Agnesian HealthCare Know & Go Showcase: Cancer Care

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Dr. Michael Vander Kooy and Dr. Michael Jones present the latest news and information from the Agnesian Cancer Center about technology and the team.

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  • Mutations may be harmless initially but with accumulation of progressive mutations may lead a cell to become malignant with uncontrollable cell growth.
  • Agnesian HealthCare Know & Go Showcase: Cancer Care

    1. 1. What’s New In Cancer Care Michael Vander Kooy, MD Radiation Oncologist Agnesian Cancer Center Know & Go Friday. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Michael Jones, MD Medical Oncologist Agnesian Cancer Center
    2. 2. Advances In Radiation Oncology Michael Vander Kooy, MD Radiation Oncologist Agnesian Cancer Center
    3. 3. Radiation Oncology Michael Vander Kooy, MD Filip Troicki, MD Timothy Korytko, MD
    4. 4. Radiation Therapy Noelle B., RTT Ellie B., RTT Bonnie D., RTT
    5. 5. Radiation Therapy Brian S., RTT Angie H., RN
    6. 6. Radiation Nursing Tammie L., RN Mary L., RNStacy S., RN
    7. 7. Ancillary Associates Tim L. Physicist Phil B. Dosimetrist Heather B., Oncology Supervisor
    8. 8. Ancillary Associates Chris B. Oncology Navigator Liz H., RD Dietitian Kristie M., MSW Social Worker
    9. 9. Agnesian Cancer Center
    10. 10. Linear Accelerator
    11. 11. THANK YOU!
    12. 12. Advances In Medical Oncology Michael Jones, MD Medical Oncologist Agnesian Cancer Center
    13. 13. Medical Oncology Joel Lundberg, MD Michael Jones, MD
    14. 14. Sara S., LPN Betsy M., LPN Rachel S., RN Medical Oncology
    15. 15. Nicki W., RN Margot B., RN Terri B., RN Medical Oncology
    16. 16. Kristin M., RN Cindy K., RN Medical Oncology
    17. 17. Patty S. Pharmacy Technician Travis D., PharmD, RPh Medical Oncology
    18. 18. General Outline What is cancer Cancer heterogeneity and implications for treatment General cancer treatments. Targeted cancer therapy The Story of BCR-ABL and chronic myelogenous leukemia. BRAF and melanoma.
    19. 19. What Is Cancer? What Has Happened?
    20. 20. Cancer Is a Genetic Disease Cancer is a genetic disease that develops in a predictable sequence of steps  Carcinogenesis  Transformation of a normal cell into a cancerous cell  Occurs by a step-by-step transformation  Involves an abnormal change in cell DNA called a mutation.  These mutations facilitate the cell to divide, invade, and metastasize independent of normal cell controls.
    21. 21. Cancer Often Involves Multiple Mutations
    22. 22. Multiple Mutations Influence Cancer Cells Survival
    23. 23. Carcinogenesis Occurs In Predictable Steps
    24. 24. Cancer Heterogeneity and Implications for Treatment
    25. 25. How is Cancer Heterogeneous?
    26. 26. We Are Just Beginning to Understand
    27. 27. General Cancer Treatments
    28. 28. How Does An Oncologist Treat Cancer? Chemotherapy Radiation Therapy Immunotherapy Targeted Therapy
    29. 29. Targeted Cancer Therapy
    30. 30. Targeted Cancer Therapy Identifying specific gene abnormalities which facilitate or allow cancer to grow and divide, and “targets” that abnormality with a specific drug. “Dumb Cancer”- Cancer has developed just a few mutations which are vital to the cancer cell’s survival. “Smart Cancer”- Cancer has developed multiple mutations which facilitate its growth. Each is important but not necessarily vital to cancer cell survival.
    31. 31. Targeted Cancer Therapy The Story of BCR-ABL and Chronic Myelogenous Leukemia
    32. 32. Chronic Myelogenous Leukemia A Simple Cancer Normal blood smear Leukemia blood smear Translocation of DNA in Chromosome
    33. 33. Variations in Chromosomal Deletions Patterns in Patients with Glioblastoma Brain Tumor p53 locus Chromosomal Loss: PTEN locus CDKN2 locus RB1 locus
    34. 34. Chronic Myelogenous Leukemia Normal blood smear Leukemia blood smear Translocation of DNA in Chromosome
    35. 35. Imatinib (Gleevac) in Chronic Myelogenous Leukemia
    36. 36. Impact of Treatment on Patients Lives Treated with Gleevac
    37. 37. Targeted Cancer Therapy Melanoma & BRAF
    38. 38. Melanoma
    39. 39. Mutational Frequency In Melanoma Hodis, Cell 2012
    40. 40. How BRAF Works in Melanoma
    41. 41. Drug Targeting BRAF
    42. 42. 14-Day Response to Vemurafenib
    43. 43. Effects of Vemurafenib On Survival in Metastatic Melanoma
    44. 44. THANK YOU!

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