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Presentation of Thomas Hanke PhD, Sourcing Director Novo Nordisk at the plenary program during the Dutch Life Sciences & Health Conference 2010

Presentation of Thomas Hanke PhD, Sourcing Director Novo Nordisk at the plenary program during the Dutch Life Sciences & Health Conference 2010

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  • 1. Novo Nordisk– your protein partner Thomas Hanke Sourcing Director Novo Nordisk A/S thnk@novonordisk.com
  • 2. Novo Nordisk history 1923 1985 1946 1986 1982 1988 1985 1996n NovoPen®, world’s first insulin pen Nordisk insulin NPH Production of NovoPen®, world’sNovoSeven®pen World’s first insulin Recombinant first insulin laboratory founded insulin human insulin in to identical Norditropin® from BHK cells “insulin LEO” yeast human insulin from E. coli
  • 3. More than 30,000 Novo Nordiskemployees world wide Copenhagen Seattle Zürich Koriyama Princeton Beijing Chatres Tokyo Tianjin Clayton Bangalore Montes ClarosR&D locations Of the more than 30,000 people working in NovoClinical Development centres Nordisk, over 3,500 are in R&DProduction sites Roughly 1,500 of these people are doing research
  • 4. Novo group structure Novo Seeds Novo Nordisk Foundation Novo Ventures Novo A/S Novo GrowthB-shareholders Equity Novozymes A/S Novo Nordisk A/S B-shareholders Novo Nordisk Novo Nordisk Biotech Fund Affiliates Service Corporate Venture Fund Companies Listed on OMX and NYSE
  • 5. Increased sales revenue and R&D spend bydouble digits annually over the last 5 years Hormone replacement therapyNovo Nordisk: 2009 6.7 1.4 0,7 9.2 0,4 Growth hormone therapySales by Haemostasis management 2008 5.9 1.3 0.7 8.2therapy area, Diabetes care 0,3USD billion 2007 5.4 1.2 0.6 7.5 +11% 0,3 2006 5.0 1.1 0.5 7.0 0,3 2005 4.1 1.1 0.5 6.0 0,3 2009 1.0 0.5 1.4 BiopharmaceuticalsNovo Nordisk: Diabetes careResearch & 2008 0.8 0.5 1.4Developmentspend, USD +12% 2007 0.9 0.4 1.3billion 2006 0.7 0.4 1.1 2005 0.6 0.3 0.9
  • 6. Novo Nordisk’s corporate strategyIndications Compounds/Capabilities Strategic focus Insulin• Diabetes Expand leadership Expand leadership GLP-1 Drug delivery and protein expertise Global commercial infrastructure GLP-1• Obesity/pre-diabetes Explore opportunity Other proteins• Haemophilia Coagulation factors• Growth hormone Expand franchise disorders Growth hormone• Menopausal symptoms Hormones Maximise value Proteins / mono-• Inflammation Build presence clonal antibodies
  • 7. Our strategy is driven by our coreprotein competencies and protein andpeptide R&D focus Mutation Half-life extension Acylation Sustained release Pegylation Liquid Modification Oral delivery • Genetic • Enzymatic • Chemical E.coli Prefilled pens Yeast Durable pensMammalian cells Infusion devices
  • 8. Novo Nordisk development pipeline This is a Phase 1 placehold er text Phase 2 Phase 3 NN9925 NN9924 Type 2 diabetes Type 2 diabetes NN9068 NN1218 Type 2 diabetes Type 1 and 2 diabetes Semaglutide Liraglutide as anti- Type 2 diabetes obesity agent Obesity NN1952 NN9161 Type 1 and 2 diabetes Obesity Fast-acting rFVIIa analogue Haemophilia with inhibitors DegludecPlus Type 1 and 2 diabetes N8-GP (rFVIII glycopegylated) N7-GP (rFVIIa Haemophilia A Degludec glycopegylated) Haemophilia with inhibitors Type 1 and 2 diabetes Subcutaneous, N7-GP (rFVIIa glycopegylated) rFXIII Haemophilia with inhibitors rFXIII FXIII Congenital deficiency Cardiac surgery N9-GP (rFIX glycopegylated) N8 (rFVIII) Haemophilia B Anti-NKG2D Haemophilia A Inflammation Anti-IL21 Anti-C5aR Anti-IL20 Inflammation Inflammation Inflammation diabetes haemophilia inflammation
  • 9. Research focus areas across Novo Nordisk World-class research in target discovery and validation, lead identification and optimization Focus disease areas at Novo Nordisk today: • Diabetes • Haemophilia • Obesity • Inflammation Måløv, Gentofte, Beijing, Seattle, DK DK China Wash., USA Protein science and technologies
  • 10. Diabetes is a growing disease area with continued unmet treatment needs Global disease impact Overweight or obese people in the US with prediabetes, Global burden of … and the epidemic diabetes 2010: diabetes and/or CV risk factors is growing fast From 6.6% today to an ~ 8% by 4 million 2030; Prediabetes Dyslipidemia deaths From 285 to 435 million patients 20M 450 Million people with diabetes 1+ million amputations 400 11M 2M 500,000+ 350 11M 18M 16M 7M 5M kidney 2M 300 failures 13M 250 300,000+ cases 14M 200 of blindness Hypertension Diabetes 150 $376 billion in 2000 2005 2010 2015 2020 2025 2030 global healthcare expenditure Source: NHANES (2007) Estimated Expected prevalence at diabetes time of prevalence in Diabetes Diabetes Atlas Atlas updates Fourth edition, 2009Sources: IDF Diabetes Atlas 2009;Revealing the cost of Type II diabetes in Europe, Z. Jönsson in Diabetologia (2002)
  • 11. Novo Nordisk is the leader in diabetes care• Global market share leader in diabetes care Total diabetes injectable Market share worldwide• Only company with full range of modern insulins 100%• Leader within insulin delivery systems• Largest number of research projects• Largest private research budget within diabetes Novo Nordisk 43% Sanofi Aventis 30% Eli Lilly 25% Others 1 % 2010
  • 12. Strongest and most diverse diabetesresearch portfolio in the industryResearch and Research Industry leadingsourcing focus strategies diabetes portfolio Optimized PK/PD Fast acting analoguesInsulin GLP-1 Long acting Increased efficacy analogues Oral Delivery Oral formulations Tailored tissue Combination selectivity treatmentsAnti Functional selective Novel MOA’sobesity Novel anti analogues diabetic drugs
  • 13. Unmet medical needin haemophiliaIndication Unmet medical need • More than 250,000 severe patients worldwideHaemophilia A • Need for improved dosing convenience and improved adherence to prophylaxis • More than 50,000 severe patients worldwideHaemophilia B • Need for more predictable outcomes in on-demand treatment and improved dosing convenience in prophylaxis, • Need for faster resolution of acute bleedingPatients with and more predictable outcomesinhibitors • Increasing need for safe and effective bleeding prophylaxis
  • 14. We aim to provide a full portfolioof haemostatic agents Factor 7 Factor 8 Fast-acting rFVIIa analogue Haemophilia with inhibitors N7-GP (rFVIIa glycopegylated) Haemophilia with inhibitors N8 (rFVIII) Haemophilia ASubcutaneous, N7-GP(rFVIIa glycopegylated) NovoSeven N8-GP (rFVIII glycopegylated)Haemophilia with inhibitors Haemophilia with inhibitors Haemophilia A Marketed N9-GP (rFIX glycopegylated) rFXIII Haemophilia B Cardiac surgery Phases rFXIII FXIII Congenital deficiency 3 2 Factor 13 1 Factor 9
  • 15. Unmet medical need inautoimmune diseasesIndication Unmet medical need • Need for improved efficacyRheumatoid Less than half of patients on biologics achieve clinically relevantArthritis response • Need for improved efficacyPsoriatic Less than half of patients on biologics achieve clinically relevantArthritis responsesInflammatory • Need for improved efficacy and safetyBowel Safe alternatives for TNFα failures needed with fast onset of action,Disease steroid free remission and avoidance of surgerySystemic • Need for improved efficacyLupus Modest efficacy of currently used productsErythematosus
  • 16. We aim for first-in-class inflammation targets Research AutoimmuneTarget focus capabilities diseases T cells Cytokines Target discovery Rheumatoid arthritis Generating, optimizing and Psoriatic arthritis expressing mAbs In vitro biology Systemic lupus Disease association; analysis of human Crohn’s disease tissue samples In vivo biology; MΦ and DCs animal models Type 1 & 2 diabetes
  • 17. We have built immunological researchcompetencies Disease association in patient samples: IHC, ISH, Transcript profiling Placeholder T cells MΦ and DCs Animal Cytokines models Treg function Costimulation IBD Structure/ function analysis Th17 function Cytokine secretion RA Signalling Co-culture monocytes Trafficking SLE Transcript profiling Proliferation T1D Target pairing assays
  • 18. We have a promising pipeline offirst-in-class anti-inflammatory antibodies First-in-class MAb against costimulatory Phase 2 Anti-NKG2D molecule involved in rheumatoid arthritis and Crohn’s disease Fully human MAb against pro- Phase 1 Anti-IL-20 inflammatory cytokine involved in psoriasis and rheumatoid arthritis Humanized MAb against complement Phase 1 Anti-C5aR receptor C5aR involved in rheumatoid arthritis and lupus Fully human MAb against IL-21 Phase 1 Anti-IL-21 for rheumatoid arthritis and other autoimmune diseases
  • 19. We develop devices for diabetes, growth andhaemostasis therapies
  • 20. Partnering and licensing are essential parts ofexecuting our strategy….StrategicpartnershipsTechnologypartnershipsDrug targetpartnerships Equity stakes
  • 21. …and we continuously look fornew partnershipsDiabetes • Novel insulin and GLP-1 peptides and peptidomimetics • Other novel proteins or peptides affecting any aspect of diabetesHaemophilia • Novel non-replacement therapies that improve haemostasisInflammation • Novel and innovative protein and peptide therapies for rheumatoid arthritis, psoriatic arthritis, systemic lupus and Crohn’s diseaseTechnology • Technologies for expressing, modifying or producing proteins and peptides • Formulation and drug delivery technologies for proteins and peptides
  • 22. We have three interrelated tools Strategic collaborations and licensing Acquisitions Equity investments