Jaideep Sarkar- Buccomucosal Drug Delivery System

BMDDS BY : JAIDEEP SARKAR

Buccomucosal routes of drug delivery involves the delivery of the drug through the mucosal linings of the oral cavity
The oral mucosa is composed of
1.outermost layer :
stratified squamous epithelium.
2.basement membrane :
lamina propria.
3.innermost layer :
submucosa.
The permeability of buccal mucosa is 4 - 4000 times greater than that of skin.
INTRODUCTION

The cells of the oral epithelia are surrounded by an intercellular ground substance, mucus which is a part of saliva secreted by salivary glands
Bioadhesion of mucoadhesive drug delivery systems
Cell-cell adhesion
Lubrication
ENVIRONMENT AND ROLE OF BUCCAL MUCOSA

Two possible routes of drug absorption through oral mucosa
DRUG DELIVERY PATHWAYS

Mucoadhesion of the device is a key element
The term ‘mucoadhesive’ is commonly used for materials that bind to the cumin layer of a biological membrane
Based on the molecular interactions
The molecular interactions composed of attractive and repulsive forces
For muco adhesion to occur, the attractive interaction should be larger than repulsions.
BUCCAL DRUG DELIVERY AND MUCOADHESIVITY

Bioadhesive polymer chains Mucus polymer chains FUSION OF MUCUS LAYER AND BIOADHESIVE POLYMER APPROACHING POLYMERS MECHANISM OF BIOADHESIVE FOR MUCOSAL DRUG DELIVERY

GENERAL PHYSIOCHEMICAL FEATURES
MUCOADHESIVE POLYMERS Predominantly anionic hydrophilicity , suitable surface property, sufficient flexibility Carboxymethyl cellulose Carbopol Polycarbophil Sodium Alginate Hydroxyethyl cellulose Hydroxypropyl methylcellulose Chitosan Gelatin Pectin

Three types based on their geometry
BUCCAL MUCOADHESIVE DOSAGE FORMS

Drug + Mucoadhesive Matrix ………………………………………………………………… . ………………………………………………………………… . DESIGN OF BUCCAL DOSAGE FORM
Matrix type : The Buccal patch designed in a matrix configuration contains drug, adhesive, and additives mixed together
Bi-directional patches release drug in both the mucosa and the mouth

Reserviour type : The buccal patch designed in a reservoir system contains a cavity for the drug and additives separate from the adhesive
Impermeable backing is applied to control the direction of drug delivery; to reduce patch deformation and disintegration while in the mouth; and to prevent drug loss Backing Layer Drug + Mucoadhesive Matrix ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Contd…

ACTIVE INGREDIENTS DELIVERED VIA A BUCCAL ROUTE

MARKET FORMULATIONS

Buccal nitroglycerin, is used for acute therapy for an anginal attack as well as for chronic prophylaxis
Novel liquid aerosol formulation of insulin
Buccal delivery of drugs that undergo a first-pass effect, such as cardiovascular drugs, analgesics, and peptides
Promote further research; more companies
Rest depend on delivery technology
RECENT & FUTURE OF BDDS

THIS RECENT SCAN IMAGE OF PFIZER PROVES THAT BMDDS HAS SYSTEMIC EFFECT AND SO IS BENEFICIAL FOR THOSE PATIENTS THAT ARE UNCOOPERATIVE FOR OTHER DOSAGE FORM

Avoids first pass effect, hostility of GIT
Abundance of blood vessel, fast cellular recovery
Since the formulation is light so less packing cost, transport cost, economy of raw material and cheap
Ease of administration and termination
Rapid absorption possible & hence relatively rapid onset of action
Directly & easily modify microenvironment
Lower intersubject variability as compared to transdermal patches as stratum corneum is absent
ADVANTAGES

Relatively small absorptive surface area (0.01 sq m vs 100 sq m for GIT)
Movement affects mucoadhesive systems
Less permeable than the small intestine
Salivation and swallowing
Taste of the drug
If formulation contains antimicrobial agents, affects the natural microbes in the buccal cavity.
The patient cannot eat/drink/speak.
DISADVANTAGES

Buccal drug delivery is a promising area for systemic delivery of orally inefficient drugs as well as an attractive alternative for noninvasive delivery by buccal films, buccal patches, gels and tablets.
With the influx of a large number of new drug molecules from drug discovery, mucoadhesive drug delivery will play an even more important role in delivering these molecules.
CONCLUSION

Jaideep Sarkar- Buccomucosal Drug Delivery System

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Jaideep Sarkar- Buccomucosal Drug Delivery System Presentation Transcript