Poster 54 hematologie

748 views
653 views

Published on

PREVALENCE OF HAEMOGLOBIN VARIANTS IN GREEK PATIENTS

Published in: Health & Medicine, Technology
0 Comments
1 Like
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total views
748
On SlideShare
0
From Embeds
0
Number of Embeds
114
Actions
Shares
0
Downloads
0
Comments
0
Likes
1
Embeds 0
No embeds

No notes for slide

Poster 54 hematologie

  1. 1. 2011 Hematologie Hematology Poster 54 PREVALENCE OF HAEMOGLOBIN VARIANTS IN GREEK PATIENTS Marilena Stamouli , Anastasios Skliris, Grigorios Totos, Dimitrios Kokoulas and Efrosini Karagianni Department of Microbiology and Immunology, Naval and Veterans Hospital, Athens, Greece
  2. 2. Hematologie Hematology Poster 54 <ul><li>Hemoglobinopathies are inherited disorders of hemoglobin synthesis or of its structure, which cause significant morbidity and mortality worldwide </li></ul><ul><li>The prevalence of carriers of abnormal hemoglobin is within the range of 5 %-7 % globally </li></ul><ul><ul><li>the number of new cases of affected infants is estimated at 300000.0 per year </li></ul></ul><ul><li>The aim of this study was the estimation of the prevalence of hemoglobin variants in Greek patients . </li></ul>Facts and Objectives 2011
  3. 3. 2011 Hematologie Hematology Poster 54 <ul><li>The present study was conducted on 875 blood samples derived from patients: </li></ul><ul><ul><li>aged between 3 and 86 years </li></ul></ul><ul><ul><li>born in different regions of Greece. </li></ul></ul><ul><li>510 (58 %) samples were males and 376 (42 %) were females. </li></ul><ul><li>Participants were hospital inpatients and outpatients, and candidates for diving certification . </li></ul>Materials and Methods (I)
  4. 4. 2011 Hematologie Hematology Poster 54 <ul><li>Venous blood samples were collected by venipuncture into K + EDTA anticoagulated tubes. Sample evaluation included: </li></ul><ul><ul><li>measurement of total Hb, Hct, RBC, MCH, MCV, RDW </li></ul></ul><ul><ul><li>sickle tests </li></ul></ul><ul><ul><li>iron and ferritin status </li></ul></ul><ul><li>Identification and quantification of hemoglobins was carried out by High Performance Liquid Chromatography (HPLC) on the MENARINI HA-8160 automated analyzer. </li></ul><ul><li>HPLC is suitable for the simultaneous detection and quantification of hemoglobin fractions. </li></ul><ul><li>Abnormal cases were confirmed by hemoglobin electrophoresis at pH 8.6 on the SEBIA Hydrasys fully automated electrophoresis system. </li></ul>Materials and Methods (II)
  5. 5. <ul><li>Out of the 875 patients: </li></ul><ul><li>660 (86.86 %) had normal HbA, HbA 2 and HbF levels, and </li></ul><ul><li>115 (13.14 %) had at least one abnormal such level. </li></ul>2011 Hematologie Hematology Poster 54 Results (I)
  6. 6. <ul><li>98 (11.2 %) patients had β -thalassaemia trait with elevated HbA 2 levels, </li></ul><ul><li>8 patients (0.91%) had sickle cell trait, </li></ul><ul><li>7 patients (0.8%) had both β -thalassaemia and sickle cell traits, and </li></ul><ul><li>2 patients (0,22 %) had hereditary persistence of fetal hemoglobin, presenting HbF levels of 15% and 30 % respectively </li></ul>2011 Hematologie Hematology Poster 54 Results (II)
  7. 7. <ul><li>The hemoglobinopathies constitute a major public health problem, because of their high frequency and clinical severity. </li></ul><ul><li>Greece is a country with considerable frequency of both β -thalassemia and sickle cell traits. </li></ul><ul><li>Our finding of a prevalence of 11.2 % for the β -thalassemia trait and 0.91 % for sickle cell trait is consistent with previous reports. </li></ul><ul><li>In national scale studies, the prevalence range of β -thalassemia trait was found 5 % to 15 % and the prevalence range of sickle cell trait was found 1 %; </li></ul><ul><ul><li>considerable regional differences have been observed. </li></ul></ul>2011 Hematologie Hematology Poster 54 Discussion
  8. 8. <ul><li>Hemoglobinopathies are now encountered in most countries of the world as a result of global population movements and their distribution changes continuously over the years. </li></ul><ul><li>In the future there will be a strong need for collaboration on information strategies, screening and genetic counseling among countries, in order to deal effectively with this serious health problem. </li></ul><ul><li>  </li></ul>2011 Hematologie Hematology Poster 54 Concluding Remarks

×