Institut Curie presentation - Dec 2010
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Institut Curie presentation - Dec 2010 Institut Curie presentation - Dec 2010 Document Transcript

  • Patient Care are r Inno Innova I nova Innovation Research Research esearch esear Commitment Achievemen Achieveme t Achievement e ent Discovery Sh Share Share Development Hope Teachin Teaching Accompany Accompany Accompany ccom comp y Training Mobilization Transfer Transfer Transfer ans ansf r D Disse Disse Dissemination Future Together,let’s beat cancer
  • The Institut Curie: a leading center for research, patient care and teachingThe Institut Curie was founded in 1909 Everyone at the Institut Curie – researchers,and became a registered charity in 1921. physicians and medical staff – is committed to ourBased on a model initiated by Marie Curie - motto “Together, let’s beat cancer”. The Institute’s“from fundamental research to innovative resources are used to create an innovation-friendlypatient care” - a model which is just as environment which allows patients to benefit fromforward thinking now as it was in 1909, high-quality healthcare as rapidly as possible.the Institut Curie operates one of thelargest cancer research centers in Europe Research and innovationas well as two hospitals providingstate-of-the-art cancer care. The multidisciplinary, fundamental research performed at the Institut Curie seeks to understand the complex mechanisms which operate in both normal and cancer cells. The ultimate goal is to improve cancer prevention, diagnosis and treatment. The Institut Curie’s research Key figures 2009-2010 data groups have access to cutting-edge imaging, bioinformatics, genomics and proteomics facilities. Translational research ensures that scientific discoveries 3,000 staff are turned into medical innovations. Our researchers and medical staff work from validated concepts to develop 625 articles published in international new diagnostic techniques and safer, more effective scientific and medical journals in 2009 therapeutic approaches. Total 2010 budget (estimate): €298 million, including Patient care 9% from public donations The Institut Curie is a leading center for the treatment 105,000 square meters of hospital of breast cancer, eye tumors and pediatric cancers. In facilities and laboratory space parallel, the Institute continues to diversify its cancer care activities. By always adopting a multidisciplinary approach, the Institut Curie uses the best available skills and high-performance techniques to continuously provide4 INSTITUT CURIE INSTITUT CURIE 1
  • Three strategic objectivescomprehensive, individualized patient care at all stages of Promoting partnerships between physicians andthe disease with the ever-present goal of improving the researchers, rapidly translating scientific discoveriespatient’s quality of life. into clinical applications and improving the qualityAs the birthplace of radiotherapy and a pioneer in of routine care are key assets to the Institut Curie’sconservative treatment and pain management, the Institut development strategy.Curie continues to innovate in complex techniques andtreatment procedures as well as to develop its clinical With 320,000 new cases diagnosedresearch activities. every year in France1, cancer is a ma- jor public health issue. The number ofTeaching and training cancers, which has risen by 12% over the last 5 years2, will continue to in-Teaching and training, high-priority activities at the crease in the immediate future.Institut Curie, contribute to progress in scientific research Discoveries in biology provide us with a better understan-and medicine by actively integrating the latest knowledge ding of cancer and enable us to develop treatments whichgenerated worldwide. Dissemination of this knowledge is are more effective, more personalized and less toxic withessential for keeping society at large informed about our a progressive move towards “made-to-measure” patientactivities and furthering our commitment to medical management.progress and innovation. Turning scientific discoveries into improved healthcare The Curie model: from basic research to innovative treatments The Institut Curie has an ambitious policy to rapidly trans- late scientific advances into better cancer care. As a major cancer center, the Institut Curie is developing novel research programs and medical expertise in cancer mana- RESEARCH TRANSLATIONAL HOSPITAL gement - from the most common to the rarest tumors. CENTER RESEARCH GROUP It is also developing innovative therapies, such as high- precision radiotherapy, oncogenetics and conservative treatment. 1. 2008 estimate from IVS (the French National Institute for Public Health Surveillance). 2. Estimate based on 2007 data from INCa (French National Cancer Institute).2 INSTITUT CURIE INSTITUT CURIE 3
  • Four development axesReaching out to share knowledge With a view to becoming a major player in basic, translational and clinical research, the Institut CurieThe Institut Curie disseminates its scientific and medical cultivates crossdisciplinarity by bringing togetheradvances and participates in the creation of high-level scientists and medical staff and enabling themscientific clusters. Collaborative projects are run within the to share their skills and attain a high level offramework of international programs including hospitals, excellence. We believe that this approach willuniversities, research centers and companies worldwide. increases the cure rate and give rise to a greaterThe Institut Curie also helps to develop relationships life expectancy and fewer side effects.between office-based and hospital physicians as well asfrom one center to another throughout the Paris area, toensure that our patients receive high-quality care once The Institut Curie is committing its human and financialthey leave us. In addition, the Institut Curie is involved in resources to four major development axes:training cancer healthcare specialists as part of the FrenchNational Federation of Cancer Centers. ❚ Boosting our technological and human resources in fundamental research, to better understand how cancer develops and to promote innovation. ❚ Reinforcing the research-care-teaching model within the institute, so that patients benefit sooner from scientific progress through better diagnosis and optimized care. ❚ Transforming the hospital. To be able to accommodateAttracting and retaining top talent more patients, allow greater focus on individualized patient care and define new patient pathways.The Institut Curie is committed to recruiting and retaininghigh-level staff and thus underpins its attractiveness through ❚ Promoting medical innovation by extending the Instituta variety of measures: hosting PhD students, postdocs and Curie’s international outreach so that more patients cansenior researchers from around the world; maintaining a benefit from our expertise.high carer/patient ratio; providing fellowships for clinicalstaff so that they can devote time to research, innovationand teaching.4 INSTITUT CURIE INSTITUT CURIE 5
  • Private-and public-sectorfundingThe Institut Curie attracts funding from a diverse Curie which also hasrange of private-and public-sector sources. 150,000 regular donors.This particular funding structure gives the Institute Of these, 13,000 havethe financial independence it needs to pursue its committed to long-term,missions of public interest. direct-debit donations and thus have become Friends of the InstitutAs a registered charity, the Institut Curie is accredited Curie. The regularity ofto receive donations and legacy gifts. The public’s gene- direct-debit donationsrosity helps to accelerate innovation in research and means that we can planpatient care. our activities several years ahead and perform work which requires significantDonations from the general public time and financial resources.In 2009, the Institut Curie received €27.3 million in dona- The Institut Curie organizes fundraising events throughouttions from the general public (i.e. 13% of its resources) but France. Every year, dozens of Courir pour la Vie, Courirmanaged to limit its fundraising costs to €3.3 million. pour Curie (Run for Life, Run for Curie) charity runs areHence, over 77% of each donation is channeled directly to organized to raise money for research. Over the last 20the Institut Curie’s social missions: cancer research, years, this event has raised more than €4.3 million.patient care, teaching and training. Corporate donationsThe generosity of private donors is essential and helpsinitiate projects that would not otherwise be possible. By The Institut Curie is fortunate to receive donations fromacting as a catalyst for innovative research programs, private long-term corporate partners. By becoming corporatedonations accelerate our scientific discoveries and thus donors, companies can see the impact of their financialthe development and implementation of new diagnostic commitment. Thanks to its corporate partners, the Instituteand therapeutic approaches. can offer additional resources to researchers and physi- cians - resources which directly benefit patients. This loyaltyEach year, over 100 legacy gifts are made to the Institut is fundamental for fulfilling the Institut Curie’s missions.6 INSTITUT CURIE INSTITUT CURIE 7
  • The Institut Curie’s funding sources 2009 data ❚ Most medical care activities are funded by public and private health insurers. 58% Public health insurance funds €127m Public generosity 13% €27.3 m 49.9% donations and 50.1% legacy gifts ❚ Research costs (salaries, opera- 9% Prior funds carried froward €18.4m ting costs and investments) are funded by the Institut Curie, the French National Center for Scien- 5% Subsidies and other public grants tific Research (CNRS), the French €11.3m National Institute for Health and Medical Research (Inserm) and universities. The Institut 5% Release of provisions Curie’s own research costs are sourced from public €10.9m donations, a grant-in-aid from the French Department of Education and Research and private-and public- 4% Other income sector research contracts (usually won through calls €9.7m for tender). 4% Other private funds €8.6m 2% Financial products €4.6m8 INSTITUT CURIE INSTITUT CURIE 9
  • RESEARCHGenerating knowledgeTo improve cancer prevention, diagnosis andtreatment, our researchers and physicians have Key figures 2009-2010 datajoined forces in a multidisciplinary fight against 84 research teams organizedcancer. The Institut Curie deploys fundamental, into 15 joint CNRS/Inserm/University unitstranslational and clinical research programs forthe benefit of cancer patients. 962 people: researchers, technicians and administrative staffThe Institut Curie strives for excellence by designing inno- 45 nationalitiesvative concepts and cutting-edge techniques. By bringing 36 average agetogether expertise and innovation-focused resources, the €63m in research expenditure in 2009institute’s Research Center constitutes a favorable envi-ronment for scienctific progress. €31m in multiyear research contracts obtained in 2009One of the largest cancer research centersin Europe Technical platforms made availableUnderstanding the complexity of life to the scientific community at largeBy involving biologists, chemists, physicists, computational ❚ High-throughput genome and DNA sequencingbiologists and physicians, the Institut Curie’s research ❚ Proteomics/mass spectrometryaims at improving cancer prevention, diagnosis and ❚ Histologytreatment by seeking to understand how both normal and ❚ Bioinformaticscancer cells work in the following disciplines: ❚ Chemolibrary (library of compounds)❚ Cell biology and developmental biology❚ Immunology One of the highest-spec imaging facilities in Europe❚ Human genetics and oncogenesis (the Nikon Imaging Center@Institut Curie-CNRS and the❚ Epigenetics and genotoxicology Pict-IBiSA Cell and Tissue Imaging Facility)❚ Pharmacochemistry ❚ 30 photon microscopy workstations❚ The physical chemistry of living systems ❚ 5 atomic force microscopes❚ Molecular mechanisms and oncogenesis ❚ 4 electron microscopes❚ Cellular and molecular imaging ❚ 1 ion microscope❚ Bioinformatics and systems biology ❚ 1 research-dedicated MRI system10 INSTITUT CURIE INSTITUT CURIE 11
  • TRANSLATIONALRESEARCH &TECHNOLOGY TRANSFEREssential bridgesto medical progressBy combining the expertise of scientific researchersand oncologists, translational research leverages Key figures 2009-2010 datafundamental scientific discoveries and accelerates More than 40 researchers, physicians,the development of diagnostic & prognostic tools, engineers and techniciansmedical devices and therapeutics. This is a priority dedicated to translational researchat the Institut Curie. 1 000 m2 of lab space for translational researchProviding physicians with novel, research-derived medical Around 120 patent familiesprocedures is at the heart of the Institut Curie’s mission. Over 50 licensing agreementsTo be able to offer high-performance, personalizedtreatments, we need to find new drug targets, establish More than 100 ongoing industrial partnershipsdiagnostic criteria and identify factors which predicttreatment response. 10 spin-off companiesThe “Curie model” in action The development of inventionsThe Institut Curie’s translational research is based on: and innovations at the Institut❚ a dedicated translational research Department Curie, relies on cutting-edge❚ the Research Center’s research groups technical facilities, biological❚ the care teams in the Hospital Group resource centers and compound libraries.The clinical research programsperformed in the Institut Curie’s Research outcomes for better patient care:hospitals target both the most ❚ New pain treatment.common and the rarest types of ❚ The first genetic test for Ewing’s tumor in children.cancer. ❚ Improved diagnosis of predisposition to breast and ovarian cancers.12 INSTITUT CURIE INSTITUT CURIE 13
  • PATIENT CAREExcellence in cancer careThe Institut Curie operates two cancer centers onthree sites (Paris and nearby Saint-Cloud and Orsay). Key figures 2009-2010 dataThe Proton Therapy Center is located in Orsay. 2,100 people: carers, engineers, technicians and administrative staffHospitals combining human 3 sites in the Paris area: Paris, Orsay and Saint-Cloudand technical expertise 10,900 patients treated each yearThe Institut Curie’s Hospital Group is an internationally (new and ongoing)renowned center for the diagnosis and treatment of breast 6,000 patients treated for breast cancercancer, eye tumors and pediatric cancers, as well as each yearsarcoma, lymphoma and prostate, head & neck, gynecolo-gical, digestive tract, bronchopulmonary, skin and nervous 160,000 consultations per yearsystem cancers. It is also a reference center for innovative 356 beds and placestreatments such as high-precision radiotherapy, oncoge- €207m spent on medical care in 2009netics and conservative treatments. The Institut Curie alsoconducts numerous clinical studies. Caring for children and adults with cancer ❚ Medical imaging ❚ Biological assays and genetic testing ❚ Surgery ❚ Radiotherapy ❚ Ooncological medicine ❚ Supportive careThanks to a consistently multidisciplinary approachbetween specialists in oncology, pain control and suppor- The Hospital Group interacts with several healthcaretive care with an ever-present concern for the patient’s networks and signs agreements with other establishmentsquality of life, the Institut Curie is able to treat cancer when a particular technology and/or complementarypatients at all stages of their disease. skills are required.14 INSTITUT CURIE INSTITUT CURIE 15
  • TEACHING& TRAININGSharing knowledgeand know-howTeaching and training are priorities at the InstitutCurie; they help develop scientific research and Key figures December 2009 datamedicine by actively integrating the latest knowledge 50 masters studentsgenerated worldwide. 200 PhD studentsTeaching and training courses offered 100 third-year medical studentsby the Institut Curie 70 postdoctoral residents❚ International, multidisciplinary courses (sometimes on inter-university programs)❚ Foundation courses❚ Multidisciplinary graduate and postgraduate courses 40 physicians working as residents in medicine and paramedical in teaching hospitals❚ University modules 45 nationalities Raising awareness is part of the fightThe Institut Curie organizes high-level courses for gra- against cancerduate and postgraduate students interested in all aspectsof cancer research, from the most fundamental work The Institut Curie organizes monthly seminarsthrough to clinical applications. for the general public. The question & answerThe Institut Curie’s dynamic, international and integrated sessions provide members of the public withenvironment creates synergy and offers a unique setting an opportunity to dialogue with the institute’sfor novel teaching and training initiatives defined in par- researchers and physicians on topical issuestnership with universities, postgraduate programs and in biology, medicine and physics.national research institutes. Tel. +33 (0)1 56 24 55 24 www.curie.fr16 INSTITUT CURIE INSTITUT CURIE 17
  • An extraordinary history2010❚ Merger between the Institut Curie and the René Huguenin Cancer Center. The Curie Museum❚ Inauguration of the new Proton Therapy Center. The Curie Museum displays the Institut Curie’s rich2008 Creation of the cancer biology and developmental biology scientific heritage. The museum recounts the personal❚ research department. and professional history of “the family with five Nobel2003 Implementation of conformational 3D radiotherapy («sculpted» Prizes” and highlights the major steps in the discovery❚ to match the shape of the tumor) for the first time in France. of radioactivity, the fight against cancer and the Institut1998 Implementation of brachytherapy for localized prostate cancer. Curie’s history. Marie Curie’s private office and1995 Creation of the cancer biology research department. chemistry laboratory constitute the historic heart1991 Inauguration of the Proton Therapy Center. of the Institut Curie.❚ The first oncogenetic consultations in France.1989 Inauguration of the Irène Joliot-Curie Parent House, The Curie Museum is temporarily closed (until the second❚ after a public fundraising campaign. half of 2011) while its facilities and exhibits are being refur-1977 Creation of the Pediatric Oncology Service (one of the first in France). bished and updated. All the refurbishment work is funded1970 Merger between the Curie Foundation and the Radium Institute: by a legacy gift from Eve Curie-Labouisse, Pierre and Marie❚ the Institut Curie is born. Curie’s youngest daughter who died in New York in 2007.1959 Creation of the René Huguenin Cancer Center. Eve always felt very close to the Institut Curie and wanted1958 The first successful bone marrow transplants in irradiated subjects. the Curie Museum to be renovated in her mother’s memory.1935 Irène and Frédéric Joliot-Curie win the Nobel Prize The work will improve access to the Curie Museum’s❚ in Chemistry for the discovery of artificial radioactivity. collections of objects, documents and archives and will1922 Development of innovative combinations of surgery and radiotherapy. enhance its international profile. The objective is to conserve1921 Granted charitable status. and display the collections more effectively. The functional1920 Creation of the Curie Foundation, France’s first ever center characteristics of the available exhibition space have been❚ for cancer treatment. optimized to meet the public’s expectations.1911 Marie Curie wins the Nobel Prize in Chemistry for her work❚ on radioactivity.1909 Following the award of the 1903 Nobel Prize in Physics The Curie Museum❚ for her discovery of natural radioactivity, Marie Curie Tel. +33 (0)1 56 24 55 33 Web site: musee.curie.fr❚ (with Professor Claudius Regaud) founds the Radium Institute❚ (research on ionizing radiation and its medical applications❚ in cancer treatment). The museum is scheduled to reopen the second half of 201118 INSTITUT CURIE INSTITUT CURIE 19
  • Corporate governance How to make a donationat the Institut Curie to the Institut CurieThe Institut Curie’s governance is overseen by a As a registered charity,Board of Directors, which ensures compliance with the Institut Curie isthe Institute’s charitable objectives, and a Scientific authorized to receive donationsAdvisory Board providing guidance on scientific strategy. and legacy gifts. The Board of DirectorsThe members of the Institut Curie’s Board of Directors At the beginning of the 20th century, several well-knownhave a wide range of skills and come from a variety of figures (like the bankers Henri de Rothschild and Andrébackgrounds guaranteeing the independence and ethical Lazard) helped Marie Curie to found the institute. Theirnature of the Institute’s strategic choices and the rigor of descendants continue to support the Institut Curie toits management procedures (particularly the approval of this day, along with 150,000 other donors.the Institute’s budget and annual accounts). The President,Professor Claude Huriet, was reelected in 2007 for another ❚ Our donors’ generosity is crucial for making essentialsix-year term of office. progress in cancer treatment and research. The Scientific Advisory Board ❚ Become part of this wonderful chain of generosity and invest in innovation to help support the fight against cancer - a major public health issue. To support the Institut Curie, you can: Contact ❚ donate ❚ Yves Congal Donor Relations Manager Tel. +33 (0)1 56 24 55 66 yves.congal@curie.fr From left to right: Prof. James Spudich, Prof.Thierry Boon-Falleur, Prof. Denis Duboule, Prof. Iain Mattaj, Prof. Nicole Le Douarin, ❚ make a donation Contact Prof. Marc Van De Vijver, Prof. Paul Nurse, Prof. Ian F. Tannock. ❚ Isabelle Le RoiThe Institut Curie’s Scientific Advisory Board is composed ❚ make a legacy gift Legacies Relations Managerof internationally renowned researchers and cancer re- ❚ take out Tel. +33 (0)1 56 24 55 01search center directors from around the world. It provides live assurance isabelle.leroi@curie.frstrategic advice on all the Institute’s policy decisions andactivities. The President, Nobel Prize winner ProfessorPaul Nurse, was re-elected in 2009 for another two-year Institut Curieterm of office. 26 rue d’Ulm 75248 PARIS CEDEX 05 - FRANCE20 INSTITUT CURIE INSTITUT CURIE 21
  • Institut CurieAn accredited charitable foundation26 rue d’Ulm, 75248 PARIS CEDEX 05, FRANCETel. +33 (0)1 56 24 55 00www.curie.frCommunications, Marketing and Fundraising Department – December 2010Graphic design Dominique Hamot - Photos Franck Perez - Pedro Lombardi - Eric Bouvet - Noak/Le barFloréal - Silvia Fre - Sylvie Robine - Michel Brisset - Dominique Hamot - ACJC/Musée Curie/ Institut Curie -Phovoir - Susanna Blavarg/Johnér/Photononstop.Printed by tcgraphite with plant-based ink on paper from sustainably managed forests.Do not litter