergency Radiology 2(1):111-113, 1995. 64. CASTILLO M, CARRIER DA, SMITH JK. Spinal cord infarction after solitary rib fracture. Emergency Radiology 2(2):105-108, 1995. Updated on January 29, 2015 9
  10. 10. 65. THOMPSON J, CASTILLO M, REDDICK RL, SMITH JK, SHOCKLEY W. Nasopharyngeal nonossifying variant of ossifying fibromyxoid tumor: CT and MR findings. AJNR: Am J Neuroradiol 16:1132-1134, 1995. 66. CASTILLO M, GREEN C, KWOCK L, SMITH JK, WILSON D, SCHIRO S, GREENWOOD R. Proton MR spectroscopy in patients with neurofibromatosis type I: evaluation of hamartomas and clinical correlation. AJNR: Am J Neuroradiol 16:141-147, 1995. 67. SMITH JK, CASTILLO M, MUKHERJI S, BUENTING J, DRAKE A. Imaging of nasopharyngeal atresia. AJNR: Am J Neuroradiol 16(9):1936-1938, 1995. 68. REITZ LA, SMITH JK, CASTILLO M. Acute spinal cord injury: Clinical aspects and magnetic resonance imaging. Emergency Radiology 1(5):221-227;1994. 69. SMITH JK, MERTEN DF, CASTILLO M. Imaging of the central nervous system in child abuse: a computer aided instructional program. Emergency Radiology 1(5):228-230, 1994. 70. SMITH JK, CARSON GC, JOHNSON JD, HARRIS JH. An Approach to Fractures of the Midface: An Interactive Tutorial Emergency Radiology 1(2):78-80, 1994. 71. EFTEKHARI F, SMITH JK. Sonography of the scrotum after orchiectomy: Normal and abnormal findings. AJR American Journal of Roentgenology:160:543-547, 1993. 72. CARDEN DL, SMITH JK, KORTHUIS RJ. Oxidant-mediated, CD18 dependent microvascular dysfunction induced by complement-activated granulocytes. Am J Physiol 260:H1144-H1152, 1991. 73. SMITH JK, CARDEN DL, KORTHUIS RJ. Activated neutrophils increase microvascular permeability in skeletal muscle: role of xanthine oxidase. J -Appl Physiol 70(5):2003-2009, 1991. 74. CARDEN DL, SMITH JK, KORTHUIS RJ. Neutrophil-mediated microvascular dysfunction in postischemic canine skeletal muscle. Role of granulocyte adherence. Circ Res 66(5):1436-1444, 1990. 75. LAUGHLIN MH, SIMPSON T, SEXTON WL, BROWN OR, SMITH JK, KORTHUIS RJ. Skeletal muscle oxidative capacity, antioxidant enzymes, and exercise training. J Appl Physiol 68(6):2337-2343, 1990. 76. KORTHUIS RJ, SMITH JK, CARDEN DL. Role of xanthine oxidase in postischemic granulocyte infiltration and microvascular injury in canine gracilis muscle. Physiologist 158, 1989. 77. KORTHUIS RJ, SMITH JK, CARDEN DL. Hypoxic reperfusion attenuates postischemic microvascular injury. Am J Physiol 256:H315-H319, 1989. Updated on January 29, 2015 10
  11. 11. 78. CARDEN DL, SMITH JK, ZIMMERMAN BJ, KORTHUIS RJ, GRANGER DN. Reperfusion injury following circulatory collapse: The role of reactive oxygen metabolites. J Critical Care Med 4(4):294-307, 1989. 79. CARDEN DL, SMITH JK. Pneumonias. Emergency Medicine Clinics of North America: 7(2):255-278, 1989. 80. SMITH JK, GRISHAM MB, GRANGER DN, KORTHUIS RJ. Free radical defense mechanisms and neutrophil infiltration in post-ischemic skeletal muscle. Am J Physiol 256:H789-H793, 1989. 81. SMITH JK, CARDEN DL, KORTHUIS RJ. Role of xanthine oxidase in postischemic microvascular injury in skeletal muscle. Am J Physiol 257:H1782-H1789, 1989. 82. SMITH JK, CARDEN DL, GRISHAM MB, GRANGER DN, KORTHUIS RJ. Role of iron in post-ischemic microvascular injury. Am J Physiol 256:H1472-H1477, 1989. 83. YRLE LF, SMITH JK, BENOIT JN, GRANGER DN, KORTHUIS RJ. Role of glucagon in the intestinal hyperemia associated with early experimental diabetes mellitus. Am J Physiol 255:G542-G546, 1988. Articles in Non-Refereed Journals and Invited Articles: 84. SMITH JK. Parasellar Tumors: suprasellar and cavernous sinuses. Topics in Magnetic Resonance Imaging 16(4):307-315, 2006. PMID: 16785846 85. SMITH JK, LURY KM, CASTILLO M. Imaging of spinal and spinal cord tumors. Seminars in Roentgenology 41(4):274-293, October, 2006. PMID: 17010691 86. LURY K, SMITH JK, CASTILLO M. Imaging of spinal infections. Semin Roentgenol. 2006 Oct;41(4):363-79. PMID: 17010695 87. LURY KM, SMITH JK, MATHEUS MG, CASTILLO M, Neurosarcoidosis-Review of Imaging Findings. Seminars in Roentgenology 39(4): 495-504 (October 2004) 88. SMITH JK, KWOCK L, CASTILLO M. Single- and multivolume MR spectroscopy of brain tumors. Oncologic Imaging. Categorical Course Review, ARRS, 2003 89. SMITH JK, CASTILLO M, KWOCK L. Magnetic resonance spectroscopy of brain tumors. Magn Reson Imaging Clin N Am, 11:415-429 (2003) Abstracts: (underlined authors are students or trainees) 1. MARKS BL, KATZ LM, STYNER M, SMITH JK. Higher aerobic fitness is related to greater fractional anisotropy in the anterior-medial segments of the cingulum in older adults. UNC Radiology-BRIC 2008 Symposium. Updated on January 29, 2015 11
  12. 12. 2. RAHMAN, F, SMITH K, BULLITT E, KATZ L, MARKS B. Relationship of exercise to cerebral vascularture and blood flow in older adults. RSNA Nov. 2008 Conference. 3. MARKS BL, KATZ LM, STYNER M, SMITH JK, BULLITT E. Body composition is related to white matter integrity in the aging brain. GSA Conference, Nov. 22 2008. 4. RAHMAN F, SMITH K, BULLITT E, MARKS B. Relationships between exercise and cerebral blood flow in older adults. ASNR Conference, New Orleans, May 31 – June 5, 2008. 5. MARKS BL, KATZ LM, SMITH JK, STYNER M, ROBERTSON K, SHIELDS E, GUSKIEWICZ K. Role of recreational sport participation on cerebral white matter integrity in older adults. Annual Radiology-BRIC Symposium, University of North Carolina at Chapel Hill, May 10, 2007. 6. MARKS BL, KATZ LM, STYNER M, SMITH JK, BABBITT M, HAWKINSJ, BULLITT E. (2008). Aerobic fitness impact on cerebral white matter integrity in the cingulum. Medicine and Science in Sports and Exercise 40:5 Supplement (May, 2008). 7. BUIE LW, LINDLEY C, SHIH T, EWEND M, SMITH JK, SKELTON M, KWOCK L, MORRIS D, TUCKER C, AND COLLICHIO F. Plasma pharmacokinetics and cerebrospinal fluid concentrations of erlotinib in high-grade gliomas: A novel, phase I, dose escalation study. Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. Vol 25, No. 18S (June 20 Supplement), 2007:2054. 8. KILPATRICK MR, LINN NU, SMITH JK, WINER EP, BULLITT E, CAREY LA, EWEND MG. Superiority of bi-dimensional measurements compared to RECIST in measuring response of metastatic brain tumors. Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings Part I. Vol 24, No. 18S (June 20 Supplement), 2006:1542. 9. LEE YZ,·SMITH JK,·EWEND M,·MORRIS D,·CASTILLO M. Evaluation of Metastases Post Radiation using MR Dynamic Susceptibility Perfusion Measurements. Proceedings, ASNR 2006, Presented at the 44th annual meeting of the American Society of Neuroradiology, April 29 - May 5, 2006 in San Diego, California. 10. PEYRE, J.·SMITH, JK.·JOMIER, J.·CASTELLANO, F.·HOLLINGSHEAD, M.·AYLWARD, S.·CASTILLO, M. Lupus CNS Vasculitis: Circulatory Pathology Demonstrated with Perfusion MRI. Proceedings, ASNR 2006, Presented at the 44th annual meeting of the American Society of Neuroradiology, April 29 - May 5, 2006 in San Diego, California. 11. LOONEY CB, SMITH JK, FAGAN LH, HAMER RM, GILMORE JH, Intracranial Hemorrhage in Asymptomatic Neonates: Prevalence on 3.0 T MR Scans and Relationship to Obstetric and Neonatal Risk Factors. Radiology supplement November 2005:p683 Presented at the RSNA 91st Scientific Assembly and Annual Meeting in Chicago IL, November 27 - December 2, 2005. *Abstract selected for RSNA Trainee Research Prize- Dr. Looney received $1000 prize.* Updated on January 29, 2015 12
  13. 13. 12. SMITH JK, VIVERT C, PEYRE J, ROBERTSON K, WILBER K, LIN W, et al. Circulatory Pathology in HIV-associated Dementia Assessed by Dynamic Susceptibility MR Perfusion at 3.0T. Radiology supplement November 2005:p206 Presented at the RSNA 91st Scientific Assembly and Annual Meeting in Chicago IL, November 27 - December 2, 2005. 13. AN H, CHEN Y, SMITH JK, HALL C, ROBERTSON K, WILBER K, et al. Whole Brain Diffusion Tensor Analysis in HIV Patients at Various Clinical Stages. Radiology supplement November 2005:p516 Presented at the RSNA 91st Scientific Assembly and Annual Meeting in Chicago IL, November 27 - December 2, 2005. 14. LURY KM, SMITH JK, MATHEUS MG, CASTILLO M, Review of Imaging Findings in Neurosarcoidosis Proceedings, ASNR 2004, Presented at the 43rd annual meeting of the American Society of Neuroradiology, May 23-27th 2005, in Toronto, Ontario, Canada. 15. PARIKH AH, SMITH JK, EWEND MG, BULLITT E Correlation of MR Perfusion Imaging and Vessel Tortuosity Parameters in Assessment of Intracranial Neoplasms. Proceedings, ASNR 2005, Presented at the 43rd annual meeting of the American Society of Neuroradiology, May 23-27th 2005, in Toronto, Ontario, Canada. 16. SMITH JK, KWOCK L, CASTILLO M. Brain Metastasis from Lung Cancer Show Distinct Pattern on Proton MRS. Proceedings, ASNR 2005, Presented at the 43rd annual meeting of the American Society of Neuroradiology, May 23-27th 2005, in Toronto, Ontario, Canada. 17. SPAMPINATO MV, KWOCK L, SMITH JK, GRIMME J, CAMACHO DL, CASTILLO M. Differentiation of low and high-grade oligodendroglial tumors using perfusion and proton spectroscopy MR imaging. AJR (S) 2005; 184: 4-5. Presented at the 105th Annual ARRS Meeting, New Orleans, Louisiana, May 15-20 2005. 18. CAMACHO DL, SMITH JK, GRIMME JD, KEYSERLING HF, SPAMPINATO MV, CASTILLO M. Perfusion MRI abnormalities in asymptomatic developmental venous anomalies. AJR (S) 2005; 184: 64. Presented at the 105th Annual ARRS Meeting, New Orleans, Louisiana, May 15-20 2005. 19. SPAMPINATO, M. V.·KWOCK, L.·SMITH, J.K.·CAMACHO, D. L.·GRIMME, J. D.·CASTILLO, M. Differentiation Of Low- And High-Grade Oligodendroglial Tumors Using Perfusion And Proton Spectroscopy MR Imaging Proceedings, ASNR 2005, Presented at the 43rd annual meeting of the American Society of Neuroradiology, May 23-27th 2005, in Toronto, Ontario, Canada. 20. SMITH JK, WILBER K, KWOCK L, LIN W, FISCHER L, ZEISEL S. Effect of Dietary Choline Depletion on Brain Choline & Memory Function Measured by MR Spectroscopy and Functional MR. FASEB Journal, 18(5) pA913. Presented at the annual FASEB meeting, April 19-21, 2004, Washington DC. Updated on January 29, 2015 13
  14. 14. 21. BULLITT E, JUNG I, MULLER K, GERIG G, AYLWARD S, JOSHI S, SMITH JK, LIN W, EWEND M. Determining Malignancy of Brain Tumors By Analysis of Vessel Shape. Proceedings of the Seventh Annual International Conference Medical Image Computing & Computer Assisted Intervention MICCAI 2004. 22. SMITH JK, HALL CD, ROBERTSON KR, WILBER K, CASTILLO M, LIN W. Decreased brain activation in patients with HIV associated dementia measured by fMRI. Proceedings, ASNR 2004, p 309 Presented at the 42nd annual meeting of the American Society of Neuroradiology, June 7-11, 2004, in Seattle, WA. 23. CASTILLO M, MATHEUS G, SMITH JK. Imaging of developmental venous anomalies with atypical features. Proceedings, ASNR 2004, pp 457-58. Presented at the 42nd annual meeting of the American Society of Neuroradiology, June 7-11, 2004, in Seattle, WA. Also appears in: Neurographics (www.asnr.org). 24. COOL DW, SMITH JK, HALL CD, ROBERTSON KR, WILBER K, AYLWARD SR, LIN W. Circulatory changes in cerebral perfusion resulting from HIV associated dementia. Proceedings, ASNR 2004, p 240 Presented at the 42nd annual meeting of the American Society of Neuroradiology, June 7-11, 2004, in Seattle, WA. 25. GRIMME JD, SMITH JK, THURNHER M, AND CASTILLO M. Atypical Diffusion- Weighted Imaging Features in Brain Abscesses. Electronic exhibit at the 104th Annual Meeting of the American Roentgen Ray Society, Miami, Florida, May 2-7, 2004. 26. CASTILLO M, MATHEUS G, SMITH JK. Imaging of developmental venous anomalies with atypical features. Proceedings, ASNR 2004, p 457 Presented at the 42nd annual meeting of the American Society of Neuroradiology, June 7-11, 2004, in Seattle, WA. 27. MATHEUS MG, CASTILLO M, MUENZER J, SMITH JK, TOWLE D. Correlation of MRI and clinical features in patients with mucopolysaccharidoses types 1 and 2. Abstract Book, 2003 ARRS, AJR 2003, 180: 37 (Presented at the 103rd Annual Meeting of the American Roentgen Ray Society, May 4-9, 2003, San Diego, California). 28. CAMACHO D, SMITH JK, CASTILLO M. Differentiation between toxoplasmosis and lymphoma in AIDS patients using apparent diffusion coefficients. Abstract Book, 2003 ARRS, AJR 2003, 180: 46 (Presented at the 103rd Annual Meeting of the American Roentgen Ray Society, May 4-9, 2003, San Diego, California). 29. HAMILTON J, ATAGA K, REDDING-LALLINGER R, HILLIKER D, SMITH JK, LIN W. Functional MRI investigation of pediatric patients with sickle cell disease. Radiology supplement November 2003:265 Presented at the Annual RSNA Meeting, Chicago, Il, Nov 29-Dec 3, 2003. 30. BRUBAKER L, CHEN E, MATSUSHIMA G, SMITH JK, AN H, LIN W. The use of diffusion tensor imaging to evaluate demyelination processes in mice. Radiology supplement November 2003:550 Presented at the Annual RSNA Meeting, Chicago, Il, Nov 29-Dec 3, 2003. Updated on January 29, 2015 14
  15. 15. 31. CAMACHO D, SMITH JK, CASTILLO M. Diffusion weighted MR imaging of toxoplasmosis and lymphoma in acquired immunodeficiency syndrome. Proceedings, ASNR 2003, p 13 Presented at the annual meeting of the American Society of Neuroradilogy, April 26- May 2, 2003, in Washington, DC. 32. BRUBAKER LM, LEE YL,·LIN W,·CASTILLO M,·SMITH JK Hemodynamic and Permeability Changes in Posterior Reversible Encephalopathy Syndrome Measured by Dynamic Susceptibility-Weighted MR Imaging. Proceedings, ASNR 2003, p 192. Presented at the annual meeting of the American Society of Neuroradiology, April 26- May 2, 2003, in Washington, DC. 33. CAMACHO DLA, SMITH JK, CASTILLO M Differentiation Between Toxoplasmsosis and Lymphoma in AIDS Patients Using Apparent Diffusion Coefficients AJR American Journal of Roentgenology (S) 2002; 180: 46. Presented at the 103rd annual meeting of the American Roentgen Ray Society, May 4-9, 2003, in San Diego, CA. 34. MATHEUS G, CASTILLO M, MUENZER J, SMITH JK, TOWLE D. MRI of brain findings in mucopolysacharidoses types 1 and 2. Presented at the American Roentgen Ray Society Meeting 2003, AJR American Journal of Roentgenology (S) 2002; 180: 37. 35. SMITH JK, KWOCK L, LONDOÑO A, CASTILLO M. Proton MR spectroscopy of brainstem lesions. Radiology supplement November 2002 225(p):335. Presented at the Annual RSNA Meeting, Chicago, Il, Nov 26-Dec 1, 2002. 36. RINGEL Y, DROSSMAN DA, LIU H, LIN W, SMITH JK, KEETER L, AN H, VOGT B, LESERMAN J, WHITEHEAD W Anterior Shift of Cingulate Activity with Painful Rectal Distension in Subjects with Sexual/Physical Abuse. Gastroenterology, 122(4) Supplement, April 2002, A-311. 37. RINGEL Y, DROSSMAN DA, LIU H, LIN W, SMITH JK, KEETER L, AN H, VOGT B, LESERMAN J, WHITEHEAD W fMRI of Cingulate (ACC) Activation to Painful Rectal Distension in ABS and Sexual/Physical Abuse. Gastroenterology, 122(4) Supplement, April 2002, A-311. 38. MATHEUS G, CASTILLO M, SMITH JK, TOWLE D, MUENZER J. MR imaging in mucopolysacharidoses with mild clinical presentation. Syllabus for the 2002 Annual Meeting of American Society of Neuroradiology, Vancouver, p 292, May 11-17, 2002. 39. SMITH JK, LEE Y, LIN W, EWEND M, CASTILLO, KWOCK L. Radiation necrosis following stereotatic radiosurgery shows peripheral increased perfusion with perfusion sensitive contrast-enhanced MR imaging. Syllabus for the 2002 Annual Meeting of American Society of Neuroradiology, p 140, Vancouver, May 11-17, 2002. 40. CASTILLO M, SMITH JK, KWOCK L. Proton MR spectroscopy of brainstem lesions: preliminary experience. Proceedings, ASNR 39th Annual Meeting, 2001, Boston, MA April 23-27. Updated on January 29, 2015 15
  16. 16. 41. CASTILLO M, SMITH JK, KWOCK L. Proton MR spectroscopy of brainstem lesions: preliminary experience. Proceedings, ASNR 39th Annual Meeting, 2001, p 47. 42. CASTILLO M, SMITH JK, KWOCK L. Presence of lactate lateralizes abnormal hippocampi by ictal proton MR spectroscopy. Proceedings, ASNR 39th Annual Meeting, 2001, p 15. 43. CASTILLO M, SMITH JK, KWOCK L. Presence of lactate lateralizes abnormal hippocampi by ictal proton MR spectroscopy. Proceedings, ASNR 39th Annual Meeting, 2001, Boston, MA April 23-27. 44. CASTILLO M, KWOCK L, SMITH JK. Correlation between myoinositol level and grading of cerebral gliomas. Proceedings, ASNR 38th Annual Meeting, Atlanta, GA, April 2-8, 2000. 45. CASTILLO M, KWOCK L, SMITH JK, WILBER K. Apparent diffusion coefficients in the evaluation of high-grade astrocytomas. Proceedings, ASNR 38th Annual Meeting, Atlanta, GA, April 2-8, 2000. 46. SMITH JK, KWOCK L, HUDSON LC, TOMKINS MB, ENGLISH RV, BOLD- FLETCHER NO, CASTILLO M. Acute changes in brain metabolites following infection with feline immunodeficiency virus in cats. Presented at the Annual RSNA Meeting, Chicago, Il, Nov 26-Dec 1, 2000. 47. SMITH JK, ARMAO DM, CASTILLO M. Imaging of central nervous system congenital malformations with pathologic correlation: a computer-aided instructional program. Radiology 1999; 213 (P): 498. 48. CLARK MB, CASTILLO M, FISHER L, MUKHERJI SK, SMITH JK. Comparison of GRE and MEDIC MR images in the evaluation of the cervical spine. Proceedings of the 38th Annual ASNR Meeting 2000 p 10. 49. KOWCK L, CASTILLO M, SMITH JK. Correlation between myoinositol level and grading of cerebral gliomas. Proceedings of the 38th Annual ASNR Meeting 2000 p 127. 50. KWOCK L, CASTILLO M, SMITH JK, WILBER K. Apparent diffusion coefficients in the evaluation of high-grade astrocytomas. Proceedings of the 38th Annual ASNR Meeting, 2000, p24. 51. CASTILLO M, ARBELAEZ A, MUKHERJI SK, SMITH JK, FISHER L. Diffusion- weighted MR imaging in patients with cervical degenerative disease. Radiology 1999; 213 (P): 391. 52. CASTILLO M, ARBELAEZ A, SMITH JK, FISHER L. Diffusion-weighted imaging vs. conventional MRI in spinal metastatic disease. Proceedings of the 37th Annual ASNR Meeting 1999, p 198. Updated on January 29, 2015 16
  17. 17. 53. SMITH JK, CASTILLO M, KWOCK L. Effects of gadolinium DTPA on single volume H-1 magnetic resonance spectroscopy (MRS) Proceedings of the 37th Annual ASNR Meeting 1999, p 173. 54. KWOCK L, CASTILLO M, SMITH JK. Comparison of proton MR spectral patterns of glioblastoma multiforme (GBM) versus metastatic brain tumors. Proceedings of the 37th Annual ASNR Meeting 1999, p 58. 55. CASTILLO M, KWOCK L, FARMER CB, SMITH JK, GREENWOOD R, WHITT JK, MUKHERJI SK, SAID S. Cerebral 1H-MRS in NF-1 children with cognitive disabilities. ASNR annual meeting syllabus 1996, p 86. 56. CASTILLO M, KWOCK L, GREEN C, SMITH JK et al. Proton MRS in patients with NF-1: evaluation of hamartomas and clinical correlation. Year Book of Neuroradiology 1995. 57. SCATLIFF JH, KWOCK L, CHANCELLOR KE, SMITH JK, CASTILLO M. Postmortem MRI of AIDS brains. Proceedings of the Annual ASNR Meeting 1995, p 229. 58. CASTILLO M, MUKHERJI SK, SMITH JK, QUENCER RM. Segmental and generalized patterns of spinal cord and nerve root enhancement: differential diagnosis. Proceedings of the Annual ASNR Meeting 1995, p 222. 59. CASTILLO M, MUKHERJI S, SMITH JK. Insults to the radial-glial unit: spectrum of abnormalities ranging from hydranencephaly to cortical dysplasia. Proceedings of the Annual ASNR Meeting 1995, p215. 60. LEITE CC, JINKINS JR, CASTILLO M, SMITH JK et al. MR of subarachnoid seeding from glial tumors. Proceedings of the Annual ASNR Meeting 1995, p 43. 61. THOMPSON JE, CASTILLO M, SMITH JK. Imaging of central nervous system hemorrhage: a computer aided instructional program. AJR American Journal of Roentgenology 164(3)Supl:167, 1995. 62. SMITH JK, CASTILLO M. Internet-accessible radiology teaching file. AJR American Journal of Roentgenology 164(3)Supl:166, 1995. 63. NOONE TC, CASTILLO M, SMITH JK. Imaging of central nervous system neoplasms in children: a computer aided instructional program. AJR American Journal of Roentgenology 164(3)Supl:168, 1995. (Presented at the 95th annual meeting of the American Roentgen Ray Society, 1995 Washington, DC.) 64. THOMPSON JE, CASTILLO M, SMITH JK, MUKHERJI SK. CT and MRI of fibroosseous lesions of the face and base of skull. AJR American Journal of Roentgenology 164(3)Supl:212, 1995. (Presented at the 95th annual meeting of the American Roentgen Ray Society, April 30-May 5, 1995 Washington, DC.) Updated on January 29, 2015 17
  18. 18. 65. SCATLIFF JH, GREEN JJ, SUZUKI K, KWOCK L, CHANCELLOR K, CASTILLO M, SMITH JK. Postmortem MRI of lobar infarctions with pathological correlation. Radiology 193(P):455, 1994 66. GREEN C, CASTILLO M, KWOCK L, WILSON D, SMITH JK, SCHIRO S, GREENWOOD R. New observations in patients with neurofibromatosis using H-MR spectroscopy. Fax 1994; 9:68 67. SMITH JK, CASTILLO M. Developmental malformations of the cerebellar vermis: Diagnosis based on the midline sagittal T1-weighted MR image. AJR American Journal of Roentgenology 162(S):267 1994. (Presented at the annual American Roentgen Ray Society meeting, April 24-29, 1994, New Orleans, Louisiana.) 68. SMITH JK, MERTEN DF, CASTILLO M. Imaging of the central nervous system in child abuse: a computer aided instructional program. Radiology 193(P):392 (Computer aided instructional program presented at the annual meeting of the American Society of Emergency Radiology, April 9-13, 1994, Orlando Florida and at the annual meeting of the Radiological Society of North America, November 27-December 2, 1994, Chicago, Illinois.) 69. SMITH JK, CARSON GC, JOHNSON JD, HARRIS JH. An Approach to Fractures of the Midface: An Interactive Tutorial. AJR American Journal of Roentgenology 160(4) supplement:144, 1993. (Presented at the annual meeting of the American Roentgen Ray Society, April 25-30, 1993, San Francisco, Ca., and at the annual meeting of the American Society of Emergency Radiology April, 1993, San Diego, California.) 70. EFTEKHARI F, SMITH JK. Sonography of the scrotum after orchiectomy: Normal and abnormal findings. AJR American Journal of Roentgenology 160(4) supplement:148, 1993. (Abstract presented at the annual meeting of the American Roentgen Ray Society, April 25-30, 1993, San Francisco, California.) 71. CARDEN DL, SMITH JK, KORTHUIS RJ. Role of xanthine oxidase and reactive oxygen metabolites in the genesis of microvascular dysfunction induced by activated granulocytes in skeletal muscle. FASEB J. 4(3):A642, 1990. 72. SADASIVAN KK, MOORE MB, CARDEN DL, SMITH JK, KORTHUIS RJ. Increased microvascular permeability in an ex-vivo model of skeletal muscle compartment syndrome. FASEB J. 3(4):A273, 1989. 73. KORTHUIS RJ, SMITH JK, CARDEN DL. Is xanthine oxidase a major source of reactive oxygen metabolites in postischemic canine gracilis muscle? Circulation, 1989. 74. CARDEN DL, SMITH JK, KORTHUIS RJ. Neutrophil adherence to microvascular endothelium: a prerequisite for neutrophil mediated microvascular injury. Circulation, 80(4) Supplement II: 400;1989. 75. CARDEN DL, SMITH JK, KORTHUIS RJ. Neutrophil-mediated microvascular injury in the absence of tissue xanthine oxidase. FASEB J. 3(4):A1233, 1989. Updated on January 29, 2015 18
  19. 19. 76. SMITH JK, CARDEN DL, KORTHUIS RJ. Xanthine oxidase and microvascular dysfunction produced by activated granulocytes. Circulation, 80(4) Supplement II: 33; 1989. (Abstract presented at the annual American Heart Association meeting, November 13-16, 1989, New Orleans, Louisiana.) 77. SMITH JK, CARDEN DL, SADASIVAN KK, KORTHUIS RJ. Role of xanthine oxidase in postischemic microvascular injury. FASEB J. 3(4):A1401, 1989. (Abstract presented at the annual FASEB meeting, March, 1989, New Orleans, Louisiana.) 78. SMITH JK, CARDEN DL, KORTHUIS RJ. Role of hydroxyl radicals in ischemia/reperfusion-induced injury to skeletal muscle microvasculature. FASEB J. 3(4):A1234; 1989. (Abstract presented at the annual FASEB meeting, March, 1989, New Orleans, Louisiana.) 79. LAUGHLIN MH, SIMPSON T, SMITH JK, BROWN OR, SEXTON WL, KORTHUIS RJ. Relationship between oxidative capacity and antioxidant enzyme levels in skeletal muscles. Physiologist 31(4):A39-A39, 1988. 80. KORTHUIS RJ, SMITH JK, CARDEN DL, GRISHAM MB, GRANGER DN. Vascular injury from oxygen radicals and granulocytes in post-ischemic skeletal muscle. Int J Microcirc Clin Exp sup:S116-S116, 1988. 81. CARDEN DL, SMITH JK, KORTHUIS RJ. Neutrophil mediated injury to the skeletal muscle microvasculature in the absence of ischemia. Physiologist 31(4):A30, 1988. 82. KORTHUIS RJ, SMITH JK, CARDEN DL. Limiting oxygen availability at reperfusion attenuates microvascular injury in postischemic skeletal muscle. Physiologist 31(4):A31- A31, 1988. 83. SMITH JK, YRLE LF, BENOIT JN, GRANGER DN, KORTHUIS RJ. Role of glucagon in the intestinal hyperemia associated with experimental diabetes mellitus. FASEB J. 2:A741-A741, 1988. (Abstract presented at the annual FASEB meeting May, 1988 Las Vegas, Nevada.) 84. SMITH JK, GRISHAM MB, GRANGER DN, KORTHUIS RJ. Alterations in free radical defense mechanisms and neutrophil infiltration in post-ischemic canine skeletal muscle. (Presented at The Second Conference on Free Radicals in Biology and Medicine: Ischemia/Reperfusion Injury. March 1988, Point Clear, Alabama.) 85. SMITH JK, CARDEN DL, GRISHAM MB, GRANGER DN, KORTHUIS RJ. Role of iron in ischemia/reperfusion injury to skeletal muscle microvasculature. Physiologist 31(4):A31-A31, 1988. (Abstract presented at the annual American Physiology Society meeting October, 1988, Montreal, Canada.) Updated on January 29, 2015 19
  20. 20. Contributions to Text Books: 1. RUMBOLDT Z, CASTILLO M, SMITH JK. The spine. In: Lee JKT, Sagel SS, Stanley RJ, Heiken JP (Eds). Computed Body Tomography with MRI Correlation. 4th Ed, Lippincott Williams & Wilkins, Philadelphia, (2006), pp 1661-1726 2. SMITH JK Congenital Spinal Abnormalities. In: Neuroradiology (Third Series) Test and Syllabus. H Cohen, M Castillo, JG Smirniotopolous, DB Price, Editors; SF Falcone, MB Fukui, SK Mukherji, ZJ Rumboldt, JK Smith, Co-authors. American College of Radiology, Reston, Virginia (2006) 3. SMITH JK Intramedullary Spinal Masses. In: In: Neuroradiology (Third Series) Test and Syllabus. H Cohen, M Castillo, JG Smirniotopolous, DB Price, Editors; SF Falcone, MB Fukui, SK Mukherji, ZJ Rumboldt, JK Smith, Co-authors. American College of Radiology, Reston, Virginia (2006) 4. SMITH JK Vertebral Body Tumors. In: Neuroradiology (Third Series) Test and Syllabus. H Cohen, M Castillo, JG Smirniotopolous, DB Price, Editors; SF Falcone, MB Fukui, SK Mukherji, ZJ Rumboldt, JK Smith, Co-authors. American College of Radiology, Reston, Virginia (2006) 5. SMITH JK Spinal Infections. In: Neuroradiology (Third Series) Test and Syllabus. H Cohen, M Castillo, JG Smirniotopolous, DB Price, Editors; SF Falcone, MB Fukui, SK Mukherji, ZJ Rumboldt, JK Smith, Co-authors. American College of Radiology, Reston, Virginia (2006) 6. SMITH JK, CASTILLO M Spinal imaging: New sequences for spinal MR imging. Basic concepts. In: Spine Imaging. State of the Art Reviews. M Castillo, Editor, Hanley and Belfus, Inc. Philadelphia. 2001, pp 1-16 7. SMITH JK, CASTILLO M. Current imaging of trauma to the spine and spinal cord. In: Spine Imaging. State of the Art Reviews. M Castillo, Editor, Hanley and Belfus, Inc. Philadelphia. 2001; pp 79-92 8. CASTILLO M, SMITH JK, MUKHERJI S. Imaging of the spine. In: Computed Tomography with MRI Correlation. 3rd E: Lee, JKT, SS Sager, RJ Stanley, JP Heiken (Eds). d, Lippincott Williams & Wilkins, Philadelphia, 1997 Updated on January 29, 2015 20
  21. 21. Letters to the Editor: 1. SMITH JK, CASTILLO M. Ruptured aneurysm presenting with a subdural hematoma. AJNR:Am J Neuroradiol 165:491-492, 1995. 2. SMITH JK, CASTILLO M. Carotid sinus syndrome secondary to iatrogenic dissection of the carotid artery. AJNR:Am J Neuroradiol 15:193, 1994. Book Reviews: 1. SMITH JK Cerebral MR perfusion Imaging: Principles and Current Applications A. Gregory Sorensen Peter Reimer in Academic Radiology 2001. 2. SMITH JK Brain Atlas for Functional Imaging: Clinical and Research Applications Nowinski, Thirunavuukarasuu, Kennedy (Eds) in Academic Radiology :924, 2001. 3. SMITH JK. Pediatric Neuroimaging. Barkovich (Ed) in: Academic Radiology 7(10) 878, 2000. 4. SMITH JK. MRI of the spine. St. Amour, Hodges, Laakman, Tamas (Eds) in: Topics in Magnetic Resonance Imaging ,6(4):275;1994. 5. SMITH JK. MR angiography: A teaching file. Brant-Zawadski, Boyko, Jensen, Gillian (Eds) in: Topics in Magnetic Resonance Imaging 6(3):203;1994. Scientific Exhibits and Posters: 1. SMITH JK, LEE Y, LIN W, EWEND M, CASTILLO, KWOCK L. Radiation necrosis following stereotatic radiosurgery shows peripheral increased perfusion with perfusion sensitive contrast-enhanced MR imaging. Annual Meeting of American Society of Neuroradiology, Vancouver, BC, Canada May 11-17, 2002 2. MATHEUS G, CASTILLO M, SMITH JK, TOWLE D, MUENZER J. MR imaging in mucopolysacharidoses with mild clinical presentation. 2002 Annual Meeting of American Society of Neuroradiology, Vancouver BC, Canada, May 11-17 2002 3. SMITH JK, KWOCK L, HUDSON LC, TOMKINS MB, ENGLISH RV, BOLD- FLETCHER NO, CASTILLO M. Acute changes in brain metabolites following infection with feline immunodeficiency virus in cats. Annual RSNA Meeting, Chicago, Il, Nov 26- Dec 1, 2000 4. SMITH JK, ARMAO DM, CASTILLO M. Imaging of central nervous system congenital malformations with pathologic correlation: a computer-aided instructional program. (Presented at the annual meeting of the Radiological Society of North America, November 27-December 2, 1999 Chicago, Illinois) Updated on January 29, 2015 21
  22. 22. 5. CASTILLO M, KWOCK L, FARMER CB, SMITH JK, GREENWOOD R, WHITT JK, MUKHERJI SK, SAID S. Cerebral 1H-MRS in NF-1 children with cognitive disabilities. (Presented at the American Society of Neuroradiology Annual Meeting, 1996, p) 6. CASTILLO M, MUKHERJI SK, SMITH JK, QUENCER RM. Segmental and generalized patterns of spinal cord enhancement: differential diagnosis. (Presented at the American Society of Neuroradiology Annual Meeting, Chicago, Ill, April 1995) 7. CASTILLO M, MUKHERJI SK, SMITH JK. Insults to the radial-glial-unit: a spectrum of abnormalities ranging from hydrencephaly to cortical dysplasia. (Presented at the American Society of Neuroradiology Annual Meeting, Chicago, Ill, April 1995) 8. NOONE TC, SMITH JK, CASTILLO M. Central nervous system tumors in children: a computer aided instructional program. (Presented at the 95th annual meeting of the American Roentgen Ray Society, April 30-May 5, 1995 Washington, DC.) 9. THOMPSON JE, SMITH JK, CASTILLO M. Imaging of central nervous system hemorrhage: a computer aided instructional program. (Presented at the 95th annual meeting of the American Roentgen Ray Society, April 30-May 5, 1995 Washington, DC.) 10. SMITH JK, CASTILLO M. Internal accessible radiology teaching file. (Presented at the American Roentgen Ray Society Annual Meeting, Washington D.C., May 1995) 11. THOMPSON JE, CASTILLO M, SMITH JK, MUKHERJI S. CT and MRI of fibro- osseous lesions of the face and base of skull. (Presented at the American Roentgen Ray society Annual Meeting, Washington D.C., May 1995) 12. SMITH JK, CASTILLO M. Developmental malformations of the cerebellar vermis: diagnosis based on the midline sagittal MR T1-weighted image. (Presented at American Roentgen Ray Society Annual Meeting. New Orleans, April 24-29, 1994.) 13. SMITH JK, CASTILLO M, MERTEN D. Imaging of the central nervous system in child abuse: a computer instructional program. 5th Annual Meeting of the American Society of Emergency Radiology, Orlando, Florida, April 9-13, 1994. 14. SMITH JK, GC CARSON, AND JH HARRIS An Approach to Fractures of the Midface: An Interactive Multimedia Teaching Program. Produced by. (Presented at The Association of University Radiologists meeting, April, 1992, Chicago Illinois.) Also: Radiological Society of North America, Chicago, Illinois, November 27-December 2, 1994 cum laude Award Updated on January 29, 2015 22
  23. 23. TEACHING RECORD: Undergraduate students: Lauren Brubaker: Biology Honors Thesis research sponsor for undergraduate student at high field MRI research center: The Use of MRI Imaging to Evaluate Twitcher Mouse Syndrome, UNC Spring Semester 2002 Derek Cool: Mentor for undergraduate research project: Circulatory changes in cerebral perfusion resulting from HIV associated dementia. UNC 2003 Medical students: Block 7 Neurosciences UNC 2nd year medical students lecturer and lab preceptor. Introduction to neuroimaging and developmental and congenital malformations of the CNS lectures, Assisted in development of labs and syllabi for neuropathology portions of course. 2004-present Block 11 Clinical Medicine Cases UNC 2nd year medical students lab preceptor for neuroimaging in acute stroke. 2003-present Introduction to Radiology Course UNC 1st year medical school class, 2003- present: lab preceptor. Radiology 411 Research Elective-Preceptor for medical students: Christopher Looney (Doris Duke Fellow 2004-2005) Anup Parikh (Doris Duke Fellow 2003-2004) Jackson Hamilton (Doris Duke Fellow 2002-2003) Matt Dyson (UNC Medical Student 2003) Rihan Khan (Dartmouth Medical School Student, 2002) Radiology Elective 404 Clinical Neuroscience Selective: Preceptor to senior medical students in neuroradiology UNC 1999-present Neuropathology section of second year medical school Pathology and Laboratory Medicine 222 class UNC 1999-2004. This includes course and syllabus development, lab preceptoring, and lectures. Human physiology course, endocrine section, 50 students Louisiana State University Medical Center, Shreveport, Louisiana 1987-89. Graduate students: Weekly journal club for high field MRI research students, UNC, 2000-present Thesis Committee Member for graduate students at MRI research center: Wei Gao: PHD candidate UNC BME department, 2007-present. Qingwei Liu: PHD candidate UNC BME department, 2006-present. Guihua Zhai: PHD candidate UNC BME department, 2002-2006. Yueh Lee: MD/PhD candidate UNC BME department, 2001-2004. Hui Liu: Masters candidate UNC BME department, 2002-2004. Updated on January 29, 2015 23
  24. 24. Residents: Daily training of radiology residents in the Neuroradiology Section Supervision of Neuroradiology Residents presenting biweekly Radiology Department Conference, Hot Seat conference, Board Review Conferences Supervision of Neurology and Neurosurgery Residents performing neuroradiology elective Training and supervision of radiology residents from the Medical College of South Carolina (2001-2002) Psychiatry Residents: Lecturer in the Neuropsychiatry Seminars, Didactic conference series: Neuroimaging Basics with Focus on CT/MRI 2004- present Neuroradiology fellows: Daily training of fellows (1-3/year) in Neuroradiology Section Fellows trained (and current location): 1. Jeffrey A. Stone, M.D. (Mayo Clinic, Jacksonville, FL) 2. Andrés Arbeláez-Medina, M.D. (Medellin, Colombia) 3. Allan Midyett, M.D. (Brooke Army Med. Ctr. San Antonio, TX) 4. Decio Kruter, M.D. (Porto Alegre, Brasil) 5. Sonia Palma, M.D. (Guatemala, Guatemala) 6. Michael Clark, M.D. (Ohio) 7. Todd Smith, M.D. (Little Rock, Arkansas) 8. Zoran Rumboldt, M.D. (Medical Univ. of South Carolina, Charleston, SC) 9. José Costa (Porto, Portugal) 10. Hugo Narcisco (San Pablo, Brazil) 11. Mónica Pedro (Curitiba, Brazil) 12. Ana Londoño (Medellin, Colombia) 13. Gisele Matheus (Medical Univ. of South Carolina, Charleston, SC) 14. Gurav Kumar (Missouri) 15. José Negrón-Soto (Ohio State Univ., Columbus, Ohio) 16. Kenneth Lury (University of North Carolina, Chapel Hill, NC) 17. Ayotunde Ogunseyinde (Laos, Nigeria) 18. Woo Mok Byum (Daegu, Korea) 19. Christopher Van der Meer (Gaston Radiology, Gastonia, NC) 20. Jay Alley (Rex Hospital, Raleigh, NC) 21. Carla Maria Gonzales (Quetzaltenango, Guatemala) 22. John Grimme (Eugene, Oregon) 23. Daniel Camacho (Milwaukee, Wisconsin) 24. Vittoria Spampinato (Medical Univ. of South Carolina, Charleston, SC) 25. Nuria Mayolas (Barcelona, Spain) 26. Fabiana Brito (Rio de Janeiro, Brazil) 27. Fernando Detoni (Blumenau, Brazil) 28. Steven Olijeski (Erie, Pennsylvania) 29. Thomas Marino (Fort Lauderdale, Florida) 30. Ben Huang (University of North Carolina, Chapel Hill, NC) Updated on January 29, 2015 24
  25. 25. 31. Arturo Alvarez-Luque (Madrid, Spain) 32. Maria Pilar Valencia (Univ. Texas, San Antonio, Tx) 33. Humberto Morales (Univ. Cincinnati, Ohio) 34. Craig Harr (Eugene, Oregon) 35. Carter Kenamond (Chester, West Virginia) 36. Craig Roberto (Fort Lauderdale, Florida) 37. Assem Mansour (Amman, Jordan) 38. Birsen Unal (Ankara, Turkey) 39. David Bañuelos (Guadalajara, Mexico) 40. Joanna Ramalho (Lisbon, Portugal) 41. Naser Aldossary (Riyad, Saudi Arabia) 42. Marta Martinez (Madrid, Spain) 43. Michael Hollingshead (Rex Hospital, Raleigh, NC) 44. Frank Castellano (Ohio) 45. Jason Pulnik (Houston, Tx) 46. Eldom Toh (Taiwan, China) 47. Carina Reis (Porto, Portugal) 48. Ronaldo Lessa (Belo Horizonte, Brazil) 49. David Chaky (Ohio) 50. Cade Martin (Arkansas) 51. Jeffrey Troy (Virginia) Interdepartmental conferences: Weekly Neuroscience Conference Weekly Neurosurgery Clinical Conference Weekly Neuropathology Conference Weekly Neuro-oncology Conference Clinical Pathology Conference March 14, 2000 Clinical Pathology Conference December 19, 2000 Clinical Pathology Conference July 24, 2001 Clinical Pathology Conference April 23, 2002 Neurology Department Grand Rounds August 13, 2003 Neurology Department Grand Rounds July 14, 2004 Invited teaching lectures: Perfusion, Diffusion, and BOLD MRI Invited Lecturer, Louisiana State University Medical Center, Department of Physiology, 2009 Just say “No” to SATCHMO Invited Lecturer, Louisiana State University Medical Center, Department of Radiology, 2009 Nurosarcoidosis Invited Lecturer, Louisiana State University Medical Center, Department of Neurosurgery, 2009 State Of The Art Imaging Of Neurosarcoidosis Part of the Clinical Categorical Course on Imaging CNS Autoimmune Diseases at The International Society for Updated on January 29, 2015 25
  26. 26. Magnetic Resonance in Medicine annual meeting in Toronto, Ontario, Canada. May 7, 2008. Pediatric Brain Imaging- Is it Normal or Child Abuse Lecture: North Carolina Radiology Society Annual Meeting, April 12, 2008 Chapel Hill, North Carolina Diagnosis and Management of Meningitis, department of medicine grand rounds University of North Carolina at Chapel Hill School of Medicine, June 2008 Neuroradiology After Five Lecture: North Carolina Chapter of the ACR Annual Meeting, October 15, 2005 Greensboro, North Carolina Neuroanatomy for Neuroimaging Lecture: UNC Psychiatry Department Core Imaging Lab seminar series October 4, 2005 Imaging of Spinal Cord Injury and Low Back Pain Lecture: UNC Department of Rehabilitation Medicine Seminar Series June 1, 2005 Normal Brain Anatomy. Lecture: UNC Medical Image Display & Analysis Research Group (MIDAG) seminar series December 2004 Multidisciplinary Evaluation for Surgical Treatment of Epilepsy Pediatric Grand Rounds, UNC Department of Pediatrics October 7, 2004 Single and Multivolume MR Spectroscopy of Brain Tumors. Part of the Categorical Course on Oncologic Imaging: American Roentgen Ray Society 2003 Annual Meeting May 4-9, 2003 San Diego, CA Clinical aspects of diffusion and perfusion MR imaging. Siemens applications specialist training course. July 11, 2000, Cary, North Carolina Medical Imaging Modalities. UNC Computer-Aided Diagnosis and Display Lab October, 9, 2000. Educational Media: 1. Imaging developmental venous anomalies with atypical features. Address: http://www.neurographics.org Castillo M, Smith JK. 2. An Approach to Fractures of the Midface: An Interactive Multimedia Teaching Program. Produced by JK Smith, GC Carson, and JH Harris. 3. Imaging of the central nervous system in child abuse: a computer aided instructional program. Produced by JK Smith, D Merten, and M Castillo. 4. Imaging of Central Nervous System Neoplasms in Children: a computer aided instructional program. Produced by T Noone, M Castillo, and JK Smith. Updated on January 29, 2015 26
  27. 27. 5. Internet Accessible Radiology Teaching File: Produced by JK Smith. 6. Imaging of Central Nervous System Hemorrhage: a computer aided instructional program. Produced by JE Thompson, M Castillo, and JK Smith. 7. Imaging of central nervous system congenital malformations with pathologic correlation: a computer-aided instructional program. Produced by JK Smith, DM Armao, and M Castillo RESEARCH Ongoing Research Support: 2/15/97-6/30/09: NIH-NIBIB 5R01EB000219-11 (Bullitt) 3D Cerebral Vessel Location for Surgical Planning. The aims of this proposal are to develop a) automated methods of segmenting tumors, b) new methods of image registration, and c) new methods of assessing tumor malignancy in human brain tumor patients using statistical measures of vessel shape. 7/1/01-7/31/12: NIMH/NIH 5P50MH064065-07 (Gilmore / Lieberman) Prospective Studies of the Pathogenesis of Schizophrenia: Project 2 Determine how fetal and neonatal ventricle size obtained with ultrasound is related to a more detailed assessment of brain structure and function obtained with MRI. 8/1/04-7/31/09: CDC 5R49CE000196-05 (Runyan / Guskiewicz) UNC Injury Prevention Research Center-Core Grant Evaluate the relationship between biomechanical, neuroanatomical and clinical factors associated with sport-related concussion. 5/1/07-4/30/12: NIH-NINDS 5R01NS055754-01-02 (Lin) Characterization of Normal Brain Development Using Parallel MRI. This proposal focuses on developing both hardware and software for imaging normal pediatric subjects. 3/1/07–2/29/12: NIH 5R01HD053000-02 (Gilmore) Early Brain Development in One and Two Year Olds This study will longitudinally image pediatric subjects at 1 and 2 years old in order to depict normal brain development. 7/1/07–6/30/12 NICHHD 5R01HD055741-02 (Piven, J) A Longitudinal MRI Study of Infants at Risk for Autism This proposal focuses on the utilization of novel MR imaging methods, including structural and diffusion tenor imaging approaches to depict brain abnormalities in infants at risk of autism. 7/1/07–6/30/09 Cure Autism Now Foundation (Hazlett, H) A Pilot Study of Infants at High Risk for Autism 2/1/08-1/31/11 Autism Speaks (Hazlett, H) MRI Study of Brain Development in School Age Children with Autism Updated on January 29, 2015 27
  28. 28. Completed Research Support: (selected) 8/1/02-7/31/07: IMH (1 P50 MH064065-01) UNC Conte Center Project 2: Early Brain Development in High Risk Children, PI: J.H. Gilmore. (5% effort) Total direct cost: $1,296,320. 6/1/03-5/31/04: UNC Center for Aids Research Development Award: Diffusion Tensor Imaging for Evaluation of White Matter Changes in HIV Related Cognitive Impairment. PI: J. Keith Smith, MD, PhD (no salary support) Total direct cost: $20,000. 4/1/97-3/31/04: NIMH (RO1 MH55466) “Neuroimaging in HIV Infection”. Co- investigator (5% effort) (Principal Investigator Colin D. Hall). Annual direct cost: $150,000. 10/1/02-9/30/03: UNC Clinical Nutrition Research Center pilot and feasibility grant “Memory function in subjects undergoing choline depletion” (no salary support) Total direct cost: $15,000. 4/1/01-3/31/06: NIH-NCI (R01CA67812) "3D vessel location for surgical planning" Co-investigator, 10% effort (Principle Investigator Elizabeth Bullitt) Annual direct cost: $364,000. 9/1/87-6/30/89: NIH-Individual National Research Service Award (HL-07710) Microcirculatory response to ischemia-reperfusion,. J. Keith Smith, Principle Investigator (100% effort), Ronald J. Korthuis, sponsor. Total direct cost: $30,000. Clinical Trials: 2005 – present: SENTIS Stroke Trial Protocol: Safety and Efficacy of NeuroFlo Technology in Ischemic Stroke with SCION (A Study of Care Intensity and Outcomes of NeuroFlo). Co-investigator, PI: Souvik Sen 2004 – present: A Double-blind, Randomized, Placebo-controlled, Parallel-group, Multicenter, phase 11b/111 Study to Assess the Efficacy and Safety of Intravenous NXY-059 in Acute Ischemic Stroke (SA-NXY-0007). Co- investigator, PI: Souvik Sen 2004 – present: Silent Cerebral Infarct in Sickle Cell Disease Multi-Center Clinical Trial (SIT). Co-investigator, PI: Rupert-Lalenger 2004 – present: Neuropsychololgical Dysfunction and Neuroimaging Abnormalities in Neurologically Intact Adult Patients With Sickle Cell Disease (CSCC). Co- investigator, PI: Eugene Orringer 2004 – present: LCCC 0409: Treatment Of Brain Metastases From Non-Small Cell Lung Cancer With Concurrent Whole Brain Radiation Therapy And Pemetrexed Co-investigator, PI: Tom Stinchcombe Updated on January 29, 2015 28
  29. 29. 2004 – present: The Interventional Management of Stroke (IMS III) Trial. A randomized, open-label multi-center study that will examine whether a combined intravenous (IV) and intra-arterial (IA) approach to recanalization is superior to standard IV t-PA alone when initiated within three hours of stroke onset. Co-investigator, UNC PI: Souvik Sen 2004-2006: SAINT NXY-089 in Acute Stroke. A randomized, placebo-controlled, international, neuroprotective trial in acute ischemic stroke, sponsored by Astra-Zeneca. Co-investigator, PI: Ana Felix 2004-present: Intravenous Vs Intra-arterial tPA (Activase) In Acute Ischemic Stroke With CT Angiogram Evidence Of Major Vessel Occlusion. Co-investigator: Investigator-initiated study PI: Souvik Sen 2003-present: Mechanical Embolus Removal in Cerebral Ischemia Trial to study "Safety and efficacy of the MERCI retriever in the treatment of thrombotic occlusion originating in the internal carotid, middle cerebral (M1 & M2 segments), basilar or vertebral arteries". Co-investigator, PI:Sten Solander, Sponsor: Concentric Medical 2003-present: RREACT study "A Randomized, Double-blind, Placebo-controlled, Multi center Study of the Effects of ONO-2506 Intravenous Infusion on the Amelioration of Neurological Damage and Improvement of Stroke Assessment Scale Scores in Patients with Acute Ischemic Stroke" Co- investigator, PI: Souvik Sen Sponsor: ONO 2003-present: mRECT study "A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetic/Pharmacodynamic Effects of a Targeted Exposure of Intravenous Repinotan HCl in Patients with Acute Ischemic Stroke (Modified RECT)." Co-investigator, PI: Souvik Sen, Sponsor: Bayer 2003-present: Phase III Multicenter Study of Intratumoral/Interstitial Therapy with TransMID Compared to Best Standard of Care in patients with Progressive and/or Recurrent Non-resectable Glioblastoma Multiforme. Co- investigator, PI: Mathew Ewend 2001-2003: Phase II Study Utilizing the Gliasite RTS for the Treatment of a Resected Solitary Brain Metastasis. Co-investigator, PI: Mathew Ewend 1999-2000: Phase III Randomized Study of SU101 versus Procarbazine for Patients with Glioblastoma Multiforme in First Relapse Co-investigator, PI: Mathew Ewend 1998-2000: Phase II Open Labeled Study of SU101 for Patients with Anaplastic Astrocytoma in First Relapse. Co-investigator, PI: Mathew Ewend Updated on January 29, 2015 29
  30. 30. 1997-2000: Phase II Trial of Surgery with Gliadel Wafer and Radiation in patients with Operable CNS Metastasis from Systemic Cancer. Co-investigator, PI: Mathew Ewend 1995-1998: Treatment of Anaplastic Gliomas with Concomitant Intra-arterial Cisplatin and Radiotherapy. Co-investigator, PI: Keith Quatroci PROFESSIONAL SERVICE: UNIVERSITY OF NORTH CAROLINA COMMITTEES: Radiology representative and member of the steering committee to The University of North Caroloina enterprise wide Radiology Information System committee 2005-Present Review Committee member for The UNC Injury Prevention Research Center’s annual Susan P. Baker Student Research Paper Prize, 2004-Present Member, Multidisciplinary Neuro-oncology Program, UNC Lineberger Comprehensive Cancer Center 1999-Present Radiology representative and member of the steering committee to The University of North Caroloina enterprise wide PACS committee 1999-Present Radiology Department Residency Selection Committee, 2001-Present Member of the multidisciplinary team for intrauterine evaluation and treatment of open neural tube defects 2000-2002 Clinical director for high field MR imaging research, UNC Department of Radiology 2000-Present EDITORIAL POSITIONS American Journal of Neuroradiology, Reviewer, 1999-present American Journal of Roentgenology, Reviewer 1999-present Transactions on Medical Imaging, Reviewer 2003-present Clinical Neuropharmacology Reviewer 2008-present PROFESSIONAL SOCIETIES: American Society of Neuroradiology American Physiological Society American College of Radiology North Carolina Medical Association Radiology Society of North America Lee County Medical Association American Society of Pediatric Neuroradiology American Society of Emergency Radiology American Heart Association Stroke Council Updated on January 29, 2015 30

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