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Flow Focusing Encapsulation

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  • 1. Flow Focusing®: Select Size 0.9 microns 5 microns 15 microns 50 microns 350 microns 1500 3500 7000 microns microns microns
  • 2. Flow Focusing®: Select Structure 11 microns 5 microns 37 microns 15 microns
  • 3. High value Starting Material, FF®Lactobacillus, 31 Omega 3, ~ 80 Flavour , 40microns microns micronsVitamin A, ~ 90 Peptide, 800 Anti inflammatory, 8microns nanometers (0.8 microns microns)
  • 4. Formulation → FF® → Hardening FORMULATION Homogeneous solutions Emulsions Suspensions API 12 microns HARDENING Spray Drying Spray Chilling Extraction/Evaporation Ionic Gelation Maltodextrin, 22 microns
  • 5. Formulation → FF® → Hardening FORMULATION Homogeneous solutions Emulsions Suspensions Oily emulsion 38 microns HARDENING Spray Drying Spray Chilling Extraction/Evaporation Ionic Gelation Protein, 14 microns
  • 6. Formulation → FF® → Hardening FORMULATION Homogeneous solutions Emulsions Suspensions Lactobacilus, 31 microns HARDENING Spray Drying Spray Chilling Extraction/Evaporation Ionic Gelation Magnetic nanoparticles, 5 microns
  • 7. Formulation → FF® → Hardening FORMULATION Homogeneous solutions Emulsions Suspensions Oily emulsion 38 microns HARDENING Spray Drying Spray Chilling Extraction/Evaporation Ionic Gelation Flavor 37 microns
  • 8. Formulation → FF® → Hardening FORMULATION Homogeneous solutions Emulsions Suspensions Omega 3, ~ 80 microns HARDENING Spray Drying Spray Chilling Extraction/Evaporation Ionic Gelation Flavor 40 microns
  • 9. Formulation → FF® → Hardening FORMULATION Homogeneous solutions Emulsions Suspensions Protein, 14 microns HARDENING Spray Drying Spray Chilling Extraction/Evaporation Ionic Gelation Magnetic nanoparticles, 5 microns
  • 10. Formulation → FF® → Hardening FORMULATION Homogeneous solutions Emulsions Suspensions Lactobacilus, 31 microns HARDENING Spray Drying Spray Chilling Extraction/Evaporation Ionic Gellation Stem cells, ~170 microns
  • 11. Flow Focusing®Flow Focusing® is able to very gently produce microparticles ofrequired composition and dimension, all the same as each other.The jet goes out through the outlet without touching it. 3-D focusing of the jet by means of a mechanical process: pressurized air, gas or liquid. No smashing, no electricity, no chemical process needed. The same nozzle allows the direct production of selectable sizes within an ample range.
  • 12. Flow Focusing® microencapsulationHigh Value Starting Material + Homogeneous solutions,Additives + suspensions, emulsions, meltedPolymeric Matrix substances, etc Developed formulation Focusing air or water Solidification/ Hardening Ionic gelation, hot air, extraction evaporation …
  • 13. Concentric Flow Focusing® microencapsulation Most common formulation Homogeneous solutions, suspensions, emulsions, etc Outer layer - Polymeric Matrix + Additives Focusing with air or waterInner layer –High Value Starting Solidification/Material + Additives HardeningHomogeneous solutions, Ionic gelation, hot air,suspensions, emulsions, melted extraction evaporation …substances, etc
  • 14. Flow Focusing® Advantages Desired Size: for each way of administration From mm down to several hundreds nm Easy and simple: in just one step High Accuracy: dose control, cost effective, CV < 8% No sieving, filtering, no cyclones, no additional steps Versatility: No limits on formulation, any liquid We just need a liquid or a emulsion to make it flow Validated for many different substances and shell materials Very smooth mechanical process: Extra stability and bioavailability
  • 15. Ingeniatrics’ capacities3 pilot-plants, 2 assembly rooms: Pharmaceutical – ISO 9001, ISO 14001, ISO 7 - GMP,* *in progress Food – ISO 9001, IS0 14001, AESAN Regulation CE 853/2004, ISO 8 Chemistry – ISO 9001, ISO 14001
  • 16. Ingeniatrics’ Capabilities QUICK SPEC ON INGENIATRICS CAPABILITIESF. Focusing® Nozzles SD FF100, SD FF200, SD FF 350, SD From several microns FF500, to tens/hundreds of microns SD FF700F. Focusing® Concentric Nozzles SD cFF 350, SD cFF500 From several microns to tens of micronsF. Blurring® Nozzles SD FB240, SDFB500 From nanometers to few tens of micronsPolymers Gums: Arabic gums, shellac, etc. Celluloses: EC, CMC, HPMCP, etc Acrylic derivatives: Eudragits (S100, E100, NM30D), etc Polyvinyl derivatives: Sureteric, Kollidon, etc Poly ester derivatives: PLGA Others: Lactose, maltodextrine, alginates, mixtures of variousProducts in formulation Drugs, Food ingredients, Oils (by emulsification), enzymes, particles (suspensions), Additives (glidance, adsorbents, plasticizers, etc)Products in inner core(for concentric) Emulsions, fragrances, drugs, oils, pigments, etc ..
  • 17. Business Model (II)Our technological service offer Development &Production of high value microspheres based on ourproprietary technology for Microencapsulation: Study and evaluation of starting material. Design of innovative solutions for the required applicationbased on our technology. Pre-formulation studies and technology fitting. Microparticle characterization : morphology, composition, analytical methods, etc. Initial studies: stability, drug delivery profiles… Scale-up and microparticle production. Plata. C/Camino Mozárabe, 41 PI Parque 41900 Camas, Sevilla. España/Spain T. (+34)954 081 214 F. (+34)955 980225 18