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Course: Challenges and Opportunities in Protein and Peptide Drug Delivery
Course: Challenges and Opportunities in Protein and Peptide Drug Delivery
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Course: Challenges and Opportunities in Protein and Peptide Drug Delivery

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When: May 4, 2014 …

When: May 4, 2014
Where: Seaport World Trade Center, Boston, MA

Proteins and peptides represent a significant segment of the therapeutics spectrum with many promising candidates under early development or in late-stage clinical trials. Several of these molecules are poised to make a substantial impact, especially in the under-represented or unrepresented categories such as neurological disorders and neurodegenerative diseases. A key challenge to be overcome with protein and peptide based biologics, however, is their effective delivery to the target site while achieving the optimum balance of stability, safety, bioavailability, and patient compliance. This short course will provide a broad overview of the opportunities and challenges in the development of the next generation of protein and peptide therapeutic delivery systems.

Published in: Science
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  • 1. Short Course: Organized by Cambridge Healthtech Institute Challenges and Opportunities in Protein and Peptide Drug Delivery Sunday, May 4, 2014 | 10:00 am - 2:00 pm Seaport World Trade Center, Boston, MA Proteins and peptides represent a significant segment of the therapeutics spectrum with many promising candidates under early development or in late-stage clinical trials. Several of these molecules are poised to make a substantial impact, especially in the under-represented or unrepresented categories such as neurological disorders and neurodegenerative diseases. A key challenge to be overcome with protein and peptide based biologics, however, is their effective delivery to the target site while achieving the optimum balance of stability, safety, bioavailability, and patient compliance. This short course will provide a broad overview of the opportunities and challenges in the development of the next generation of protein and peptide therapeutic delivery systems. Therapeutic spectrum • Introduction to biologics based on proteins and peptides • Different classes of protein and peptide biologics • Representative examples in clinical use • New molecules under development – next-generation biologics • Clinical needs and opportunities • Clinical advantages of biologics over small molecules • Current niche served by protein and peptide biologics • Unrepresented clinical indications and opportunities • Key challenges in protein and peptide delivery • Issues related to stability • Route of administration • Biological barriers (e.g. blood-brain barrier) • Bioavailability for therapeutic benefit • Safety/toxicity balance New developments in enhancing protein stability • Use of biostable/synthetic scaffolds • Chemical modifications • Packaging in nano and mesoporous carriers • Molecular chaperones for enhanced serum stability
  • 2. New developments in overcoming delivery challenges • Integration of delivery vectors with biologics • Protein/peptide API-based nanomaterials • Alternate routes/interfaces for administration • Transgenic delivery systems Future directions in protein and peptide delivery • New clinical indications • Novel delivery systems • New routes of administration Instructor: Pankaj Karande, Ph.D., Assistant Professor, Department of Chemical & Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute How to Register: Web: http://chidb.com/register/2014/pfm/reg.asp Call: 781-972-5400 Email: reg@healthtech.com This course is part of the Biologics, Formulation & Delivery Summit. www.healthtech.com/biologics-delivery

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