Flow Focusing®Flow Focusing® is able to very gently produce microparticles ofrequired composition and dimension, all the same as each other.The jet goes out through the outlet without touching it. 3-D focusing of the jet by means of a mechanical process: pressurized air, gas or liquid. No smashing, no electricity, no chemical process needed. The same nozzle allows the direct production of selectable sizes within an ample range.
Flow Focusing® microencapsulationHigh Value Starting Material + Homogeneous solutions,Additives + suspensions, emulsions, meltedPolymeric Matrix substances, etc Developed formulation Focusing air or water Solidification/ Hardening Ionic gelation, hot air, extraction evaporation …
Concentric Flow Focusing® microencapsulation Most common formulation Homogeneous solutions, suspensions, emulsions, etc Outer layer - Polymeric Matrix + Additives Focusing with air or waterInner layer –High Value Starting Solidification/Material + Additives HardeningHomogeneous solutions, Ionic gelation, hot air,suspensions, emulsions, melted extraction evaporation …substances, etc
Flow Focusing® Advantages Desired Size: for each way of administration From mm down to several hundreds nm Easy and simple: in just one step High Accuracy: dose control, cost effective, CV < 8% No sieving, filtering, no cyclones, no additional steps Versatility: No limits on formulation, any liquid We just need a liquid or a emulsion to make it flow Validated for many different substances and shell materials Very smooth mechanical process: Extra stability and bioavailability
Ingeniatrics’ capacities3 pilot-plants, 2 assembly rooms: Pharmaceutical – ISO 9001, ISO 14001, ISO 7 - GMP,* *in progress Food – ISO 9001, IS0 14001, AESAN Regulation CE 853/2004, ISO 8 Chemistry – ISO 9001, ISO 14001
Ingeniatrics’ Capabilities QUICK SPEC ON INGENIATRICS CAPABILITIESF. Focusing® Nozzles SD FF100, SD FF200, SD FF 350, SD From several microns FF500, to tens/hundreds of microns SD FF700F. Focusing® Concentric Nozzles SD cFF 350, SD cFF500 From several microns to tens of micronsF. Blurring® Nozzles SD FB240, SDFB500 From nanometers to few tens of micronsPolymers Gums: Arabic gums, shellac, etc. Celluloses: EC, CMC, HPMCP, etc Acrylic derivatives: Eudragits (S100, E100, NM30D), etc Polyvinyl derivatives: Sureteric, Kollidon, etc Poly ester derivatives: PLGA Others: Lactose, maltodextrine, alginates, mixtures of variousProducts in formulation Drugs, Food ingredients, Oils (by emulsification), enzymes, particles (suspensions), Additives (glidance, adsorbents, plasticizers, etc)Products in inner core(for concentric) Emulsions, fragrances, drugs, oils, pigments, etc ..
Business Model (II)Our technological service offer Development &Production of high value microspheres based on ourproprietary technology for Microencapsulation: Study and evaluation of starting material. Design of innovative solutions for the required applicationbased on our technology. Pre-formulation studies and technology fitting. Microparticle characterization : morphology, composition, analytical methods, etc. Initial studies: stability, drug delivery profiles… Scale-up and microparticle production. Plata. C/Camino Mozárabe, 41 PI Parque 41900 Camas, Sevilla. España/Spain T. (+34)954 081 214 F. (+34)955 980225 18