CHI's Next-Gen Kinase Inhibitors Conference, June 17-19, 2013, Boston, MA
Upcoming SlideShare
Loading in...5
×
 

CHI's Next-Gen Kinase Inhibitors Conference, June 17-19, 2013, Boston, MA

on

  • 767 views

This established and well-recognized kinase conference addresses reoccurring questions about selectivity, safety, resistance and novelty. After many years of research and therapeutic developments of ...

This established and well-recognized kinase conference addresses reoccurring questions about selectivity, safety, resistance and novelty. After many years of research and therapeutic developments of kinase inhibitors, the field still offers new opportunities as novel kinases and their inhibitors are making an appearance. In addition, interest in repurposing of already developed drugs is growing immensely.

“Next-Gen Kinase Inhibitors” addresses what lies ahead, what is in store for the pharmaceutical industry and what new avenues are opening up in regards to technologies and methods used, and in regards to novel targets and therapeutic approaches explored.

Statistics

Views

Total Views
767
Views on SlideShare
767
Embed Views
0

Actions

Likes
0
Downloads
5
Comments
0

0 Embeds 0

No embeds

Accessibility

Categories

Upload Details

Uploaded via as Adobe PDF

Usage Rights

© All Rights Reserved

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Processing…
Post Comment
Edit your comment

CHI's Next-Gen Kinase Inhibitors Conference, June 17-19, 2013, Boston, MA CHI's Next-Gen Kinase Inhibitors Conference, June 17-19, 2013, Boston, MA Document Transcript

  • Final AgendaNext-GenCambridge Healthtech Institute’s Eleventh AnnualKinase InhibitorsMoving Towards a Successful PipelineJune 17-19, 2013 | The Revere Hotel | Boston, MA TOPIC HIGHLIGHTS: • Non-Cancer Indications • Overcoming Resistance •  esigning Selective Inhibitors D • Structure-Based Design • Property-Based Design • Screening and Validation Short Course: The Art and Science of Kinases* Monday, June 17 Course Instructors: Kent D. Stewart, Ph.D., Research Fellow, Structural Biology, Abbvie Maricel Torrent, Ph.D., Senior Scientist III, Molecular Modeling, AbbVie *Separate Registration Required. Co-Located with: 13th Annual Structure-Based Drug Register by Design Conference Genome to Drug Lead with Big Data Approach March 29 June 19-21 | healthtech.com/SBD & Save upCorporate Sponsor to $350! Organized by: Cambridge Healthtech Institute healthtech.com/KIN
  • Next-Gen Cambridge Healthtech Institute’s Eleventh Annual June 17-19, 2013 The Revere Hotel | Boston, MA Kinase Inhibitors Moving Towards a Successful Pipeline This established and well-recognized kinase conference addresses reoccurring questions about selectivity, safety, resistance and novelty. After many years of research and therapeutic developments of kinase inhibitors, the field still offers new opportunities as novel kinases and their inhibitors are making an appearance. In addition, interest in repurposing of already developed drugs is growing immensely. “Next-Gen Kinase Inhibitors” addresses what lies ahead, what is in store for the pharmaceutical industry and what new avenues are opening up in regards to technologies and methods used, and in regards to novel targets and therapeutic approaches explored. Monday, June 17 selective PKCθ inhibitors, which show exceptional potency in cells and in vivo. 8:00 – 9:00 am Pre-Conference Short Course Registration and Morning Coffee 2:10 JAK Inhibition Suppresses Osteoclast Activation through Decreased RANKL Production Timothy P. LaBranche, DVM, Ph.D., Dipl ACVP, Senior Principal Scientist, 9:00 – 12:00 pm Short Course: The Art and Science Pathologist, Pfizer Drug Safety R&D, Cambridge, MA of Kinases* Potent inhibition of human T lymphocyte RANKL production by the JAK Course Instructors: Kent D. Stewart, Ph.D., Research Fellow, inhibitor tofacitinib (Xeljanz), combined with the lack of an effect on Structural Biology, Abbvie human osteoclast differentiation/function suggests that JAK inhibition Maricel Torrent, Ph.D., Senior Scientist III, Molecular suppresses osteoclast-mediated bone resorption through decreased Modeling, AbbVie RANKL production. Although T lymphocytes clearly appear to play a role *Separate Registration Required in osteoclast activation by producing RANKL, it is possible that they do not represent the totality of RANKL production in the arthritic joint. 11:00 am Main Conference Registration 2:40 Sponsored Presentation (Opportunity Available) 1:30 pm Chairperson’s Opening Remarks Guido Zaman, Ph.D., Founder, Head, Biology, Netherlands Translational 3:10 Refreshment Break in the Exhibit Hall with Poster Viewing Research Center B.V. 3:40 Combining Cellular and Biochemical Panel Profiling for the Non-Cancer Indications Development of Selective Kinase Inhibitors Guido Zaman, Ph.D., Founder, Head, Biology, Netherlands Translational 1:40 The Design and Optimization of Selective Protein Research Center B.V. Kinase C theta (PKCθ) Inhibitors for the Treatment of The Netherlands Translational Research Center B.V. (NTRC) aids in Autoimmune Diseases the development of new personalized therapies for the treatment of Juan-Miguel Jimenez, Ph.D., Director, Chemistry, Vertex cancer, autoimmuneand neurodegenerative diseases. Selective kinase Pharmaceuticals (Europe) Ltd. inhibitors are optimized for increased target residence time and profiled Protein kinase C theta (PKCθ) has a central role in T cell activation and on large panels of biochemical and cell-based assays. Genotypic, survival. Studies in PKCθ-deficient mice have demonstrated that whilst phenotypic and pathway information are combined to determine the anti-viral responses are PKCθ-independent, T cell responses associated optimal compound for a particular patient responder population. Kinase with autoimmune diseases are PKCθ- dependent. Thus, potent and inhibitors are tested in combination with existing drugs to identify new selective inhibition of PKCθ is expected to block autoimmune T cell synergies that improve the efficiency of established therapies responses without compromising antiviral immunity. The presentation will describe the design and optimisation of a novel class of potent and 4:10 Structural and Biophysical Insights into Syk Function from an Allosteric Inhibitor2 | Next-Gen Kinase Inhibitors healthtech.com/KIN
  • Justin Hall, Ph.D., Senior Scientist, Pfizer The traditional protein kinase inhibitor design process is being Syk is a soluble kinase responsible for transmission of the B-cell expanded as we learn more about the changing nature of the ATP- receptor or mast cell FcεRI receptor activation signal from the binding cleft and its switching between active and inactive states. The membrane to cytosolic targets. Control of Syk function is important presentation will describe the utilization of a new understanding of the to the human antigenic and inflammation immune response, and an role of hydrophobic residues within the cleft and how the ligand-protein inhibitor of Syk could provide therapy for autoimmune or inflammation interactions influence conformational changes, providing new inhibitor diseases. This talk describes the discovery and characterization of a design opportunities. novel allosteric Syk inhibitor which is noncompetitive against ATP and substrate peptides, and competitive against activation of Syk by its 9:30 Sponsored Presentations (Opportunities Available) upstream regulatory kinase LynB. 10:00 Coffee Break in the Exhibit Hall with Poster viewing 4:40 Targeting Aurora A Kinase to Overcome CML 10:45 Structure and Property Based Design of CK2 Acquired Resistance Kinase Inhibitors WenYong Chen, Ph.D., Associate Professor, Department of Cancer James Dowling, Ph.D., Scientist, Astrazeneca Biology, Beckman Research Institute/City of Hope CML develops acquired resistance to tyrosine kinase inhibitors by Developing Selective Inhibitors acquisition of BCR-ABL kinase domain mutations. We found that an early event for emergence of BCR-ABL mutant cells is mitotic crisis 11:15 Evolutionary and Semantic Web Applications in Protein of CML cells triggered by tyrosine kinase inhibitor treatment, and it is Kinase Inhibitor Design controlled by mitotic kinase Aurora A. Specific inhibition of Aurora A is Natarajan Kannan, Ph.D., Assistant Professor, Biochemistry and able to prevent acquisition of BCR-ABL mutations and block CML cell Molecular Biology & Institute of Bioinformatics, University of relapse from tyrosine kinase inhibitors. Georgia, Athens Protein kinases display complex sequence-structure-function 5:10 Welcome Reception in the Exhibit Hall with Poster Viewing relationships, a detailed understanding of which is necessary for the development of selective protein kinase inhibitors. This talk describes 6:45 Close of Day One how evolutionary- and ontology-based analysis of protein kinase data can provide new insights into sequence-structure-function relationships, Tuesday, June 18 and aid in the development of selective protein kinase inhibitors. 7:45 am Breakfast Breakout Discussions 11:45 Selective Inhibition of Kinase-Driven Pathways; Exploiting These are moderated discussions with brainstorming and interactive Demure Features problem solving, allowing conference participants from diverse Ellen R. Laird, Ph.D. Research Fellow, Array BioPharma backgrounds to exchange ideas, experiences, and develop future Selective inhibition of nearly any given protein kinase continues to collaborations around a focused topic. challenge investigators. Literature reviews generally focus upon gross differences in kinase fold, with emphasis on “inactive” vs. “active” Table 1: Multi-Parameter Drug Optimization – Is It Working? conformations, yet many of these compounds remain stubbornly • Is data quality good enough? promiscuous. We have curated and analyzed a sizeable collection • How many compounds should be made and in what stage? of X-ray crystal structures of diverse kinases, many of which are • What is the ideal path for optimization and how do you find proprietary. We have identified additional sources for selectivity by it efficiently? consideration of nuances at the periphery of active or inactive folds. • What role does informatics have? – small companies vs Differences in sidechain rotamer preferences and solvation, cleft large companies dimension, features of the active site floor, the P-loop, and the C-helix Moderator: Mark Ashwell, Ph.D., Vice President, Chemistry, ArQule often contribute to hypotheses that enable SAR interpretation and further compound design. This talk will draw upon prominent examples Table 2: How Can We Leverage Existing Data on Protein Kinases of inhibitors that owe their selectivity to these subtle differences, for Inhibitor Design? with particular emphasis on our own experiences with AKT, B-Raf, • Challenges in protein kinase data mining and Erb-B2. • Resources needed to address data mining challenges 12:15 pm Luncheon Presentation Sponsored by Moderator: Natarajan Kannan, Ph.D., Assistant Professor, Biochemistry Speaker to be Announced and Molecular Biology; Institute of Bioinformatics, University of Georgia 1:35 Chairperson’s Remarks 8:55 Chairperson’s Remarks Natarajan Kannan, Ph.D., Assistant Professor, Biochemistry and Mark Ashwell, Ph.D., Vice President, Chemistry, ArQule Molecular Biology, Institute of Bioinformatics, University of Georgia Property-Based Design 1:40 Structure-Based Design of Selective hSmg-1 9:00 Focusing on the Ligand-Protein Relationship in Activation- Kinase Inhibitors State Dependent Conformational Changes of Protein Kinases Ariamala Gopalsamy Ph.D., Associate Research Fellow, Worldwide Mark Ashwell, Ph.D., Vice President, Chemistry, ArQule Medicinal Chemistry, Pfizer Global Research and Developmenthealthtech.com/KIN Next-Gen Kinase Inhibitors | 3 View slide
  • hSmg-1 kinase plays a key role in cellular genotoxic stress response and contributes to tumor growth and resistance to chemotherapy. To »» Keynote Presentation understand the functional role of inhibiting this underexplored Ser-Thr 8:30 Kinase Inhibitors: Lessons Learned? kinase, we identified pyrimidine-based, highly hSmg-1 selective kinase Doriano Fabbro, Ph.D., CSO, Piqur Therapeutics inhibitors. Use of structure based optimization to achieve selectivity will Our knowledge on the structural determinants of kinase inhibition be discussed in detail. by small molecules binding to the ATP pocket has advanced steadily in the past years. We will give an overview on the status 2:10 Sponsored Presentation (Opportunity Available) quo of kinase inhibition and discuss an example on how protein kinases can be structurally affected by selective kinase inhibitors. 2:40 The SYK–BTK Axis as a Drug Target for In addition we will also discuss on how to target kinases whose Autoimmune Disorders cellular signaling pathways are only poorly understood. Thomas Tan, Ph.D., Consultant, Medical Affairs, F- Hoffmann-La Roche Ltd. Screening and Validation Spleen Tyrosine Kinase (SYK) and Bruton’s Tyrosine Kinase (BTK) are non-receptor cytoplasmic tyrosine kinases that are primarily expressed 9:00 Evaluation of the PI4KIIIα Lipid Kinase as a Hepatitis C in cells of hematopoietic lineage. Both are key mediators in coupling Virus Drug Target: From Inhibitor Screening to Animal Models activated immunoreceptors to downstream signaling events that affect Frederic Vaillancourt, Ph.D., former Senior Research Scientist, diverse biological functions, from cellular proliferation, differentiation Department of Biological Sciences, Research and Development, and adhesion to innate and adaptive immune responses. As such, Boehringer Ingelheim (Canada) Ltd. pharmacological inhibitors of SYK or BTK are being actively pursued as PI4KIII is an essential host cell factor for HCV replication. Screening, potential immunomodulatory agents for the treatment of autoimmune using an in vitro biochemical lipid kinase assay, led to the identification and inflammatory disorders. Here, we review and discuss recent of potent inhibitors. In cell culture studies these inhibitors were used insights into the emerging role of the SYK–BTK axis in innate immune to demonstrate that the kinase activity was essential for HCV RNA cell functions, and our experience in developing selective SYK and replication, and a resistance study performed, using two of these BTK inhibitors. inhibitors, provided additional insight into the potential role of PI4KIIIα and its product in the HCV viral life cycle. A comprehensive assessment 3:10 Refreshment Break in the Exhibit Hall with Poster Viewing of PI4KIIIα as a drug target in vivo through conditional transgenic murine lines that mimic target-specific inhibition in adult mice demonstrated an Case Studies essential host physiologic role for PI4KIIIα. 4:00 Talk Title to be Announced Stephen J. Shuttleworth, Ph.D., FRSC CChem, CSO, Karus 9:30 Coffee Break Therapeutics Ltd. 10:00 Fitting Technology to Screening Strategy: A Probe 4:30 Discovery and Development of Jakafi for Myelofibrosis Displacement Assay to Help Identify Novel Protein Kinase Inhibitors Kris Vaddi, DVM, Ph.D., Group Vice President, Pharmacology and Toxicology, Incyte Pharmaceuticals Ramesh Padmanabha, Ph.D., Principal Scientist, Lead Discovery, Lead Profiling and Compound Management, Bristol-Myers Squibb R&D Jakafi (ruxolitinib) is a potent, selective and first in-class JAK1 and JAK2 inhibitor, approved by USFDA for the treatment of patients with The talk will outline assay design process to select the probe intermediate- and high-risk myelofibrosis. Myelofibrosis is a serious and displacement assay over standard kinase activity assays. The details life-threatening myeloproliferative neoplasm (MPN), but unlike CML of the HTS will also be discussed and will include validation, quality is Philadelphia chromosome negative. An important discovery in late control, and data analysis. The outcome from the screen and selectivity 2004 that identified a somatic gain-of-function mutation known as JAK2 data will also be presented. V617F in MPN patients provided first molecular and genetic evidence 10:30 Talk Title to be Announced that linked JAK-STAT dysregulation to the pathogenesis of MPNs. Drug discovery program at Incyte aimed at developing JAK inhibitors began Yaya Liu, Ph.D., Associate Research Fellow, AbbVie Inc. in early 2003, almost 2 years ahead of the discovery of JAK2V617F with Structure - Based Design the recognition that JAK-STAT pathway is an important oncogenic and inflammatory mechanism. This early start allowed Incyte to identify 11:00 Structure-Based Drug Design: Redefining Jakafi in Protein-Ligand Interactions Jose Duca, Ph.D., Head, Computer-Aided Drug Discovery, Novartis 5:30 Close of Day Since the introduction of the lock and key hypothesis, structure-based drug design has been equivalent to understanding and designing Wednesday, June 19 protein-ligand interactions. A novel theory of binding that encompasses protein-ligand interactions will be introduced and exemplified. 7:30 am Morning Coffee 11:30 Luncheon Presentation (Opportunity Available) or Lunch on 8:25 Chairperson’s Remarks Your Own Doriano Fabbro, Ph.D., CSO, Piqur Therapeutics4 | Next-Gen Kinase Inhibitors healthtech.com/KIN View slide
  • 1:15 pm Chairperson’s Remarks Drug Resistance Adam C. Palmer, Ph.D., Postdoctoral Fellow, Department of Systems Biology, Harvard Medical School 4:00 Towards a New Generation of Antimicrobial Antifolates • the special role that structure-based drug design can play in treating Dennis L. Wright, Ph.D., Professor of Pharmaceutical Sciences and drug resistant infectious disease Chemistry, University of Connecticut We are using a structure-based design approach to develop potent • how considering the evolution of resistance during drug development and selective inhibitors of the enzyme dihydrofolate reductase (DHFR) could produce drugs with more long-lasting clinical efficacy from a variety of pathogenic organisms. Analysis of crystal structures • how drug resistance can be used as a tool to understand mechanism of trimethoprim-resistant and naturally insensitive enzymes led to the of drug action design of a series of propargyl-linked antifolates characterized by high potency, good selectivity over the human form of the enzyme and good 1:20 Structure-Based Design of Potent and Selective Inhibitors of anti-microbial activity. PI3-Kinase Delta Jeremy M. Murray, Ph.D., Scientist, Structural Biology, Genentech 4:30 Understanding Drug Mechanism of Action by Target Inhibition of PI3Kδ is considered to be an attractive mechanism for the Gene Overexpression treatment of inflammatory diseases and leukocyte malignancies. Using Adam C. Palmer, Ph.D., Postdoctoral Fellow, Department of Systems a structure-based design approach, we have identified a series of potent Biology, Harvard Medical School and selective inhibitors of PI3Kδ. These inhibitors do not occupy the The molecular targets of drugs can sometimes, but not always, induced selectivity pocket between Trp760 and Met752 that is observed be identified amongst genes that confer drug resistance when for other families of selective PI3Kδ inhibitors. Instead, the selectivity overexpressed. We quantitatively overexpressed genes encoding of the compounds for inhibition of PI3Kδ relative to other PI3K isoforms known antibiotic targets and observed that drug resistance does not appears to be due primarily to the strong interactions these inhibitors only increase; it can remain unchanged, decrease, or even have a are able to make with Trp760 in the PI3Kδ binding pocket. This talk will non-monotonic dependence on target expression. These diverse effects discuss the structural understanding of the selectivity of these inhibitors are explained by simple models considering gene toxicity and drug- against other isoforms, pharmacokinetic properties and the ability of induction of harmful target-catalyzed reactions. The relation between select compounds to inhibit the function of B-cells in vivo. drug resistance and target expression may reveal unexpectedly complex mechanisms of drug action. 1:50 MD Simulations of Mutant and WT PI3Kα: Insights into the Mechanism of Overactivation and Implications for Drug Design 5:00 Close of Conference Zoe Cournia, Ph.D., Investigator, Biomedical Research Foundation, Academy of Athens Understanding how the p110α H1047R mutation causes tumorigenesis is central to developing new therapeutics for cancer. To this end, MD simulations in aqueous solution were carried out for 100 ns for both WT and mutant proteins. Our results indicate that key regions of the protein, such as the catalytic, activation, membrane binding loops and the C-terminus, all exhibit significantly different dynamics in the mutant with respect to the WT protein. 2:20 Sponsored Presentation (Opportunity Available) 2:50 Refreshment Break in the Exhibit Hall with Poster Viewing 3:30 Sponsored Presentation (Opportunity Available)healthtech.com/KIN Next-Gen Kinase Inhibitors | 5
  • Sponsorship, Exhibit, and Lead Looking for additional Generation Opportunities ways to drive leads to CHI offers comprehensive sponsorship packages which include presentation opportunities, exhibit space and branding, as well as the use of the pre and post-show your sales team? delegate lists. Customizable sponsorship packages allow you to achieve your objectives before, during, and long after the event. Signing on early will allow you to maximize exposure to hard-to-reach decision makers CHI can help! Agenda Presentations We offer clients numerous options for custom lead Showcase your solutions to a guaranteed, highly-targeted audience. Package includes a generation programs to address their marketing & 15 or 30-minute podium presentation within the scientific agenda, exhibit space, on-site sales needs, including: branding, and access to cooperative marketing efforts by CHI. Custom Lead Generation Programs: Breakfast & Luncheon Presentations Opportunity includes a 30-minute podium presentation. Boxed lunches are delivered •  argeted campaign promotion to unparalleled T into the main session room, which guarantees audience attendance and participation. database of 800,000+ individuals in the life A limited number of presentations are available for sponsorship and they will sell out sciences quickly. Sign on early to secure your talk! •  xperienced marketing team promotes campaign, E Invitation-Only VIP Dinner/Hospitality Suite increasing awareness and leads Sponsors will select their top prospects from the conference pre-registration list for an evening of networking at the hotel or at a choice local venue. CHI will extend invitations Live Webinars: and deliver prospects. Evening will be customized according to sponsor’s objectives •  ssistance in procuring speakers A • Purely social • Reception style •  xperienced moderators E • Focus group • Plated dinner with specific  •  edicated operations team to coordinate all efforts D conversation focus Exhibit Space White Papers: Exhibitors will enjoy facilitated networking opportunities with high-level conference • ndustry recognized authors, with vast editorial I delegates. Speak face-to-face with prospective clients and showcase your latest product, experience, available to help write your white paper service, or solution. *nquire about additional branding opportunities! I CHI also offers market surveys, podcasts, and more! To customize your participation at this event, please contact: Jon Stroup Business Development Manager 781-972-5483 | jstroup@healthtech.com Hotel & Travel Information Flight Discounts: Special discount rentals have been established with American Airlines Conference Hotel: for this conference. The Revere Hotel • Call American Airlines 1-800-433-1790 use Conference code 4463BU.  200 Stuart St. • Go online www.aa.com/group enter Conference code 4463BU  Boston, MA 02116 in promotion discount box. Tel: 617-482-1800 • Contact our dedicated travel agent Rona Meizler at 1-617-559-3735  Discounted Room Rate: $249 s/d or rona.meizler@protravelinc.com. Discounted Reseveration Cut-off Date: May 17, 2013 Car Rental Discounts: Please visit our conference website to make your reservation online or you Special discount rentals have been established with Hertz for this conference. may call the hotel directly. You will need to identify yourself as a Cambridge Please use one of the following methods: Healthtech Institute conference attendee to receive the discounted room rate with the host hotel. Reservations made after the cut-off date or after the • Call Hertz 1-800-654-3131 use our Hertz Convention Number (CV): 04KL0003  group room block has been filled (whichever comes first) will be accepted on • Go online www.hertz.com use our Hertz Convention Number (CV): 04KL0003  a space and rate-availability basis. Rooms are limited, so please book early. Media Partners:healthtech.com/KIN Next-Gen Kinase Inhibitors | 6
  • Pricing and Registration Information Receive a FREE eNewsletter by signing up at chimediagroup.comShort Course Academic, Government, The latest industry news, commentary and highlights from Bio-IT World Commercial Hospital-affiliatedPre-Conference Morning Short Course – June 17 $695 $395 Innovative management in clinical trialsConference Pricing(Includes access to 1 conference, excludes short courses) A series of diverse reports designed to keep life science professionals informed of theEarly Registration until March 29, 2013 $1745 $845 salient trends in pharmaceutical technology, business, clinical development, andAdvance Registration until May 10, 2013 $1895 $925 therapeutic disease markets.For a detailed list of reports, visit InsightPharmaReports.Registrations after May 10, 2013, and on-site $2095 $995 com, or contact Rose LaRaia, rlaraia@ healthtech.com, +1-781-972-5444.Special Package Pricing(Includes access to Next-Gen Kinase Inhibitors & Structure-Based Drug Design, excludes short courses) Barnett is a recognized leader in clinical education, training, and reference guidesEarly Registration until March 29, 2013 $2995 $1495 for life science professionals involved in the drug development process. For moreAdvance Registration until May 10, 2013 $3145 $1565 information, visit barnettinternational.com.Registrations after May 10, 2013, and on-site $3345 $1585Conference Discounts Cambridge Healthtech Associates™ (CHA™) leverages its extensive networkPoster Submission-Discount ($50 Off) and unique collaborative model inPoster abstracts are due by May 10, 2013. Once your registration has been fully processed, we will send an email containing a unique link consulting, technology evaluationsallowing you to submit your poster abstract. If you do not receive your link within 5 business days, please contact jring@healthtech.com. and community-based communication services to help clients in the life*CHI reserves the right to publish your poster title and abstract in various marketing materials and products. sciences industry commercialize and penetrate the marketplace to increaseREGISTER 3 ­ 4th IS FREE: Individuals must register for the same conference or conference combination and submit completed registration form together - revenue. Visit www.chacorporate.com.for discount to apply.Additional discounts are available for multiple attendees from the same organization. For more information on group rates contactDavid Cunningham at +1-781-972-5472 Additional registration details Each registration includes all conference sessions, posters and exhibits, food If you are unable to attend but would like to purchase the Next-Gen Kinase Inhibitors CD for $350 (plus shipping), please visit healthtech.com/KIN. functions, and access to the conference Massachusetts delivery will include sales tax. proceedings link. Handicapped Equal Access: In accordance with the ADA, Cambridge Healthtech Institute is pleased to arrange special accommodations for attendees with Thirteenth Annual BEST VALUE! special needs. All requests for such Structure-Based assistance must be submitted in writing CO-LOCATED June 19-21, 2013 Register for both to CHI at least 30 days prior to the start Drug Design of the meeting. conferences at a EVENT The Revere Hotel To view our Substitutions/ Boston, MA special rate. Cancellations Policy, go to http://www.healthtech.com/regdetails Video and or audio recording of any kind is prohibited onsite at all CHI events. How to Register: healthtech.com/KIN Please use keycode KIN F reg@healthtech.com • P: 781.972.5400 or Toll-free in the U.S. 888.999.6288 when registering!Please refer to the Registration Code below: Cambridge Healthtech Institute 250 First Avenue, Suite 300, Needham, MA 02494 www.healthtech.com  •  Fax: 781-972-5425