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The discussion will focus on non-injectable technologies such as nasal, pulmonary, and oral delivery technologies, and the challenges and opportunities in development for converting these technologies into successful products. In addition, the discussion will address the category of technologies sometimes referred to as minimally-invasive that has the potential to significantly improve the patient experience. Technologies in development in this area will be discussed along with the pros and cons. Finally, a number of commercial examples will be reviewed as case studies where non-invasive or minimally invasive technologies have been successfully commercialized.